{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:57:24Z","timestamp":1790189844292,"version":"4.1.0"},"reference-count":87,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2015.00138","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T13:17:30Z","timestamp":1428585450000},"source":"Crossref","is-referenced-by-count":30,"title":["Additional mechanisms conferring genetic susceptibility to Alzheimer\u00e2\u20ac\u2122s disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Miguel","family":"Calero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"G\u00c3\u00b3mez-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Calero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00c3\u00bas","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.neuron.2009.12.016","article-title":"The transcellular spread of cytosolic amyloids, prions, and prionoids.","volume":"64","author":"Aguzzi","year":"2009","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1002\/ajmg.b.31099","article-title":"Somatic mosaicism in a case of apparently sporadic Creutzfeldt-Jakob disease carrying a de novo D178N mutation in the PRNP gene.","author":"Alzualde","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1385\/JMN:23:3:157","article-title":"APOE genotype effects on Alzheimer\u00e2\u20ac\u2122s disease onset and epidemiology.","volume":"23","author":"Ashford","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"15307","DOI":"10.1073\/pnas.1201632109","article-title":"Role of genes linked to sporadic Alzheimer\u00e2\u20ac\u2122s disease risk in the production of \u00ce\u00b2-amyloid peptides.","volume":"109","author":"Bali","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.tins.2004.07.005","article-title":"Free radicals and aging.","volume":"27","author":"Barja","year":"2004","journal-title":"Trends Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/hmg\/ddh134","article-title":"Somatic and germline mosaicism in sporadic early-onset Alzheimer\u00e2\u20ac\u2122s disease.","volume":"13","author":"Beck","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"1510","key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.12.010","article-title":"Missense variant in TREML2 protects against Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Benitez","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B8","first-page":"1993","article-title":"Early-Onset Familial Alzheimer Disease","author":"Bird","year":"1999","journal-title":"GeneReviews\u00c2\u00ae [Internet]"},{"key":"B9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/sj.ejhg.5201966","article-title":"Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer\u00e2\u20ac\u2122s disease.","volume":"16","author":"Blom","year":"2008","journal-title":"Eur. J. Hum. Genet."},{"issue":"1309","key":"B10","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.neurobiolaging.2012.08.010","article-title":"Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX\/IDE\/KIF11 locus in the risk of Alzheimer\u00e2\u20ac\u2122s disease.","volume":"34","author":"Bullock","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"e22090","key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022090","article-title":"Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer\u00e2\u20ac\u2122s and Creutzfeldt-Jakob diseases.","volume":"6","author":"Calero","year":"2011","journal-title":"PLoS ONE"},{"key":"B12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.clinpsy.2.022305.095232","article-title":"Endophenotypes in the genetic analyses of mental disorders.","volume":"2","author":"Cannon","year":"2006","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"1958","key":"B13","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.neurobiolaging.2014.03.007","article-title":"Exome array study did not identify novel variants in Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Chung","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.neurobiolaging.2007.11.027","article-title":"Epistasis in sporadic Alzheimer\u00e2\u20ac\u2122s disease.","volume":"30","author":"Combarros","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrg2579","article-title":"Detecting gene-gene interactions that underlie human diseases.","volume":"10","author":"Cordell","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.","volume":"7","author":"Corder","year":"1994","journal-title":"Nat. Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u00e2\u20ac\u2122s disease in late onset families.","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"B18","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nature12825","article-title":"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer\u00e2\u20ac\u2122s disease.","volume":"505","author":"Cruchaga","year":"2014","journal-title":"Nature"},{"issue":"726","key":"B19","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.neurobiolaging.2013.09.009","article-title":"Investigating the role of rare heterozygous TREM2 variants in Alzheimer\u00e2\u20ac\u2122s disease and frontotemporal dementia.","volume":"35","author":"Cuyvers","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1126\/science.1168979","article-title":"A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.","volume":"323","author":"Di