{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:35:38Z","timestamp":1791300938603,"version":"4.1.0"},"reference-count":177,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2016-0302"],"award-info":[{"award-number":["FO2016-0302"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","award":["130328"],"award-info":[{"award-number":["130328"]}],"id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["04X-715"],"award-info":[{"award-number":["04X-715"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2017.00037","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T03:34:30Z","timestamp":1487648070000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":109,"title":["Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Dasiel O.","family":"Borroto-Escuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ambrogini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Narv\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wydra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander O.","family":"Tarakanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Mill\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Cuppini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tanganelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Diaz-Cabiale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Fuxe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1748-1716.1983.tb07244.x","article-title":"Cholecystokinin peptides in vitro modulate the characteristics of the striatal 3H-N-propylnorapomorphine sites","volume":"118","author":"Agnati","year":"1983a","journal-title":"Acta Physiol. Scand."},{"key":"B2","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1748-1716.1983.tb07363.x","article-title":"Neurotensin in vitro markedly reduces the affinity in subcortical limbic 3H-N-propylnorapomorphine binding sites","volume":"119","author":"Agnati","year":"1983b","journal-title":"Acta Physiol. Scand."},{"key":"B3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.brainresrev.2010.03.003","article-title":"Understanding wiring and volume transmission","volume":"64","author":"Agnati","year":"2010","journal-title":"Brain Res. Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.neuropharm.2011.05.023","article-title":"Functional crosstalk and heteromerization of serotonin 5-HT2A and dopamine D2 receptors","volume":"61","author":"Albizu","year":"2011","journal-title":"Neuropharmacology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/cercor\/bhg128","article-title":"Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex","volume":"14","author":"Amarg\u00f3s-Bosch","year":"2004","journal-title":"Cereb. Cortex"},{"key":"B6","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1748-1716.1966.tb03318.x","article-title":"Ascending monoamine neurons to the telencephalon and diencephalon","volume":"67","author":"And\u00e9n","year":"1966","journal-title":"Acta Physiol. Scand."},{"key":"B7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.pharmthera.2012.09.006","article-title":"Serotonin receptors involved in antidepressant effects","volume":"137","author":"Artigas","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.biopsych.2014.05.008","article-title":"Deep brain stimulation in major depression: plastic changes of 5-hydroxytryptamine neurons","volume":"76","author":"Artigas","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.euroneuro.2013.04.013","article-title":"Developments in the field of antidepressants, where do we go now?","volume":"25","author":"Artigas","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/j.1460-9568.2008.06369.x","article-title":"Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose \u2018binge\u2019 cocaine administration paradigm","volume":"28","author":"Bailey","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/bs.apha.2016.01.006","article-title":"The NMDA receptor and schizophrenia: from pathophysiology to treatment","volume":"76","author":"Balu","year":"2016","journal-title":"Adv. Pharmacol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/s0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/s0304-3940(01)02446-6","article-title":"Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression","volume":"317","author":"Bellido","year":"2002","journal-title":"Neurosci. Lett."},{"key":"B14","doi-asserted-by":"publisher","first-page":"20140183","DOI":"10.1098\/rstb.2014.0183","article-title":"The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks","volume":"370","author":"Borroto-Escuela","year":"2015a","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.15379\/2409-3564.2015.02.01.5","article-title":"On the role of the balance of GPCR homo\/ heteroreceptor complexes in the brain","volume":"2","author":"Borroto-Escuela","year":"2015b","journal-title":"J. Adv. Neurosci. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.bbrc.2014.11.112","article-title":"Evidence for the existence of FGFR1\u20135-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system","volume":"456","author":"Borroto-Escuela","year":"2015c","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bbrc.2015.04.133","article-title":"Enhancement of the FGFR1 signaling in the FGFR1\u20135-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression","volume":"463","author":"Borroto-Escuela","year":"2015d","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B36","first-page":"93","article-title":"Role of D2-like heteroreceptor compelxes in the effects of cocaine, morphine and hallucinogens","volume-title":"Neurophatology of Drug Addictions and Substance Misuse","author":"Borroto-Escuela","year":"2015e"},{"key":"B15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/138945012798868506","article-title":"Muscarinic acetylcholine receptor-interacting proteins (mAChRIPs): targeting the receptorsome","volume":"13","author":"Borroto-Escuela","year":"2012a","journal-title":"Curr. Drug. Targets"},{"key":"B29","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.biopsych.2011.09.012","article-title":"Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity","volume":"71","author":"Borroto-Escuela","year":"2012b","journal-title":"Biol. