{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:28:54Z","timestamp":1778660934816,"version":"3.51.4"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2019.00247","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T10:08:37Z","timestamp":1559729317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Generation of Oligodendrocyte Progenitor Cells From Mouse Bone Marrow Cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Yu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Casella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-Qing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan-Juan","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Yu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdolmohamad","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"B1","first-page":"62","article-title":"Bone marrow stromal cell transdifferentiation into oligodendrocyte-like cells using triiodothyronine as a inducer with expression of platelet-derived growth factor alpha as a maturity marker.","volume":"17","author":"Abbaszadeh","year":"2013","journal-title":"Iran. Biomed. J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1750-3639.2012.00637.x","article-title":"Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson\u2019s disease.","volume":"23","author":"Ahmed","year":"2013","journal-title":"Brain Pathol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/ncb3271","article-title":"The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.","volume":"18","author":"Baskin","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00245","article-title":"Plasmid-based generation of induced neural stem cells from adult human fibroblasts.","volume":"10","author":"Capetian","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/nprot.2007.149","article-title":"Isolation and culture of rat and mouse oligodendrocyte precursor cells.","volume":"2","author":"Chen","year":"2007","journal-title":"Nat. Protoc."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00268","article-title":"The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases.","volume":"7","author":"Clemente","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1089\/scd.2010.0547","article-title":"Mesenchymal stem cells enhance the engraftment and myelinating ability of allogeneic oligodendrocyte progenitors in dysmyelinated mice.","volume":"20","author":"Cristofanilli","year":"2011","journal-title":"Stem Cells Dev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/glia.22769","article-title":"Human oligodendrocytes in remyelination research.","volume":"63","author":"Czepiel","year":"2015","journal-title":"Glia"},{"key":"B9","doi-asserted-by":"publisher","first-page":"6241","DOI":"10.1039\/c7cs00330g","article-title":"Small molecule-induced cellular conversion.","volume":"46","author":"De","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/glia.10116","article-title":"Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells.","volume":"40","author":"Dietrich","year":"2002","journal-title":"Glia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jneumeth.2012.06.017","article-title":"Isolation of cortical mouse oligodendrocyte precursor cells.","volume":"209","author":"Dincman","year":"2012","journal-title":"J. Neurosci. Methods"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/nprot.2015.075","article-title":"Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells.","volume":"10","author":"Douvaras","year":"2015","journal-title":"Nat. Protoc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.stemcr.2014.06.012","article-title":"Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells.","volume":"3","author":"Douvaras","year":"2014","journal-title":"Stem Cell Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"E11807","DOI":"10.1073\/pnas.1808064115","article-title":"The adult oligodendrocyte can participate in remyelination.","volume":"115","author":"Duncan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1159\/000111284","article-title":"Conditionally immortalized oligodendrocyte cell lines migrate to different brain regions and elaborate \u2018myelin-like\u2019 membranes after transplantation into neonatal shiverer mouse brains.","volume":"17","author":"Foster","year":"1995","journal-title":"Dev. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"569","DOI":"10.2174\/1574888x10666150902095312","article-title":"Stem cell-derived oligodendroglial cells for therapy in neurological diseases.","volume":"11","author":"Garcia-Leon","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1242\/dev.126409","article-title":"How to make an oligodendrocyte.","volume":"142","author":"Goldman","year":"2015","journal-title":"Development"},{"key":"B18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.stem.2012.02.021","article-title":"Direct reprogramming of fibroblasts into neural stem cells by defined factors.","volume":"10","author":"Han","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"62","DOI":"10.6091\/ibj.11162.2013","article-title":"Bone marrow stromal cell transdifferentiation into oligodendrocyte-like cells using triiodothyronine as a inducer with expression of platelet-derived growth factor \u03b1 as a maturity marker.","volume":"17","author":"Hojjat-Allah","year":"2013","journal-title":"Iran. Biomed. J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.3109\/00207454.2011.642037","article-title":"In vitro differentiation of bone marrow stromal cells into oligodendrocyte-like cells using triiodothyronine as inducer.","volume":"122","author":"Kaka","year":"2012","journal-title":"Int. J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2820","DOI":"10.1002\/stem.1218","article-title":"Immunomodulation by transplanted human embryonic stem cell-derived oligodendroglial progenitors in experimental autoimmune encephalomyelitis.","volume":"30","author":"Kim","year":"2012","journal-title":"Stem Cells"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-015-0024-2","article-title":"Transplantation of mouse embryonic stem cell-derived oligodendrocytes in the murine model of globoid cell leukodystrophy.","volume":"6","author":"Kuai","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/mt.2016.104","article-title":"Neural stem cells engineered to express three therapeutic factors mediate recovery from chronic stage CNS autoimmunity.","volume":"24","author":"Li","year":"2016","journal-title":"Mol. Ther."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1089\/scd.2012.0508","article-title":"Differentiation of oligodendrocyte progenitor cells from human embryonic stem cells on vitronectin-derived synthetic peptide acrylate surface.","volume":"22","author":"Li","year":"2013","journal-title":"Stem Cells Dev."