Fede","year":"2009","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1002\/ajpa.21298","article-title":"Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history.","volume":"143","author":"Eisenberg","year":"2010","journal-title":"Am. J. Phys. Anthropol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.4161\/cc.9.10.11582","article-title":"A novel hypothesis for Alzheimer disease based on neuronal tetraploidy induced by p75 (NTR).","volume":"9","author":"Frade","year":"2010","journal-title":"Cell Cycle"},{"issue":"e101412","key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101412","article-title":"Similarities and differences between exome sequences found in a variety of tissues from the same individual.","volume":"9","author":"G\u00c3\u00b3mez-Ramos","year":"2014","journal-title":"PLoS ONE"},{"key":"B24","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.cell.2013.10.037","article-title":"SnapShot: genetics of Alzheimer\u00e2\u20ac\u2122s disease.","volume":"155","author":"Guerreiro","year":"2013a","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u00e2\u20ac\u2122s disease.","volume":"368","author":"Guerreiro","year":"2013b","journal-title":"N. Engl. J. Med."},{"issue":"2656","key":"B26","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.neurobiolaging.2014.05.013","article-title":"A nonsense mutation in PRNP associated with clinical Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Guerreiro","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neurobiolaging.2010.03.025","article-title":"The genetic architecture of Alzheimer\u00e2\u20ac\u2122s disease: beyond APP, PSENs and APOE.","volume":"33","author":"Guerreiro","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1056\/NEJMc1306509#SA1","article-title":"TREM2 and neurodegenerative disease.","volume":"369","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1016\/j.neurobiolaging.2014.05.014","article-title":"Genome-wide association interaction analysis for Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Gusareva","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.10.007","article-title":"Down syndrome and Alzheimer\u00e2\u20ac\u2122s disease: common pathways, common goals.","author":"Hartley","year":"2014","journal-title":"Alzheimers Dement."},{"key":"B31","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1034\/j.1600-0404.2001.103003188.x","article-title":"Limited somatic mosaicism for Friedreich\u00e2\u20ac\u2122s ataxia GAA triplet repeat expansions identified by small pool PCR in blood leukocytes.","volume":"103","author":"Hellenbroich","year":"2001","journal-title":"Acta Neurol. Scand."},{"issue":"e80839","key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080839","article-title":"Epistatic genetic effects among Alzheimer\u00e2\u20ac\u2122s candidate genes.","volume":"8","author":"Hohman","year":"2013","journal-title":"PLoS ONE"},{"key":"B33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.nbd.2009.01.003","article-title":"Aneuploidy in the normal, Alzheimer\u00e2\u20ac\u2122s disease and ataxia-telangiectasia brain: differential expression and pathological meaning.","volume":"34","author":"Iourov","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000347053","article-title":"Somatic cell genomics of brain disorders: a new opportunity to clarify genetic-environmental interactions.","volume":"139","author":"Iourov","year":"2013","journal-title":"Cytogenet. Genome. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/ng.2270","article-title":"Detectable clonal mosaicism and its relationship to aging and cancer.","volume":"44","author":"Jacobs","year":"2012","journal-title":"Nat. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.pneurobio.2011.04.013","article-title":"DNA repair deficiency in neurodegeneration.","volume":"94","author":"Jeppesen","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"34","key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt137","article-title":"Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer\u00e2\u20ac\u2122s disease Ibero-American cohort.","volume":"4","author":"Jin","year":"2012","journal-title":"Alzheimers Res. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature11283","article-title":"A mutation in APP protects against Alzheimer\u00e2\u20ac\u2122s disease and age-related cognitive decline.","volume":"488","author":"Jonsson","year":"2012","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u00e2\u20ac\u2122s disease.","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0304-3940(00)01029-6","article-title":"The expanded CAG repeat associated with juvenile Huntington disease shows a common origin of most or all neurons and glia in human cerebrum.","volume":"286","author":"Kahlem","year":"2000","journal-title":"Neurosci. Lett."},{"key":"B41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuron.2014.05.041","article-title":"Alzheimer\u00e2\u20ac\u2122s disease genetics: from the bench to the clinic.","volume":"83","author":"Karch","year":"2014","journal-title":"Neuron"},{"key":"B42","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biopsych.2014.05.006","article-title":"Alzheimer\u00e2\u20ac\u2122s disease risk genes and mechanisms of disease pathogenesis.","volume":"77","author":"Karch","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1136\/jnnp.2008.161703","article-title":"Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease.","volume":"80","author":"Kasuga","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"e1004758","key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004758","article-title":"Genome-wide association study of CSF levels of 59 alzheimer\u00e2\u20ac\u2122s disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.","volume":"10","author":"Kauwe","year":"2014","journal-title":"PLoS Genet."