{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:10:12Z","timestamp":1791407412497,"version":"4.3.3"},"reference-count":67,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2014.00291","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T13:47:41Z","timestamp":1410875261000},"source":"Crossref","is-referenced-by-count":73,"title":["Neural precursor cells in the ischemic brain \u00e2\u20ac\u201c integration, cellular crosstalk, and consequences for stroke recovery"],"prefix":"10.3389","volume":"8","author":[{"given":"Dirk M.","family":"Hermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Peruzzotti-Jametti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Schlechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Bernstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten R.","family":"Doeppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pluchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1161\/STROKEAHA.110.606368","article-title":"The CCR2\/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain.","volume":"42","author":"Andres","year":"2011a","journal-title":"Stroke"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1093\/brain\/awr094","article-title":"Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.","volume":"134","author":"Andres","year":"2011b","journal-title":"Brain"},{"key":"B3","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nature04940","article-title":"Notch signalling regulates stem cell numbers in vitro and in vivo.","volume":"442","author":"Androutsellis-Theotokis","year":"2006","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke.","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1093\/brain\/awp174","article-title":"Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.","volume":"132","author":"Bacigaluppi","year":"2009","journal-title":"Brain"},{"key":"B6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/S1044-7431(03)00218-5","article-title":"Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells.","volume":"24","author":"Ben-Hur","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/01.STR.0000247888.25985.62","article-title":"Cell transplantation therapy for stroke.","volume":"38","author":"Bliss","year":"2007","journal-title":"Stroke"},{"key":"B8","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/glia.20616","article-title":"In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia.","volume":"56","author":"Cacci","year":"2008","journal-title":"Glia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jns.2005.08.015","article-title":"Neuroregenerative effects of BMP7 after stroke in rats.","volume":"240","author":"Chou","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"B10","first-page":"149","article-title":"Aging of the subventricular zone neural stem cell niche.","volume":"2","author":"Conover","year":"2011","journal-title":"Aging Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/brain\/awr339","article-title":"Transplanted neural stem\/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord.","volume":"135","author":"Cusimano","year":"2012","journal-title":"Brain"},{"key":"B12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/jcbfm.2010.81","article-title":"Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain.","volume":"31","author":"Darsalia","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1002\/stem.1098","article-title":"Transduction of neural precursor cells with TAT-heat shock protein 70 chaperone: therapeutic potential against ischemic stroke after intrastriatal and systemic transplantation.","volume":"30","author":"Doeppner","year":"2012","journal-title":"Stem Cells"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/S0140-6736(08)60694-7","article-title":"Stroke.","volume":"371","author":"Donnan","year":"2008","journal-title":"Lancet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/j.biochi.2013.06.020","article-title":"The stem cell secretome and its role in brain repair.","volume":"95","author":"Drago","year":"2013","journal-title":"Biochimie"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.neuroscience.2008.06.052","article-title":"Brain inflammation and adult neurogenesis: the dual role of microglia.","volume":"158","author":"Ekdahl","year":"2009","journal-title":"Neuroscience"},{"issue":"1797","key":"B17","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005568","article-title":"Cell-based therapeutics: the next pillar of medicine.","volume":"5","author":"Fischbach","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"468748","key":"B18","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/468748","article-title":"Stem cell-based therapies for ischemic stroke.","volume":"2014","author":"Hao","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"e50444","key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050444","article-title":"Human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke.","volume":"7","author":"Hassani","year":"2012","journal-title":"PLoS ONE"},{"key":"B20","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.expneurol.2005.07.024","article-title":"TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts in adult rat brain.","volume":"196","author":"Heldmann","year":"2005","journal-title":"Exp. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S1474-4422(12)70039-X","article-title":"Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation.","volume":"11","author":"Hermann","year":"2012","journal-title":"Lancet Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1161\/01.STR.0000190020.30282.cc","article-title":"Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin.","volume":"36","author":"Hoehn","year":"2005","journal-title":"Stroke"},{"key":"B23","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.nbd.2004.10.010","article-title":"Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat.","volume":"18","author":"Jin","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S1044-7431(03)00159-3","article-title":"Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum.","volume":"24","author":"Jin","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.brainres.2010.12.037","article-title":"Effect of human neural precursor cell transplantation on endogenous neurogenesis after focal cerebral ischemia in the rat.","volume":"1374","author":"Jin","year":"2011","journal-title":"Brain Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.nbd.2012.08.020","article-title":"Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice.","volume":"49C","author":"Kang","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.nbd.2009.11.002","article-title":"Forebrain neurogenesis after focal Ischemic and traumatic brain injury.","volume":"37","author":"Kernie","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B28","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S0006-8993(99)01563-2","article-title":"Induction of glial cell line-derived neurotrophic factor receptor proteins in cerebral cortex and striatum after permanent middle cerebral artery occlusion in rats.","volume":"834","author":"Kitagawa","year":"1999","journal-title":"Brain Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1006\/exnr.1995.1085","article-title":"Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage.","volume":"136","author":"Kokaia","year":"1995","journal-title":"Exp. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.neulet.2008.05.090","article-title":"The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats.","volume":"440","author":"Lappalainen","year":"2008","journal-title":"Neurosci. Lett."