{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:10:24Z","timestamp":1789953024515,"version":"4.0.1"},"reference-count":153,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y Competitividad","doi-asserted-by":"publisher","award":["SAF2013-43900"],"award-info":[{"award-number":["SAF2013-43900"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y Competitividad","doi-asserted-by":"publisher","award":["CIBERNED CB06\/05\/0042"],"award-info":[{"award-number":["CIBERNED CB06\/05\/0042"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Economia y Competitividad","doi-asserted-by":"publisher","award":["BES-2011-044405"],"award-info":[{"award-number":["BES-2011-044405"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A2014417S"],"award-info":[{"award-number":["A2014417S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2014 SGR 0984"],"award-info":[{"award-number":["2014 SGR 0984"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2015.00318","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T04:28:57Z","timestamp":1440476937000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Gene expression parallels synaptic excitability and plasticity changes in Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Carlos A.","family":"Saura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Parra-Damas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Enriquez-Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-\u03b2 as a positive endogenous regulator of release probability at hippocampal synapses.","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.nbd.2011.10.022","article-title":"Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.","volume":"45","author":"Alldred","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease.","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.biopsych.2008.10.017","article-title":"Abnormal functional connectivity of hippocampus during episodic memory retrieval processing network in amnestic mild cognitive impairment.","volume":"65","author":"Bai","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment.","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1093\/brain\/awl089","article-title":"Familial risk for Alzheimer\u2019s disease alters fMRI activation patterns.","volume":"129","author":"Bassett","year":"2006","journal-title":"Brain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3109\/1354750X.2013.814073","article-title":"MicroRNA in Alzheimer\u2019s disease: an exploratory study in brain, cerebrospinal fluid and plasma.","volume":"18","author":"Bekris","year":"2013","journal-title":"Biomarkers"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1016\/j.neurobiolaging.2012.11.024","article-title":"Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer\u2019s disease.","volume":"34","author":"Berchtold","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B9","doi-asserted-by":"publisher","first-page":"15605","DOI":"10.1073\/pnas.0806883105","article-title":"Gene expression changes in the course of normal brain aging are sexually dimorphic.","volume":"105","author":"Berchtold","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1016\/j.neurobiolaging.2014.03.031","article-title":"Brain gene expression patterns differentiate mild cognitive impairment from normal aged and Alzheimer\u2019s disease.","volume":"35","author":"Berchtold","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-\u03b2 deposition.","volume":"14","author":"Bero","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal A\u03b2 causes the onset of early Alzheimer\u2019s disease-related cognitive deficits in transgenic mice.","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1073\/pnas.0308512100","article-title":"Incipient Alzheimer\u2019s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.","volume":"101","author":"Blalock","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/brain\/awq258","article-title":"Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer\u2019s disease.","volume":"133","author":"Bossers","year":"2010","journal-title":"Brain"},{"key":"B15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes.","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol. (Berl.)"},{"issue":"53","key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-53","article-title":"SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer\u2019s disease.","volume":"9","author":"Brinkmalm","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease.","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer\u2019s disease.","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"issue":"200","key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00200","article-title":"Age-dependent modifications of AMPA receptor subunit expression levels and related cognitive effects in 3xTg-AD mice.","volume":"6","author":"Cantanelli","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/6374","article-title":"Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.","volume":"2","author":"Chapman","year":"1999","journal-title":"Nat. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.nbd.2011.05.023","article-title":"Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer\u2019s disease.","volume":"43","author":"Chen","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1212\/WNL.0b013e3182a1aafe","article-title":"Impaired default network functional connectivity in autosomal dominant Alzheimer disease.","volume":"81","author":"Chhatwal","year":"2013","journal-title":"Neurology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer\u2019s disease patients.","volume":"34","author":"Chouliaras","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/cne.20828","article-title":"Nurr1 in Parkinson\u2019s disease and related