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"8570","DOI":"10.3390\/ijms15058570","article-title":"The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components","volume":"15","author":"Borroto-Escuela","year":"2014a","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.bbrc.2014.08.061","article-title":"Preferential activation by galanin 1\u201315 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex","volume":"452","author":"Borroto-Escuela","year":"2014b","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.bbrc.2013.11.104","article-title":"Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2\u20135-HT2A heteroreceptor complexes","volume":"443","author":"Borroto-Escuela","year":"2014c","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.bbrc.2013.10.067","article-title":"Dynamic modulation of FGFR1\u20135-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of \u03b2-arrestin2","volume":"441","author":"Borroto-Escuela","year":"2013a","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.bbrc.2013.04.058","article-title":"Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers","volume":"435","author":"Borroto-Escuela","year":"2013b","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/B978-0-12-391862-8.00015-6","article-title":"G protein-coupled receptor heterodimerization in the brain","volume":"521","author":"Borroto-Escuela","year":"2013c","journal-title":"Methods Enzymol."},{"key":"B20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4939-3064-7_9","article-title":"In situ proximity ligation assay to study and understand the distribution and balance of GPCR homo- and heteroreceptor complexes in the brain","volume-title":"Receptor and Ion Channel Detection in the Brain","author":"Borroto-Escuela","year":"2016a"},{"key":"B23","article-title":"FGFR1\u20135-HT1A heteroreceptor complexes in the hippocampus and midbrain raphe as a novel target for antidepressant drugs","volume-title":"30th CINP World Congress of Neuropsychopharmacology","author":"Borroto-Escuela","year":"2016b"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.tins.2015.11.003","article-title":"FGFR1\u20135-HT1A heteroreceptor complexes: implications for understanding and treating major depression","volume":"39","author":"Borroto-Escuela","year":"2016c","journal-title":"Trends Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4827268","DOI":"10.1155\/2016\/4827268","article-title":"Understanding the functional plasticity in neural networks of the basal ganglia in cocaine use disorder: a role for allosteric receptor\u2013receptor interactions in A2A-D2 heteroreceptor complexes","volume":"2016","author":"Borroto-Escuela","year":"2016d","journal-title":"Neural Plast."},{"key":"B21","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbrc.2010.02.168","article-title":"A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R","volume":"394","author":"Borroto-Escuela","year":"2010a","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.bbrc.2010.02.078","article-title":"Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization","volume":"393","author":"Borroto-Escuela","year":"2010b","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.bbrc.2010.10.122","article-title":"Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices","volume":"402","author":"Borroto-Escuela","year":"2010c","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.bbrc.2010.09.110","article-title":"Dopamine D2 and 5-hydroxytryptamine 5-HT2A receptors assemble into functionally interacting heteromers","volume":"401","author":"Borroto-Escuela","year":"2010d","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.bbrc.2010.12.083","article-title":"Dopamine D2 and D4 receptor heteromerization and its allosteric receptor\u2013receptor interactions","volume":"404","author":"Borroto-Escuela","year":"2010e","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/iub.473","article-title":"Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration","volume":"63","author":"Borroto-Escuela","year":"2011","journal-title":"IUBMB Life"},{"key":"B38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1749-6632.1998.tb10687.x","article-title":"Molecular biology and pharmacology of galanin receptors","volume":"863","author":"Branchek","year":"1998","journal-title":"Ann. N Y Acad. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2969","DOI":"10.1038\/npp.2008.18","article-title":"Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine","volume":"33","author":"Briand","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1111\/j.1471-4159.2009.06078.x","article-title":"Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells","volume":"109","author":"Cabello","year":"2009","journal-title":"J. Neurochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/sj.mp.4002150","article-title":"Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice","volume":"14","author":"Caldwell","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/j.2042-7158.1968.tb09706.x","article-title":"The effect of imipramine on central 5-hydroxytryptamine neurons","volume":"20","author":"Carlsson","year":"1968","journal-title":"J. Pharm. Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s40263-013-0071-0","article-title":"Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research","volume":"27","author":"Celada","year":"2013","journal-title":"CNS Drugs"},{"key":"B44","first-page":"252","article-title":"The therapeutic role of 5-HT1A and 5-HT2A receptors in depression","volume":"29","author":"Celada","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1192\/bjp.113.504.1237","article-title":"The biochemistry of affective disorders","volume":"113","author":"Coppen","year":"1967","journal-title":"Br. J. Psychiatry"},{"key":"B46","first-page":"1","article-title":"Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons","volume":"232","author":"Dahlstroem","year":"1964","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1021\/jm034234f","article-title":"A bivalent ligand (KDAN-18) containing \u03b4-antagonist and \u03ba-agonist pharmacophores bridges \u03b42 and \u03ba1 opioid receptor phenotypes","volume":"48","author":"Daniels","year":"2005","journal-title":"J. Med. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00213-012-2921-8","article-title":"Serotonin-glutamate and serotonin-dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins","volume":"225","author":"de Bartolomeis","year":"2013","journal-title":"Psychopharmacology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1016\/j.bbadis.2016.07.004","article-title":"Signaling in dopamine D2 receptor-Oxytocin receptor heterocomplexes and its relevance for the anxiolytic effects of dopamine and oxytocin interactions in the amygdala of the rat","volume":"1862","author":"de la Mora","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B50","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bbagen.2016.10.026","article-title":"Existence of muscarinic acetylcholine receptor (mAChR) and fibroblast growth factor receptor (FGFR) heteroreceptor complexes and their enhancement of neurite outgrowth in neural hippocampal cultures","volume":"1861","author":"Di Liberto","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"B51","doi-asserted-by":"publisher","first-page":"10286","DOI":"10.1021\/bi9013775","article-title":"GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions","volume":"48","author":"Dunham","year":"2009","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/sj.npp.1301062","article-title":"Addiction-related alterations in D1 and D2 dopamine receptor behavioral responses following chronic cocaine self-administration","volume":"32","author":"Edwards","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"B53","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1124\/mol.111.073304","article-title":"Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor","volume":"80","author":"Espinoza","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/npp.2011.184","article-title":"Oxytocin as a potential therapeutic target for schizophrenia and other neuropsychiatric conditions","volume":"37","author":"Feifel","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.biopsych.2010.04.039","article-title":"Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients","volume":"68","author":"Feifel","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"681","DOI":"10.2174\/1389203715666140901105253","article-title":"Neurotensin NTS1-dopamine D2 receptor\u2013receptor interactions in putative receptor heteromers: relevance for Parkinson\u2019s disease and schizophrenia","volume":"15","author":"Ferraro","year":"2014","journal-title":"Curr. Protein Pept. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1460-9568.2011.07949.x","article-title":"Striatal NTS1 , dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release\u2013a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat","volume":"35","author":"Ferraro","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.brainresrev.2007.11.001","article-title":"Neurotensin receptors as modulators of glutamatergic transmission","volume":"58","author":"Ferraro","year":"2008","journal-title":"Brain Res. Rev."},{"key":"B59","doi-asserted-by":"publisher","first-page":"11940","DOI":"10.1073\/pnas.172393799","article-title":"Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function","volume":"99","author":"Ferr\u00e9","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B60","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.brainres.2006.01.038","article-title":"Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine","volume":"1077","author":"Filip","year":"2006","journal-title":"Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"317","DOI":"10.2174\/092986712803414231","article-title":"The importance of the adenosine A2A receptor-dopamine D2 receptor interaction in drug addiction","volume":"19","author":"Filip","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1038\/nn.2216","article-title":"FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity","volume":"11","author":"Flajolet","year":"2008","journal-title":"Nat. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1369-1600.2012.00452.x","article-title":"Effects of cocaine self-administration and extinction on D2 -like and A2A receptor recognition and D2 -like\/Gi protein coupling in rat striatum","volume":"18","author":"Frankowska","year":"2013","journal-title":"Addict. Biol."},{"key":"B64","first-page":"39","article-title":"Evidence for the existence of monoamine neurons in the central nervous system. IV. Distribution of monoamine nerve terminals in the central nervous system","volume":"247","author":"Fuxe","year":"1965","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"B65","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/med.2610050404","article-title":"Receptor\u2013receptor interactions in the central nervous system. A new integrative mechanism in synapses","volume":"5","author":"Fuxe","year":"1985","journal-title":"Med. Res. Rev."},{"key":"B66","first-page":"165","article-title":"Evidence for the existence of receptor\u2013receptor interactions in the central nervous system. Studies on the regulation of monoamine receptors by neuropeptides","volume":"18","author":"Fuxe","year":"1983","journal-title":"J. Neural Transm. Suppl."