{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:08:10Z","timestamp":1790165290181,"version":"4.1.0"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2019.00367","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:20:18Z","timestamp":1565338818000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":86,"title":["Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats"],"prefix":"10.3389","volume":"13","author":[{"given":"Erica","family":"Zamberletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gabaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Woolley-Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Bingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Parolaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bbr.2015.02.041","article-title":"Astaxanthin improves behavioral disorder and oxidative stress in prenatal valproic acid-induced mice model of autism.","volume":"286","author":"Al-Amin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B2","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-019-0256-6","article-title":"Lower circulating endocannabinoid levels in children with autism spectrum disorder.","volume":"10","author":"Aran","year":"2019","journal-title":"Mol. Autism."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss6706a1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years \u2013 autism and developmental disabilities monitoring network, 11 sites, United States, 2014.","volume":"67","author":"Baio","year":"2018","journal-title":"MMWR Surveill. Summ."},{"key":"B5","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.neulet.2014.09.039","article-title":"Resveratrol prevents social deficits in animal model of autism induced by valproic acid.","volume":"583","author":"Bambini-Junior","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.brainres.2011.06.063","article-title":"Amelioration of behavioral aberrations and oxidative markers by green tea extract in valproate induced autism in animals.","volume":"1410","author":"Banji","year":"2011","journal-title":"Brain Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12026-011-8210-5","article-title":"Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease.","volume":"51","author":"Basu","year":"2011","journal-title":"Immunol. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/cns.12648","article-title":"Beneficial effects of co-ultramicronized palmitoylethanolamide\/luteolin in a mouse model of autism and in a case report of autism.","volume":"23","author":"Bertolino","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071425","article-title":"Endocannabinod signal dysregulation in autism spectrum disorders: a correlation link between inflammatory state and neuro-immune alterations.","volume":"18","author":"Brigida","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0254-0","article-title":"Neuroglia in the autistic brain: evidence from a preclinical model.","volume":"9","author":"Bronzuoli","year":"2019","journal-title":"Mol. Autism"},{"key":"B11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nm.3127","article-title":"Targeting the endocannabinoid system in the treatment of fragile X syndrome.","volume":"19","author":"Busquets-Garcia","year":"2013","journal-title":"Nat. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00213-008-1168-x","article-title":"Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats.","volume":"199","author":"Campos","year":"2008","journal-title":"Psychopharmacology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.1098\/rstb.2011.0389","article-title":"Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.","volume":"367","author":"Campos","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"B15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000375489","article-title":"Differential local connectivity and neuroinflammation profiles in the medial prefrontal cortex and hippocampus in the valproic acid rat model of autism.","volume":"37","author":"Codagnone","year":"2015","journal-title":"Dev. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000492113","article-title":"Neuroimmune alterations in autism: a translational analysis focusing on the animal model of autism induced by prenatal exposure to valproic acid.","volume":"25","author":"Deckmann","year":"2018","journal-title":"Neuroimmunomodulation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neulet.2009.12.054","article-title":"Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism.","volume":"470","author":"Dufour-Rainfray","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.neubiorev.2010.12.013","article-title":"Fetal exposure to teratogens: evidence of genes involved in autism.","volume":"35","author":"Dufour-Rainfray","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1097\/WCO.0b013e32805866fb","article-title":"Teratogenesis of sodium valproate.","volume":"20","author":"Duncan","year":"2007","journal-title":"Curr. Opin. Neurol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-2-29","article-title":"Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.","volume":"2","author":"Ehrhart","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.reprotox.2016.04.024","article-title":"Genetic and non-genetic animal models for autism spectrum disorders (ASD).","volume":"64","author":"Ergaz","year":"2016","journal-title":"Reprod Toxicol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00235","article-title":"Microglia morphological categorization in a rat model of neuroinflammation by hierarchical cluster and principal components analysis.","volume":"11","author":"Fern\u00e1ndez-Arjona","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.neuron.2013.02.036","article-title":"Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling.","volume":"78","author":"Foldy","year":"2013","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2018.00009","article-title":"resveratrol prevents cellular and behavioral sensory alterations in the animal model of autism induced by valproic acid.","volume":"10","author":"Fontes-Dutra","year":"2018","journal-title":"Front. Synaptic. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.biopsych.2010.09.031","article-title":"Validating \u03b3 oscillations and delayed auditory responses as translational biomarkers of autism.","volume":"68","author":"Gandal","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ijdevneu.2015.11.006","article-title":"Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model.","volume":"49","author":"Gao","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/genes7090056","article-title":"Possible therapeutic doses of cannabinoid type 1 receptor antagonist reverses key alterations in fragile X syndrome mouse model.","volume":"7","author":"Gomis-Gonz\u00e1lez","year":"2016","journal-title":"Genes"},{"key":"B28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuropharm.2019.01.002","article-title":"Preclinical safety and efficacy of cannabidivarin for early life seizures.","volume":"148","author":"Huizenga","year":"2019","journal-title":"Neuropharmacology"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2045","article-title":"Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome.","volume":"3","author":"Jung","year":"2012","journal-title":"Nat. Commun."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0203-y","article-title":"Plasma anandamide concentrations are lower in children with autism spectrum disorder.","volume":"9","author":"Karhson","year":"2018","journal-title":"Mol Autism."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00519","article-title":"Relevance of neuroinflammation and encephalitis in autism.","volume":"9","author":"Kern","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbr.2013.04.043","article-title":"Alterations in the endocannabinoid system in the rat valproic acid model of autism.","volume":"249","author":"Kerr","year":"2013","journal-title":"Behav. Brain Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.phrs.2016.08.033","article-title":"Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid.","volume":"113","author":"Kerr","year":"2016","journal-title":"Pharmacol. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"207","DOI":"10.4062\/biomolther.2016.061","article-title":"Clinical and neurobiological relevance of current animal models of autism spectrum disorders.","volume":"24","author":"Kim","year":"2016","journal-title":"Biomol Ther."},{"key":"B35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.toxlet.2010.12.018","article-title":"The critical period of valproate exposure to induce autistic symptoms in sprague-dawley rats.","volume":"201","author":"Kim","year":"2011","journal-title":"Toxicol Lett."},{"key":"B36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.brainres.2015.10.052","article-title":"Minocycline ameliorates prenatal valproic acid induced autistic behaviour, biochemistry and blood brain barrier impairments in rats.","volume":"1630","author":"Kumar","year":"2016","journal-title":"Brain Res."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00422","article-title":"molecular pathology and pharmacological treatment of autism spectrum disorder-like phenotypes using rodent models.","volume":"12","author":"Kuo","year":"2018","journal-title":"Front. Cell Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1152\/physrev.00002.2016","article-title":"From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology.","volume":"96","author":"Ligresti","year":"2016","journal-title":"Physiol. Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jaac.2017.03.013","article-title":"What Is the Male-to-female ratio in autism spectrum disorder? A systematic review and meta-analysis.","volume":"56","author":"Loomes","year":"2017","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered peripheral and central inflammatory responses in a mouse model of autism.","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5607\/en.2015.24.4.285","article-title":"Exploring the validity of valproic acid animal model of autism.","volume":"24","author":"Mabunga","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/npp.2010.19","article-title":"Abnormal mGlu 5 receptor\/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.","volume":"35","author":"Maccarrone","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4103\/sni.sni_45_18","article-title":"Review of the neurological benefits of phytocannabinoids.","volume":"9","author":"Maroon","year":"2018","journal-title":"Surg. Neurol. Int."},{"key":"B44","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bbi.2015.06.002","article-title":"Endocannabinoids drive the acquisition of an alternative phenotype in microglia.","volume":"49","author":"Mecha","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1002\/cbdv.200790147","article-title":"Cannabidiol\u2013recent advances.","volume":"4","author":"Mechoulam","year":"2007","journal-title":"Chem. Biodivers."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026077","article-title":"mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism.","volume":"6","author":"Mehta","year":"2011","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1111\/bph.14435","article-title":"Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling.","volume":"175","author":"Melancia","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1124\/pr.110.003491","article-title":"the highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications.","volume":"63","author":"Miller","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1161\/01.STR.0000163083.59201.34","article-title":"Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism.","volume":"36","author":"Mishima","year":"2005","journal-title":"Stroke"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3206561","article-title":"Autistic-like behaviors, oxidative stress status, and histopathological changes in cerebellum of valproic acid rat model of autism are improved by the combined extract of purple rice and silkworm pupae.","volume":"2016","author":"Morakotsriwan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-3-319-45541-9_4","article-title":"Molecular targets of the phytocannabinoids: a complex picture.","volume":"103","author":"Morales","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"B52","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism.","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.4155\/fmc.09.93","article-title":"Cannabinoids as novel anti-inflammatory drugs.","volume":"1","author":"Nagarkatti","year":"2009","journal-title":"Future Med. Chem."