},{"key":"B31","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke.","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"B32","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neuroscience.2009.05.050","article-title":"Transforming growth factor alpha induces angiogenesis and neurogenesis following stroke.","volume":"163","author":"Leker","year":"2009","journal-title":"Neuroscience"},{"key":"B33","doi-asserted-by":"publisher","first-page":"22680","DOI":"10.1074\/jbc.M109.006551","article-title":"Angiopoietin 2 mediates the differentiation and migration of neural progenitor cells in the subventricular zone after stroke.","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1161\/01.STR.0000251791.64910.cd","article-title":"Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia.","volume":"38","author":"Liu","year":"2007","journal-title":"Stroke"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1161\/CIRCULATIONAHA.108.191261","article-title":"Heart disease and stroke statistics\u00e2\u20ac\u201c2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1093\/brain\/awr115","article-title":"Therapeutic stem cell plasticity orchestrates tissue plasticity.","volume":"134","author":"Martino","year":"2011","journal-title":"Brain"},{"key":"B37","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nrn1908","article-title":"The therapeutic potential of neural stem cells.","volume":"7","author":"Martino","year":"2006","journal-title":"Nat. Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.nbd.2012.12.006","article-title":"Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioral recovery after middle cerebral artery occlusion in rats.","volume":"52","author":"Mine","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1161\/STROKEAHA.110.599282","article-title":"Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke.","volume":"42","author":"Minnerup","year":"2011","journal-title":"Stroke"},{"key":"B40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.stem.2008.07.004","article-title":"Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brain.","volume":"3","author":"Mirzadeh","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1634\/stemcells.2005-0568","article-title":"Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins.","volume":"24","author":"Mueller","year":"2006","journal-title":"Stem Cells"},{"key":"B42","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/ana.10393","article-title":"Rat forebrain neurogenesis and striatal neuron replacement after focal stroke.","volume":"52","author":"Parent","year":"2002","journal-title":"Ann. Neurol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.04.036","article-title":"The role of the immune system in central nervous system plasticity after acute injury.","author":"Peruzzotti-Jametti","year":"2014","journal-title":"Neuroscience"},{"key":"B44","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/(SICI)1098-1136(199806)23:2120::AID-GLIA33.0.CO;2-A","article-title":"Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain.","volume":"23","author":"Planas","year":"1998","journal-title":"Glia"},{"key":"B45","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.expneurol.2008.08.006","article-title":"Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke.","volume":"214","author":"Plane","year":"2008","journal-title":"Exp. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/glia.22500","article-title":"How stem cells speak with host immune cells in inflammatory brain diseases.","volume":"61","author":"Pluchino","year":"2013","journal-title":"Glia"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1093\/brain\/awt330","article-title":"Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons.","volume":"136","author":"Pluchino","year":"2013","journal-title":"Brain"},{"issue":"e5959","key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005959","article-title":"Immune regulatory neural stem\/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function.","volume":"4","author":"Pluchino","year":"2009","journal-title":"PLoS ONE"},{"key":"B49","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nature03889","article-title":"Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.","volume":"436","author":"Pluchino","year":"2005","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/sj.jcbfm.9600172","article-title":"Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia.","volume":"26","author":"Robin","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1172\/JCI23559","article-title":"The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis.","volume":"115","author":"Schneider","year":"2005","journal-title":"J. Clin. Invest."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1161\/STROKEAHA.109.561951","article-title":"Sonic hedgehog regulates ischemia\/hypoxia-induced neural progenitor proliferation.","volume":"40","author":"Sims","year":"2009","journal-title":"Stroke"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia.","volume":"111","author":"Sun","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1038\/jcbfm.2014.61","article-title":"Neural stem cell protects aged rat brain from ischemia-reperfusion injury through neurogenesis and angiogenesis.","volume":"34","author":"Tang","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/JCI200317170","article-title":"EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.","volume":"111","author":"Teramoto","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B56","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1634\/stemcells.2005-0281","article-title":"Persistent production of neurons from adult brain stem cells during recovery after stroke.","volume":"24","author":"Thored","year":"2006","journal-title":"Stem Cells"},{"key":"B57","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/glia.20810","article-title":"Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.","volume":"57","author":"Thored","year":"2009","journal-title":"Glia"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1161\/STROKEAHA.107.488445","article-title":"Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke.","volume":"38","author":"Thored","year":"2007","journal-title":"Stroke"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1093\/brain\/awt278","article-title":"Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery.","volume":"136","author":"Tornero","year":"2013","journal-title":"Brain"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1227\/01.NEU.0000186040.96929.8A","article-title":"EGF and FGF-2 infusion increases post-ischemic neural progenitor cell proliferation in the adult rat brain.","volume":"57","author":"Tureyen","year":"2005","journal-title":"Neurosurgery"},{"key":"B61","doi-asserted-by":"publisher","first-page":"5996","DOI":"10.1523\/JNEUROSCI.5380-05.2006","article-title":"Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration.","volume":"26","author":"Wang","year":"2006","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/jcbfm.2009.83","article-title":"Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo.","volume":"29","author":"Wang","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1038\/sj.jcbfm.9600432","article-title":"Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia.","volume":"27","author":"Yan","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B64","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1440-1789.2010.01182.x","article-title":"Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri-infarct angiogenesis after focal cerebral ischemia.","volume":"31","author":"Zhang","year":"2011","journal-title":"Neuropathology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/jcbfm.2009.55","article-title":"Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse.","volume":"29","author":"Zhang","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1038\/sj.jcbfm.9600430","article-title":"Stroke induces ependymal cell transformation into radial glia in the subventricular zone of the adult rodent brain.","volume":"27","author":"Zhang","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5810","DOI":"10.1523\/JNEUROSCI.1109-04.2004","article-title":"Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat.","volume":"24","author":"Zhang","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T19:50:06Z","timestamp":1424289006000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2014.00291\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,16]]},"references-count":67,"URL":"https:\/\/doi.org\/10.3389\/fncel.2014.00291","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,16]]}}}