{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:05:35Z","timestamp":1791399935534,"version":"4.3.3"},"reference-count":197,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH095741"],"award-info":[{"award-number":["R01MH095741"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19MH106434"],"award-info":[{"award-number":["U19MH106434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000952","name":"Paul G. Allen Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","award":["#2012-PG-MED002"],"award-info":[{"award-number":["#2012-PG-MED002"]}],"id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001229","name":"G. Harold and Leila Y. Mathers Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2017.00030","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T03:37:17Z","timestamp":1487043437000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":95,"title":["Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges"],"prefix":"10.3389","volume":"11","author":[{"given":"Yeni","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred H.","family":"Gage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Marchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1034\/j.1399-5618.4.s1.2.x","article-title":"Myo-inositol-1-phosphate (MIP) synthase: a possible new target for antibipolar drugs","volume":"4","author":"Agam","year":"2002","journal-title":"Bipolar Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1001\/archinte.1956.00250250041006","article-title":"Carbohydrate metabolism in brain disease. VI. Lactate metabolism after infusion of sodium d-lactate in manic-depressive and schizophrenic psychoses","volume":"98","author":"Altschule","year":"1956","journal-title":"AMA. Arch. Intern. Med."},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and Statistical Manual of Mental Disorders DSM-5.","author":"American Psychiatric Association","year":"2013","edition":"5th Edn."},{"key":"B4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.jpsychires.2006.07.013","article-title":"Serum S100B and antioxidant enzymes in bipolar patients","volume":"41","author":"Andreazza","year":"2007","journal-title":"J. Psychiatr. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jad.2008.04.013","article-title":"Oxidative stress markers in bipolar disorder: a meta-analysis","volume":"111","author":"Andreazza","year":"2008a","journal-title":"J. Affect. Disord."},{"key":"B6","first-page":"516","article-title":"Effects of mood stabilizers on DNA damage in an animal model of mania","volume":"33","author":"Andreazza","year":"2008b","journal-title":"J. Psychiatry Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/archgenpsychiatry.2010.22","article-title":"Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder","volume":"67","author":"Andreazza","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1017\/s1461145713000096","article-title":"The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment","volume":"17","author":"Andreazza","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1001\/archinte.163.2.205","article-title":"A prospective study of sleep duration and coronary heart disease in women","volume":"163","author":"Ayas","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nrm1666","article-title":"Autophagy: dual roles in life and death?","volume":"6","author":"Baehrecke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"R75","DOI":"10.1530\/JOE-14-0200","article-title":"Circadian regulation of metabolism","volume":"222","author":"Bailey","year":"2014","journal-title":"J. Endocrinol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neulet.2009.03.022","article-title":"Mood stabilizing drugs lamotrigine and olanzapine increase expression and activity of glutathione s-transferase in primary cultured rat cerebral cortical cells","volume":"455","author":"Bakare","year":"2009","journal-title":"Neurosci. Lett."},{"key":"B13","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/j.1399-5618.2007.00385.x","article-title":"Effects of treatment latency on response to maintenance treatment in manic-depressive disorders","volume":"9","author":"Baldessarini","year":"2007","journal-title":"Bipolar Disord."},{"key":"B14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.pnpbp.2011.12.006","article-title":"Effects of lithium therapy on Na+-K+- ATPase activity and lipid peroxidation in bipolar disorder","volume":"37","author":"Banerjee","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jpsychires.2011.11.010","article-title":"Increased levels of adipokines in bipolar disorder","volume":"46","author":"Barbosa","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/mp.2014.176","article-title":"Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder","volume":"20","author":"Bavamian","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cell.2007.11.041","article-title":"A \u03b2-arrestin 2 signaling complex mediates lithium action on behavior","volume":"132","author":"Beaulieu","year":"2008","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fpsyt.2015.00118","article-title":"Circadian rhythms and mood disorders: are the phenomena and mechanisms causally related?","volume":"6","author":"Bechtel","year":"2015","journal-title":"Front. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4088\/JCP.13m08455","article-title":"Rapid treatment response of suicidal symptoms to lithium, sleep deprivation and light therapy (chronotherapeutics) in drug-resistant bipolar depression","volume":"75","author":"Benedetti","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/nyas.12885","article-title":"Calcium signaling as a mediator of cell energy demand a trigger to cell death","volume":"1350","author":"Bhosale","year":"2015","journal-title":"Ann. N Y Acad. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.jpsychires.2016.10.003","article-title":"Epidemiology of DSM-5 bipolar I disorder: results from the National epidemiologic survey on alcohol and related conditions\u2014III","volume":"84","author":"Blanco","year":"2017","journal-title":"J. Psychiatr. Res."