},{"issue":"e15918","key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015918","article-title":"Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer\u00e2\u20ac\u2122s disease.","volume":"6","author":"Kauwe","year":"2011","journal-title":"PLoS ONE"},{"key":"B46","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.mad.2011.10.009","article-title":"Somatic mutations in aging, cancer and neurodegeneration.","volume":"133","author":"Kennedy","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1093\/hmg\/ddp323","article-title":"Potential late-onset Alzheimer\u00e2\u20ac\u2122s disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.","volume":"18","author":"Kim","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u00e2\u20ac\u2122s disease.","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"issue":"2419","key":"B49","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1016\/j.neurobiolaging.2014.04.010","article-title":"Homozygous TREM2 mutation in a family with atypical frontotemporal dementia.","volume":"35","author":"Le Ber","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B50","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/mgg3.85","article-title":"Disease-related mutations among Caribbean Hispanics with familial dementia.","volume":"2","author":"Lee","year":"2014","journal-title":"Mol. Genet. Genomic Med."},{"issue":"202","key":"B51","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.neurobiolaging.2010.07.018","article-title":"Transferrin and HFE genes interact in Alzheimer\u00e2\u20ac\u2122s disease risk: the Epistasis Project.","volume":"33","author":"Lehmann","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B52","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.jalz.2014.06.010","article-title":"Two rare AKAP9 variants are associated with Alzheimer\u00e2\u20ac\u2122s disease in African Americans.","volume":"10","author":"Logue","year":"2014","journal-title":"Alzheimers Dement"},{"issue":"369","key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00369","article-title":"Identification of rare variants in Alzheimer\u00e2\u20ac\u2122s disease.","volume":"5","author":"Lord","year":"2014","journal-title":"Front. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.tig.2010.05.003","article-title":"Evolution of the mutation rate.","volume":"26","author":"Lynch","year":"2010","journal-title":"Trends Genet."},{"issue":"e1003321","key":"B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003321","article-title":"Gene-based testing of interactions in association studies of quantitative traits.","volume":"9","author":"Ma","year":"2013","journal-title":"PLoS Genet."},{"key":"B56","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases.","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"B58","author":"Medawar","year":"1952","journal-title":"An Unsolved Problem of Biology."},{"key":"B59","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/S0898-6568(03)00041-X","article-title":"RIPped out by presenilin-dependent gamma-secretase.","volume":"15","author":"Medina","year":"2003","journal-title":"Cell. Signal."},{"issue":"e1001242","key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001242","article-title":"Continuous and periodic expansion of CAG repeats in Huntington\u00e2\u20ac\u2122s disease R6\/1 mice.","volume":"6","author":"M\u00c3\u00b8llersen","year":"2010","journal-title":"PLoS Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00415-012-6588-1","article-title":"A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer\u00e2\u20ac\u2122s diseases in three patients with divergent clinical phenotypes.","volume":"260","author":"Mu\u00c3\u00b1oz-Nieto","year":"2013","journal-title":"J. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1001\/jamaneurol.2014.1491","article-title":"Effects of multiple genetic Loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.","volume":"71","author":"Naj","year":"2014","journal-title":"JAMA Neurol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.3233\/JAD-140891","article-title":"Somatic signature of brain-specific single nucleotide variations in sporadic Alzheimer\u00e2\u20ac\u2122s disease.","volume":"42","author":"Parcerisas","year":"2014","journal-title":"J. Alzheimers. Dis."},{"key":"B64","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jalz.2013.01.016","article-title":"Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects.","volume":"10","author":"Pedraza","year":"2014","journal-title":"Alzheimers Dement"},{"key":"B65","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/nrg2452","article-title":"Epistasis\u00e2\u20ac\u201cthe essential role of gene interactions in the structure and evolution of genetic systems.","volume":"9","author":"Phillips","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/nrg2670","article-title":"Common disorders are quantitative traits.","volume":"10","author":"Plomin","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"1237758","key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237758","article-title":"Somatic mutation, genomic variation, and neurological disease.","volume":"341","author":"Poduri","year":"2013","journal-title":"Science"},{"key":"B68","first-page":"145","article-title":"Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer\u00e2\u20ac\u2122s disease, Parkinson\u00e2\u20ac\u2122s disease, and related disorders.","volume":"2","author":"Ramanan","year":"2013","journal-title":"Am. J. Neurodegener. Dis."