{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:01:27Z","timestamp":1781157687505,"version":"3.54.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>False contextual fear memory has been attributed to a time-dependent loss of precision in contextual memory representations. In this study, we investigated the role of protein kinase M zeta (PKM\u03b6), a key molecule in the maintenance of hippocampus-dependent long-term memory, in false contextual fear memory within the dorsal (dHPC) and ventral hippocampus (vHPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two weeks prior to behavioral testing, male C57BL\/6J mice (7\u201310 weeks old) received bilateral injections of adeno-associated virus (AAV PHP.eB) into the dHPC or vHPC to induce PKM\u03b6 knockdown (PKM\u03b6 KD), overexpression of wild-type PKM\u03b6 (PKM\u03b6 WT), or kinase-inactive PKM\u03b6 (PKM\u03b6 K281R). False contextual fear memory was assessed by measuring freezing behavior in Context B at 3 and 24 h following exposure to Context A with or without unconditioned stimulus presentation [US(+) and US(\u2212), respectively]. Spatial recognition memory was evaluated using the two-trial novel arm recognition test in the Y-maze.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>As shown in our previous work, mice exhibited freezing in Context B after receiving a US in Context A, whereas mice that did not receive such a stimulus showed minimal freezing. These data confirmed that freezing in Context B reflects false contextual fear memory. False fear responses were evident at 3 h and were further increased at 24 h. Freezing at 24 h was markedly enhanced in dHPC PKM\u03b6 knockdown mice compared with that in AAV control-injected mice. PKM\u03b6 WT overexpression prevented the increase in freezing at 24 h, whereas PKM\u03b6 K281R overexpression mimicked the effects of PKM\u03b6 KD. Furthermore, PKM\u03b6 knockdown in the dHPC impaired spatial recognition memory, indicating that hippocampus-dependent spatial processing was disrupted. In contrast, PKM\u03b6 manipulation in the vHPC did not affect false contextual fear memory but did impair spatial recognition memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings are consistent with the possibility that functional loss of PKM\u03b6 in the dHPC affects contextual memory processes in a manner that may contribute to the time-dependent increase in false contextual fear and impaired spatial recognition memory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnbeh.2026.1837349","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:48:15Z","timestamp":1781156895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional loss of PKM\u03b6 in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice"],"prefix":"10.3389","volume":"20","author":[{"given":"Haruna","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Science, Ohu University, Koriyama","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuna","family":"Kanemoto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Science, Ohu University, Koriyama","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuka","family":"Ohnuma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Science, Ohu University, Koriyama","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Tsuneura","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Aichi Developmental Disability Center, Institute for Developmental Research, Kasugai","place":["Aichi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology, Aichi Developmental Disability Center, Institute for Developmental Research, Kasugai","place":["Aichi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Science, Ohu University, Koriyama","place":["Fukushima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.11.27.625768","article-title":"Hippocampal CA2 neurons disproportionately express AAV-delivered genetic cargo.","author":"Alexander","year":"2024","journal-title":"bioRxiv"},{"key":"B2","doi-asserted-by":"publisher","first-page":"40000","DOI":"10.31083\/jin40000","article-title":"Time-dependent potentiation of false context fear memory through glucocorticoid receptor activation and mineralocorticoid receptor inactivation.","volume":"24","author":"Asano","year":"2025","journal-title":"J. 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