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.15m10189","article-title":"A longitudinal study of the relationships between mood symptoms, body mass index and serum adipokines in bipolar disorder","author":"Bond","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"39155","DOI":"10.1074\/jbc.m306409200","article-title":"Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate","volume":"278","author":"Bose","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.eurpsy.2014.04.006","article-title":"Links between sleep and body mass index in bipolar disorders: an exploratory study","volume":"30","author":"Boudebesse","year":"2015","journal-title":"Eur. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/cdd.2010.142","article-title":"Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress","volume":"18","author":"Bouman","year":"2011","journal-title":"Cell Death Differ."},{"key":"B26","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/tpj.2016.50","article-title":"Lithium-responsive genes and gene networks in bipolar disorder patient-derived lymphoblastoid cell lines","volume":"16","author":"Breen","year":"2016","journal-title":"Pharmacogenomics J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature09915","article-title":"Modelling schizophrenia using human induced pluripotent stem cells","volume":"473","author":"Brennand","year":"2011","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj2840001","article-title":"Control of respiration and ATP synthesis in mammalian mitochondria and cells","volume":"284","author":"Brown","year":"1992","journal-title":"Biochem. J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.psychres.2014.04.005","article-title":"An updated meta-analysis of oxidative stress markers in bipolar disorder","volume":"218","author":"Brown","year":"2014","journal-title":"Psychiatry Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.2174\/1381612054065729","article-title":"Oxidative stress, antioxidants and neurodegenerative diseases","volume":"11","author":"Casetta","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"B31","first-page":"832","article-title":"Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations","volume":"21","author":"Castillo","year":"2000","journal-title":"Am. J. Neuroradiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2353\/ajpath.2010.081068","article-title":"Abnormalities in mitochondrial structure in cells from patients with bipolar disorder","volume":"177","author":"Cataldo","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1503\/jpn.090083","article-title":"Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness","volume":"35","author":"Che","year":"2010","journal-title":"J. Psychiatry Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e375","DOI":"10.1038\/tp.2014.12","article-title":"Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients","volume":"4","author":"Chen","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1046\/j.1471-4159.1994.63062361.x","article-title":"Chronic sodium valproate selectively decreases protein kinase C \u03b1 and \u03b5 in vitro","volume":"63","author":"Chen","year":"1994","journal-title":"J. Neurochem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/ajmg.b.32271","article-title":"The -116C\/G polymorphism in XBP1 gene is associated with psychiatric illness in Asian population: a meta-analysis","volume":"165B","author":"Cheng","year":"2014","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/j.jad.2013.06.003","article-title":"Risky alcohol use in young persons with emerging bipolar disorder is associated with increased oxidative stress","volume":"150","author":"Chitty","year":"2013","journal-title":"J. Affect. Disord."},{"key":"B38","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/WNP.0b013e31816ef739","article-title":"Persistent suppression of postexercise facilitation of motor evoked potentials during alternate phases of bipolar disorder","volume":"25","author":"Chroni","year":"2008","journal-title":"J. Clin. Neurophysiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.pscychresns.2013.03.004","article-title":"Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder","volume":"213","author":"Chu","year":"2013","journal-title":"Psychiatry Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jad.2015.09.076","article-title":"Sleep, residual mood symptoms and time to relapse in recovered patients with bipolar disorder","volume":"190","author":"Cretu","year":"2016","journal-title":"J. Affect. Disord."},{"key":"B41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40345-016-0050-8","article-title":"Biological rhythms are independently associated with quality of life in bipolar disorder","volume":"4","author":"Cudney","year":"2016","journal-title":"Int. J. Bipolar Disord."},{"key":"B42","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1017\/s1461145713001740","article-title":"Alterations in circadian rhythms are associated with increased lipid peroxidation in females with bipolar disorder","volume":"17","author":"Cudney","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.neuroscience.2006.11.010","article-title":"Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate","volume":"144","author":"Cui","year":"2007","journal-title":"Neuroscience"},{"key":"B44","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1001\/archpsyc.61.5.450","article-title":"Brain metabolic alterations in medication-free patients with bipolar disorder","volume":"61","author":"Dager","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"B45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pnpbp.2016.09.004","article-title":"Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology","volume":"72","author":"Data-Franco","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2165\/11632000-000000000-00000","article-title":"Minocycline: therapeutic potential in psychiatry","volume":"26","author":"Dean","year":"2012","journal-title":"CNS Drugs"},{"key":"B48","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1176\/ajp.152.6.915","article-title":"Abnormal frontal lobe phosphorous metabolism in bipolar disorder","volume":"152","author":"Deicken","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jpsychires.2013.11.011","article-title":"Oxidative stress in early stage bipolar disorder and the association with response to lithium","volume":"50","author":"de Sousa","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/nrm2275","article-title":"Functions and dysfunctions of mitochondrial dynamics","volume":"8","author":"Detmer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.jad.2015.07.004","article-title":"Biological rhythms in bipolar and depressive disorders: a community study with drug-na\u00efve young adults","volume":"186","author":"Duarte Faria","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jad.2014.04.025","article-title":"Increased platelet intracellular calcium ion concentration is specific to bipolar disorder","volume":"164","author":"Dubovsky","year":"2014","journal-title":"J. Affect. Disord."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.biopsych.2009.12.004","article-title":"Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder","volume":"67","author":"Eastwood","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pscychresns.2015.05.010","article-title":"Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder","volume":"233","author":"Ehrlich","year":"2015","journal-title":"Psychiatry Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1038\/ejhg.2014.261","article-title":"Association of rare variation in the glutamate receptor gene SLC1A2 with susceptibility to bipolar disorder and schizophrenia","volume":"23","author":"Fiorentino","year":"2014","journal-title":"Eur. J. Hum. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"719","DOI":"10.2147\/NDT.S100846","article-title":"Prevalence and clinical features associated with bipolar disorder polypharmacy: a systematic review","volume":"12","author":"Fornaro","year":"2016","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B56","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1399-5618.2007.00454.x","article-title":"Abnormal cellular energy and phospholipid metabolism in the left dorsolateral prefrontal cortex of medication-free individuals with bipolar disorder: an in vivo1H MRS study","volume":"9","author":"Frey","year":"2007","journal-title":"Bipolar Disord."},{"key":"B57","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.biopsych.2004.06.012","article-title":"Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder","volume":"56","author":"Friedman","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.jad.2013.07.027","article-title":"Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder","volume":"152\u2013154","author":"Fries","year":"2014","journal-title":"J. Affect. Disord."},{"key":"B59","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3109\/10409238.2013.786672","article-title":"Metabolism as an integral cog in the mammalian circadian clockwork","volume":"48","author":"Gamble","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1176\/appi.ajp.161.2.217","article-title":"Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials","volume":"161","author":"Geddes","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","article-title":"Treatment of bipolar disorder","volume":"381","author":"Geddes","year":"2013","journal-title":"Lancet"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1038\/sj.cdd.4402147","article-title":"Mitochondrial Ca2+ as a key regulator of cell life and death","volume":"14","author":"Giacomello","year":"2007","journal-title":"Cell Death Differ."},{"key":"B63","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1111\/j.1399-5618.2012.01033.x","article-title":"Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis","volume":"14","author":"Gigante","year":"2012","journal-title":"Bipolar Disord."},{"key":"B64","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1177\/0269881116636545","article-title":"Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology","volume":"30","author":"Goodwin","year":"2016","journal-title":"J. Psychopharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"pyu019","DOI":"10.1093\/ijnp\/pyu019","article-title":"Proteomic enrichment analysis of psychotic and affective disorders reveals common signatures in presynaptic glutamatergic signaling and energy metabolism","volume":"18","author":"Gottschalk","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1601-183x.2005.00186.x","article-title":"Psychiatric endophenotypes and the development of valid animal models","volume":"5","author":"Gould","year":"2006","journal-title":"Genes Brain Behav."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40345-015-0043-z","article-title":"Circadian rhythmicity in emerging mood disorders: state or trait marker?","volume":"4","author":"Grierson","year":"2016","journal-title":"Int. J. Bipolar Disord."},{"key":"B68","doi-asserted-by":"publisher","first-page":"318596","DOI":"10.1155\/2013\/318596","article-title":"Immature dentate gyrus: an endophenotype of neuropsychiatric disorders","volume":"2013","author":"Hagihara","year":"2013","journal-title":"Neural Plast."