{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:45:25Z","timestamp":1791297925079,"version":"4.1.0"},"reference-count":84,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2016.00037","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T23:13:37Z","timestamp":1457478817000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6\/2 Mouse Model of Huntington\u2019s Disease"],"prefix":"10.3389","volume":"10","author":[{"given":"Khanh Q.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir V.","family":"Rymar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas F.","family":"Sadikot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1523\/JNEUROSCI.17-10-03623.1997","article-title":"TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death","volume":"17","author":"Alc\u00e1ntara","year":"1997","journal-title":"J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/39885","article-title":"Anterograde transport of brain-derived neurotrophic factor and its role in the brain","volume":"389","author":"Altar","year":"1997","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1093\/hmg\/ddi443","article-title":"Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1\/2 protects against mutant huntingtin-associated toxicity","volume":"15","author":"Apostol","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mcn.2008.04.007","article-title":"CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6\/2 mice","volume":"39","author":"Apostol","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/s0896-6273(00)00035-0","article-title":"The TrkB-Shc site signals neuronal survival and local axon growth via MEK and PI3-kinase","volume":"27","author":"Atwal","year":"2000","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1523\/JNEUROSCI.23-12-05149.2003","article-title":"Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways","volume":"23","author":"Barnabe-Heider","year":"2003","journal-title":"J. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nrg1686","article-title":"History of genetic disease: the molecular genetics of Huntington disease \u2013 a history","volume":"6","author":"Bates","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1073\/pnas.1004744108","article-title":"TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons","volume":"108","author":"Baydyuk","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3389\/fncel.2014.00254","article-title":"BDNF signaling and survival of striatal neurons","volume":"8","author":"Baydyuk","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B11","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1523\/JNEUROSCI.16-17-05523.1996","article-title":"Expression of normal and mutant huntingtin in the developing brain","volume":"16","author":"Bhide","year":"1996","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"6809","DOI":"10.1073\/pnas.120166397","article-title":"Severe deficiencies in dopamine signaling in presymptomatic Huntington\u2019s disease mice","volume":"97","author":"Bibb","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e20696","DOI":"10.1371\/journal.pone.0020696","article-title":"Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6\/2 mouse model of Huntington\u2019s disease","volume":"6","author":"Bobrowska","year":"2011","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/bies.201100116","article-title":"A novel target for Huntington\u2019s disease: ERK at the crossroads of signaling: the ERK signaling pathway is implicated in Huntington\u2019s disease and its upregulation ameliorates pathology","volume":"34","author":"Bodai","year":"2012","journal-title":"Bioessays"},{"key":"B15","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/jnr.490420510","article-title":"Serum-free B27\/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum and dentate gyrus","volume":"42","author":"Brewer","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e595","DOI":"10.1038\/cddis.2013.116","article-title":"Imbalance of p75(NTR)\/TrkB protein expression in Huntington\u2019s disease: implication for neuroprotective therapies","volume":"4","author":"Brito","year":"2013","journal-title":"Cell Death Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1093\/hmg\/ddn206","article-title":"Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse","volume":"17","author":"Brown","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/currents.rrn1182","article-title":"Rescuing the corticostriatal synaptic disconnection in the R6\/2 mouse model of huntington\u2019s disease: exercise, adenosine receptors and ampakines","volume":"2:RRN1182","author":"Cepeda","year":"2010","journal-title":"PLoS Curr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/B978-0-444-63425-2.00010-6","article-title":"The role of dopamine in Huntington\u2019s disease","volume":"211","author":"Cepeda","year":"2014","journal-title":"Prog. Brain Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1097\/00041327-200306000-00028","article-title":"TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo","volume":"22","author":"Cheng","year":"2002","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0165-3806(90)90148-r","article-title":"DARPP-32 development in the caudate nucleus is independent of afferent input from the substantia nigra","volume":"54","author":"Ehrlich","year":"1990","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"8837","DOI":"10.1074\/jbc.272.14.8837","article-title":"Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes","volume":"272","author":"Fawcett","year":"1997","journal-title":"J. Biol. Chem."},{"key":"B23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/s0006-8993(00)02237-x","article-title":"Brain-derived neurotrophic factor in Huntington disease","volume":"866","author":"Ferrer","year":"2000","journal-title":"Brain Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fncel.2014.00295","article-title":"Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington\u2019s disease","volume":"8","author":"Francelle","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B25","volume-title":"The Mouse Brain in Stereotaxic Coordinates.","author":"Franklin","year":"2008"},{"key":"B26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/(sici)1096-9861(19961007)374:121::aid-cne23.0.co;2-p","article-title":"Developmental and mature expression of full-length and truncated TrkB, receptors in the rat forebrain","volume":"374","author":"Fryer","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2174\/1381612820666140826113957","article-title":"Phosphodiesterases as therapeutic targets for Huntington\u2019s disease","volume":"21","author":"Fusco","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"B28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.nbd.2012.01.011","article-title":"Changes