{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:38:39Z","timestamp":1773920319415,"version":"3.50.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>The use of lithium (Li) for borderline personality disorder (BPD) is limited as the result of a lack of robust clinical evidence with few clinical studies reported. Although a few studies provide supportive evidence for Li use in addressing certain symptoms such as anger management, impulsivity, and inducing self-harm. Therapies for BPD are psychosocial in nature and serve as the primary treatment for BPD. Based on prior clinical management of lithium use in mental health disorders, providers should investigate its usage in the treatment of BPD. The topic is the subject of this review.<\/jats:p>","DOI":"10.3389\/fnbeh.2026.1707007","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:51:21Z","timestamp":1773903081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lithium in borderline personality disorder: neuroplasticity, anti-inflammatory action, and therapeutic potential"],"prefix":"10.3389","volume":"20","author":[{"given":"Leah","family":"Simon","sequence":"first","affiliation":[{"name":"Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University","place":["Davie, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"IV","given":"Halford","family":"Warlick","sequence":"additional","affiliation":[{"name":"The Chicago School","place":["Chicago, IL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armena","family":"Jafarmadar","sequence":"additional","affiliation":[{"name":"Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University","place":["Davie, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Joubran","sequence":"additional","affiliation":[{"name":"Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University","place":["Davie, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Koleng","sequence":"additional","affiliation":[{"name":"Dr. Kiran C. 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