{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:23:54Z","timestamp":1788960234721,"version":"build-2803163510"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002046","name":"Hearing Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2019.00445","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:24:06Z","timestamp":1570163046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Investigations of the Microvasculature of the Human Macula Utricle in Meniere\u2019s Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Gail","family":"Ishiyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Acuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,10,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.171592","article-title":"Graph analysis of cell clusters forming vascular networks.","volume":"5","author":"Alves","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"B2","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/archneur.58.7.1151","article-title":"Prosper Meniere\u2019s and his disease.","volume":"58","author":"Baloh","year":"2001","journal-title":"Arch. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3174\/ajnr.A3856","article-title":"Detection and grading of endolymphatic hydrops in Meniere\u2019s disease using MR imaging.","volume":"35","author":"Barath","year":"2014","journal-title":"AJNR"},{"key":"B4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00441-01201481-x","article-title":"The expression of cochlin and extracellular matrix proteins in vestibular endorgans obtained from Meniere\u2019s disease patients.","volume":"350","author":"Calzada","year":"2012","journal-title":"Cell Tissue Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular endothelial dysfunction.","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1016\/j.mehy.2013.10.015","article-title":"The Meniere\u2019s attack: an ischemia\/reperfusion disorder of inner ear sensory tissues.","volume":"81","author":"Foster","year":"2013","journal-title":"Med. Hypotheses"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00071","article-title":"Nanoparticle mediated drug delivery of rolipram to tyrosine kinase B positive cells in the inner ear with targeting peptides and agonistic antibodies.","volume":"7","author":"Glueckert","year":"2015","journal-title":"Front. Aging Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1080\/0001640801901774","article-title":"Observations on the pathology of Meniere\u2019s s\u00edndrome: section of otology.","volume":"31","author":"Hallpike","year":"1938","journal-title":"Proc. R. Soc. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s10162-014-0476-476","article-title":"Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum, fluorescein into the perilymph.","volume":"15","author":"Hirose","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1212\/WNL.57.6.1103","article-title":"Drop attacks in older patients secondary to an otologic cause.","volume":"57","author":"Ishiyama","year":"2001","journal-title":"Neurology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s00441-010-0975-977","article-title":"Immunohistochemical localization and mRNA expression of aquaporins in the macula utricle of patients with Meniere\u2019s disease and acoustic neuroma.","volume":"340","author":"Ishiyama","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00330-335","article-title":"The blood labyrinthine barrier in the human normal and Meniere\u2019s macula utricle.","volume":"7","author":"Ishiyama","year":"2017","journal-title":"Sci. Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/nyas.12699","article-title":"Meniere\u2019s disease: histopathology, cytochemistry, and imaging.","volume":"1343","author":"Ishiyama","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01068","article-title":"Oxidative stress in the blood labyrinthine barrier in the macula utricle of Meniere\u2019s disease patients.","volume":"9","author":"Ishiyama","year":"2018","journal-title":"Front. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.heares.2018.11.02","article-title":"Microvascular networks in the area of the auditory peripheral nervous system.","volume":"371","author":"Jiang","year":"2019","journal-title":"Hear. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/jmri.24144","article-title":"Markers of cochlear inflammation using MRI.","volume":"39","author":"LeFloc\u2019h","year":"2014","journal-title":"J. Magn. Reson. Imaging."},{"key":"B17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neumeth.2004.11.024","article-title":"Estimation of the number of nerve fibers in the human vestibular endorgans using unbiased stereology and immunohistochemistry.","volume":"145","author":"Lopez","year":"2005","journal-title":"J. Neurosci. Methods"},{"key":"B18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00418-016-1471-1472","article-title":"Immunohistochemical techniques for the human inner ear.","volume":"146","author":"Lopez","year":"2016","journal-title":"Histochem. Cell Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/00016489009121137","article-title":"The vascular anatomy of the vestibular labyrinth in man.","volume":"472","author":"Mazzoni","year":"1990","journal-title":"Acta Otolaryngol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6815-94","article-title":"Histopathological and ultrastructural analysis of vestibular endorgans obtained from patients with Meniere\u2019s disease.","volume":"9","author":"McCall","year":"2009","journal-title":"BMC Ear Nose Throat Disord."},{"key":"B21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1080\/03009734.2018.1492654","article-title":"Human inner ear blood supply revisited: the uppsala collection of temporal bone- an international resource of education and collaboration.","volume":"123","author":"Mei","year":"2018","journal-title":"Ups. J. Med. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/00129492-200501000-00013","article-title":"Pathophysiology of Meniere\u2019s syndrome: are symptoms caused by endolymphatic hydrops?","volume":"26","author":"Merchant","year":"2005","journal-title":"Otol. Neurotol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1080\/00016480902924469","article-title":"The vascularization of the human cochlea: its historical background.","volume":"129","author":"Mudry","year":"2009","journal-title":"Acta Oto. Laryngol."},{"key":"B24","first-page":"1","article-title":"A study in the comparative anatomy of the blood-vascular system on the internal ear in mammalian and in homo (Japanese).","volume":"6","author":"Nabeya","year":"1923","journal-title":"Acta Sch. Med. Univ. Imp. Kyoto"},{"key":"B25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10162-012-0365-369","article-title":"Endothelial cell, pericytes, and perivascular macrophage-type melanocyte interactions regulate cochlear intrastrial fluid-blood barrier permeability.","volume":"14","author":"Neng","year":"","journal-title":"JARO"},{"key":"B26","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nprot.2013.033","article-title":"Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear.","volume":"8","author":"Neng","year":"","journal-title":"Nat. Protoc."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao0935","article-title":"Delivery of therapeutics to the inner ear: the challenge of the blood-labyrinth barrier.","volume":"11","author":"Nyberg","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.3174\/ajnr.A48822","article-title":"Blood-labyrinth barrier permeability in Meniere\u2019s disease and idiopathic sudden sensorineural hearing loss: findings on delayed contrast 3D-Flair MRI.","volume":"37","author":"Pakdaman","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00300","article-title":"Local drug delivery for prevention of hearing loss.","volume":"13","author":"Rybak","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B30","author":"Schuknecht","year":"1993","journal-title":"Pathology of the Ear"},{"key":"B31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/01.moo.0000186335.44206.1c","article-title":"The basic science of Meniere\u2019s disease and endolymphatic hydrops.","volume":"13","author":"Semaan","year":"2005","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"B32","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/MOO.)b)13e32833d3164","article-title":"Contemporary perspectives on the pathophysiology of Meniere\u2019s disease: implications for treatment.","volume":"18","author":"Semaan","year":"2010","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"B33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clinimag.2014.09.014","article-title":"Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere\u2019s disease: correlation of quantitative measures of endolymphatic hydrops with hearing.","volume":"39","author":"Sepahdari","year":"2015","journal-title":"Clin. Imaging"},{"key":"B34","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3174\/ajnr.A4462","article-title":"Endolymphatic hydrops reversal following acetazolamide therapy: demonstrated with delayed intravenous contrast-enhanced 3D-FLAIR MRI.","volume":"37","author":"Sepahdari","year":"2016","journal-title":"Am. J. Neuroradiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.heares.2011.08.006","article-title":"Physiopathology of the cochlear microcirculation.","volume":"282","author":"Shi","year":"2011","journal-title":"Hear. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.hearres.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier (review).","volume":"338","author":"Shi","year":"2016","journal-title":"Hear. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1080\/107396808002047445","article-title":"The cochlear pericytes.","volume":"15","author":"Shi","year":"2008","journal-title":"Microcirculation"},{"key":"B38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3109\/00016489.2010.534114","article-title":"Endolymphatic hydrops and blood-labyrinthine barrier in Meniere\u2019s disease.","volume":"131","author":"Tagaya","year":"2011","journal-title":"Acta Otolaryngol."},{"key":"B39","first-page":"2310","article-title":"Uber die pathologisch veranderung bei einem Meniere\u2019s-kranken.","volume":"4","author":"Yamakawa","year":"1938","journal-title":"J. Otorhinolaryngol. Soc. Japn."},{"key":"B40","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3174\/ajnr.A2821","article-title":"Comparison of contrast effect on the cochlear perilymph after intratympanic and intravenous gadolinium injection.","volume":"33","author":"Yamazaki","year":"2012","journal-title":"AJNR"},{"key":"B41","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10162-013-0403-2","article-title":"Characterization and inflammatory response of perivascular macrophage-resident macrophage-like melanocytes in the vestibular system.","volume":"14","author":"Zhang","year":"2013","journal-title":"JARO"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027385","article-title":"A computational tool for quantitative analysis of vascular networks.","volume":"6","author":"Zudaire","year":"2011","journal-title":"PLoS One"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00445\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:24:08Z","timestamp":1570163048000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2019.00445\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,4]]},"references-count":42,"alternative-id":["10.3389\/fncel.2019.00445"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2019.00445","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,4]]},"article-number":"445"}}