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjy088","article-title":"Conversion of mouse fibroblasts into oligodendrocyte progenitor-like cells through a chemical approach.","author":"Liu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.brainresbull.2015.08.008","article-title":"Isolation and culture of human oligodendrocyte precursor cells from neurospheres.","volume":"118","author":"Lu","year":"2015","journal-title":"Brain Res. Bull."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1002\/sctm.17-0065","article-title":"Human embryonic stem cell-derived oligodendrocyte progenitor cells: preclinical efficacy and safety in cervical spinal cord injury.","volume":"6","author":"Manley","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.pneurobio.2012.01.008","article-title":"Oligodendrocyte-protection and remyelination post-spinal cord injuries: a review.","volume":"96","author":"Mekhail","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/nbt.2561","article-title":"Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.","volume":"31","author":"Najm","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000437350","article-title":"Remyelination after lysophosphatidyl choline-induced demyelination is stimulated by bone marrow stromal cell-derived oligoprogenitor cell transplantation.","volume":"200","author":"Nazm Bojnordi","year":"2015","journal-title":"Cell. Tissues Org."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010145","article-title":"Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.","volume":"5","author":"Neri","year":"2010","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.stemcr.2018.10.017","article-title":"Human oligodendrogenic neural progenitor cells delivered with chondroitinase abc facilitate functional repair of chronic spinal cord injury.","volume":"11","author":"Nori","year":"2018","journal-title":"Stem Cell Rep."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0369-18.2018","article-title":"Exogenous neural precursor cell transplantation results in structural and functional recovery in a hypoxic-ischemic hemiplegic mouse model.","volume":"5","author":"Rumajogee","year":"2018","journal-title":"eNeuro"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.3727\/096368911x637443","article-title":"Intraventricularly injected Olig2-NSCs attenuate established relapsing-remitting EAE in mice.","volume":"21","author":"Sher","year":"2012","journal-title":"Cell Trans."},{"key":"B35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-c","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/nbt.1972","article-title":"CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells.","volume":"29","author":"Sim","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3791\/50586","article-title":"Isolation, purification and labeling of mouse bone marrow neutrophils for functional studies and adoptive transfer experiments.","volume":"10","author":"Swamydas","year":"2013","journal-title":"J. Vis. Exp."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.5966\/sctm.2016-0024","article-title":"Survival and Functionality of Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes in a Nonhuman Primate Model for Multiple Sclerosis.","volume":"5","author":"Thiruvalluvan","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1001\/jamaneurol.2015.1807","article-title":"Nerve growth factor gene therapy: activation of neuronal responses in alzheimer disease.","volume":"72","author":"Tuszynski","year":"2015","journal-title":"JAMA Neurol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.stem.2012.12.002","article-title":"Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.","volume":"12","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113368","article-title":"Administration of downstream ApoE attenuates the adverse effect of brain ABCA1 deficiency on stroke.","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nchembio1207-739","article-title":"Recognizing and exploiting differences between RNAi and small-molecule inhibitors.","volume":"3","author":"Weiss","year":"2007","journal-title":"Nat. Chem. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.injury.2011.09.013","article-title":"Transplantation of oligodendrocyte precursor cells improves myelination and promotes functional recovery after spinal cord injury.","volume":"43","author":"Wu","year":"2012","journal-title":"Injury"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171947","article-title":"Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells.","volume":"12","author":"Yamashita","year":"2017","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1172\/jci37914","article-title":"Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.","volume":"119","author":"Yang","year":"2009","journal-title":"J. Clin. Invest."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.2353\/ajpath.2010.091203","article-title":"Evaluation of bone marrow- and brain-derived neural stem cells in therapy of central nervous system autoimmunity.","volume":"177","author":"Yang","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nbt.2564","article-title":"Generation of oligodendroglial cells by direct lineage conversion.","volume":"31","author":"Yang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00014","article-title":"Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism.","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1016\/j.cell.2015.11.017","article-title":"A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming.","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/9780470151808.sc02d17s31","article-title":"Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain.","volume":"31","author":"Zhu","year":"2014","journal-title":"Curr. Protoc. Stem Cell Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1242\/dev.004895","article-title":"NG2 cells generate both oligodendrocytes and gray matter astrocytes.","volume":"135","author":"Zhu","year":"2008","journal-title":"Development"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00247\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T10:08:40Z","timestamp":1559729320000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00247\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":51,"alternative-id":["10.3389\/fncel.2019.00247"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2019.00247","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]},"article-number":"247"}}