disorders.","volume":"494","author":"Chu","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain.","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B26","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.neuropharm.2013.10.018","article-title":"Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment.","volume":"79","author":"Counts","year":"2014","journal-title":"Neuropharmacology"},{"issue":"179","key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-179","article-title":"Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.","volume":"9","author":"Cribbs","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nn.2709","article-title":"Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer\u2019s disease.","volume":"14","author":"D\u2019Amelio","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"e91203","key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091203","article-title":"Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer\u2019s disease in vivo.","volume":"9","author":"Davis","year":"2014","journal-title":"PLoS ONE"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer\u2019s disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1523\/JNEUROSCI.5980-08.2009","article-title":"A role for synaptic zinc in activity-dependent A\u03b2 oligomer formation and accumulation at excitatory synapses.","volume":"29","author":"Deshpande","year":"2009","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neurobiolaging.2007.06.011","article-title":"Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice.","volume":"30","author":"Dewachter","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"B33","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1523\/JNEUROSCI.22-09-03445.2002","article-title":"Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.","volume":"22","author":"Dewachter","year":"2002","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD.","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3233\/BEN-2009-0227","article-title":"Large-scale functional brain network abnormalities in Alzheimer\u2019s disease: insights from functional neuroimaging.","volume":"21","author":"Dickerson","year":"2009","journal-title":"Behav. Neurol."},{"key":"B36","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.23-12-05219.2003","article-title":"Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice.","volume":"23","author":"Dickey","year":"2003","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1037\/0735-7044.113.5.982","article-title":"Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.","volume":"113","author":"Dodart","year":"1999","journal-title":"Behav. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1111\/j.1460-9568.2004.03643.x","article-title":"An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer\u2019s disease.","volume":"20","author":"Dominguez-del-Toro","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1056\/NEJMoa1312889","article-title":"Phase 3 trials of solanezumab for mild-to-moderate Alzheimer\u2019s disease.","volume":"370","author":"Doody","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"24","key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00024","article-title":"Circulating microRNAs in Alzheimer\u2019s disease: the search for novel biomarkers.","volume":"6","author":"Dorval","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.biopsych.2009.06.015","article-title":"Intraneuronal \u03b2-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer\u2019s disease transgenic mice.","volume":"67","author":"Espa\u00f1a","year":"2010a","journal-title":"Biol. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"9402","DOI":"10.1523\/JNEUROSCI.2154-10.2010","article-title":"\u03b2-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1.","volume":"30","author":"Espa\u00f1a","year":"2010b","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1212\/WNL.0b013e318230a16c","article-title":"Chronic divalproex sodium use and brain atrophy in Alzheimer disease.","volume":"77","author":"Fleisher","year":"2011","journal-title":"Neurology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1016\/j.celrep.2014.04.024","article-title":"APP homodimers transduce an amyloid-\u03b2-mediated increase in release probability at excitatory synapses.","volume":"7","author":"Fogel","year":"2014","journal-title":"Cell Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"13629","DOI":"10.1523\/JNEUROSCI.1353-14.2014","article-title":"Alzheimer\u2019s disease-like pathology induced by amyloid-\u03b2 oligomers in nonhuman primates.","volume":"34","author":"Forny-Germano","year":"2014","journal-title":"J. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.11","article-title":"Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.","volume":"5","author":"Gatta","year":"2014","journal-title":"Cell Death Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.nbd.2011.07.013","article-title":"Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer\u2019s disease.","volume":"45","author":"Ginsberg","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3233\/JAD-2010-101080","article-title":"Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer\u2019s disease.","volume":"22","author":"Ginsberg","year":"2010","journal-title":"J. Alzheimers Dis."},{"issue":"e10153","key":"B49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010153","article-title":"Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus\u2019 gene expression profiles in Alzheimer\u2019s disease.","volume":"5","author":"Gomez Ravetti","year":"2010","journal-title":"PLoS ONE"},{"key":"B50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer\u2019s disease.","volume":"41","author":"Gomez-Isla","year":"1997","journal-title":"Ann. Neurol."