{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:21:50Z","timestamp":1792801310914,"version":"4.5.0"},"reference-count":154,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DC014720, RO1DC01910"],"award-info":[{"award-number":["RO1DC014720, RO1DC01910"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006521","name":"Stanford University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2017.00325","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T04:11:53Z","timestamp":1508299913000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":91,"title":["Towards the Prevention of Aminoglycoside-Related Hearing Loss"],"prefix":"10.3389","volume":"11","author":[{"given":"Mary E.","family":"O\u2019Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autefeh","family":"Sajjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,10,18]]},"reference":[{"key":"B1","unstructured":"Specialised neural barriers136 AbbottN. J. BlakleyB. Stevenson, WAInternational Brain Barriers SocietyStrategies for Advancing Brain-Barriers Translational Research\u2014Meeting Proceedings2007"},{"key":"B2","unstructured":"Antibiotics for the prevention and treatment of early-onset neonatal infectionAgency for Healthcare Research and Quality, National Guideline Clearing House.2012"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e22347","DOI":"10.1371\/journal.pone.0022347","article-title":"Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity","volume":"6","author":"Alharazneh","year":"2011","journal-title":"PLoS One"},{"key":"B4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.jcf.2014.07.009","article-title":"High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis","volume":"14","author":"Al-Malky","year":"2015","journal-title":"J. of Cyst. Fibros."},{"key":"B5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3109\/14992027.2010.524253","article-title":"Aminoglycoside antibiotics cochleotoxicity in paediatric cystic fibrosis (CF) patients: a study using extended high-frequency audiometry and distortion product otoacoustic emissions","volume":"50","author":"Al-Malky","year":"2011","journal-title":"Int. J. Audiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1242\/jeb.029454","article-title":"Molecular physiology and genetics of Na+-independent SLC4 anion exchangers","volume":"212","author":"Alper","year":"2009","journal-title":"J. Exp. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"B8","unstructured":"Gentamicin sulphate according to EP and USP method\u2014application note aminoglycoside antibiotics2014"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1345\/aph.1l001","article-title":"Aminoglycoside-induced vestibular injury: maintaining a sense of balance","volume":"42","author":"Ariano","year":"2008","journal-title":"Annu. Pharmacother."},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1002\/9780470149676","volume-title":"Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery.","author":"Arya","year":"2007"},{"key":"B11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1445-5994.2011.02452.x","article-title":"Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity","volume":"41","author":"Avent","year":"2011","journal-title":"Intern. Med. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1073\/pnas.1620982114","article-title":"Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity","volume":"114","author":"Baradaran-Heravi","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/0196-0709(89)90002-1","article-title":"Incidence of amikacin ototoxicity: a sigmoid function of total drug exposure independent of plasma levels","volume":"10","author":"Beaubien","year":"1989","journal-title":"Am. J. Otolaryngol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10992","DOI":"10.1523\/jneurosci.2188-06.2006","article-title":"A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells","volume":"26","author":"Beurg","year":"2006","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1056\/NEJMc0806396","article-title":"Prevalence of mitochondrial 1555A\u2192G mutation in European children","volume":"360","author":"Bitner-Glindzicz","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/isrctn39982239","article-title":"Gentamicin, genetic variation and deafness in preterm children","volume":"14","author":"Bitner-Glindzicz","year":"2014","journal-title":"BMC Pediatr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/S0076-6879(99)94027-2","article-title":"Mechanosensitive channels of bacteria","volume":"294","author":"Blount","year":"1999","journal-title":"Methods Enzymol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1093\/hmg\/ddt309","article-title":"Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency","volume":"22","author":"Boczonadi","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1128\/aac.01819-09","article-title":"Mutant A1555G mitochondrial 12S rRNA and aminoglycoside susceptibility","volume":"54","author":"B\u00f6ttger","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"B20","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp. Gerontol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/0006-2952(85)90607-0","article-title":"Interaction