in the expression of extracellular regulated kinase (ERK 1\/2) in the R6\/2 mouse model of Huntington\u2019s disease after phosphodiesterase IV inhibition","volume":"46","author":"Fusco","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fncel.2015.00025","article-title":"Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, huntington and addiction diseases","volume":"9","author":"Gardoni","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing bdnf vesicular transport along microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1471-4159.2007.05137.x","article-title":"Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington\u2019s disease phenotypes in mice","volume":"105","author":"Gharami","year":"2008","journal-title":"J. Neurochem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1460-9568.2006.04590.x","article-title":"Reduced expression of the TrkB receptor in Huntington\u2019s disease mouse models and in human brain","volume":"23","author":"Gin\u00e9s","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"21537","DOI":"10.1074\/jbc.M109.084202","article-title":"Impaired TrkB-mediated ERK1\/2 activation in Huntington disease knock-in striatal cells involves reduced p52\/p46 shc expression","volume":"285","author":"Gin\u00e9s","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e5292","DOI":"10.1371\/journal.pone.0005292","article-title":"Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation","volume":"4","author":"Gokce","year":"2009","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"6182","DOI":"10.1523\/JNEUROSCI.0857-08.2008","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice","volume":"28","author":"Gray","year":"2008","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/s0968-0004(03)00168-3","article-title":"The hunt for huntingtin function: interaction partners tell many different stories","volume":"28","author":"Harjes","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"B37","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1523\/JNEUROSCI.19-13-05409.1999","article-title":"Expression of the striatal DARPP-32\/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro","volume":"19","author":"Ivkovic","year":"1999","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/s0306-4522(96)00684-7","article-title":"Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro","volume":"79","author":"Ivkovic","year":"1997","journal-title":"Neuroscience"},{"key":"B39","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.nbd.2012.11.016","article-title":"Phosphodiesterase 10A (PDE10A) localization in the R6\/2 mouse model of Huntington\u2019s disease","volume":"52","author":"Leuti","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"15491","DOI":"10.1073\/pnas.1212899109","article-title":"Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B41","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1006\/mcne.2002.1152","article-title":"Abnormal phosphorylation of synapsin I predicts a neuronal transmission impairment in the R6\/2 Huntington\u2019s disease transgenic mice","volume":"20","author":"Li\u00e9vens","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"6298","DOI":"10.1523\/JNEUROSCI.2033-12.2013","article-title":"Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites","volume":"33","author":"Liot","year":"2013","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1523\/JNEUROSCI.23-06-02239.2003","article-title":"Glutamate promotes proliferation of striatal neuronal progenitors by an NMDA receptor-mediated mechanism","volume":"23","author":"Luk","year":"2003","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1159\/000082139","article-title":"Glutamate and regulation of proliferation in the developing mammalian telencephalon","volume":"26","author":"Luk","year":"2004","journal-title":"Dev. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.nbd.2015.08.008","article-title":"Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington\u2019s disease","volume":"82","author":"Ma","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/s0092-8674(00)81369-0","article-title":"Exon 1 of the HD Gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.nbd.2009.09.012","article-title":"Remodeling of striatal NMDA receptors by chronic A2A receptor blockade in Huntington\u2019s disease mice","volume":"37","author":"Martire","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"3547","DOI":"10.1074\/jbc.M113.536912","article-title":"Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy","volume":"289","author":"Mealer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.nbd.2009.05.007","article-title":"Systematic behavioral evaluation of Huntington\u2019s disease transgenic and knock-in mouse models","volume":"35","author":"Menalled","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","article-title":"Early synaptic pathophysiology in neurodegeneration: insights from Huntington\u2019s disease","volume":"33","author":"Milnerwood","year":"2010","journal-title":"Trends Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/dbio.1994.1250","article-title":"Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons","volume":"165","author":"Mizuno","year":"1994","journal-title":"Dev. Biol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/bf00228749","article-title":"Platelet-derived growth factor exerts trophic effects on rat striatal DARPP-32-containing neurons in culture","volume":"101","author":"Nakao","year":"1994","journal-title":"Exp. Brain Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/0165-3806(96)83489-4","article-title":"Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro","volume":"90","author":"Nakao","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12920-014-0060-2","article-title":"A common gene expression signature in Huntington\u2019s disease patient brain regions","volume":"7","author":"Neueder","year":"2014","journal-title":"BMC Med. Genomics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1523\/JNEUROSCI.0988-07.2008","article-title":"Trk: a neuromodulator of age-specific behavioral and neurochemical responses to cocaine in mice","volume":"28","author":"Niculescu","year":"2008","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.neuroscience.2006.04.013","article-title":"Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington\u2019s disease transgenic mice","volume":"141","author":"Pang","year":"2006","journal-title":"Neuroscience"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1093\/hmg\/10.12.1243","article-title":"Expanded CAG repeats in exon 1 of the Huntington\u2019s disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration","volume":"10","author":"Peters\u00e9n","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"B58","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington\u2019s disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s11302-007-9066-y","article-title":"Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington\u2019s disease","volume":"3","author":"Potenza","year":"2007","journal-title":"Purinergic Signal."