},{"key":"B67","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1586\/14737175.2014.922878","article-title":"The impact of receptor\u2013receptor interactions in heteroreceptor complexes on brain plasticity","volume":"14","author":"Fuxe","year":"2014a","journal-title":"Expert Rev. Neurother."},{"key":"B73","doi-asserted-by":"publisher","first-page":"6","DOI":"10.7243\/2052-6946-2-6","article-title":"Receptor\u2013receptor interactions in heteroreceptor complexes: a new principle in biology. Focus on their role in learning and memory","volume":"2","author":"Fuxe","year":"2014b","journal-title":"Neurosci. Discov."},{"key":"B70","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2174\/138920371507140916122738","article-title":"Understanding the role of heteroreceptor complexes in the central nervous system","volume":"15","author":"Fuxe","year":"2014c","journal-title":"Curr. Protein Pept. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/npp.2013.242","article-title":"Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field","volume":"39","author":"Fuxe","year":"2014d","journal-title":"Neuropsychopharmacology"},{"key":"B78","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/B978-0-444-63425-2.00005-2","article-title":"Dopamine D2 heteroreceptor complexes and their receptor\u2013receptor interactions in ventral striatum: novel targets for antipsychotic drugs","volume":"211","author":"Fuxe","year":"2014e","journal-title":"Prog. Brain Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fendo.2014.00071","article-title":"Diversity and bias through receptor\u2013receptor interactions in GPCR heteroreceptor complexes. Focus on examples from dopamine D2 receptor heteromerization","volume":"5","author":"Fuxe","year":"2014f","journal-title":"Front. Endocrinol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1212\/01.WNL.0000095206.44418.5c","article-title":"Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson\u2019s disease","volume":"61","author":"Fuxe","year":"2003","journal-title":"Neurology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.brainresrev.2008.05.002","article-title":"The basal ganglia-from neuronal systems to molecular networks. Preface","volume":"58","author":"Fuxe","year":"2008a","journal-title":"Brain Res. Rev."},{"key":"B89","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1152\/physiol.00028.2008","article-title":"Heterodimers and receptor mosaics of different types of G-protein-coupled receptors","volume":"23","author":"Fuxe","year":"2008b","journal-title":"Physiology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.brainresrev.2007.11.007","article-title":"Receptor\u2013receptor interactions within receptor mosaics. Impact on neuropsychopharmacology","volume":"58","author":"Fuxe","year":"2008c","journal-title":"Brain Res. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1517\/13543784.2015.1074175","article-title":"Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5","volume":"24","author":"Fuxe","year":"2015","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B72","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/npp.2015.244","article-title":"Heteroreceptor complexes and their allosteric receptor\u2013receptor interactions as a novel biological principle for integration of communication in the cns: targets for drug development","volume":"41","author":"Fuxe","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"356","DOI":"10.2174\/092986712803414259","article-title":"GPCR heteromers and their allosteric receptor\u2013receptor interactions","volume":"19","author":"Fuxe","year":"2012a","journal-title":"Curr. Med. Chem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.brainres.2012.01.062","article-title":"On the role of volume transmission and receptor\u2013receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons","volume":"1476","author":"Fuxe","year":"2012b","journal-title":"Brain Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fendo.2012.00127","article-title":"On the existence and function of galanin receptor heteromers in the central nervous system","volume":"3","author":"Fuxe","year":"2012c","journal-title":"Front. Endocrinol."},{"key":"B80","volume-title":"Evidence for the Existence of Central Monoamine Neurons.","author":"Fuxe","year":"2009"},{"key":"B79","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.brainresrev.2007.02.009","article-title":"From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: wiring and volume transmission","volume":"55","author":"Fuxe","year":"2007","journal-title":"Brain Res. Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.pneurobio.2009.10.012","article-title":"The discovery of central monoamine neurons gave volume transmission to the wired brain","volume":"90","author":"Fuxe","year":"2010a","journal-title":"Prog. Neurobiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.1111\/j.1755-5949.2009.00126.x","article-title":"Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders","volume":"16","author":"Fuxe","year":"2010b","journal-title":"CNS Neurosci. Ther."},{"key":"B84","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/s0165-0173(97)00049-0","article-title":"Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A\/dopamine D2 and adenosine A1\/dopamine D1 receptor interactions in the basal ganglia","volume":"26","author":"Fuxe","year":"1998","journal-title":"Brain Res. Rev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1517\/14728222.2014.981529","article-title":"Dopamine heteroreceptor complexes as therapeutic targets in Parkinson\u2019s disease","volume":"19","author":"Fuxe","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"B87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-349-12664-4_16","article-title":"Galanin\/5-HT interactions in the rat central nervous system. Relevance for depression","volume-title":"Galanin: A New Multifunctional Peptide in the Neuroendocrine System","author":"Fuxe","year":"1991"},{"key":"B91","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0304-3940(77)90095-7","article-title":"On the mechanism of action of the antidepressant drugs amitriptyline and nortriptyline. Evidence for 5-hydroxytryptamine receptor blocking activity","volume":"6","author":"Fuxe","year":"1977","journal-title":"Neurosci. Lett."