of streptomycin and streptomycylamine derivatives with negatively charged lipid layers: correlation between binding, conformation of complexes and inhibition of lysosomal phospholipase activities","volume":"34","author":"Brasseur","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/0006-2952(84)90319-8","article-title":"Interactions of aminoglycoside antibiotics with negatively charged lipid layers: biochemical and conformational studies","volume":"33","author":"Brasseur","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6265","DOI":"10.1093\/nar\/13.17.6265","article-title":"Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside anthiotics G-418 and paromomycin","volume":"13","author":"Burke","year":"1985","journal-title":"Nucleic Acids Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ymgme.2004.01.020","article-title":"Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation","volume":"82","author":"Bykhovskaya","year":"","journal-title":"Mol. Genet. Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ymgme.2004.07.009","article-title":"Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3","volume":"83","author":"Bykhovskaya","year":"","journal-title":"Mol. Genet. Metab."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1002\/pbc.24631","article-title":"Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides","volume":"60","author":"Chen","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"B27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.otohns.2009.03.020","article-title":"Sensorineural hearing loss in patients with cystic fibrosis","volume":"141","author":"Cheng","year":"2009","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"B28","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.heares.2009.03.004","article-title":"Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line","volume":"253","author":"Coffin","year":"2009","journal-title":"Hear. Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1093\/hmg\/ddp208","article-title":"Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness","volume":"18","author":"Cotney","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.heares.2005.11.011","article-title":"Uptake of fluorescent gentamicin by vertebrate sensory cells in vivo","volume":"213","author":"Dai","year":"2006","journal-title":"Hear. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.heares.2007.10.010","article-title":"A systemic gentamicin pathway across the stria vascularis","volume":"235","author":"Dai","year":"2008","journal-title":"Hear. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nrg2662","article-title":"The evolutionary consequences of erroneous protein synthesis","volume":"10","author":"Drummond","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1472-6815-7-5","article-title":"Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up","volume":"7","author":"Duggal","year":"2007","journal-title":"BMC Ear Nose Throat Disord."},{"key":"B34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s00405-004-0793-1","article-title":"Dose-dependent dual effect of melatonin on ototoxicity induced by amikacin in adult rats","volume":"262","author":"Erdem","year":"2005","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7513","DOI":"10.1523\/jneurosci.4559-12.2013","article-title":"Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death","volume":"33","author":"Esterberg","year":"2013","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"9703","DOI":"10.1523\/jneurosci.0281-14.2014","article-title":"ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage","volume":"34","author":"Esterberg","year":"2014","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1172\/jci84939","article-title":"Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death","volume":"126","author":"Esterberg","year":"2016","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1086\/301676","article-title":"Familial progressive sensorineural deafness is mainly due to the mtDNA A1555G mutation and is enhanced by treatment with aminoglycosides","volume":"62","author":"Estivill","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3389\/fphys.2010.00155","article-title":"Physiology and pathophysiology of ClC-K\/barttin channels","volume":"1","author":"Fahlke","year":"2010","journal-title":"Front. Physiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3410\/f.1006705.251756","article-title":"Probing the pore of the auditory hair cell mechanotransducer channel in turtle","volume":"558","author":"Farris","year":"2004","journal-title":"J. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/infdis\/165.6.1026","article-title":"High-frequency audiometric monitoring for early detection of aminoglycoside ototoxicity","volume":"165","author":"Fausti","year":"1992","journal-title":"J. Infect. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1152\/physrev.00038.2013","article-title":"The physiology of mechanoelectrical transduction channels in hearing","volume":"94","author":"Fettiplace","year":"2014","journal-title":"Physiol. Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000013861","article-title":"Aminoglycoside antibiotics","volume":"5","author":"Forge","year":"2000","journal-title":"Audiol. Neurootol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.3410\/f.717997761.793474294","article-title":"A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity","volume":"33","author":"Francis","year":"2013","journal-title":"J. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1093\/jac\/39.6.677","article-title":"Once-daily dosing of aminoglycosides: review and recommendations for clinical practice","volume":"39","author":"Freeman","year":"1997","journal-title":"J. Antimicrob. Chemother."},{"key":"B46","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0005-2736(89)90529-4","article-title":"Binding of neomycin to phosphatidylinositol 4,5-biphosphate (PIP2)","volume":"979","author":"Gabev","year":"1989","journal-title":"Biochim. Biophys. Acta"},{"key":"B47","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1523\/JNEUROSCI.21-18-07013.2001","article-title":"FM1\u201343 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel","volume":"21","author":"Gale","year":"2001","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0006-291X(02)00256-5","article-title":"Pathogenesis of the deafness-associated A1555G mitochondrial DNA mutation","volume":"293","author":"Giordano","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1042\/BST20140145","article-title":"Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death","volume":"42","author":"Giraldo","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B50","doi-asserted-by":"publisher","first-page":"9939","DOI":"10.1523\/jneurosci.1124-08.2008","article-title":"Aminoglycoside-induced phosphatidylserine externalization in sensory hair cells is regionally restricted, rapid, and reversible","volume":"28","author":"Goodyear","year":"2008","journal-title":"J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1126\/science.aaa3872","article-title":"The complete structure of the 55S mammalian mitochondrial ribosome","volume":"348","author":"Greber","year":"2015","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.mito.2010.10.006","article-title":"Mitochondrial 12S rRNA mutations associated with aminoglycoside ototoxicity","volume":"11","author":"Guan","year":"2011","journal-title":"Mitochondrion"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/hmg\/9.12.1787","article-title":"A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity","volume":"9","author":"Guan","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"B54","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1086\/506389","article-title":"Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations","volume":"79","author":"Guan","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1172\/JCI85052","article-title":"Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells","volume":"127","author":"Hailey","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0006-8993(95)01198-6","article-title":"Endocytosis of aminoglycoside antibiotics in sensory hair cells","volume":"704","author":"Hashino","year":"1995","journal-title":"Brain Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/s0006-8993(97)00977-3","article-title":"Lysosomal targeting and accumulation of aminoglycoside antibiotics in sensory hair cells","volume":"777","author":"Hashino","year":"1997","journal-title":"Brain Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/s0006-8993(00)02971-1","article-title":"Lysosomal augmentation during aminoglycoside uptake in cochlear hair cells","volume":"887","author":"Hashino","year":"2000","journal-title":"Brain Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3109\/00206097309071652","article-title":"Ototoxic mechanisms: a working hypothesis","volume":"12","author":"Hawkins","year":"1973","journal-title":"Audiology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.neuron.2004.09.020","article-title":"Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation","volume":"44","author":"Hirono","year":"2004","journal-title":"Neuron"},{"key":"B62","doi-asserted-by":"publisher","first-page":"20888","DOI":"10.1073\/pnas.0811258106","article-title":"Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity","volume":"105","author":"Hobbie","year":"","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1073\/pnas.0707265105","article-title":"Mitochondrial deafness alleles confer misreading of the genetic code","volume":"105","author":"Hobbie","year":"","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.biochi.2006.04.008","article-title":"A genetic model to investigate drug-target interactions at the ribosomal decoding site","volume":"88","author":"Hobbie","year":"2006","journal-title":"Biochimie"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1002\/bies.201400052","article-title":"Unique features of DNA replication in mitochondria: a functional and evolutionary perspective","volume":"36","author":"Holt","year":"2014","journal-title":"Bioessays"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1093\/nar\/21.18.4174","article-title":"A molecular basis for human hypersensitivity of aminoglyscoside