{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:57:34Z","timestamp":1782917854627,"version":"3.54.5"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Behav. Neurosci."],"abstract":"<jats:p>Fear-related disorders\u2014including post-traumatic stress disorder (PTSD), specific phobias, and generalized anxiety disorder\u2014are among the most prevalent and treatment-resistant psychiatric conditions. Despite decades of molecular and cellular advances, systemic pharmacological interventions and approaches targeting isolated brain regions have had limited therapeutic capacity, particularly in refractory patients. This mini-review argues that the translational impasse stems from a reductionist framework that treats mental disorders in general, and fear-related disorders in particular, as a localized phenomenon rather than a distributed network property. We synthesize recent evidence from engram research, oscillatory dynamics, and systems consolidation demonstrating that fear memories are encoded, maintained, and retrieved through brain-wide networks. We outline how emerging technologies such as high-density electrophysiology, calcium imaging, and functional neuroimaging combined with graph-theoretical analysis can map memory networks at scale, enabling precision interventions such as closed-loop neuromodulation and connectivity-based treatment prediction. Adopting a transdiagnostic perspective aligned with the Research Domain Criteria (RDoC), we position persistent aversive memory as a dimensional mechanism that crosses diagnostic boundaries, a perspective we propose as necessary for the development of more effective clinical interventions.<\/jats:p>","DOI":"10.3389\/fnbeh.2026.1844305","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:38:57Z","timestamp":1782916737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mapping memory at scale: systems-level insights with translational and transdiagnostic relevance to fear-related disorders"],"prefix":"10.3389","volume":"20","author":[{"given":"Rodrigo O.","family":"Sierra","sequence":"first","affiliation":[{"name":"Programa de Psicolog\u00eda, Facultad de Humanidades y Ciencias Sociales, Universidad Ean","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ortega-Ferreira","sequence":"additional","affiliation":[{"name":"Programa de Psicolog\u00eda, Facultad de Humanidades y Ciencias Sociales, Universidad Ean","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M.","family":"Duran","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Sociales y Humanas, Fundaci\u00f3n Universitaria del \u00c1rea Andina","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizeth K.","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Laboratorio de Bases Biol\u00f3gicas del Comportamiento, Facultad de Ciencias del Comportamiento, Universidad de La Sabana","place":["Ch\u00eda, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"B1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"B2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nn.4502","article-title":"Network neuroscience.","volume":"20","author":"Bassett","year":"2017","journal-title":"Nat. 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