},{"key":"B93","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.2042-7158.1967.tb08097.x","article-title":"Localization of 5-hydroxytryptamine uptake in rat brain after intraventricular injection","volume":"19","author":"Fuxe","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0304-3940(88)90448-x","article-title":"Galanin selectively modulates 5-hydroxytryptamine 1A receptors in the rat ventral limbic cortex","volume":"85","author":"Fuxe","year":"1988","journal-title":"Neurosci. Lett."},{"key":"B95","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/nrd913","article-title":"G-protein-coupled receptor oligomerization and its potential for drug discovery","volume":"1","author":"George","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"B96","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1037\/0735-7044.114.1.173","article-title":"Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster)","volume":"114","author":"Gingrich","year":"2000","journal-title":"Behav. Neurosci."},{"key":"B97","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/978-1-60327-333-6_16","article-title":"Dopamine receptors and the treatment of schizophrenia","volume-title":"The Dopamine Receptor","author":"Ginovart","year":"2010"},{"key":"B98","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1124\/mol.112.079137","article-title":"Computational and experimental analysis of the transmembrane domain 4\/5 dimerization interface of the serotonin 5-HT1A receptor","volume":"82","author":"Gorinski","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.biopsych.2015.11.007","article-title":"Dopamine system dysregulation and the pathophysiology of schizophrenia: insights from the methylazoxymethanol acetate model","volume":"81","author":"Grace","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"B100","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1517\/14728222.2014.981155","article-title":"G-protein-coupled receptor type A heteromers as an emerging therapeutic target","volume":"19","author":"Guidolin","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1038\/emboj.2008.153","article-title":"Dopamine D2 receptors form higher order oligomers at physiological expression levels","volume":"27","author":"Guo","year":"2008","journal-title":"EMBO J."},{"key":"B102","doi-asserted-by":"publisher","first-page":"40","DOI":"10.2174\/1568026616666160719164207","article-title":"Structure-based rational design of adenosine receptor ligands","volume":"17","author":"Guti\u00e9rrez-de-Ter\u00e1n","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"B103","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nchembio.199","article-title":"Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation","volume":"5","author":"Han","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca2+ signaling and cell survival","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"B105","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0006-8993(94)90271-2","article-title":"Galanin-(1\u201315), but not galanin-(1\u201329), modulates 5-HT1A receptors in the dorsal hippocampus of the rat brain: possible existence of galanin receptor subtypes","volume":"634","author":"Hedlund","year":"1994","journal-title":"Brain Res."},{"key":"B106","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0014-2999(92)90806-f","article-title":"Evidence for specific N-terminal galanin fragment binding sites in the rat brain","volume":"224","author":"Hedlund","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"18091","DOI":"10.1074\/jbc.M107731200","article-title":"Coaggregation, cointernalization and codesensitization of adenosine A2A receptors and dopamine D2 receptors","volume":"277","author":"Hillion","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1210\/en.2006-0933","article-title":"GPR39 signaling is stimulated by zinc ions but not by obestatin","volume":"148","author":"Holst","year":"2007","journal-title":"Endocrinology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bmc.2011.10.063","article-title":"Bivalent molecular probes for dopamine D2-like receptors","volume":"20","author":"Huber","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"12298","DOI":"10.1038\/ncomms12298","article-title":"Structure-guided development of heterodimer-selective GPCR ligands","volume":"7","author":"H\u00fcbner","year":"2016","journal-title":"Nat. Commun."},{"key":"B111","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/35053579","article-title":"The neurobiology of attachment","volume":"2","author":"Insel","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"B112","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1176\/appi.ajp.160.1.13","article-title":"Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia","volume":"160","author":"Kapur","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1124\/mol.107.040352","article-title":"Functional selectivity through protean and biased agonism: who steers the ship?","volume":"72","author":"Kenakin","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1124\/mol.108.050062","article-title":"Seven transmembrane receptors as nature\u2019s prototype allosteric protein: de-emphasizing the geography of binding","volume":"74","author":"Kenakin","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1124\/jpet.110.173948","article-title":"Functional selectivity and biased receptor