antibiotics","volume":"21","author":"Hutchin","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"937861","DOI":"10.1155\/2011\/937861","article-title":"Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection","volume":"2011","author":"Huth","year":"2011","journal-title":"Int. J. Otolaryngol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1172\/JCI77424","article-title":"Designer aminoglycosides prevent cochlear hair cell loss and hearing loss","volume":"125","author":"Huth","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1042\/bse0470053","article-title":"Mitochondrial proton and electron leaks","volume":"47","author":"Jastroch","year":"2010","journal-title":"Essays Biochem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/ncb1104-1039","article-title":"Ion channels: function unravelled by dysfunction","volume":"6","author":"Jentsch","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"10630","DOI":"10.1021\/jm3012992","article-title":"Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations","volume":"55","author":"Kandasamy","year":"2012","journal-title":"J. Med. Chem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1242\/jcs.023705","article-title":"TRPV4 enhances the cellular uptake of aminoglycoside antibiotics","volume":"121","author":"Karasawa","year":"2008","journal-title":"J. Cell Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.3410\/f.13372023.14859074","article-title":"Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes","volume":"121","author":"Kawashima","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B73","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/sj.emboj.7600951","article-title":"Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness","volume":"25","author":"Kharkovets","year":"2006","journal-title":"EMBO J."},{"key":"B74","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1073\/pnas.97.8.4333","article-title":"KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway","volume":"97","author":"Kharkovets","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B75","doi-asserted-by":"publisher","first-page":"640","DOI":"10.2210\/pdb4ug0\/pdb","article-title":"Structure of the human 80S ribosome","volume":"520","author":"Khatter","year":"2015","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"298ra118","DOI":"10.1126\/scitranslmed.aac5546","article-title":"Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity","volume":"7","author":"Koo","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nsmb.1614","article-title":"The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins","volume":"16","author":"Kramer","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/s0092-8674(00)80556-5","article-title":"KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness","volume":"96","author":"Kubisch","year":"1999","journal-title":"Cell"},{"key":"B79","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1086\/514620","article-title":"The pharmacodynamics of aminoglycosides","volume":"27","author":"Lacy","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"B80","doi-asserted-by":"publisher","first-page":"7286","DOI":"10.1093\/hmg\/ddv427","article-title":"Overexpression of the mitochondrial methyltransferase TFB1M in the mouse does not impact mitoribosomal methylation status or hearing","volume":"24","author":"Lee","year":"2015","journal-title":"Neurosurgery"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e19130","DOI":"10.1371\/journal.pone.0019130","article-title":"Acoustic trauma increases cochlear and hair cell uptake of gentamicin","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"B82","doi-asserted-by":"publisher","first-page":"7701","DOI":"10.1128\/mcb.22.21.7701-7711.2002","article-title":"A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation","volume":"22","author":"Li","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"9825","DOI":"10.1523\/JNEUROSCI.2597-05.2005","article-title":"Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate","volume":"25","author":"Li","year":"2005","journal-title":"J. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1126\/science.277.5330.1262","article-title":"A conformational switch in Escherichia coli 16S ribosomal RNA during decoding of messenger RNA","volume":"277","author":"Lodmell","year":"1997","journal-title":"Science"},{"key":"B85","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fncel.2015.00143","article-title":"Cellular glutathione content in the organ of Corti and its role during ototoxicity","volume":"9","author":"Majumder","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1113\/JP272220","article-title":"The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI","volume":"594","author":"Marcotti","year":"2016","journal-title":"J. Physiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3410\/f.1026826.323564","article-title":"The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels","volume":"567","author":"Marcotti","year":"2005","journal-title":"J. Physiol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/978-1-62703-245-2_23","article-title":"Patch clamp electrophysiology for the study of bacterial ion channels in giant spheroplasts of E. coli","volume":"966","author":"Martinac","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"10984","DOI":"10.1073\/pnas.1204073109","article-title":"Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin","volume":"109","author":"Matt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B90","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.cmet.2009.03.001","article-title":"Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome","volume":"9","author":"Metodiev","year":"2009","journal-title":"Cell Metab."