},{"issue":"178","key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00178","article-title":"Neuronal dark matter: the emerging role of microRNAs in neurodegeneration.","volume":"7","author":"Goodall","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B52","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1523\/JNEUROSCI.23-03-00986.2003","article-title":"Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer\u2019s disease.","volume":"23","author":"Grady","year":"2003","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1460-9568.2009.06787.x","article-title":"Epigenetic dysregulation in cognitive disorders.","volume":"30","author":"Graff","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.nbd.2008.03.001","article-title":"Aged wild-type and APP, PS1, and APP + PS1 mice present similar deficits in associative learning and synaptic plasticity independent of amyloid load.","volume":"30","author":"Gruart","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1093\/cercor\/bhs105","article-title":"Increased cortical and thalamic excitability in freely moving APPswe\/PS1dE9 mice modeling epileptic activity associated with Alzheimer\u2019s disease.","volume":"23","author":"Gurevicius","year":"2013","journal-title":"Cereb. Cortex"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1016\/j.neurobiolaging.2006.08.008","article-title":"Increased fMRI responses during encoding in mild cognitive impairment.","volume":"28","author":"Hamalainen","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B57","doi-asserted-by":"publisher","first-page":"12686","DOI":"10.1523\/JNEUROSCI.3189-09.2009","article-title":"Disruption of functional connectivity in clinically normal older adults harboring amyloid burden.","volume":"29","author":"Hedden","year":"2009","journal-title":"J. Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/nn.4017","article-title":"The case for rejecting the amyloid cascade hypothesis.","volume":"18","author":"Herrup","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1073\/pnas.96.6.3228","article-title":"Plaque-independent disruption of neural circuits in Alzheimer\u2019s disease mouse models.","volume":"96","author":"Hsia","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B60","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, A\u03b2 elevation, and amyloid plaques in transgenic mice.","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1212\/WNL.40.11.1721","article-title":"Memory-related neural systems in Alzheimer\u2019s disease: an anatomic study.","volume":"40","author":"Hyman","year":"1990","journal-title":"Neurology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer\u2019s disease: cell-specific pathology isolates the hippocampal formation.","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"B63","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/ana.410200406","article-title":"Perforant pathway changes and the memory impairment of Alzheimer\u2019s disease.","volume":"20","author":"Hyman","year":"1986","journal-title":"Ann. Neurol."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.11.013","article-title":"Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer\u2019s disease without reducing amyloid and tau pathology.","author":"Isopi","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1073\/pnas.0600948103","article-title":"Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer\u2019s disease.","volume":"103","author":"Jacobsen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B66","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1006\/nbdi.2002.0557","article-title":"Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe\/ind) CRND8 mice.","volume":"11","author":"Jolas","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0197-4580(02)00098-2","article-title":"Progressive age-related impairment of cognitive behavior in APP23 transgenic mice.","volume":"24","author":"Kelly","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"B68","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1136\/jnnp.2006.104877","article-title":"Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding.","volume":"78","author":"Kircher","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/cne.21346","article-title":"Macaque monkey retrosplenial cortex: III. Cortical efferents.","volume":"502","author":"Kobayashi","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu151","article-title":"Disrupted intrinsic networks link amyloid-\u03b2 pathology and impaired cognition in prodromal Alzheimer\u2019s disease.","author":"Koch","year":"2014","journal-title":"Cereb. Cortex"},{"key":"B71","doi-asserted-by":"publisher","first-page":"14675","DOI":"10.1073\/pnas.261562998","article-title":"Specific spatial learning deficits become severe with age in \u03b2-amyloid precursor protein transgenic mice that harbor diffuse \u03b2-amyloid deposits but do not form plaques.","volume":"98","author":"Koistinaho","year":"2001","journal-title":"PNAS"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.neurobiolaging.2012.10.021","article-title":"Age-associated changes in gene expression in human brain and isolated neurons.","volume":"34","author":"Kumar","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"B73","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nicl.2013.08.007","article-title":"Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer\u2019s disease and semantic dementia.","volume":"3","author":"La Joie","year":"2013","journal-title":"Neuroimage Clin."},{"key":"B74","doi-asserted-by":"publisher","first-page":"10191","DOI":"10.1523\/JNEUROSCI.3432-04.2004","article-title":"Synaptic targeting by Alzheimer\u2019s-related amyloid beta oligomers.","volume":"24","author":"Lacor","year":"2004","journal-title":"J. Neurosci."},{"issue":"33","key":"B75","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-9-33","article-title":"Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer\u2019s disease.","volume":"9","author":"Landel","year":"2014","journal-title":"Mol. Neurodegener."