signaling","volume":"336","author":"Kenakin","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B116","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.neuron.2011.10.038","article-title":"Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism","volume":"73","author":"Kern","year":"2012","journal-title":"Neuron"},{"key":"B117","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1021\/cn200020y","article-title":"Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics","volume":"2","author":"Koschatzky","year":"2011","journal-title":"ACS Chem. Neurosci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cell.2012.12.004","article-title":"Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine","volume":"152","author":"Kourrich","year":"2013","journal-title":"Cell"},{"key":"B119","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1021\/jm4005219","article-title":"Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance","volume":"56","author":"Le Naour","year":"2013","journal-title":"J. Med. Chem."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.celrep.2016.06.060","article-title":"Three-dimensional study of Alzheimer\u2019s disease hallmarks using the idisco clearing method","volume":"16","author":"Liebmann","year":"2016","journal-title":"Cell Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.neuron.2006.10.011","article-title":"Modulation of D2R-NR2B interactions in response to cocaine","volume":"52","author":"Liu","year":"2006","journal-title":"Neuron"},{"key":"B121","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/35002014","article-title":"Direct protein-protein coupling enables cross-talk between dopamine D5 and \u03b3-aminobutyric acid A receptors","volume":"403","author":"Liu","year":"2000","journal-title":"Nature"},{"key":"B123","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.npep.2008.04.009","article-title":"Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests","volume":"42","author":"Lu","year":"2008","journal-title":"Neuropeptides"},{"key":"B124","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1124\/jpet.105.083121","article-title":"The origins of diversity and specificity in g protein-coupled receptor signaling","volume":"314","author":"Maudsley","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B125","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.pharmthera.2009.07.001","article-title":"The pharmacology of sigma-1 receptors","volume":"124","author":"Maurice","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"B126","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1097\/FBP.0b013e32834aff98","article-title":"Pimavanserin, a 5-HT2A inverse agonist, reverses psychosis-like behaviors in a rodent model of Parkinson\u2019s disease","volume":"22","author":"McFarland","year":"2011","journal-title":"Behav. Pharmacol."},{"key":"B127","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0022-3565(25)20710-8","article-title":"Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values","volume":"251","author":"Meltzer","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B128","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1038\/npp.2009.176","article-title":"Pimavanserin, a serotonin2A receptor inverse agonist, for the treatment of parkinson\u2019s disease psychosis","volume":"35","author":"Meltzer","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B129","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1523\/JNEUROSCI.3333-15.2016","article-title":"Blocking synaptic removal of GluA2-containing AMPA receptors prevents the natural forgetting of long-term memories","volume":"36","author":"Migues","year":"2016","journal-title":"J. Neurosci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/cne.24113","article-title":"Cell- and region-specific expression of depression-related protein p11 (S100a10) in the brain","volume":"525","author":"Milosevic","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1007\/s00429-015-1180-y","article-title":"Galanin (1\u201315) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT. Involvement of the raphe-hippocampal 5-HT neuron system","volume":"221","author":"Mill\u00f3n","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"B132","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/ijnp\/pyu064","article-title":"A role for galanin N-terminal fragment (1\u201315) in anxiety- and depression-related behaviors in rats","volume":"18","author":"Mill\u00f3n","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bbr.2012.10.020","article-title":"The role of the GPR39 receptor in zinc deficient-animal model of depression","volume":"238","author":"M\u0142yniec","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbr.2015.03.053","article-title":"Study of antidepressant drugs in GPR39 (zinc receptor(-)\/(-)) knockout mice, showing no effect of conventional antidepressants, but effectiveness of NMDA antagonists","volume":"287","author":"M\u0142yniec","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B135","doi-asserted-by":"publisher","first-page":"18676","DOI":"10.1073\/pnas.1008911107","article-title":"Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine","volume":"107","author":"Navarro","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B136","doi-asserted-by":"publisher","first-page":"e61245","DOI":"10.1371\/journal.pone.0061245","article-title":"Cocaine inhibits dopamine D2 receptor signaling via sigma-1\u2013D2 receptor heteromers","volume":"8","author":"Navarro","year":"2013","journal-title":"PLoS One"},{"key":"B137","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/bf01250331","article-title":"Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs","volume":"46","author":"Ogren","year":"1979","journal-title":"J. Neural Transm."},{"key":"B138","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0026-895X(25)13812-1","article-title":"Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol","volume":"16","author":"Peroutka","year":"1979","journal-title":"Mol. Pharmacol."