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"B70","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.freeradbiomed.2008.11.008","article-title":"The wanderings of a free radical","volume":"46","author":"Halliwell","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/iub.1272","article-title":"The many functions of the endoplasmic reticulum chaperones and folding enzymes","volume":"66","author":"Halperin","year":"2014","journal-title":"IUBMB Life"},{"key":"B72","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.mp.4001618","article-title":"Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited","volume":"10","author":"Harwood","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.biopsych.2007.03.017","article-title":"Increased levels of glutamate in brains from patients with mood disorders","volume":"62","author":"Hashimoto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B74","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jpsychores.2015.04.005","article-title":"Cardiovascular and psychiatric characteristics associated with oxidative stress markers among adolescents with bipolar disorder","volume":"79","author":"Hatch","year":"2015","journal-title":"J. Psychosom. Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1017\/s1461145708009358","article-title":"Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder","volume":"12","author":"Hayashi","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"161","DOI":"10.4088\/jcp.v64n0209","article-title":"Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder","volume":"64","author":"Hirschfeld","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"B78","first-page":"450","article-title":"Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions","volume":"5","author":"Hunsberger","year":"2013","journal-title":"Am. J. Transl. Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"29397","DOI":"10.1074\/jbc.m503526200","article-title":"A role for glycogen synthase kinase-3\u03b2 in the mammalian circadian clock","volume":"280","author":"Iitaka","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B80","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/hmg\/ddi022","article-title":"Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis","volume":"14","author":"Iwamoto","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"B81","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s12264-015-1548-2","article-title":"Molecular network of neuronal autophagy in the pathophysiology and treatment of depression","volume":"31","author":"Jia","year":"2015","journal-title":"Neurosci. Bull."},{"key":"B82","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.schres.2016.04.029","article-title":"Altered circadian clock gene expression in patients with schizophrenia","volume":"174","author":"Johansson","year":"2016","journal-title":"Schizophr. Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jpsychires.2010.05.011","article-title":"Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania","volume":"45","author":"Jornada","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"B84","volume-title":"Die Gruppirung der Psychischen Krankheiten und die Eintheilung der Seelenst\u00f6rungen.","author":"Kahlbaum","year":"1863"},{"key":"B85","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/ng1235","article-title":"Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder","volume":"35","author":"Kakiuchi","year":"2003","journal-title":"Nat. Genet."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1740-3391-5-3","article-title":"Glycogen synthase kinase 3, circadian rhythms and bipolar disorder: a molecular link in the therapeutic action of lithium","volume":"5","author":"Kaladchibachi","year":"2007","journal-title":"J. Circadian Rhythms"},{"key":"B88","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuroscience.2015.08.016","article-title":"Animal models of recurrent or bipolar depression","volume":"321","author":"Kato","year":"2016","journal-title":"Neuroscience"},{"key":"B87","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1034\/j.1399-5618.2000.020305.x","article-title":"Mitochondrial dysfunction in bipolar disorder","volume":"2","author":"Kato","year":"2000","journal-title":"Bipolar Disord."},{"key":"B89","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/s0165-0327(99)00173-1","article-title":"Mitochondrial DNA polymorphisms in bipolar disorder","volume":"62","author":"Kato","year":"2001","journal-title":"J. Affect. Disord."},{"key":"B90","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0925-4927(94)90010-8","article-title":"Phosphorus-31 magnetic resonance spectroscopy and ventricular enlargement in bipolar disorder","volume":"55","author":"Kato","year":"1994","journal-title":"Psychiatry Res."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.4088\/jcp.v64n1205","article-title":"Bipolar disorder, obesity and pharmacotherapy-associated weight gain","volume":"63","author":"Keck","year":"2003","journal-title":"J. Clin. Psychiatry"},{"key":"B92","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1399-5618.2010.00823.x","article-title":"Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine\/metabolic system and treatment outcome","volume":"12","author":"Kemp","year":"2010","journal-title":"Bipolar Disord."},{"key":"B93","doi-asserted-by":"publisher","first-page":"a018812","DOI":"10.1101\/cshperspect.a018812","article-title":"Neurogenesis in the adult hippocampus","volume":"7","author":"Kempermann","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jad.2015.03.027","article-title":"Causes of decreased life expectancy over the life span in bipolar disorder","volume":"180","author":"Kessing","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.pnpbp.2007.04.009","article-title":"Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy","volume":"31","author":"Kim","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B96","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3109\/07420528.2011.611602","article-title":"The CLOCK gene and mood disorders: a case-control study and meta-analysis","volume":"28","author":"Kishi","year":"2011","journal-title":"Chronobiol. Int."