},{"key":"B76","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/S0969-9961(03)00079-2","article-title":"Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype.","volume":"13","author":"Lanz","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer\u2019s disease.","volume":"5","author":"Lau","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.cell.2005.01.015","article-title":"Environmental enrichment reduces A\u03b2 levels and amyloid deposition in transgenic mice.","volume":"120","author":"Lazarov","year":"2005","journal-title":"Cell"},{"issue":"e5424","key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005424","article-title":"Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects.","volume":"4","author":"Li","year":"2009","journal-title":"PLoS ONE"},{"key":"B80","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neurobiolaging.2008.05.013","article-title":"Neuronal gene expression in non-demented individuals with intermediate Alzheimer\u2019s disease neuropathology.","volume":"31","author":"Liang","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"B81","doi-asserted-by":"publisher","first-page":"4441","DOI":"10.1073\/pnas.0709259105","article-title":"Alzheimer\u2019s disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons.","volume":"105","author":"Liang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"286","key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-286","article-title":"Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains.","volume":"7","author":"Liu","year":"2006","journal-title":"BMC Genomics"},{"key":"B83","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1385\/JMN:18:1-2:53","article-title":"Synaptic proteins in Alzheimer\u2019s disease.","volume":"18","author":"Marksteiner","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"B84","first-page":"1293","article-title":"Diffuse plaques do not accentuate synapse loss in Alzheimer disease.","volume":"137","author":"Masliah","year":"1990","journal-title":"Am. J. Path."},{"key":"B85","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.celrep.2014.12.041","article-title":"A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.","volume":"10","author":"Matarin","year":"2015","journal-title":"Cell Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.tig.2006.03.007","article-title":"A decade of modeling Alzheimer\u2019s disease in transgenic mice.","volume":"22","author":"McGowan","year":"2006","journal-title":"Trends Genet."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1093\/brain\/awt088","article-title":"The influence of phospho-tau on dendritic spines of cortical pyramidal neurons in patients with Alzheimer\u2019s disease.","volume":"136","author":"Merino-Serrais","year":"2013","journal-title":"Brain"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1523\/JNEUROSCI.4098-07.2008","article-title":"A systems level analysis of transcriptional changes in Alzheimer\u2019s disease and normal aging.","volume":"28","author":"Miller","year":"2008","journal-title":"J. Neurosci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"27311","DOI":"10.1074\/jbc.M111.227504","article-title":"Soluble oligomers of amyloid-beta peptide disrupt membrane trafficking of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction.","volume":"286","author":"Mi\u00f1ano-Molina","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B90","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1523\/JNEUROSCI.5215-08.2009","article-title":"Amyloid \u03b2-induced neuronal hyperexcitability triggers progressive epilepsy.","volume":"29","author":"Minkeviciene","year":"2009","journal-title":"J. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1093\/brain\/awl266","article-title":"Enhanced brain activity may precede the diagnosis of Alzheimer\u2019s disease by 30 years.","volume":"129","author":"Mondadori","year":"2006","journal-title":"Brain"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1212\/01.WNL.0000163856.13524.08","article-title":"Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis.","volume":"64","author":"Mosconi","year":"2005","journal-title":"Neurology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3233\/JAD-140606","article-title":"Blood genome-wide transcriptional profiles reflect broad molecular impairments and strong blood-brain links in Alzheimer\u2019s disease.","volume":"43","author":"Naughton","year":"2015","journal-title":"J. Alzheimers. Dis."},{"key":"B94","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature.","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1212\/WNL.0b013e3181e3966e","article-title":"Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline.","volume":"74","author":"O\u2019Brien","year":"2010","journal-title":"Neurology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.1523\/JNEUROSCI.2829-05.2005","article-title":"Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice.","volume":"25","author":"Palop","year":"2005","journal-title":"J. Neurosci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease.","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.neurobiolaging.2006.08.014","article-title":"Inflammatory changes parallel the early stages of Alzheimer disease.","volume":"28","author":"Parachikova","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"B99","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1002\/ana.20653","article-title":"Alzheimer\u2019s patients engage an alternative network during a memory task.","volume":"58","author":"Pariente","year":"2005","journal-title":"Ann. Neurol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"5776","DOI":"10.1523\/JNEUROSCI.5288-13.2014","article-title":"Crtc1 activates a transcriptional program deregulated at early Alzheimer\u2019s disease-related stages.","volume":"34","author":"Parra-Damas","year":"2014","journal-title":"J. Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1523\/JNEUROSCI.6142-10.2011","article-title":"Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer\u2019s disease.","volume":"31","author":"Perez-Cruz","year":"2011","journal-title":"J. Neurosci."