{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:11:58Z","timestamp":1788617518646,"version":"build-2803163510"},"reference-count":46,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY024265"],"award-info":[{"award-number":["EY024265"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY010572"],"award-info":[{"award-number":["P30EY010572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Unrestricted Grant to Department of Ophthalmology, OHSU"],"award-info":[{"award-number":["Unrestricted Grant to Department of Ophthalmology, OHSU"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2015.00486","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T03:59:09Z","timestamp":1450756749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Alterations in Kainate Receptor and TRPM1 Localization in Bipolar Cells after Retinal Photoreceptor Degeneration"],"prefix":"10.3389","volume":"9","author":[{"given":"Jacqueline","family":"Gayet-Primo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Puthussery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,12,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.neuroscience.2008.06.042","article-title":"Functional and structural modifications during retinal degeneration in the rd10 mouse.","volume":"155","author":"Barhoum","year":"2008","journal-title":"Neuroscience"},{"key":"B2","first-page":"1545","article-title":"Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment.","volume":"20","author":"Barone","year":"2014","journal-title":"Mol. Vis."},{"issue":"e99075","key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099075","article-title":"Pharmacological analysis of intrinsic neuronal oscillations in rd10 retina.","volume":"9","author":"Biswas","year":"2014","journal-title":"PLoS ONE"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.1523\/JNEUROSCI.4941-13.2014","article-title":"Kainate receptors mediate signaling in both transient and sustained OFF bipolar cell pathways in mouse retina.","volume":"34","author":"Borghuis","year":"2014","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.1523\/JNEUROSCI.5800-10.2011","article-title":"An intrinsic neural oscillator in the degenerating mouse retina.","volume":"31","author":"Borowska","year":"2011","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1152\/jn.00924.2011","article-title":"Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.","volume":"107","author":"Buldyrev","year":"2012","journal-title":"J. Neurophysiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1126\/science.1190897","article-title":"Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa.","volume":"329","author":"Busskamp","year":"2010","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.visres.2006.11.020","article-title":"Two mouse retinal degenerations caused by missense mutations in the \u03b2-subunit of rod cGMP phosphodiesterase gene.","volume":"47","author":"Chang","year":"2007","journal-title":"Vision Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1073\/pnas.0306520101","article-title":"Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1.","volume":"101","author":"Chow","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/cne.22029","article-title":"Functional remodeling of glutamate receptors by inner retinal neurons occurs from an early stage of retinal degeneration.","volume":"514","author":"Chua","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nrn3335","article-title":"Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function.","volume":"13","author":"Copits","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15252\/emmm.201404077","article-title":"Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter.","volume":"6","author":"Cronin","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.neuroscience.2004.04.042","article-title":"Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina.","volume":"127","author":"Cuenca","year":"2004","journal-title":"Neuroscience"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1038\/mt.2011.69","article-title":"Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness.","volume":"19","author":"Doroudchi","year":"2011","journal-title":"Mol. Ther."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1523\/JNEUROSCI.4284-14.2015","article-title":"Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.","volume":"35","author":"Dunn","year":"2015","journal-title":"J. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/cne.21390","article-title":"Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina.","volume":"503","author":"Elshatory","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1152\/jn.00600.2015","article-title":"Functional changes in Tg P23h-1 retinal responses: differences between ON and OFF pathway transmission to the superior colliculus.","volume":"114","author":"Fransen","year":"2015","journal-title":"J. Neurophysiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study.","volume":"500","author":"Gargini","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"E5574","DOI":"10.1073\/pnas.1414162111","article-title":"Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.","volume":"111","author":"Gaub","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/cne.10491","article-title":"Immunocytochemical description of five bipolar cell types of the mouse retina.","volume":"455","author":"Haverkamp","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/cne.1081","article-title":"Localization of kainate receptors at the cone pedicles of the primate retina.","volume":"436","author":"Haverkamp","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/1096-9861(20000814)424:11::AID-CNE13.0.CO;2-V","article-title":"Immunocytochemical analysis of the mouse