{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:08:50Z","timestamp":1788952130659,"version":"build-2803163510"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cognitive dysfunction and cardiometabolic disturbances frequently coexist in neurological and metabolic disorders. Chronic systemic inflammation in cardiometabolic syndrome may promote neuroinflammation, damaging neurons and synapses and impairing memory pathways.\n                      <jats:italic>Cola nitida<\/jats:italic>\n                      is a medicinal plant widely recognized for its stimulant and therapeutic properties, yet its neuroprotective and cardiometabolic effects remain underexplored. Objective: This study investigated the effects of methanol extract of\n                      <jats:italic>Cola nitida<\/jats:italic>\n                      (CN) in a mouse model of memory and metabolic dysfunction induced by scopolamine and dexamethasone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male mice were randomly divided into six groups (\n                      <jats:italic>n<\/jats:italic>\n                      = 5): control (saline), scopolamine (3 mg\/kg), scopolamine + dexamethasone (0.2 mg\/kg), CN (50 mg\/kg) + scopolamine, CN + scopolamine + dexamethasone, and donepezil (1 mg\/kg) + scopolamine + dexamethasone. Treatments lasted 7 days, followed by behavioral testing (Morris Water Maze, Y-Maze). Biochemical analyses included acetylcholinesterase activity, oral glucose tolerance, lactate\/LDH, oxidative stress markers, and lipid profiles. Hippocampal histology assessed neurodegeneration, while molecular docking evaluated CN phytochemicals against proteins linked to glucose metabolism, oxidative stress, and cholinergic signaling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Co-administration of dexamethasone and scopolamine impaired memory, elevated AChE activity, fasting glucose, and oxidative stress in the brain and heart. CN treatment improved memory and glucose tolerance, reduced oxidative stress and AChE activity, and preserved hippocampal neuronal integrity. Docking revealed strong affinities of CN flavonoids and procyanidins for Akt, GLP-1 receptor, Keap1, AChE, and TYK2, implicating them in glucose regulation, redox balance, and cholinergic neurotransmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings highlight the neuroprotective and cardiometabolic benefits of\n                      <jats:italic>Cola nitida<\/jats:italic>\n                      and support its therapeutic potential for cognitive and metabolic disorders.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnbeh.2026.1803200","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:11:52Z","timestamp":1788948712000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of Cola nitida against dexamethasone- and scopolamine-induced cognitive and cardiac dysfunction"],"prefix":"10.3389","volume":"20","author":[{"given":"Lawrence Dayo","family":"Adedayo","sequence":"first","affiliation":[{"name":"Neurophysiology Unit, Department of Human Physiology, College of Health Sciences, Federal University Wukari","place":["Taraba, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga S.","family":"Michael","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Health Sciences","place":["Bowen University, Iwo, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon Opeyemi","family":"Ayilara","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Basic Medical Sciences, Adeleke University, Ede","place":["Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayode Elizabeth","family":"Olumoroti","sequence":"additional","affiliation":[{"name":"Physiology Programme, College of Health Sciences","place":["Bowen University, Iwo, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olubayode","family":"Bamidele","sequence":"additional","affiliation":[{"name":"Physiology Programme, College of Health Sciences","place":["Bowen University, Iwo, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saminu","family":"Samaila","sequence":"additional","affiliation":[{"name":"Neurophysiology Unit, Department of Human Physiology, College of Health Sciences, Federal University Wukari","place":["Taraba, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtihel","family":"Dhaya","sequence":"additional","affiliation":[{"name":"Laboratory of Neurophysiology, Cellular Physiopathology and Biomolecule Valorization, Faculty of Sciences, University of Tunis El Manar","place":["Tunis, Tunisia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisat Dasola","family":"Akorede","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Sciences, Eko University of Medicine and Health Sciences","place":["Lagos, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Oluwole","family":"Abolarin","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Babcock University, Ilishan-Remo","place":["Ogun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurette N.","family":"Ofodile","sequence":"additional","affiliation":[{"name":"Department of Biological Science, School of Science, Yaba College of Technology","place":["Lagos, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100027","DOI":"10.1016\/j.ynpai.2019.100027","article-title":"Methanol extract of Cola nitida ameliorates inflammation and nociception in experimental animals.","volume":"5","author":"Adedayo","year":"2019","journal-title":"Neurobiol. 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