},{"key":"B91","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: nephrotoxicity","volume":"43","author":"Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"B92","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0378-5955(98)00221-4","article-title":"Ultrastructural localization of megalin in the rat cochlear duct","volume":"129","author":"Mizuta","year":"1999","journal-title":"Hear. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1128\/aac.01050-15","article-title":"Amikacin concentrations predictive of ototoxicity in multidrug-resistant tuberculosis patients","volume":"59","author":"Modongo","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"B94","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1046\/j.1365-2958.1998.00821.x","article-title":"Functional and structural conservation in the mechanosensitive channel MscL implicates elements crucial for mechanosensation","volume":"28","author":"Moe","year":"1998","journal-title":"Mol. Microbiol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1172\/jci118176","article-title":"Evidence that epithelial glycoprotein 330\/megalin mediates uptake of polybasic drugs","volume":"96","author":"Moestrup","year":"1995","journal-title":"J. Clin. Invest."},{"key":"B96","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.heares.2005.02.005","article-title":"TRPV1 regulators mediate gentamicin penetration of cultured kidney cells","volume":"204","author":"Myrdal","year":"2005","journal-title":"Hea. Res."},{"key":"B97","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bcp.2014.05.018","article-title":"Entry of aminoglycosides into renal tubular epithelial cells via endocytosis-dependent and endocytosis-independent pathways","volume":"90","author":"Nagai","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"B98","unstructured":"National center for biotechnology information. PubChem compound database2017"},{"key":"B99","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fncel.2017.00242","article-title":"An antioxidant screen identifies candidates for protection of cochlear hair cells from gentamicin toxicity","volume":"11","author":"Noack","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1046\/j.1460-9568.2003.02715.x","article-title":"Degeneration of sensory outer hair cells following pharmacological blockade of cochlear KCNQ channels in the adult guinea pig","volume":"17","author":"Nouvian","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3735","DOI":"10.1016\/j.bmc.2010.03.060","article-title":"Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations","volume":"18","author":"Nudelman","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/hmg\/ddu518","article-title":"Mitochondrial m.1584A 12S m62A rRNA methylation in families with m.1555A>G associated hearing loss","volume":"24","author":"O\u2019Sullivan","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B103","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","article-title":"The role of endoplasmic reticulum stress in human pathology","volume":"10","author":"Oakes","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev.biochem.74.061903.155440","article-title":"Structural insights into translational fidelity","volume":"74","author":"Ogle","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10162-012-0353-0","article-title":"Quinoline ring derivatives protect against aminoglycoside-induced hair cell death in the zebrafish lateral line","volume":"13","author":"Ou","year":"2012","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-cellbio-111315-125125","article-title":"The lysosome as a regulatory hub","volume":"32","author":"Perera","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1038\/ncomms4112","article-title":"4\u2032-O-substitutions determine selectivity of aminoglycoside antibiotics","volume":"5","author":"Perez-Fernandez","year":"2014","journal-title":"Nat. Commun."},{"key":"B108","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","article-title":"Free radicals: properties, sources, targets, and their implication in various diseases","volume":"30","author":"Phaniendra","year":"2015","journal-title":"Indian J. Clin. Biochem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/jmg.30.10.885","article-title":"Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness","volume":"4","author":"Prezant","year":"1993","journal-title":"Nat. Genet."