{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:39:15Z","timestamp":1777426755409,"version":"3.51.4"},"reference-count":85,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CNMPB"],"award-info":[{"award-number":["CNMPB"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["regular research grant 2817"],"award-info":[{"award-number":["regular research grant 2817"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2016.00266","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T06:30:46Z","timestamp":1479191446000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Systemic Radical Scavenger Treatment of a Mouse Model of Rett Syndrome: Merits and Limitations of the Vitamin E Derivative Trolox"],"prefix":"10.3389","volume":"10","author":[{"given":"Oliwia A.","family":"Janc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"H\u00fcser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Kempkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Menzfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen","family":"H\u00fclsmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18208","DOI":"10.1073\/pnas.1012104107","article-title":"Correction of respiratory disorders in a mouse model of Rett syndrome","volume":"107","author":"Abdala","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/0896-6273(89)90310-3","article-title":"Selective modulation of NMDA responses by reduction and oxidation","volume":"2","author":"Aizenman","year":"1989","journal-title":"Neuron"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1039\/c3cp43319f","article-title":"A physicochemical examination of the free radical scavenging activity of Trolox: mechanism, kinetics and influence of the environment","volume":"15","author":"Alberto","year":"2013","journal-title":"Phys. Chem. Chem. Phys."},{"key":"B3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.ntt.2009.09.003","article-title":"Trolox ameliorates 3-nitropropionic acid-induced neurotoxicity in rats","volume":"32","author":"Al Mutairy","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/pl00005718","article-title":"Modulation of the spinal network for locomotion by substance P in the neonatal rat","volume":"115","author":"Barthe","year":"1997","journal-title":"Exp. Brain Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/nu4060467","article-title":"Plasma and tissue concentrations of \u03b1-tocopherol and \u03b4-tocopherol following high dose dietary supplementation in mice","volume":"4","author":"Baxter","year":"2012","journal-title":"Nutrients"},{"key":"B9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/cne.21673","article-title":"Comparative study of brain morphology in Mecp2 mutant mouse models of Rett syndrome","volume":"508","author":"Belichenko","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/cne.22009","article-title":"Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks","volume":"514","author":"Belichenko","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"19796","DOI":"10.1038\/srep19796","article-title":"Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice","volume":"6","author":"Bittolo","year":"2016","journal-title":"Sci. Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1006\/exnr.1999.7030","article-title":"Altered development of glutamate and GABA receptors in the basal ganglia of girls with Rett syndrome","volume":"156","author":"Blue","year":"1999","journal-title":"Exp. Neurol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1152\/jn.00800.2010","article-title":"Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging","volume":"105","author":"Calfa","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"B15","doi-asserted-by":"publisher","first-page":"358","DOI":"10.2174\/15748847113086660069","article-title":"Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives","volume":"8","author":"Chapleau","year":"2013","journal-title":"Curr. Clin. Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B17","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.freeradbiomed.2009.05.016","article-title":"Systemic oxidative stress in classic Rett syndrome","volume":"47","author":"De Felice","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.nbd.2014.04.006","article-title":"Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome","volume":"68","author":"De Felice","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s12263-012-0285-7","article-title":"Partial rescue of Rett syndrome by \u03c9-3 polyunsaturated fatty acids (PUFAs) oil","volume":"7","author":"De Felice","year":"2012a","journal-title":"Genes Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1749-6632.2012.06611.x","article-title":"The role of oxidative stress in Rett syndrome: an overview","volume":"1259","author":"De Felice","year":"2012b","journal-title":"Ann. N Y Acad. Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1194\/jlr.p017798","article-title":"F2-dihomo-isoprostanes as potential early biomarkers of lipid oxidative damage in Rett syndrome","volume":"52","author":"De Felice","year":"2011","journal-title":"J. Lipid Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2015.02.014","article-title":"Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1","volume":"83","author":"De Filippis","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1167\/iovs.05-0727","article-title":"Structural and functional consequences of trolox C treatment in the rat model of postnatal hyperoxia","volume":"47","author":"Dorfman","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0387-7604(93)90045-a","article-title":"Mitochondrial dysfunction in Rett syndrome. An ultrastructural and biochemical study","volume":"15","author":"Dotti","year":"1993","journal-title":"Brain Dev."},{"key":"B25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1113\/jphysiol.1992.sp019114","article-title":"Mitochondrial function in type I cells isolated from rabbit arterial chemoreceptors","volume":"450","author":"Duchen","year":"1992","journal-title":"J. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.neubiorev.2004.09.002","article-title":"An overview of the tasks used to test working memory in rodents","volume":"28","author":"Dudchenko","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1177\/088307389000500311","article-title":"Rett syndrome: a mitochondrial disease?","volume":"5","author":"Eeg-Olofsson","year":"1990","journal-title":"J. Child Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/0005-2728(86)90112-x","article-title":"Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties","volume":"850","author":"Emaus","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"B29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1051\/rnd:19860413","article-title":"Changes in energy-metabolism during the suckling and weaning period in the newborn","volume":"26","author":"Ferr\u00e9","year":"1986","journal-title":"Reprod. Nutr. Dev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2015.04.019","article-title":"Exploring the possible link between MeCP2 and oxidative stress in Rett syndrome","volume":"88","author":"Filosa","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1152\/jn.91124.2008","article-title":"Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett syndrome","volume":"101","author":"Fischer","year":"2009","journal-title":"J. Neurophysiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0022-510x(98)00035-5","article-title":"Vitamin E serum levels in Rett syndrome","volume":"156","author":"Formichi","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.pneurobio.2006.07.001","article-title":"Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration","volume":"79","author":"Foster","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"C508","DOI":"10.1152\/ajpcell.00253.2006","article-title":"Imaging of respiratory-related population activity with single-cell resolution","volume":"292","author":"Funke","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1016\/j.neuroimage.2010.11.031","article-title":"Dynamic, semi-quantitative imaging of intracellular ROS levels and redox status in rat hippocampal neurons","volume":"54","author":"Funke","year":"2011","journal-title":"Neuroimage"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1152\/jn.00550.2010","article-title":"Hydrogen peroxide differentially affects activity in the pre-B\u00f6tzinger complex and hippocampus","volume":"106","author":"Garcia","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1152\/jn.01015.2005","article-title":"Mitochondrial inhibition prior to oxygen-withdrawal facilitates the occurrence of hypoxia-induced spreading depression in rat hippocampal slices","volume":"96","author":"Gerich","year":"2006","journal-title":"J. Neurophysiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.nbd.2012.06.007","article-title":"Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome","volume":"48","author":"Gro\u00dfer","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1248\/bpb.29.957","article-title":"Neuroprotective effects of trolox in global cerebral ischemia in gerbils","volume":"29","author":"Gupta","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"B40","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1651-2227.1985.tb10993.x","article-title":"Rett\u2019s syndrome: prevalence and impact on progressive severe mental retardation in girls","volume":"74","author":"Hagberg","year":"1985","journal-title":"Acta Paediatr. Scand."},{"key":"B42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1469-7793.2000.00107.x","article-title":"Oxygen-sensing persistent sodium channels in rat hippocampus","volume":"529","author":"Hammarstr\u00f6m","year":"2000","journal-title":"J. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"13044","DOI":"10.1074\/jbc.M312846200","article-title":"Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators","volume":"279","author":"Hanson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1152\/jn.00291.2005","article-title":"Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK-channels","volume":"94","author":"Hepp","year":"2005","journal-title":"J. Neurophysiol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"539","DOI":"10.4067\/s0716-97602004000400007","article-title":"Redox regulation of RyR-mediated Ca2+ release in muscle and neurons","volume":"37","author":"Hidalgo","year":"2004","journal-title":"Biol Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fncel.2014.00056","article-title":"The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity and improves hypoxia tolerance in a mouse model of Rett syndrome","volume":"8","author":"Janc","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/adc.85.1.29","article-title":"Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder","volume":"85","author":"Julu","year":"2001","journal-title":"Arch. Dis. Child."},{"key":"B48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.resp.2009.04.017","article-title":"Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth","volume":"168","author":"Katz","year":"2009","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/s0166-2236(98)01322-8","article-title":"Stress: metaplastic effects in the hippocampus","volume":"21","author":"Kim","year":"1998","journal-title":"Trends Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1074\/JBC.273.8.4516","article-title":"A role for superoxide in protein kinase C activation and induction of long-term potentiation","volume":"273","author":"Klann","year":"1998","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1128\/mcb.01665-05","article-title":"Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome","volume":"26","author":"Kriaucionis","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1172\/JCI80323","article-title":"PTP1B inhibition suggests a therapeutic strategy for Rett syndrome","volume":"125","author":"Krishnan","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B54","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2337\/db07-1056","article-title":"Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion","volume":"58","author":"Leloup","year":"2009","journal-title":"Diabetes"},{"key":"B55","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/ana.22363","article-title":"Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy","volume":"70","author":"L\u00f3pez-Erauskin","year":"2011","journal-title":"Ann. Neurol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"983178","DOI":"10.1155\/2014\/983178","article-title":"Effects of omega-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome","volume":"2014","author":"Maffei","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.tem.2007.04.004","article-title":"Mitochondria as key components of the stress response","volume":"18","author":"Manoli","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"B58","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1152\/jn.00826.2007","article-title":"Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome","volume":"99","author":"Medrihan","year":"2008","journal-title":"J. Neurophysiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/hmg\/ddi016","article-title":"Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome","volume":"14","author":"Moretti","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2990","DOI":"10.1152\/jn.00790.2001","article-title":"Differential