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00406","article-title":"Targeting cannabinoid cb2 receptors in the central nervous system. medicinal chemistry approaches with focus on neurodegenerative disorders.","volume":"10","author":"Navarro","year":"2016","journal-title":"Front. Neurosci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.reprotox.2015.05.007","article-title":"Prenatal factors associated with autism spectrum disorder (ASD).","volume":"56","author":"Ornoy","year":"2015","journal-title":"Reprod Toxicol."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051074","article-title":"Prevention or amelioration of autism-like symptoms in animal models: will it bring us closer to treating human ASD?","volume":"20","author":"Ornoy","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1093\/brain\/awp23","article-title":"Microglial CB2 cannabinoid receptors are neuroprotective in Huntington\u2019s disease excitotoxicity.","volume":"132","author":"Palazuelos","year":"2009","journal-title":"Brain"},{"key":"B58","first-page":"32","article-title":"The pharmacology and therapeutic potential of cannabidiol","author":"Pertwee","year":"2004","journal-title":"Cannabinoids"},{"key":"B59","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.bbr.2014.04.045","article-title":"Ameliorating effect of piperine on behavioral abnormalities and oxidative markers in sodium valproate induced autism in BALB\/C mice.","volume":"270","author":"Pragnya","year":"2014","journal-title":"Behav. Brain Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.bbr.2015.05.003","article-title":"Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.","volume":"291","author":"Qin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ntt.2013.01.004","article-title":"In utero exposure to valproic acid and autism-a current review of clinical and animal studies.","volume":"36","author":"Roullet","year":"2013","journal-title":"Neurotoxicol Teratol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism.","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.182","article-title":"Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid.","volume":"6","author":"Servadio","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.880","article-title":"Preparation of pre- and post-synaptic density fraction from mouse cortex.","volume":"3","author":"Shen","year":"2013","journal-title":"Bio Protoc."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-78","article-title":"The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.","volume":"11","author":"Siniscalco","year":"2014","journal-title":"J Neuroinflammation"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1007\/s10803-013-1824-9","article-title":"Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders.","volume":"43","author":"Siniscalco","year":"2013","journal-title":"J. Autism. Dev. Disord."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.,pone.0140638","article-title":"Increased cortical inhibition in autism-linked neuroligin-3R451C mice is due in part to loss of endocannabinoid signaling.","volume":"10","author":"Speed","year":"2015","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder.","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder.","author":"Tartaglione","year":"2019","journal-title":"Neuropharmacology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jneuroim.2011.12.021","article-title":"Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.","volume":"244","author":"Tumati","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1007\/s00018-016-2300-4","article-title":"The CB2 receptor and its role as a regulator of inflammation.","volume":"73","author":"Turcotte","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism.","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.neuropharm.2018.07.029","article-title":"Chronic treatment with the phytocannabinoid cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome.","volume":"140","author":"Vigli","year":"2018","journal-title":"Neuropharmacology"},{"key":"B74","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1089\/can.2015.0008","article-title":"Enhancement of anandamide-mediated endocannabinoid signaling corrects autism-related social impairment.","volume":"1","author":"Wei","year":"2016","journal-title":"Cannabis Cannabinoid Res."},{"key":"B75","doi-asserted-by":"crossref","DOI":"10.21926\/obm.neurobiol.1702005","article-title":"Perspectives on the role of endocannabinoids in autism spectrum disorders.","volume":"1","author":"Yeh","year":"2017","journal-title":"OBM Neurobiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2013.10.028","article-title":"Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats.","volume":"63","author":"Zamberletti","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091916","article-title":"The endocannabinoid system and autism spectrum disorders: insights from animal models.","volume":"18","author":"Zamberletti","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1177\/0269881119844184","article-title":"Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.","volume":"33","author":"Zamberletti","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1111\/j.1476-5381.2009.00521.x","article-title":"Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.","volume":"159","author":"Zanelati","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1111\/bph.12607","article-title":"Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice.","volume":"171","author":"Zoppi","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1590\/S1516-44462008000300015","article-title":"Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action.","volume":"30","author":"Zuardi","year":"2008","journal-title":"Rev. Bras. Psiquiatr."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00367\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:20:20Z","timestamp":1565338820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00367\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,9]]},"references-count":81,"alternative-id":["10.3389\/fncel.2019.00367"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2019.00367","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,9]]},"article-number":"367"}}