{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:39:57Z","timestamp":1790375997509,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2019.00035","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T04:49:52Z","timestamp":1549601392000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake"],"prefix":"10.3389","volume":"13","author":[{"given":"Etienne","family":"Cartier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Garcia-Olivares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Janezic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Landon","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Caplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/bf02527762","article-title":"Characterization and transplantation of two neuronal cell lines with dopaminergic properties","volume":"21","author":"Adams","year":"1996","journal-title":"Neurochem. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1091\/mbc.e12-09-0678","article-title":"Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway","volume":"24","author":"Ahner","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3389\/fnmol.2014.00063","article-title":"Ubiquitin pathways in neurodegenerative disease","volume":"7","author":"Atkin","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"22053","DOI":"10.1074\/jbc.m116.749119","article-title":"Pharmacological chaperones of the dopamine transporter rescue dopamine transporter deficiency syndrome mutations in heterologous cells","volume":"291","author":"Beerepoot","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-3-319-50044-7_8","article-title":"Sumo modification of ion channels","volume":"963","author":"Benson","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1124\/pr.115.012260","article-title":"Kinase-dependent regulation of monoamine neurotransmitter transporters","volume":"68","author":"Bermingham","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"7024","DOI":"10.1523\/jneurosci.1863-04.2004","article-title":"Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions","volume":"24","author":"Bjerggaard","year":"2004","journal-title":"J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"12845","DOI":"10.1523\/jneurosci.1391-15.2015","article-title":"Brain region-specific trafficking of the dopamine transporter","volume":"35","author":"Block","year":"2015","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e464","DOI":"10.1038\/tp.2014.90","article-title":"SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking","volume":"4","author":"Bowton","year":"2014","journal-title":"Transl. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ebiom.2015.01.007","article-title":"Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors","volume":"2","author":"Cartier","year":"2015","journal-title":"EBioMedicine"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1038\/emm.2014.117","article-title":"Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies","volume":"47","author":"Ciechanover","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1073\/pnas.95.3.1265","article-title":"Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells","volume":"95","author":"Clarkson","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"35794","DOI":"10.1074\/jbc.274.50.35794","article-title":"Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters","volume":"274","author":"Daniels","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/s1097-2765(00)80133-1","article-title":"SUMO-1 modification of I\u03baB\u03b1 inhibits NF-\u03baB activation","volume":"2","author":"Desterro","year":"1998","journal-title":"Mol. Cell"},{"key":"B15","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.bbamcr.2007.03.017","article-title":"SUMO on the road to neurodegeneration","volume":"1773","author":"Dorval","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"B16","doi-asserted-by":"publisher","first-page":"24316","DOI":"10.1074\/jbc.m113.474924","article-title":"CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking","volume":"288","author":"Dustrude","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s12017-013-8259-5","article-title":"SUMO and Parkinson\u2019s disease","volume":"15","author":"Eckermann","year":"2013","journal-title":"Neuromolecular Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"6794","DOI":"10.1523\/jneurosci.4177-08.2009","article-title":"Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs","volume":"29","author":"Eriksen","year":"2009","journal-title":"J. Neurosci."},{"key":"B19","first-page":"877","article-title":"Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type","volume":"289","author":"Eshleman","year":"1999","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B20","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1146\/annurev-biochem-061909-093311","article-title":"Sumoylation: a regulatory protein modification in health and disease","volume":"82","author":"Flotho","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5175","DOI":"10.1074\/jbc.m110.187872","article-title":"Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation","volume":"286","author":"Foster","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"17836","DOI":"10.1523\/jneurosci.3284-13.2013","article-title":"Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton","volume":"33","author":"Gabriel","year":"2013","journal-title":"J. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1124\/pr.114.010397","article-title":"Regulation of the dopamine and vesicular monoamine transporters: pharmacological targets and implications for disease","volume":"67","author":"German","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1073\/pnas.97.3.1125","article-title":"The sentrin-conjugating enzyme mUbc9 interacts with GLUT4 and GLUT1 glucose transporters and regulates transporter levels in skeletal muscle cells","volume":"97","author":"Giorgino","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B25","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1161\/circresaha.115.304760","article-title":"Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes","volume":"115","author":"Gupta","year":"2014","journal-title":"Circ. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1172\/JCI73778","article-title":"Missense dopamine transporter mutations associate with adult parkinsonism and ADHD","volume":"124","author":"Hansen","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molcel.2005.03.012","article-title":"SUMO: a history of modification","volume":"18","author":"Hay","year":"2005","journal-title":"Mol. Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1006\/excr.2002.5634","article-title":"Ubc9 is essential for viability of higher eukaryotic cells","volume":"280","author":"Hayashi","year":"2002","journal-title":"Exp. Cell Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1152\/physrev.00008.2014","article-title":"Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction","volume":"94","author":"Henley","year":"2014","journal-title":"Physiol. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"7250","DOI":"10.1074\/jbc.ra118.001753","article-title":"Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes","volume":"293","author":"Herborg","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B31","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrn3689","article-title":"Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases","volume":"15","author":"Hetz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1096\/fj.12-218727","article-title":"Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons","volume":"27","author":"Hong","year":"2013","journal-title":"FASEB J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0278-5846(82)80179-6","article-title":"Citalopram\u2014pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity","volume":"6","author":"Hyttel","year":"1982","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"54380","DOI":"10.1074\/jbc.m409282200","article-title":"Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter","volume":"279","author":"Jiang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1046\/j.1365-2818.2003.01100.x","article-title":"Fluorescence resonance energy transfer from cyan to yellow fluorescent protein detected by acceptor photobleaching using confocal microscopy and a single laser","volume":"209","author":"Karpova","year":"2003","journal-title":"J. Microsc."},{"key":"B36","doi-asserted-by":"publisher","first-page":"Unit12.7","DOI":"10.1002\/0471142956.cy1207s35","article-title":"Detecting protein-protein interactions with CFP-YFP FRET by acceptor photobleaching","author":"Karpova","year":"2006","journal-title":"Curr. Protoc. Cytom."},{"key":"B37","doi-asserted-by":"publisher","first-page":"20876","DOI":"10.1074\/jbc.m116.737551","article-title":"Functional rescue of a misfolded Drosophila melanogaster dopamine transporter mutant associated with a sleepless phenotype by pharmacological chaperones","volume":"291","author":"Kasture","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.jns.2011.04.015","article-title":"Proteasome inhibition induces \u03b1-synuclein SUMOylation and aggregate formation","volume":"307","author":"Kim","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.chembiol.2013.04.001","article-title":"An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation","volume":"20","author":"Kim","year":"2013","journal-title":"Chem. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"L99","DOI":"10.1529\/biophysj.106.096206","article-title":"Cerulean, Venus, and VenusY67C FRET reference standards","volume":"91","author":"Koushik","year":"2006","journal-title":"Biophys. J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1083\/jcb.201010117","article-title":"Sumoylation inhibits \u03b1-synuclein aggregation and toxicity","volume":"194","author":"Krumova","year":"2011","journal-title":"J. Cell Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1172\/JCI38292","article-title":"Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I","volume":"119","author":"Kruse","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B43","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/s1474-4422(10)70269-6","article-title":"Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study","volume":"2011","author":"Kurian","year":"2011","journal-title":"Lancet Neurol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1172\/JCI39060","article-title":"Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia","volume":"119","author":"Kurian","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B45","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.brainres.2015.06.018","article-title":"The combination of lithium and L-dopa\/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) in mice: relevance for Parkinson\u2019s disease therapy","volume":"1622","author":"Lazzara","year":"2015","journal-title":"Brain Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e25852","DOI":"10.1371\/journal.pone.0025852","article-title":"Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"21012","DOI":"10.1074\/jbc.m311972200","article-title":"The role of N-glycosylation in function and surface trafficking of the human dopamine transporter","volume":"279","author":"Li","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B48","doi-asserted-by":"publisher","first-page":"C284","DOI":"10.1152\/ajpcell.00091.2016","article-title":"Ubiquitin-dependent and independent roles of SUMO in proteostasis","volume":"311","author":"Liebelt","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.2337\/db06-1100","article-title":"The SUMO-conjugating enzyme Ubc9 is a regulator of GLUT4 turnover and targeting