{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:41:27Z","timestamp":1783575687019,"version":"3.55.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2019.00384","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T04:37:02Z","timestamp":1566362222000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival"],"prefix":"10.3389","volume":"13","author":[{"given":"Roc\u00edo Beatriz","family":"Foltran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Melany","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonela","family":"Bonafina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Resasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvina Laura","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1002\/jnr.21139","article-title":"Mouse and rat BDNF gene structure and expression revisited.","volume":"85","author":"Aid","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbr.2012.03.022","article-title":"Object recognition testing: methodological considerations on exploration and discrimination measures.","volume":"232","author":"Akkerman","year":"2012","journal-title":"Behav. Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1046\/j.0953-816X.2001.01763.x","article-title":"Serotonin mediates oestrogen stimulation of cell proliferation in the adult dentate gyrus.","volume":"14","author":"Banasr","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/sj.npp.1300320","article-title":"Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone.","volume":"29","author":"Banasr","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuron.2004.04.001","article-title":"p75NTR Is positively promiscuous: novel partners and new insights.","volume":"42","author":"Barker","year":"2004","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.bcp.2017.06.129","article-title":"Emerging pharmacological approaches to promote neurogenesis from endogenous glial cells.","volume":"141","author":"Boda","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/s0306-4522(98)00693-9","article-title":"Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats.","volume":"89","author":"Brezun","year":"1999","journal-title":"Neuroscience"},{"key":"B8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/(sici)1098-1063(2000)10:1<37::aid-hipo4>3.0.co;2-c","article-title":"Serotonergic reinnervation reverses lesion-induced decreases in PSA-NCAM labeling and proliferation of hippocampal cells in adult rats.","volume":"10","author":"Brezun","year":"2000","journal-title":"Hippocampus"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00389","article-title":"TPH2 deficiency influences neuroplastic mechanisms and alters the response to an acute stress in a sex specific manner citation.","volume":"11","author":"Brivio","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1111\/ejn.12297","article-title":"Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.","volume":"38","author":"Diaz","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/jnc.13658","article-title":"BDNF isoforms: a round trip ticket between neurogenesis and serotonin?","volume":"138","author":"Foltran","year":"2016","journal-title":"J. Neurochem."},{"key":"B12","article-title":"Validation of a protocol for oral administration of PCPA, an Inhibitor of Serotonin Synthesis.","volume":"11","author":"Foltran","year":"2019","journal-title":"ASN Neuro"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1126\/science.287.5457.1433","article-title":"Mammalian neural stem cells.","volume":"287","author":"Gage","year":"2000","journal-title":"Science"},{"key":"B14","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.neuroscience.2005.03.064","article-title":"The role of 5-HT1A receptors in the proliferation and survival of progenitor cells in the dentate gyrus of the adult hippocampus and their regulation by corticoids.","volume":"135","author":"Huang","year":"2005","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.pnpbp.2017.04.014","article-title":"The postnatal 5-HT1A receptor regulates adult anxiety and depression differently via multiple molecules.","volume":"78","author":"Ishikawa","year":"2017","journal-title":"Prog. Neuro. Psychopharmacol. Biol. Psychiatry"},{"key":"B16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.brainres.2005.12.110","article-title":"Selective serotonin depletion does not regulate hippocampal neurogenesis in the adult rat brain: differential effects of p-chlorophenylalanine and 5,7-dihydroxytryptamine.","volume":"1075","author":"Jha","year":"2006","journal-title":"Brain Res."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00325","article-title":"Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells.","volume":"8","author":"Jia","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0078238","article-title":"5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the morris water maze but not in the barnes maze.","volume":"8","author":"Karabeg","year":"2013","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.stem.2018.04.004","article-title":"Human adult neurogenesis: evidence and remaining questions.","volume":"23","author":"Kempermann","year":"2018","journal-title":"Cell Stem Cell."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2010.00014","article-title":"Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis.","volume":"3","author":"Klempin","year":"2010","journal-title":"Front. Mol. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.nbd.2015.10.021","article-title":"Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC \u03b1-synuclein transgenic rat model of Parkinson\u2019s disease.","volume":"85","author":"Kohl","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00406-015-0611-613","article-title":"Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin.","volume":"266","author":"Kronenberg","year":"2016","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"9104","DOI":"10.1523\/jneurosci.20-24-09104.2000","article-title":"Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus.","volume":"20","author":"Malberg","year":"2000","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/mp.2012.128","article-title":"Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation.","volume":"18","author":"Migliarini","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cell.2012.01.046","article-title":"Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.","volume":"149","author":"Nakashiba","year":"2012","journal-title":"Cell"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1523\/ENEURO.0376-16.2017","article-title":"Perturbation of serotonin homeostasis during adulthood affects serotonergic neuronal circuitry.","volume":"4","author":"Pratelli","year":"2017","journal-title":"eNeuro"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.65","article-title":"The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.","volume":"3","author":"Sachs","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to imagej: 25 years of image analysis.","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"B31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0166-4328(03)00117-7","article-title":"Performance of different mouse strains in an object recognition task.","volume":"147","author":"\u015fik","year":"2003","journal-title":"Behav. Brain Res."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/srep20338","article-title":"Reducing central serotonin in adulthood promotes hippocampal neurogenesis.","volume":"6","author":"Song","year":"2016","journal-title":"Sci. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.scr.2016.12.018","article-title":"Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice.","volume":"19","author":"Song","year":"2017","journal-title":"Stem Cell Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.bbr.2014.10.041","article-title":"The object pattern separation (OPS) task: a behavioral paradigm derived from the object recognition task.","volume":"285","author":"van Hagen","year":"2015","journal-title":"Behav. Brain Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00026","article-title":"Regulation of neurogenesis by neurotrophins during adulthood: expected and unexpected roles.","volume":"10","author":"Vilar","year":"2016","journal-title":"Front. Neurosci."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00384\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T18:41:13Z","timestamp":1569091273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00384\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":35,"alternative-id":["10.3389\/fncel.2019.00384"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2019.00384","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"article-number":"384"}}