},{"key":"B139","first-page":"S609","article-title":"Dopamine D2 receptor dynamic and modulation in the D2R-Sigma1R heteroreceptor complexes: role in cocaine actions","volume-title":"European Neuropsychopharmacology","author":"Pinton","year":"2015a"},{"key":"B140","doi-asserted-by":"publisher","first-page":"P37","DOI":"10.1186\/2193-1801-4-s1-p37","article-title":"Evidence for the existence of dopamine D2R and Sigma 1 allosteric receptor\u2013receptor interaction in the rat brain: role in brain plasticity and cocaine action","volume":"4","author":"Pinton","year":"2015b","journal-title":"Springerplus"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.10.027","article-title":"Alterations in ventral and dorsal striatal allosteric A2AR-D2R receptor\u2013receptor interactions after amphetamine challenge: relevance for schizophrenia","author":"Pintsuk","year":"2016a","journal-title":"Life Sci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.pbb.2016.03.004","article-title":"Cocaine self-administration differentially affects allosteric A2A-D2 receptor\u2013receptor interactions in the striatum. Relevance for cocaine use disorder","volume":"144","author":"Pintsuk","year":"2016b","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1021\/jm010158+","article-title":"From models to molecules: opioid receptor dimers, bivalent ligands and selective opioid receptor probes","volume":"44","author":"Portoghese","year":"2001","journal-title":"J. Med. Chem."},{"key":"B144","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1124\/jpet.109.162701","article-title":"Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers","volume":"332","author":"Przybyla","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1242\/jcs.101337","article-title":"Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking","volume":"125","author":"Renner","year":"2012","journal-title":"J. Cell Sci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0893-133X(97)00033-X","article-title":"Adenosine A2A agonists: a potential new type of atypical antipsychotic","volume":"17","author":"Rimondini","year":"1997","journal-title":"Neuropsychopharmacology"},{"key":"B147","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1126\/science.288.5463.154","article-title":"Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity","volume":"288","author":"Rocheville","year":"2000","journal-title":"Science"},{"key":"B148","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/mp.2012.103","article-title":"Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor\u2013receptor interactions","volume":"18","author":"Romero-Fernandez","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B149","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/s0893-133X(01)00391-8","article-title":"Involvement of the sigma1 receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade","volume":"26","author":"Romieu","year":"2002","journal-title":"Neuropsychopharmacology"},{"key":"B150","doi-asserted-by":"publisher","first-page":"15482","DOI":"10.1074\/jbc.M201539200","article-title":"Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation","volume":"277","author":"Salim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B151","doi-asserted-by":"publisher","first-page":"30308","DOI":"10.1074\/jbc.M102297200","article-title":"D2\/D3 dopamine receptor heterodimers exhibit unique functional properties","volume":"276","author":"Scarselli","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1073\/pnas.1524303113","article-title":"p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism","volume":"113","author":"Schintu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B153","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3371\/CSRP.4.1.5","article-title":"Dopamine D2 receptors as treatment targets in schizophrenia","volume":"4","author":"Seeman","year":"2010","journal-title":"Clin. Schizophr. Relat. Psychoses"},{"key":"B154","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/syn.10139","article-title":"Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges","volume":"46","author":"Seeman","year":"2002","journal-title":"Synapse"},{"key":"B155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/978-1-60327-333-6_17","article-title":"Dopamine receptor subtypes in reward and relapse","volume-title":"The Dopamine Receptors","author":"Self","year":"2010"},{"key":"B156","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1124\/mol.108.051805","article-title":"Calcium signaling by dopamine D5 receptor and D5\u2013D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1\u2013D2 receptor hetero-oligomers","volume":"75","author":"So","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"5590","DOI":"10.1021\/jm900298c","article-title":"Adenosine A2A receptor-antagonist\/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers","volume":"52","author":"Soriano","year":"2009","journal-title":"J. Med. Chem."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.neuron.2014.11.007","article-title":"A dopamine D2 receptor-DISC1 protein complex may contribute to antipsychotic-like effects","volume":"84","author":"Su","year":"2014","journal-title":"Neuron"},{"key":"B159","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2014.08.011","article-title":"Reductions of p11 and 5-HT1B receptor availability in limbic brain regions in cocaine dependence","volume":"76","author":"Svenningsson","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B160","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrn3564","article-title":"p11 and its role in depression and therapeutic responses to antidepressants","volume":"14","author":"Svenningsson","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B161","doi-asserted-by":"publisher","first-page":"304","DOI":"10.2174\/092986712803414268","article-title":"Relevance of dopamine D2\/neurotensin NTS1 and NMDA\/neurotensin NTS1 receptor interaction in psychiatric and neurodegenerative disorders","volume":"19","author":"Tanganelli","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"B162","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.parkreldis.2004.02.015","article-title":"Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson\u2019s Disease","volume":"10","author":"Tanganelli","year":"2004","journal-title":"Parkinsonism Relat. Disord."