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1126\/science.290.5497.1717","article-title":"Autophagy as a regulated pathway of cellular degradation","volume":"290","author":"Klionsky","year":"2000","journal-title":"Science"},{"key":"B98","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/oby.2007.133","article-title":"Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder","volume":"16","author":"Kolotkin","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"B99","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.3174\/ajnr.A3844","article-title":"A review of MR spectroscopy studies of pediatric bipolar disorder","volume":"35","author":"Kondo","year":"2014","journal-title":"Am. J. Neuroradiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1001\/archpsyc.61.3.300","article-title":"Molecular evidence for mitochondrial dysfunction in bipolar disorder","volume":"61","author":"Konradi","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"B101","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.jpsychires.2012.12.006","article-title":"In vivo glutathione levels in young persons with bipolar disorder: a magnetic resonance spectroscopy study","volume":"47","author":"Lagopoulos","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"B102","doi-asserted-by":"crossref","first-page":"333","DOI":"10.31887\/DCNS.2007.9.3\/elamont","article-title":"The role of circadian clock genes in mental disorders","volume":"9","author":"Lamont","year":"2007","journal-title":"Dialogues Clin. Neurosci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/ng.3749","article-title":"Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits","volume":"49","author":"Lane","year":"2017","journal-title":"Nat. Genet."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2011.12.049","article-title":"Can bipolar disorder be viewed as a multi-system inflammatory disease?","volume":"141","author":"Leboyer","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B105","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/jcp.0b013e31814ce524","article-title":"Cortical inhibitory dysfunction in bipolar disorder: a study using transcranial magnetic stimulation","volume":"27","author":"Levinson","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1176\/ajp.139.11.1496","article-title":"Bright artificial light treatment of a manic-depressive patient with a seasonal mood cycle","volume":"139","author":"Lewy","year":"1982","journal-title":"Am. J. Psychiatry"},{"key":"B107","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/j.1399-5618.2010.00866.x","article-title":"Regulation of glycogen synthase kinase-3 during bipolar mania treatment","volume":"12","author":"Li","year":"2010","journal-title":"Bipolar Disord."},{"key":"B108","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.neuroscience.2015.08.041","article-title":"Animal models of bipolar mania: the past, present and future","volume":"321","author":"Logan","year":"2016","journal-title":"Neuroscience"},{"key":"B109","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/mp.2015.7","article-title":"Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities","volume":"20","author":"Madison","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B110","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fpsyt.2014.00098","article-title":"Integrated neurobiology of bipolar disorder","volume":"5","author":"Maletic","year":"2014","journal-title":"Front. Psychiatry"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1111\/j.1471-4159.1993.tb07474.x","article-title":"Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the \u03b1 isozyme","volume":"61","author":"Manji","year":"1993","journal-title":"J. Neurochem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nrn1519","article-title":"Interneurons of the neocortical inhibitory system","volume":"5","author":"Markram","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.stem.2013.04.008","article-title":"Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells","volume":"12","author":"Maroof","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00213-015-4189-2","article-title":"Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla","volume":"233","author":"Masaki","year":"2016","journal-title":"Psychopharmacology"},{"key":"B116","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1111\/j.1399-5618.2009.00729.x","article-title":"Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue","volume":"11","author":"Maurer","year":"2009","journal-title":"Bipolar Disord."},{"key":"B117","doi-asserted-by":"publisher","first-page":"R551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: more than just a powerhouse","volume":"16","author":"McBride","year":"2006","journal-title":"Curr. Biol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4088\/jcp.v63n0306","article-title":"Correlates of overweight and obesity in 644 patients with bipolar disorder","volume":"63","author":"McElroy","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"B119","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/10401230590932380","article-title":"Bipolar disorder and diabetes mellitus: epidemiology, etiology and treatment implications","volume":"17","author":"McIntyre","year":"2005","journal-title":"Ann. Clin. Psychiatry"},{"key":"B120","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jad.2015.04.032","article-title":"Mortality and secular trend in the incidence of bipolar disorder","volume":"183","author":"Medici","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.06.007","article-title":"Chronotype and circadian rhythm in bipolar disorder: a systematic review","author":"Melo","year":"2016a","journal-title":"Sleep Med. Rev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.jpsychires.2016.09.005","article-title":"Sleep and circadian alterations in people at risk for bipolar disorder: a systematic review","volume":"83","author":"Melo","year":"2016b","journal-title":"J. Psychiatr. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/mp.2013.174","article-title":"Autophagy has a key role in the pathophysiology of schizophrenia","volume":"20","author":"Merenlender-Wagner","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B124","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","article-title":"Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative","volume":"68","author":"Merikangas","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"B125","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nature15526","article-title":"Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder","volume":"527","author":"Mertens","year":"2015","journal-title":"Nature"},{"key":"B126","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s00213-003-1440-z","article-title":"Acute mania is accompanied by elevated glutamate\/glutamine levels within the left dorsolateral prefrontal cortex","volume":"168","author":"Michael","year":"2003","journal-title":"Psychopharmacology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nrn2151","article-title":"Neuronal subtype specification in the cerebral cortex","volume":"8","author":"Molyneaux","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.jad.2006.08.023","article-title":"Mania, glutamate\/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex","volume":"99","author":"Moore","year":"2007","journal-title":"J. Affect. Disord."},{"key":"B129","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/b978-0-444-59427-3.00019-8","article-title":"The impact of the circadian timing system on cardiovascular and metabolic function","volume":"199","author":"Morris","year":"2012","journal-title":"Prog. Brain Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.ygeno.2004.08.015","article-title":"Mitochondrial DNA 3644T\u2190C mutation associated with bipolar disorder","volume":"84","author":"Munakata","year":"2004","journal-title":"Genomics"},{"key":"B131","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"Narenda","year":"2008","journal-title":"J. Cell Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal models of neuropsychiatric disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1586\/14737175.8.1.93","article-title":"Neurobiology of bipolar disorder","volume":"8","author":"Newberg","year":"2008","journal-title":"Expert Rev. Neurother."},{"key":"B134","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1080\/15402002.2015.1065407","article-title":"Eveningness and its associated impairments in remitted bipolar disorder","volume":"14","author":"Ng","year":"2016","journal-title":"Behav. Sleep Med."},{"key":"B135","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.stem.2013.04.005","article-title":"Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development","volume":"12","author":"Nicholas","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000314307","article-title":"Lithium: still a cornerstone in the long-term treatment in bipolar disorder?","volume":"62","author":"Nivoli","year":"2010","journal-title":"Neuropsychobiology"},{"key":"B137","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mcn.2015.11.006","article-title":"Neurodevelopmental origins of bipolar disorder: iPSC models","volume":"73","author":"O\u2019Shea","year":"2016","journal-title":"Mol. Cell. Neurosci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"5588","DOI":"10.1073\/pnas.0501703102","article-title":"The contribution of GABA to glutamate\/glutamine cycling and energy metabolism in the rat cortex in vivo","volume":"102","author":"Patel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B139","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1017\/s1461145707007973","article-title":"Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder","volume":"11","author":"Perova","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"427318","DOI":"10.1155\/2014\/427318","article-title":"Oxidative stress in Alzheimer\u2019s disease: why did antioxidant therapy fail?","volume":"2014","author":"Persson","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B141","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/s0149-7634(04)00025-9","article-title":"The selfish brain: competition for energy resources","volume":"28","author":"Peters","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1017\/S1461145714000443","article-title":"Impaired endoplasmic reticulum stress response in bipolar disorder: cellular evidence of illness progression","volume":"17","author":"Pfaffenseller","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/s0140-6736(13)60989-7","article-title":"Bipolar disorder diagnosis: challenges and future directions","volume":"381","author":"Phillips","year":"2013","journal-title":"Lancet"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12442","article-title":"The association between biological rhythms, depression and functioning in bipolar disorder: a large multi-center study","author":"Pinho","year":"2015","journal-title":"Acta Psychiatr. Scand."},{"key":"B145","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.tcb.2007.07.011","article-title":"Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics","volume":"17","author":"Pizzo","year":"2007","journal-title":"Trends Cell Biol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1073\/pnas.0709336105","article-title":"The PINK1\/Parkin pathway regulates mitochondrial morphology","volume":"105","author":"Poole","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B147","doi-asserted-by":"publisher","first-page":"9022","DOI":"10.1523\/JNEUROSCI.5216-05.2006","article-title":"Transgenic mice overexpressing glycogen synthase kinase 3\u03b2: a putative model of hyperactivity and mania","volume":"26","author":"Prickaerts","year":"2006","journal-title":"J. Neurosci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.tibs.2016.09.001","article-title":"Calcium at the center of cell signaling: interplay between endoplasmic reticulum, mitochondria and lysosomes","volume":"41","author":"Raffaello","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"B149","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/s0006-3223(00)00950-1","article-title":"Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells","volume":"48","author":"Rajkowska","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"B150","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.bbabio.2016.04.002","article-title":"Bioenergetic