oxidative modulation of voltage-dependent K+ currents in rat hippocampal neurons","volume":"87","author":"M\u00fcller","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1042\/BST20140071","article-title":"Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome","volume":"42","author":"M\u00fcller","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e64863","DOI":"10.1371\/journal.pone.0064863","article-title":"Vascular dysfunction in a mouse model of Rett syndrome and effects of curcumin treatment","volume":"8","author":"Panighini","year":"2013","journal-title":"PLoS One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1093\/brain\/awl022","article-title":"Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice","volume":"129","author":"Pelka","year":"2006","journal-title":"Brain"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1093\/hmg\/ddt111","article-title":"Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function","volume":"22","author":"Pitcher","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B66","first-page":"723","article-title":"\u00dcber ein eigenartiges hirnatrophisches Syndrom bei Hyperammon\u00e4mie im Kindesalter","volume":"116","author":"Rett","year":"1966","journal-title":"Wien. Med. Wochenschr."},{"key":"B67","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s0091-3057(98)00239-1","article-title":"Different levels of Fos immunoreactivity after repeated handling and injection stress in two inbred strains of mice","volume":"63","author":"Ryabinin","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B68","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1046\/j.0022-3042.2001.00706.x","article-title":"Modulation of the GABAA-gated chloride channel by reactive oxygen species","volume":"80","author":"Sah","year":"2002","journal-title":"J. Neurochem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1601-183x.2006.00258.x","article-title":"Evidence for abnormal early development in a mouse model of Rett syndrome","volume":"6","author":"Santos","year":"2007","journal-title":"Genes Brain Behav."},{"key":"B70","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.arr.2004.05.002","article-title":"Reactive oxygen species and synaptic plasticity in the aging hippocampus","volume":"3","author":"Serrano","year":"2004","journal-title":"Ageing Res. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0896-6273(02)00768-7","article-title":"Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3","volume":"35","author":"Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"B72","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/00019052-200104000-00006","article-title":"Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations","volume":"14","author":"Shahbazian","year":"2001","journal-title":"Curr. Opin. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"S236","DOI":"10.1016\/s0387-7604(01)00369-2","article-title":"Oxidative stress in Rett syndrome","volume":"23","author":"Sierra","year":"2001","journal-title":"Brain Dev."},{"key":"B74","doi-asserted-by":"publisher","first-page":"e0150101","DOI":"10.1371\/journal.pone.0150101","article-title":"MECP2 duplication syndrome: evidence of enhanced oxidative stress. A comparison with Rett syndrome","volume":"11","author":"Signorini","year":"2016","journal-title":"PLoS One"},{"key":"B75","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/978-0-387-73693-8_88","article-title":"Disturbances of breathing in Rett syndrome: results from patients and animal models","volume":"605","author":"Stettner","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.addr.2008.05.001","article-title":"The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies","volume":"60","author":"Tarnopolsky","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1152\/jn.00676.2001","article-title":"Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network","volume":"88","author":"Telgkamp","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B78","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1523\/JNEUROSCI.20-20-07631.2000","article-title":"Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase","volume":"20","author":"Thiels","year":"2000","journal-title":"J. Neurosci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.freeradbiomed.2011.05.017","article-title":"Vitamins C and E: beneficial effects from a mechanistic perspective","volume":"51","author":"Traber","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/s0887-8994(02)00399-5","article-title":"Brain glucose metabolism in Rett syndrome","volume":"27","author":"Villemagne","year":"2002","journal-title":"Pediatr. Neurol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/bio.2975","article-title":"Quantitative and antioxidative behavior of Trolox in rats\u2019 blood and brain by HPLC-UV and SMFIA-CL methods","volume":"31","author":"Wada","year":"2016","journal-title":"Luminescence"},{"key":"B82","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1203\/01.pdr.0000238302.84552.d0","article-title":"Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome","volume":"60","author":"Weese-Mayer","year":"2006","journal-title":"Pediatr. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e115444","DOI":"10.1371\/journal.pone.0115444","article-title":"Characterization of the MeCP2R168X knockin mouse model for Rett syndrome","volume":"9","author":"Wegener","year":"2014","journal-title":"PLoS One"},{"key":"B84","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.resp.2007.08.009","article-title":"Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model","volume":"160","author":"Zanella","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1002\/hipo.20389","article-title":"The MeCP2-null mouse hippocampus displays altered basal inhibitory rhythms and is prone to hyperexcitability","volume":"18","author":"Zhang","year":"2008","journal-title":"Hippocampus"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2016.00266\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T12:04:17Z","timestamp":1568549057000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2016.00266\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":85,"URL":"https:\/\/doi.org\/10.3389\/fncel.2016.00266","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}