},{"key":"B163","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s12031-009-9313-5","article-title":"Triplet puzzle: homologies of receptor heteromers","volume":"41","author":"Tarakanov","year":"2010","journal-title":"J. Mol. Neurosci."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1016\/j.bbadis.2015.09.003","article-title":"The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity","volume":"1852","author":"Tena-Campos","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B165","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s12035-015-9153-y","article-title":"Zinc is involved in depression by modulating G protein-coupled receptor heterodimerization","volume":"53","author":"Tena-Campos","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2144\/000113719","article-title":"Detection of antigen interactions ex vivo, by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum","volume":"51","author":"Trifilieff","year":"2011","journal-title":"Biotechniques"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/j.1742-4658.2011.08052.x","article-title":"Dopamine D4 receptor oligomerization\u2013contribution to receptor biogenesis","volume":"278","author":"Van Craenenbroeck","year":"2011","journal-title":"FEBS J."},{"key":"B168","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.biopsych.2013.12.009","article-title":"Antidepressant-like effects of cortical deep brain stimulation coincide with pro-neuroplastic adaptations of serotonin systems","volume":"76","author":"Veerakumar","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B169","doi-asserted-by":"publisher","first-page":"35092","DOI":"10.1074\/jbc.M109.088625","article-title":"Dopamine D1\u2013D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2","volume":"285","author":"Verma","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"15037","DOI":"10.1073\/pnas.1010654108","article-title":"Addiction: beyond dopamine reward circuitry","volume":"108","author":"Volkow","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B171","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1748-1716.1987.tb08285.x","article-title":"Neurotensin reduces the affinity of D-2 dopamine receptors in rat striatal membranes","volume":"131","author":"Von Euler","year":"1987","journal-title":"Acta Physiol. Scand."},{"key":"B172","doi-asserted-by":"publisher","first-page":"9050","DOI":"10.1073\/pnas.0501112102","article-title":"A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers","volume":"102","author":"Waldhoer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B173","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1756-6606-3-25","article-title":"Schizophrenia, amphetamine-induced sensitized state and acute amphetamine exposure all show a common alteration: increased dopamine D2 receptor dimerization","volume":"3","author":"Wang","year":"2010","journal-title":"Mol. Brain"},{"key":"B174","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.pharmthera.2015.10.007","article-title":"Metabotropic glutamate receptors as targets for new antipsychotic drugs: historical perspective and critical comparative assessment","volume":"157","author":"Wieronska","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"B175","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.tins.2013.11.003","article-title":"Dopaminergic basis of salience dysregulation in psychosis","volume":"37","author":"Winton-Brown","year":"2014","journal-title":"Trends Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.npep.2005.09.001","article-title":"Homodimerization and internalization of galanin type 1 receptor in living CHO cells","volume":"39","author":"Wirz","year":"2005","journal-title":"Neuropeptides"},{"key":"B177","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00213-014-3675-2","article-title":"On the role of adenosine (A)2A receptors in cocaine-induced reward: a pharmacological and neurochemical analysis in rats","volume":"232","author":"Wydra","year":"2015a","journal-title":"Psychopharmacology"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s00213-014-3818-5","article-title":"On the role of A(2)A and D(2) receptors in control of cocaine and food-seeking behaviors in rats","volume":"232","author":"Wydra","year":"2015b","journal-title":"Psychopharmacology (Berl)"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1038\/nn1327","article-title":"The neurobiology of pair bonding","volume":"7","author":"Young","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jprot.2015.10.018","article-title":"Cross-talk between \u03b17 nAchR and NMDAR revealed by protein profiling","volume":"131","author":"Zhang","year":"2016","journal-title":"J. Proteomics"},{"key":"B181","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/BF02769180","article-title":"Receptor\u2013receptor interactions as an integrative mechanism in nerve cells","volume":"7","author":"Zoli","year":"1993","journal-title":"Mol. Neurobiol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00037\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T14:44:31Z","timestamp":1749998671000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00037\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":177,"URL":"https:\/\/doi.org\/10.3389\/fncel.2017.00037","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}