roles of mitochondrial fusion","volume":"1857","author":"Ramos","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B151","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/mp.2009.47","article-title":"Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients","volume":"15","author":"Rao","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"B152","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.biopsych.2008.11.010","article-title":"Elevated cerebrospinal fluid lactate concentrations in patients with bipolar disorder and schizophrenia: implications for the mitochondrial dysfunction hypothesis","volume":"65","author":"Regenold","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B153","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1034\/j.1399-5618.4.s1.3.x","article-title":"Bipolar disorders and suicidal behaviour","volume":"4","author":"Rihmer","year":"2002","journal-title":"Bipolar Disord."},{"key":"B154","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1017\/S0033291714000014","article-title":"Altered plasma glutathione levels in bipolar disorder indicates higher oxidative stress; a possible risk factor for illness onset despite normal brain-derived neurotrophic factor (BDNF) levels","volume":"44","author":"Rosa","year":"2014","journal-title":"Psychol. Med."},{"key":"B155","doi-asserted-by":"publisher","first-page":"6406","DOI":"10.1073\/pnas.0609625104","article-title":"Mania-like behavior induced by disruption of CLOCK","volume":"104","author":"Roybal","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B156","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1021\/cn5000277","article-title":"Response to lithium in bipolar disorder: clinical and genetic findings","volume":"5","author":"Rybakowski","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/bdi.12136","article-title":"Polymorphism of circadian clock genes and prophylactic lithium response","volume":"16","author":"Rybakowski","year":"2014","journal-title":"Bipolar Disord."},{"key":"B158","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.neubiorev.2016.06.040","article-title":"Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications","volume":"68","author":"Scaini","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B159","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.3109\/07420528.2015.1062024","article-title":"Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment","volume":"32","author":"Schnell","year":"2015","journal-title":"Chronobiol. Int."},{"key":"B160","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from mitochondria to metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell"},{"key":"B161","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy and mitochondria crosstalk underlies the ER stress response,","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"B162","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/s0278-5846(01)00154-3","article-title":"The mechanism of lithium action: state of the art, ten years later","volume":"25","author":"Shaldubina","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B163","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/j.1399-5618.2012.01040.x","article-title":"Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder: a phosphorus-31 magnetic resonance spectroscopy study","volume":"14","author":"Shi","year":"2012","journal-title":"Bipolar Disord."},{"key":"B164","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1073\/pnas.95.1.316","article-title":"Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity","volume":"95","author":"Sibson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/ncomms2320","article-title":"A safe lithium mimetic for bipolar disorder","volume":"4","author":"Singh","year":"2013","journal-title":"Nat. Commun."},{"key":"B166","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.biopsych.2006.10.014","article-title":"Impaired endoplasmic reticulum stress response in B-lymphoblasts from patients with bipolar-I disorder","volume":"15","author":"So","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1017\/S1461145713000047","article-title":"Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder","volume":"16","author":"Soeiro-de-Souza","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1080\/07420520902929060","article-title":"Chronotype and body composition in bipolar disorder","volume":"26","author":"Soreca","year":"2009","journal-title":"Chronobiol. Int."},{"key":"B169","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jad.2012.01.046","article-title":"Sleep duration is associated with dyslipidemia in patients with bipolar disorder in clinical remission","volume":"141","author":"Soreca","year":"2012","journal-title":"J. Affect. Disord."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1016\/s0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr. Biol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"14D","DOI":"10.1016\/j.amjcard.2008.02.003","article-title":"Why have antioxidants failed in clinical trials?","volume":"101","author":"Steinhubl","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/sj.mp.4001711","article-title":"Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research","volume":"10","author":"Stork","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"B173","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.jaac.2012.03.009","article-title":"Glutamatergic effects of divalproex in adolescents with mania: a proton magnetic resonance spectroscopy study","volume":"51","author":"Strawn","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1101\/gad.1658508","article-title":"Mitochondrial dynamics and apoptosis","volume":"22","author":"Suen","year":"2008","journal-title":"Genes Dev."