retina.","volume":"424","author":"Haverkamp","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"8356","DOI":"10.1167\/iovs.11-7575","article-title":"Ultrastructural localization and expression of TRPM1 in the human retina.","volume":"52","author":"Klooster","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1073\/pnas.0912730107","article-title":"TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.","volume":"107","author":"Koike","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2460","DOI":"10.1016\/j.visres.2010.08.034","article-title":"Plasticity of TRPM1 expression and localization in the wild type and degenerating mouse retina.","volume":"50","author":"Kri\u017eaj","year":"2010","journal-title":"Vision Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nn.2117","article-title":"Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.","volume":"11","author":"Lagali","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1113\/jphysiol.2013.265033","article-title":"Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells.","volume":"592","author":"Lindstrom","year":"2014","journal-title":"J. Physiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/0092-8674(95)90354-2","article-title":"Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene.","volume":"80","author":"Masu","year":"1995","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"19174","DOI":"10.1073\/pnas.0908711106","article-title":"TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells.","volume":"106","author":"Morgans","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0092-8674(94)90151-1","article-title":"Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells.","volume":"77","author":"Nomura","year":"1994","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1172\/JCI81380","article-title":"Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV\u2013 RS1 transfer.","volume":"125","author":"Ou","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B32","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature10997","article-title":"Restoration of vision after transplantation of photoreceptors.","volume":"485","author":"Pearson","year":"2012","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1002\/cne.22322","article-title":"Progression of neuronal and synaptic remodeling in the rd 10 mouse model of retinitis pigmentosa.","volume":"518","author":"Phillips","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"9539","DOI":"10.1523\/JNEUROSCI.1340-15.2015","article-title":"Early events of synapse disassembly in the damaged retina.","volume":"35","author":"Pottackal","year":"2015","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1167\/iovs.05-1450","article-title":"Visual response properties of retinal ganglion cells in the royal college of surgeons dystrophic rat.","volume":"47","author":"Pu","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.03.054","article-title":"OFF bipolar cells express distinct types of dendritic glutamate receptors in the mouse retina.","volume":"243","author":"Puller","year":"2013","journal-title":"Neuroscience"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1111\/j.1460-9568.2009.06728.x","article-title":"Differential loss and preservation of glutamate receptor function in bipolar cells in the rd10 mouse model of retinitis pigmentosa.","volume":"29","author":"Puthussery","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/cne.22234","article-title":"Localization of the calcium-binding protein secretagogin in cone bipolar cells of the mammalian retina.","volume":"518","author":"Puthussery","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"7611","DOI":"10.1523\/JNEUROSCI.4855-13.2014","article-title":"Kainate receptors mediate synaptic input to transient and sustained OFF visual pathways in primate retina.","volume":"34","author":"Puthussery","year":"2014","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6088","DOI":"10.1523\/JNEUROSCI.0132-09.2009","article-title":"A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.","volume":"29","author":"Shen","year":"2009","journal-title":"J. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6800","DOI":"10.1523\/JNEUROSCI.1044-12.2013","article-title":"Restoration of retinal structure and function after selective photocoagulation.","volume":"33","author":"Sher","year":"2013","journal-title":"J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1126\/science.6131536","article-title":"An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons.","volume":"219","author":"Slaughter","year":"1983","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1152\/jn.00144.2007","article-title":"Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse.","volume":"99","author":"Stasheff","year":"2008","journal-title":"J. Neurophysiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"11020","DOI":"10.1073\/pnas.190291097","article-title":"Modifications of retinal neurons in a mouse model of retinitis pigmentosa.","volume":"97","author":"Strettoi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1113\/jphysiol.2011.221101","article-title":"Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors.","volume":"590","author":"Tomita","year":"2012","journal-title":"J. Physiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1152\/jn.00933.2011","article-title":"mGluR6 deletion renders the TRPM1 channel in retina inactive.","volume":"107","author":"Xu","year":"2012","journal-title":"J. Neurophysiol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T16:27:50Z","timestamp":1451924870000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fncel.2015.00486\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,22]]},"references-count":46,"URL":"https:\/\/doi.org\/10.3389\/fncel.2015.00486","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,22]]}}}