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1288\/00005537-197309000-00007","article-title":"The relationship between cochlea and kidney","volume":"83","author":"Quick","year":"1973","journal-title":"Laryngoscope"},{"key":"B111","doi-asserted-by":"publisher","first-page":"e000411","DOI":"10.1136\/bmjopen-2011-000411","article-title":"Hearing in 44\u201345 year olds with m.1555A>G, a genetic mutation predisposing to aminoglycoside-induced deafness: a population based cohort study","volume":"2","author":"Rahman","year":"2012","journal-title":"BMJ Open"},{"key":"B112","doi-asserted-by":"publisher","first-page":"716","DOI":"10.3410\/f.14263963.15777086","article-title":"Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness","volume":"148","author":"Raimundo","year":"2012","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/s0092-8674(02)00619-0","article-title":"Ribosome structure and the mechanism of translation","volume":"108","author":"Ramakrishnan","year":"2002","journal-title":"Cell"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1152\/jn.00574.2001","article-title":"Differences in mechano-transducer channel kinetics underlie tonotopic distribution of fast adaptation in auditory hair cells","volume":"87","author":"Ricci","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B115","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1523\/JNEUROSCI.22-01-00044.2002","article-title":"Mechanisms of active hair bundle motion in auditory hair cells","volume":"22","author":"Ricci","year":"2002","journal-title":"J. Neurosci."},{"key":"B116","doi-asserted-by":"crossref","first-page":"8261","DOI":"10.1523\/JNEUROSCI.18-20-08261.1998","article-title":"The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells","volume":"18","author":"Ricci","year":"1998","journal-title":"J. Neurosci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3410\/f.1016611.201037","article-title":"Tonotopic variation in the conductance of the hair cell mechanotransducer channel","volume":"40","author":"Ricci","year":"2003","journal-title":"Neuron"},{"key":"B118","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/0378-5955(91)90062-e","article-title":"Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity","volume":"53","author":"Richardson","year":"1991","journal-title":"Hear. Res."},{"key":"B119","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/j.1460-2075.1984.tb02176.x","article-title":"Hyper-accurate ribosomes inhibit growth","volume":"3","author":"Ruusala","year":"1984","journal-title":"EMBO J."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/s1359-6446(05)03552-x","article-title":"Ototoxicity: therapeutic opportunities","volume":"10","author":"Rybak","year":"2005","journal-title":"Drug Discov. Today"},{"key":"B121","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/s1359-6446(05)03574-9","article-title":"Local inner-ear drug delivery and pharmacokinetics","volume":"10","author":"Salt","year":"2005","journal-title":"Drug Discov. Today"},{"key":"B122","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1681\/ASN.V92167","article-title":"Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells","volume":"9","author":"Sandoval","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"13864","DOI":"10.1074\/jbc.m115.665364","article-title":"Negatively charged lipids as a potential target for new amphiphilic aminoglycoside antibiotics: a biophsyical study","volume":"291","author":"Sautrey","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1111\/j.1471-4159.1976.tb00318.x","article-title":"Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro","volume":"27","author":"Schacht","year":"1976","journal-title":"J. Neurochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1074\/jbc.m109959200","article-title":"Megalin deficiency offers protection from renal aminoglycoside accumulation","volume":"277","author":"Schmitz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1183\/09031936.00044812","article-title":"Hearing loss in patients on treatment for drug-resistant tuberculosis","volume":"40","author":"Seddon","year":"2012","journal-title":"Eur. Respir. J."},{"key":"B127","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/ng1064","article-title":"Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop","volume":"33","author":"Seidel-Rogol","year":"2003","journal-title":"Nat. Genetics"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1056\/nejmc053428","article-title":"Aspirin to prevent gentamicin-induced hearing loss","volume":"354","author":"Sha","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"B129","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.1093\/hmg\/ddu288","article-title":"Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes","volume":"23","author":"Sharoyko","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B130","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1074\/jbc.m113.533588","article-title":"Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity a strategy for the treatment of genetic diseases","volume":"289","author":"Shulman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B132","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1016\/j.bmc.2016.06.044","article-title":"A Gestalt approach to Gram-negative entry","volume":"24","author":"Silver","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0140-6736(05)17906-9","article-title":"Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis\u2014the TOPIC study: a randomised controlled trial","volume":"365","author":"Smyth","year":"2005","journal-title":"Lancet"},{"key":"B134","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0378-5955(97)00072-5","article-title":"Localization of pH regulating proteins H+ ATPase and Cl- HCO3- exchanger in the guinea pig inner ear","volume":"114","author":"Stankovic","year":"1997","journal-title":"Hear. Res."