},{"key":"B175","first-page":"189","article-title":"Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder","volume":"31","author":"Sun","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"B177","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.euroneuro.2006.09.002","article-title":"CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study","volume":"17","author":"Takao","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B178","doi-asserted-by":"crossref","first-page":"217","DOI":"10.31887\/DCNS.2006.8.2\/mthase","article-title":"Depression and sleep: pathophysiology and treatment","volume":"8","author":"Thase","year":"2006","journal-title":"Dialogues Clin. Neurosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.2147\/NDT.s70346","article-title":"Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects","volume":"11","author":"Toker","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.euroneuro.2016.03.001","article-title":"Light therapy in the treatment of patients with bipolar depression: a meta-analytic study","volume":"26","author":"Tseng","year":"2016","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/s0920-9964(03)00181-6","article-title":"Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium","volume":"67","author":"Uranova","year":"2004","journal-title":"Schizophr. Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.cell.2014.02.029","article-title":"SnapShot: adult hippocampal neurogenesis","volume":"156","author":"Vadodaria","year":"2014","journal-title":"Cell"},{"key":"B183","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1002\/bies.201600127","article-title":"Generating human serotonergic neurons in vitro: methodological advances","volume":"38","author":"Vadodaria","year":"2016a","journal-title":"Bioessays"},{"key":"B184","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/mp.2015.161","article-title":"Generation of functional human serotonergic neurons from fibroblasts","volume":"21","author":"Vadodaria","year":"2016b","journal-title":"Mol. Psychiatry"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.10.015","article-title":"Lithium and valproate act on GSK-3\u03b2 signaling pathway to reverse the manic-like behavior in an animal model of mania induced by ouabain","author":"Valvassori","year":"2016","journal-title":"Neuropharmacology"},{"key":"B186","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1007\/s10495-010-0481-0","article-title":"Molecular and cellular mechanisms of excitotoxic neuronal death","volume":"15","author":"Wang","year":"2010","journal-title":"Apoptosis"},{"key":"B187","volume-title":"The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research.","author":"WHO","year":"1993"},{"key":"B188","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jad.2012.12.025","article-title":"Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression","volume":"148","author":"Wu","year":"2013","journal-title":"J. Affect. Disord."},{"key":"B189","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1756-6606-1-6","article-title":"Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders","volume":"1","author":"Yamasaki","year":"2008","journal-title":"Mol. Brain"},{"key":"B190","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/archgenpsychiatry.2007.43","article-title":"Protein kinase C inhibition in the treatment of mania: a double-blind, placebo-controlled trial of tamoxifen","volume":"65","author":"Yildiz","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"B191","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/npp.2010.192","article-title":"Efficacy of antimanic treatments: meta-analysis of randomized, controlled trials","volume":"36","author":"Yildiz","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"B192","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.pnpbp.2006.03.012","article-title":"Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings","volume":"30","author":"Yildiz-Yesiloglu","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B193","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1126\/science.1121613","article-title":"Nuclear receptor Rev-erb\u03b1 is a critical lithium-sensitive component of the circadian clock","volume":"311","author":"Yin","year":"2006","journal-title":"Science"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1038\/mp.2015.217","article-title":"Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis","volume":"21","author":"Yoshimi","year":"2016a","journal-title":"Mol. Psychiatry"},{"key":"B195","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbacli.2016.03.008","article-title":"Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle and amino acid metabolism in bipolar disorder","volume":"5","author":"Yoshimi","year":"2016b","journal-title":"BBA Clin."},{"key":"B196","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.stemcr.2014.01.009","article-title":"Modeling hippocampal neurogenesis using human pluripotent stem cells","volume":"2","author":"Yu","year":"2014","journal-title":"Stem Cell Reports"},{"key":"B197","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.neuron.2013.05.029","article-title":"Rapid single-step induction of functional neurons from human pluripotent stem cells","volume":"78","author":"Zhang","year":"2013","journal-title":"Neuron"},{"key":"B198","doi-asserted-by":"publisher","first-page":"e13374","DOI":"10.7554\/eLife.13374","article-title":"Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation","volume":"5","author":"Zheng","year":"2016","journal-title":"Elife"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00030\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T02:52:00Z","timestamp":1658631120000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00030\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":197,"URL":"https:\/\/doi.org\/10.3389\/fncel.2017.00030","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,14]]}}}