},{"key":"B69","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1136\/jmg.2005.033456","article-title":"Molecular diagnosis of autosomal dominant early onset Alzheimer\u00e2\u20ac\u2122s disease: an update.","volume":"42","author":"Raux","year":"2005","journal-title":"J. Med. Genet."},{"issue":"19","key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson\u00e2\u20ac\u2122s disease.","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1523\/JNEUROSCI.4560-04.2005","article-title":"Constitutional aneuploidy in the normal human brain.","volume":"25","author":"Rehen","year":"2005","journal-title":"J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.bcp.2013.12.024","article-title":"Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers.","volume":"88","author":"Reitz","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature12415","article-title":"Integrative genomics identifies APOE \u00ce\u00b54 effectors in Alzheimer\u00e2\u20ac\u2122s disease.","volume":"500","author":"Rhinn","year":"2013","journal-title":"Nature"},{"issue":"e79771","key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079771","article-title":"Alzheimer\u00e2\u20ac\u2122s disease: analyzing the missing heritability.","volume":"8","author":"Ridge","year":"2013","journal-title":"PLoS ONE"},{"key":"B75","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-4939-2155-3_2","article-title":"Finding the epistasis needles in the genome-wide haystack.","volume":"1253","author":"Ritchie","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1136\/jmg.2003.015552","article-title":"Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer\u00e2\u20ac\u2122s disease.","volume":"41","author":"Robson","year":"2004","journal-title":"J. Med. Genet."},{"issue":"2422","key":"B77","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1016\/j.neurobiolaging.2014.04.026","article-title":"Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Sassi","year":"2014a","journal-title":"Neurobiol. Aging"},{"issue":"2881","key":"B78","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.neurobiolaging.2014.06.002","article-title":"Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer\u00e2\u20ac\u2122s disease.","volume":"35","author":"Sassi","year":"2014b","journal-title":"Neurobiol. Aging"},{"key":"B79","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11682-013-9262-z","article-title":"Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.","volume":"8","author":"Shen","year":"2014","journal-title":"Brain Imag. Behav."},{"key":"B80","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/clinchem\/41.8.1068","article-title":"Apolipoprotein E: an important gene and protein to follow in laboratory medicine.","volume":"1","author":"Siest","year":"1995","journal-title":"Clin. Chem. 41(Pt"},{"key":"B81","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.jalz.2014.05.1751","article-title":"R47H TREM2 variant increases risk of typical early-onset Alzheimer\u00e2\u20ac\u2122s disease but not of prion or frontotemporal dementia.","volume":"10","author":"Slattery","year":"2014","journal-title":"Alzheimers Dement"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1093\/brain\/awl203","article-title":"APP duplication is sufficient to cause early onset Alzheimer\u00e2\u20ac\u2122s dementia with cerebral amyloid angiopathy.","author":"Sleegers","year":"2006","journal-title":"Brain"},{"key":"B83","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/ana.410380120","article-title":"Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer\u00e2\u20ac\u2122s disease.","volume":"38","author":"Sorbi","year":"1995","journal-title":"Ann. Neurol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to \u00ce\u00b2-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B85","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1002\/ana.21321","article-title":"A new amyloid \u00ce\u00b2 variant favoring oligomerization in Alzheimer\u00e2\u20ac\u2122s-type dementia.","volume":"63","author":"Tomiyama","year":"2008","journal-title":"Ann. Neurol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrg3747","article-title":"Detecting epistasis in human complex traits.","volume":"15","author":"Wei","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrg3457","article-title":"Pitfalls of predicting complex traits from SNPs.","volume":"14","author":"Wray","year":"2013","journal-title":"Nat. Rev. Genet."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T17:42:29Z","timestamp":1598895749000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2015.00138\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":87,"URL":"https:\/\/doi.org\/10.3389\/fncel.2015.00138","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}