},{"issue":"e16032","key":"B102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016032","article-title":"Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer\u2019s disease.","volume":"6","author":"Perrin","year":"2011","journal-title":"PLoS ONE"},{"key":"B103","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1056\/NEJMcp0910237","article-title":"Clinical practice. Mild cognitive impairment.","volume":"364","author":"Petersen","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0896-6273(91)90273-3","article-title":"BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer\u2019s disease.","volume":"7","author":"Phillips","year":"1991","journal-title":"Neuron"},{"issue":"e29610","key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029610","article-title":"Molecular insights into the pathogenesis of Alzheimer\u2019s disease and its relationship to normal aging.","volume":"6","author":"Podtelezhnikov","year":"2011","journal-title":"PLoS ONE"},{"key":"B106","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/341054a0","article-title":"Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging.","volume":"341","author":"Press","year":"1989","journal-title":"Nature"},{"key":"B107","volume":"Vols, 1 and 2","author":"Ram\u00f3n y Cajal","year":"1911","journal-title":"Histologie du Syst\u00e8me Nerveux de l\u2019Homme et des Vert\u00e9br\u00e9s."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer\u2019s disease in the presenilin 1 E280A kindred: a case-control study.","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1002\/hipo.20883","article-title":"Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.","volume":"22","author":"Ricobaraza","year":"2012","journal-title":"Hippocampus"},{"key":"B110","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.nbd.2008.07.014","article-title":"Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice.","volume":"32","author":"Rocher","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"B111","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3233\/JAD-122404","article-title":"Prediction of mild cognitive impairment that evolves into Alzheimer\u2019s disease dementia within two years using a gene expression signature in blood: a pilot study.","volume":"35","author":"Roed","year":"2013","journal-title":"J. Alzheimers. Dis."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/nn.3199","article-title":"Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer\u2019s disease.","volume":"15","author":"Rudinskiy","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0002-9440(10)62963-X","article-title":"Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS1M146L, and APP751SL\/PS1M146L transgenic mice.","volume":"167","author":"Rutten","year":"2005","journal-title":"Am. J. Pathol."},{"issue":"1460","key":"B114","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839","article-title":"Phase 3 trials of solanezumab and bapineuzumab for Alzheimer\u2019s disease.","volume":"370","author":"Salloway","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"B115","doi-asserted-by":"publisher","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model.","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1093\/brain\/awt237","article-title":"DNA methylation map of mouse and human brain identifies target genes in Alzheimer\u2019s disease.","volume":"136","author":"Sanchez-Mut","year":"2013","journal-title":"Brain"},{"key":"B117","first-page":"153","article-title":"Network excitability dysfunction in Alzheimer\u2019s disease: insights from in vitro and in vivo models.","volume":"21","author":"Santos","year":"2010","journal-title":"Rev. Neurosci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"6755","DOI":"10.1523\/JNEUROSCI.1247-05.2005","article-title":"Conditional inactivation of presenilin-1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.","volume":"25","author":"Saura","year":"2005","journal-title":"J. Neurosci."},{"key":"B119","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1515\/RNS.2011.018","article-title":"The role of CREB signaling in Alzheimer\u2019s disease and other cognitive disorders.","volume":"22","author":"Saura","year":"2011","journal-title":"Rev. Neurosci."},{"key":"B120","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0197-4580(90)90059-9","article-title":"Quantitative assessment of cortical synaptic density in Alzheimer\u2019s disease.","volume":"11","author":"Scheff","year":"1990","journal-title":"Neurobiol. Aging"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment.","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.neurobiolaging.2014.09.027","article-title":"Alzheimer\u2019s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes.","volume":"36","author":"Sekar","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B123","doi-asserted-by":"publisher","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural oligomers of the Alzheimer amyloid-\u03b2 protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.","volume":"27","author":"Shankar","year":"2007","journal-title":"J. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.biopsych.2009.08.024","article-title":"Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly.","volume":"67","author":"Sheline","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"e48751","key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048751","article-title":"Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer\u2019s disease.","volume":"7","author":"Silva","year":"2012","journal-title":"PLoS ONE"},{"key":"B126","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.neurobiolaging.2007.01.011","article-title":"Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer\u2019s disease.","volume":"29","author":"Simonsen","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/j.neurobiolaging.2011.04.013","article-title":"Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer\u2019s pathology and APOE genotype.","volume":"32","author":"Simpson","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"B128","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1212\/WNL.54.10.1960","article-title":"Cytoskeleton