to the insulin-responsive storage compartment in 3T3\u2013L1 adipocytes","volume":"56","author":"Liu","year":"2007","journal-title":"Diabetes"},{"key":"B50","doi-asserted-by":"publisher","first-page":"22168","DOI":"10.1074\/jbc.m301845200","article-title":"The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines","volume":"278","author":"Loder","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature05736","article-title":"SUMOylation regulates kainate-receptor-mediated synaptic transmission","volume":"447","author":"Martin","year":"2007","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1091\/mbc.e06-08-0704","article-title":"Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter","volume":"18","author":"Miranda","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"B53","doi-asserted-by":"publisher","first-page":"35617","DOI":"10.1074\/jbc.m506618200","article-title":"Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C","volume":"280","author":"Miranda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"8480","DOI":"10.1523\/jneurosci.23-24-08480.2003","article-title":"Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity","volume":"23","author":"Mor\u00f3n","year":"2003","journal-title":"J. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/brain\/awu022","article-title":"Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood","volume":"137","author":"Ng","year":"2014","journal-title":"Brain"},{"key":"B56","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.celrep.2013.06.034","article-title":"SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation","volume":"4","author":"O\u2019Rourke","year":"2013","journal-title":"Cell Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2005.01.019","article-title":"Sumoylation silences the plasma membrane leak K+ channel K2P1","volume":"121","author":"Rajan","year":"2005","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"13176","DOI":"10.1073\/pnas.1704351114","article-title":"SUMOylation and ubiquitination reciprocally regulate \u03b1-synuclein degradation and pathological aggregation","volume":"114","author":"Rott","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e36768","DOI":"10.7554\/eLife.36768","article-title":"Depleting Trim28 in adult mice is well tolerated and reduces levels of \u03b1-synuclein and tau","volume":"7","author":"Rousseaux","year":"2018","journal-title":"Elife"},{"key":"B60","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00424-013-1410-1","article-title":"The SLC6 transporters: perspectives on structure, functions, regulation and models for transporter dysfunction","volume":"466","author":"Rudnick","year":"2014","journal-title":"Pflugers Arch."},{"key":"B61","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1523\/JNEUROSCI.6033-11.2012","article-title":"Attention deficit\/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation","volume":"32","author":"Sakrikar","year":"2012","journal-title":"J. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"28274","DOI":"10.1074\/jbc.m210652200","article-title":"Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy","volume":"278","author":"Sorkina","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1600-0854.2005.00259.x","article-title":"Constitutive and protein kinase C-induced internalization of the dopamine transporter is mediated by a clathrin-dependent mechanism","volume":"6","author":"Sorkina","year":"2005","journal-title":"Traffic"},{"key":"B64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO modification of Huntingtin and Huntington\u2019s disease pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1038\/ncomms5980","article-title":"Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation","volume":"5","author":"Sun","year":"2014","journal-title":"Nat. Commun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"38153","DOI":"10.1074\/jbc.m508168200","article-title":"Pias1 interaction and sumoylation of metabotropic glutamate receptor 8","volume":"280","author":"Tang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/ncb1716","article-title":"RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation","volume":"10","author":"Tatham","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"rs4","DOI":"10.1126\/scisignal.2001484","article-title":"Comparative proteomic analysis identifies a role for SUMO in protein quality control","volume":"4","author":"Tatham","year":"2011","journal-title":"Sci. Signal."},{"key":"B69","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1074\/jbc.m201926200","article-title":"Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter","volume":"278","author":"Torres","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"15480","DOI":"10.1073\/pnas.1512957112","article-title":"Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant","volume":"112","author":"Wu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B71","doi-asserted-by":"publisher","first-page":"C1351","DOI":"10.1152\/ajpcell.00240.2005","article-title":"Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of \u03b2-cell ATP-sensitive potassium channels","volume":"289","author":"Yan","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.semcdb.2009.01.004","article-title":"Trafficking of dopamine transporters in psychostimulant actions","volume":"20","author":"Zahniser","year":"2009","journal-title":"Semin. Cell Dev. Biol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00035\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T16:23:47Z","timestamp":1550247827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00035\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":72,"alternative-id":["10.3389\/fncel.2019.00035"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2019.00035","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"article-number":"35"}}