},{"key":"B60","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington\u2019s disease: time-dependent alterations in synaptic and receptor function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways","volume":"361","author":"Reichardt","year":"2006","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1523\/JNEUROSCI.4974-09.2010","article-title":"Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington\u2019s disease","volume":"30","author":"Ribeiro","year":"2010","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1096\/fj.07-9814","article-title":"Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death","volume":"22","author":"Roze","year":"2008","journal-title":"FASEB J."},{"key":"B64","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnana.2011.00055","article-title":"Huntington\u2019s disease and striatal signaling","volume":"5","author":"Roze","year":"2011","journal-title":"Front. Neuroanat."},{"key":"B65","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/cne.11008","article-title":"Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum","volume":"469","author":"Rymar","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"8150","DOI":"10.1523\/JNEUROSCI.3446-10.2011","article-title":"Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington\u2019s disease: a STEP in the resistance to excitotoxicity","volume":"31","author":"Saavedra","year":"2011","journal-title":"J. Neurosci."},{"key":"B68","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/0-387-28066-9_20","article-title":"Anterograde trophic mechanisms participate in pattern formation in the striatum: a role for BDNF in glutamatergic afferents","volume-title":"The Basal Ganglia VIII","author":"Sadikot","year":"2005"},{"key":"B67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/(sici)1096-9861(19971215)389:2193::aid-cne13.3.co;2-f","article-title":"Neurogenesis in the mammalian neostriatum and nucleus accumbens: parvalbumin-immunoreactive GABAergic interneurons","volume":"389","author":"Sadikot","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1601-183X.2012.00858.x","article-title":"Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6\/2 mouse model of Huntington\u2019s disease","volume":"12","author":"Samadi","year":"2013","journal-title":"Genes Brain Behav."},{"key":"B70","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1093\/hmg\/ddn211","article-title":"Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II\/III in YAC72 and R6\/2 transgenic mice partially model Huntington\u2019s disease patients","volume":"17","author":"Seo","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"18712","DOI":"10.1523\/JNEUROSCI.1310-13.2013","article-title":"A small molecule TrkB ligand reduces motor impairment and neuropathology in R6\/2 and BACHD mouse models of Huntington\u2019s disease","volume":"33","author":"Simmons","year":"2013","journal-title":"J. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1093\/hmg\/ddu166","article-title":"Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington\u2019s disease","volume":"23","author":"Smith","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B73","doi-asserted-by":"publisher","first-page":"12908","DOI":"10.1523\/jneurosci.4318-07.2007","article-title":"Neuroprotective effects of synaptic modulation in Huntington\u2019s disease R6\/2 mice","volume":"27","author":"Stack","year":"2007","journal-title":"J. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/cne.20680","article-title":"Chronology of behavioral symptoms and neuropathological sequela in R6\/2 Huntington\u2019s disease transgenic mice","volume":"490","author":"Stack","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1126\/science.1172871","article-title":"Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity","volume":"324","author":"Subramaniam","year":"2009","journal-title":"Science"},{"key":"B76","first-page":"3","article-title":"Basal ganglia macrocircuits","volume-title":"Progress in Brain Research","author":"Tepper","year":"2007"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1097\/wnr.0b013e3282f262ca","article-title":"Reduced activity of cortico-striatal fibres in the R6\/2 mouse model of Huntington\u2019s disease","volume":"18","author":"Traficante","year":"2007","journal-title":"Neuroreport"},{"key":"B78","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/ng0595-104","article-title":"Cellular localization of the Huntington\u2019s disease protein and discrimination of the normal and mutated form","volume":"10","author":"Trottier","year":"1995","journal-title":"Nat. Genet."},{"key":"B79","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1460-9568.1995.tb01057.x","article-title":"The neurotrophins BDNF, NT-3 and NT-4\/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro","volume":"7","author":"Ventimiglia","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1002\/mds.26007","article-title":"Targets for future clinical trials in Huntington\u2019s disease: what\u2019s in the pipeline?","volume":"29","author":"Wild","year":"2014","journal-title":"Mov. Disord."},{"key":"B81","doi-asserted-by":"publisher","first-page":"14708","DOI":"10.1523\/JNEUROSCI.1637-10.2010","article-title":"BDNF overexpression in the forebrain rescues Huntington\u2019s disease phenotypes in YAC128 mice","volume":"30","author":"Xie","year":"2010","journal-title":"J. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"B83","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.phrs.2005.01.001","article-title":"Progressive loss of BDNF in a mouse model of Huntington\u2019s disease and rescue by BDNF delivery","volume":"52","author":"Zuccato","year":"2005","journal-title":"Pharmacol. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","article-title":"Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington\u2019s disease","volume":"18","author":"Zuccato","year":"2008","journal-title":"Brain Pathol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T06:20:37Z","timestamp":1567664437000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fncel.2016.00037\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,9]]},"references-count":84,"URL":"https:\/\/doi.org\/10.3389\/fncel.2016.00037","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,9]]}}}