proteins in CSF distinguish frontotemporal dementia from AD.","volume":"54","author":"Sj\u00f6gren","year":"2000","journal-title":"Neurology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/1531-8249(199904)45:4466::AID-ANA83.0.CO;2-Q","article-title":"Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer\u2019s disease.","volume":"45","author":"Small","year":"1999","journal-title":"Ann. Neurol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"16877","DOI":"10.1073\/pnas.0908706106","article-title":"Reversal of long-term dendritic spine alterations in Alzheimer disease models.","volume":"106","author":"Smith","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B131","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/jnnp.74.1.44","article-title":"fMRI studies of associative encoding in young and elderly controls and mild Alzheimer\u2019s disease.","volume":"74","author":"Sperling","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B132","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12017-009-8109-7","article-title":"Functional alterations in memory networks in early Alzheimer\u2019s disease.","volume":"12","author":"Sperling","year":"2010","journal-title":"Neuromolecular Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","article-title":"The evolution of preclinical Alzheimer\u2019s disease: implications for prevention trials.","volume":"84","author":"Sperling","year":"2014","journal-title":"Neuron"},{"key":"B134","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer\u2019s disease.","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1126\/science.1896849","article-title":"The medial temporal lobe memory system.","volume":"253","author":"Squirre","year":"1991","journal-title":"Science"},{"key":"B136","doi-asserted-by":"publisher","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1002\/jnr.22290","article-title":"Genome wide profiling of altered gene expression in the neocortex of Alzheimer\u2019s disease.","volume":"88","author":"Tan","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"B138","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/jnen\/59.12.1118","article-title":"Cell death or synaptic loss in Alzheimer disease.","volume":"59","author":"Terry","year":"2000","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment.","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"e825","DOI":"10.1016\/j.neurobiolaging.2011.05.018","article-title":"Structural MRI changes detectable up to ten years before clinical Alzheimer\u2019s disease.","volume":"33","author":"Tondelli","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B141","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1046\/j.1460-9568.2003.02444.x","article-title":"Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.","volume":"17","author":"Van Dam","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0006-8993(75)90206-1","article-title":"Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections.","volume":"95","author":"Van Hoesen","year":"1975","journal-title":"Brain Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"B144","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0197-4580(99)00035-4","article-title":"Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer\u2019s disease.","volume":"20","author":"Wakabayashi","year":"1999","journal-title":"Neurobiol. Aging"},{"issue":"a005744","key":"B145","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005744","article-title":"Neuronal activity-regulated gene transcription in synapse development and cognitive function.","volume":"3","author":"West","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"e84349","key":"B146","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084349","article-title":"Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer\u2019s disease.","volume":"9","author":"Wilke","year":"2014","journal-title":"PLoS ONE"},{"key":"B147","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1176\/appi.ajp.163.9.1603","article-title":"Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.","volume":"163","author":"Wishart","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"B148","doi-asserted-by":"publisher","first-page":"7141","DOI":"10.1073\/pnas.0402147101","article-title":"Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses.","volume":"101","author":"Wu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B149","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0969-9961(02)00009-8","article-title":"Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer\u2019s disease.","volume":"12","author":"Yao","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"B150","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s10571-013-0012-y","article-title":"Valproate improves memory deficits in an Alzheimer\u2019s disease mouse model: investigation of possible mechanisms of action.","volume":"34","author":"Yao","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1212\/01.wnl.0000312288.45119.d1","article-title":"Altered fMRI activation during mental rotation in those at genetic risk for Alzheimer disease.","volume":"70","author":"Yassa","year":"2008","journal-title":"Neurology"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1038\/npp.2011.107","article-title":"Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer\u2019s disease.","volume":"36","author":"Yiu","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B153","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1523\/JNEUROSCI.06-10-02950.1986","article-title":"Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus.","volume":"6","author":"Zola-Morgan","year":"1986","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T16:20:45Z","timestamp":1567095645000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fncel.2015.00318\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":153,"URL":"https:\/\/doi.org\/10.3389\/fncel.2015.00318","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}