{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:18:19Z","timestamp":1792451899238,"version":"4.5.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500842, 81671288, 81771455"],"award-info":[{"award-number":["31500842, 81671288, 81771455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313082"],"award-info":[{"award-number":["2016A030313082"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2018.00500","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T23:44:06Z","timestamp":1545349446000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Aberrant Development and Synaptic Transmission of Cerebellar Cortex in a VPA Induced Mouse Autism Model"],"prefix":"10.3389","volume":"12","author":[{"given":"Ruanna","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Fai","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.mcn.2014.01.007","article-title":"Increased BDNF expression in fetal brain in the valproic acid model of autism","volume":"59","author":"Almeida","year":"2014","journal-title":"Mol. Cell. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1177\/1362361311423385","article-title":"Motor anticipation failure in infants with autism: a retrospective analysis of feeding situations","volume":"16","author":"Brisson","year":"2012","journal-title":"Autism"},{"key":"B36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.brainres.2012.11.048","article-title":"Animal model of autism induced by prenatal exposure to valproate: altered glutamate metabolism in the hippocampus","volume":"1495","author":"Bristot Silvestrin","year":"2013","journal-title":"Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4031","DOI":"10.1242\/dev.106559","article-title":"Development of the cerebellum: simple steps to make a \u2018little brain\u2019","volume":"141","author":"Butts","year":"2014","journal-title":"Development"},{"key":"B4","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000375489","article-title":"Differential local connectivity and neuroinflammation profiles in the medial prefrontal cortex and hippocampus in the valproic acid rat model of autism","volume":"37","author":"Codagnone","year":"2015","journal-title":"Dev. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1038\/npp.2015.339","article-title":"Autistic-Like traits and cerebellar dysfunction in Purkinje cell PTEN knock-out mice","volume":"41","author":"Cupolillo","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.nicl.2015.02.007","article-title":"Cerebellar gray matter and lobular volumes correlate with core autism symptoms","volume":"7","author":"D\u2019Mello","year":"2015","journal-title":"Neuroimage Clin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum"},{"key":"B8","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3389\/fnins.2015.00420","article-title":"Autism spectrum disorders and neuropathology of the cerebellum","volume":"9","author":"Hampson","year":"2015","journal-title":"Front. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s12311-013-0475-x","article-title":"Altered microstructural connectivity of the superior cerebellar peduncle is related to motor dysfunction in children with autistic spectrum disorders","volume":"12","author":"Hanaie","year":"2013","journal-title":"Cerebellum"},{"key":"B10","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.neuroscience.2005.09.037","article-title":"11\u03b2-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids","volume":"137","author":"Holmes","year":"2006","journal-title":"Neuroscience"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1007\/s11064-016-1969-y","article-title":"Prenatal exposure to histone deacetylase inhibitors affects gene expression of autism-related molecules and delays neuronal maturation","volume":"41","author":"Kawanai","year":"2016","journal-title":"Neurochem. Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbr.2013.04.043","article-title":"Alterations in the endocannabinoid system in the rat valproic acid model of autism","volume":"249","author":"Kerr","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3892\/mmr.2013.1518","article-title":"Treadmill exercise ameliorates motor disturbance through inhibition of apoptosis in the cerebellum of valproic acid-induced autistic rat pups","volume":"8","author":"Kim","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/1362361311402230","article-title":"Motor skills of toddlers with autism spectrum disorders","volume":"17","author":"Lloyd","year":"2013","journal-title":"Autism"},{"key":"B15","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered peripheral and central inflammatory responses in a mouse model of autism","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/jcpp.12501","article-title":"Annual research review: the role of the environment in the developmental psychopathology of autism spectrum condition","volume":"57","author":"Mandy","year":"2016","journal-title":"J. Child Psychol. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/sj.npp.1301453","article-title":"Abnormal fear conditioning and amygdala processing in an animal model of autism","volume":"33","author":"Markram","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3389\/fncel.2014.00450","article-title":"Cellular commitment in the developing cerebellum","volume":"8","author":"Marzban","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/aur.1408","article-title":"Motor deficits in children with autism spectrum disorder: a cross-syndrome study","volume":"7","author":"McPhillips","year":"2014","journal-title":"Autism Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/WCO.0000000000000301","article-title":"Brain connectivity in autism spectrum disorder","volume":"29","author":"Mohammad-Rezazadeh","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1523\/JNEUROSCI.2731-14.2015","article-title":"Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder","volume":"35","author":"Mosconi","year":"2015","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s12311-015-0696-2","article-title":"Emotion and theory of mind in schizophrenia-investigating the role of the cerebellum","volume":"15","author":"Mothersill","year":"2016","journal-title":"Cerebellum"},{"key":"B23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ijdevneu.2014.10.003","article-title":"Embryological exposure to valproic acid disrupts morphology of the deep cerebellar nuclei in a sexually dimorphic way","volume":"40","author":"Mowery","year":"2015","journal-title":"Int. J. Dev. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neulet.2016.06.035","article-title":"Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats\u2014an animal model of autism","volume":"629","author":"Olexov\u00e1","year":"2016","journal-title":"Neurosci. Lett."},{"key":"B26","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/s12311-014-0591-2","article-title":"Apoptosis of Purkinje and granular cells of the cerebellum following chronic ethanol intake","volume":"13","author":"Oliveira","year":"2014","journal-title":"Cerebellum"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus?","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ijdevneu.2016.07.001","article-title":"Prenatal exposure to sodium valproate alters androgen receptor expression in the developing cerebellum in a region and age specific manner in male and female rats","volume":"53","author":"Perez-Pouchoulen","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"12627","DOI":"10.1038\/ncomms12627","article-title":"Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice","volume":"7","author":"Peter","year":"2016","journal-title":"Nat. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bbr.2014.04.045","article-title":"Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB\/C mice","volume":"270","author":"Pragnya","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s12640-013-9393-4","article-title":"Altered cytokine and BDNF levels in autism spectrum disorder","volume":"24","author":"Ricci","year":"2013","journal-title":"Neurotox. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism\u2014a current review of clinical and animal studies","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.neuroscience.2010.06.069","article-title":"Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid","volume":"170","author":"Roullet","year":"2010","journal-title":"Neuroscience"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1177\/0883073815601500","article-title":"Early infant development and intervention for autism spectrum disorder","volume":"30","author":"Sacrey","year":"2015","journal-title":"J. Child Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1038\/s41467-018-05656-w","article-title":"Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction","volume":"9","author":"Sathyanesan","year":"2018","journal-title":"Nat. Commun."},{"key":"B37","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1002\/syn.21759","article-title":"Prefrontal cortex, hippocampus, and basolateral amygdala plasticity in a rat model of autism spectrum","volume":"68","author":"Sosa-D\u00edaz","year":"2014","journal-title":"Synapse"},{"key":"B38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1186\/s12888-014-0321-9","article-title":"Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies","volume":"14","author":"Su","year":"2014","journal-title":"BMC Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1007\/s11064-009-0073-y","article-title":"Dendrite formation of cerebellar Purkinje cells","volume":"34","author":"Tanaka","year":"2009","journal-title":"Neurochem. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/s0074-7742(10)91011-8","article-title":"A review of synaptic plasticity at Purkinje neurons with a focus on ethanol-induced cerebellar dysfunction","volume":"91","author":"Valenzuela","year":"2010","journal-title":"Int. Rev. Neurobiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.neuron.2008.03.016","article-title":"Role of olivary electrical coupling in cerebellar motor learning","volume":"58","author":"Van Der Giessen","year":"2008","journal-title":"Neuron"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1007\/s00429-014-0870-1","article-title":"Cerebellar control of gait and interlimb coordination","volume":"220","author":"Vinueza Veloz","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"B45","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.neuron.2014.07.016","article-title":"The cerebellum, sensitive periods, and autism","volume":"83","author":"Wang","year":"2014","journal-title":"Neuron"},{"key":"B44","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3389\/fncel.2017.00382","article-title":"Secretin modulates the postnatal development of mouse cerebellar cortex Via PKA- and ERK-dependent pathways","volume":"11","author":"Wang","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fnint.2013.00051","article-title":"Sensory-motor problems in Autism","volume":"7","author":"Whyatt","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0166-4328(96)00159-3","article-title":"A behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant","volume":"75","author":"Wolf","year":"1996","journal-title":"Behav. Brain Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.bbr.2010.02.032","article-title":"Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment","volume":"210","author":"Yochum","year":"2010","journal-title":"Behav. Brain Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.brainres.2008.01.055","article-title":"VPA-induced apoptosis and behavioral deficits in neonatal mice","volume":"1203","author":"Yochum","year":"2008","journal-title":"Brain Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1038\/npp.2013.344","article-title":"The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning","volume":"39","author":"Zhang","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.bbr.2013.04.004","article-title":"Early identification of autism spectrum disorders","volume":"251","author":"Zwaigenbaum","year":"2013","journal-title":"Behav. Brain Res."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2018.00500\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T23:44:08Z","timestamp":1545349448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2018.00500\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,21]]},"references-count":51,"alternative-id":["10.3389\/fncel.2018.00500"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2018.00500","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,21]]},"article-number":"500"}}