},{"key":"B135","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3389\/fncel.2015.00046","article-title":"Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death","volume":"9","author":"Stawicki","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1681\/ASN.2006101072","article-title":"Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-\/HCO3- exchanger (slc4a1)","volume":"18","author":"Stehberger","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s10162-011-0288-x","article-title":"TRPA1-mediated accumulation of aminoglycosides in mouse cochlear outer hair cells","volume":"12","author":"Stepanyan","year":"2011","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B138","first-page":"F602","article-title":"Inter-and intracompartmental osmotic gradients within the rat cochlea","volume":"247","author":"Sterkers","year":"1984","journal-title":"Am. J. Physiol."},{"key":"B139","first-page":"F173","article-title":"K, Cl, and H2O entry in endolymph, perilymph, and cerebrospinal fluid of the rat","volume":"243","author":"Sterkers","year":"1982","journal-title":"Am. J. Physiol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10162-003-4002-5","article-title":"Uptake of gentamicin by bullfrog saccular hair cells in vitro","volume":"4","author":"Steyger","year":"2003","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1126\/science.1131163","article-title":"Rapid chemically induced changes of PtdIns (4,5) P2 gate KCNQ ion channels","volume":"314","author":"Suh","year":"2006","journal-title":"Science"},{"key":"B142","volume-title":"A Scientific Roadmap for Antibiotic Discovery\u2014Antibiotic Resistance Report.","year":"2016"},{"key":"B143","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/s0021-9924(98)00014-8","article-title":"Sensorineural hearing loss caused by mitochondrial DNA mutations: special reference to the A1555G mutation","volume":"31","author":"Usami","year":"1998","journal-title":"J. Commun. Disord."},{"key":"B144","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/s1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"Van Boeckel","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"B145","doi-asserted-by":"publisher","first-page":"e54794","DOI":"10.1371\/journal.pone.0054794","article-title":"Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death","volume":"8","author":"Vu","year":"2013","journal-title":"PLoS One"},{"key":"B146","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1113\/jphysiol.2005.094474","article-title":"Aminoglycoside ototoxicity: permeant drugs cause permanent hair cell loss","volume":"567","author":"Waguespack","year":"2005","journal-title":"J. Physiol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","article-title":"Mitochondrial energetics and therapeutics","volume":"5","author":"Wallace","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10162-009-0160-4","article-title":"Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells","volume":"10","author":"Wang","year":"2009","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.heares.2010.06.008","article-title":"Competitive antagonism of fluorescent gentamicin uptake in the cochlea","volume":"268","author":"Wang","year":"2010","journal-title":"Hear. Res."},{"key":"B150","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.jcf.2015.07.010","article-title":"Prolongation of antibiotic treatment for cystic fibrosis pulmonary exacerbations","volume":"14","author":"Waters","year":"2015","journal-title":"J. Cyst. Fibros."},{"key":"B151","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3389\/fnagi.2015.00058","article-title":"Mechanisms of sensorineural cell damage, death and survival in the cochlea","volume":"7","author":"Wong","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B152","volume-title":"Critically Important Antimicrobials for Human Medicine.","year":"2011"},{"key":"B153","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.conb.2015.08.006","article-title":"The elusive mechanotransduction machinery of hair cells","volume":"34","author":"Zhao","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/jp.2012.105","article-title":"Ototoxicity in preterm infants: effects of genetics, aminoglycosides, and loud environmental noise","volume":"33","author":"Zimmerman","year":"2013","journal-title":"J. Perinatol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00325\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T20:23:24Z","timestamp":1659644604000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fncel.2017.00325\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,18]]},"references-count":154,"alternative-id":["10.3389\/fncel.2017.00325"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2017.00325","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,18]]},"article-number":"325"}}