{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:54:50Z","timestamp":1778864090933,"version":"3.51.4"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["ZIA DC000079, ZIA DC000086-03, NIH R01 DC013817"],"award-info":[{"award-number":["ZIA DC000079, ZIA DC000086-03, NIH R01 DC013817"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["MR130240"],"award-info":[{"award-number":["MR130240"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2020.00123","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T13:27:29Z","timestamp":1589808449000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium"],"prefix":"10.3389","volume":"14","author":[{"given":"Erica","family":"Sadler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew M.","family":"Ryals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey A.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich T.","family":"Boger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Morell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronna","family":"Hertzano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa L.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.heares.2006.04.001","article-title":"The fate of outer hair cells after acoustic or ototoxic insults","volume":"218","author":"Abrashkin","year":"2006","journal-title":"Hear. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1007\/s10162-014-0480-x","article-title":"How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse","volume":"15","author":"Anttonen","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s10162-014-0491-7","article-title":"Heat shock protein-mediated protection against cisplatin-induced hair cell death","volume":"16","author":"Baker","year":"2015","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"12545","DOI":"10.1523\/JNEUROSCI.3042-10.2010","article-title":"Supporting cells eliminate dying sensory hair cells to maintain epithelial integrity in the avian inner ear","volume":"30","author":"Bird","year":"2010","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.stemcr.2014.01.008","article-title":"Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea","volume":"2","author":"Bramhall","year":"2014","journal-title":"Stem Cell Reports"},{"key":"B101","doi-asserted-by":"publisher","first-page":"128867","DOI":"10.1172\/JCI128867","article-title":"Exosomes mediate sensory hair cell protection in the inner ear","author":"Breglio","year":"2020","journal-title":"J. Clin. Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e18128","DOI":"10.7554\/eLife.18128","article-title":"Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice","volume":"6","author":"Bucks","year":"2017","journal-title":"Elife"},{"key":"B7","doi-asserted-by":"publisher","first-page":"8557","DOI":"10.1038\/ncomms9557","article-title":"Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear","volume":"6","author":"Burns","year":"2015","journal-title":"Nat. Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5870","DOI":"10.1523\/JNEUROSCI.5083-14.2015","article-title":"Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor","volume":"35","author":"Cai","year":"2015","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41586-018-0728-4","article-title":"Helios is a key transcriptional regulator of outer hair cell maturation","volume":"563","author":"Chessum","year":"2018","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10162-006-0043-x","article-title":"Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death","volume":"7","author":"Cunningham","year":"2006","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e46261","DOI":"10.1371\/journal.pone.0046261","article-title":"Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings","volume":"7","author":"Dalet","year":"2012","journal-title":"PLoS One"},{"key":"B12","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1210\/me.2013-1391","article-title":"Research resource: genome-wide identification of AR-regulated genes translated in sertoli cells in vivo using the ribotag approach","volume":"28","author":"De Gendt","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1152\/jn.00746.2003","article-title":"Comparative morphology of rodent vestibular periphery","volume":"93","author":"Desai","year":"2005","journal-title":"J. Neurophysiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1006\/jsbi.2001.4380","article-title":"Review: cellular substrates of the eukaryotic chaperonin TRiC\/CCT","volume":"135","author":"Dunn","year":"2001","journal-title":"J. Struct. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00441-014-2079-2","article-title":"Applications for single cell trajectory analysis in inner ear development and regeneration","volume":"361","author":"Durruthy-Durruthy","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3389\/fgene.2018.00473","article-title":"Single cell transcriptomics reveal abnormalities in neurosensory patterning of the Chd7 mutant mouse ear","volume":"9","author":"Durruthy-Durruthy","year":"2018","journal-title":"Front. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"8549","DOI":"10.1038\/ncomms9549","article-title":"RFX transcription factors are essential for hearing in mice","volume":"6","author":"Elkon","year":"2015","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12881-017-0372-0","article-title":"Genetic characterization of Italian patients with Bardet-Biedl syndrome and correlation to ocular, renal and audio-vestibular phenotype: identification of eleven novel pathogenic sequence variants","volume":"18","author":"Esposito","year":"2017","journal-title":"BMC Med. Genet."},{"key":"B20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0378-5955(85)90121-2","article-title":"Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment","volume":"19","author":"Forge","year":"1985","journal-title":"Hear. Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fncel.2017.00252","article-title":"Non-autonomous cellular responses to ototoxic drug-induced stress and death","volume":"11","author":"Francis","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e195","DOI":"10.1038\/cddis.2011.76","article-title":"Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32","volume":"2","author":"Francis","year":"2011","journal-title":"Cell Death Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/stem.2554","article-title":"Concise review: regeneration in mammalian cochlea hair cells: help from supporting cell transdifferentiation","volume":"35","author":"Franco","year":"2017","journal-title":"Stem Cells"},{"key":"B24","doi-asserted-by":"publisher","first-page":"7659","DOI":"10.1523\/JNEUROSCI.1545-06.2006","article-title":"The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea","volume":"26","author":"Glowatzki","year":"2006","journal-title":"J. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"15093","DOI":"10.1523\/JNEUROSCI.1709-12.2012","article-title":"Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin","volume":"32","author":"Golub","year":"2012","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e1002309","DOI":"10.1371\/journal.pgen.1002309","article-title":"Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis","volume":"7","author":"Hertzano","year":"2011","journal-title":"PLoS Genet."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1093\/hmg\/ddh218","article-title":"Transcription profiling of inner ears from Pou4f3ddl\/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene","volume":"13","author":"Hertzano","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1523\/JNEUROSCI.2267-16.2016","article-title":"Global analysis of protein expression of inner ear hair cells","volume":"37","author":"Hickox","year":"2017","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.heares.2017.04.006","article-title":"Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear","volume":"352","author":"Hirose","year":"2017","journal-title":"Hear. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1620\/tjem.200.137","article-title":"Expression of glutamate transporter GLAST in the developing mouse cochlea","volume":"200","author":"Jin","year":"2003","journal-title":"Tohoku J. Exp. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"W96","DOI":"10.1093\/nar\/gkq418","article-title":"ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems","volume":"38","author":"Kaimal","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fncel.2015.00150","article-title":"Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle","volume":"9","author":"Kaur","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e27434","DOI":"10.7554\/eLife.27434","article-title":"A recombinant BBSome core complex and how it interacts with ciliary cargo","volume":"6","author":"Klink","year":"2017","journal-title":"Elife"},{"key":"B34","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fnmol.2019.00316","article-title":"Single cell and single nucleus RNA-Seq reveal cellular heterogeneity and homeostatic regulatory networks in adult mouse stria vascularis","volume":"12","author":"Korrapati","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/6804","article-title":"Notch signalling pathway mediates hair cell development in mammalian cochlea","volume":"21","author":"Lanford","year":"1999","journal-title":"Nat. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"15329","DOI":"10.1523\/JNEUROSCI.2057-11.2011","article-title":"Inhibition of Notch activity promotes nonmitotic regeneration of hair cells in the adult mouse utricles","volume":"31","author":"Lin","year":"2011","journal-title":"J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3389\/fnmol.2018.00356","article-title":"Cell-specific transcriptome analysis shows that adult pillar and Deiters\u2019 cells express genes encoding machinery for specializations of cochlear hair cells","volume":"11","author":"Liu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"11085","DOI":"10.1523\/JNEUROSCI.1690-14.2014","article-title":"Characterization of transcriptomes of cochlear inner and outer hair cells","volume":"34","author":"Liu","year":"2014","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"6600","DOI":"10.1523\/JNEUROSCI.0818-12.2012","article-title":"Age-dependent in vivo conversion of mouse cochlear pillar and Deiters\u2019 cells to immature hair cells by Atoh1 ectopic expression","volume":"32","author":"Liu","year":"2012","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e44431","DOI":"10.7554\/eLife.44431","article-title":"scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling","volume":"8","author":"Lush","year":"2019","journal-title":"Elife"},{"key":"B42","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s12859-019-2879-1","article-title":"pcaExplorer: an R\/Bioconductor package for interacting with RNA-seq principal components","volume":"20","author":"Marini","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"B44","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3389\/fcell.2018.00047","article-title":"Transcriptomic profiling of zebrafish hair cells using RiboTag","volume":"6","author":"Matern","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"42079","DOI":"10.1038\/srep42079","article-title":"Gfi1Cre mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells","volume":"7","author":"Matern","year":"2017","journal-title":"Sci. Rep."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1172\/JCI68480","article-title":"Inner ear supporting cells protect hair cells by secreting HSP70","volume":"123","author":"May","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B46","doi-asserted-by":"publisher","first-page":"dev171009","DOI":"10.1242\/dev.171009","article-title":"Multiple supporting cell subtypes are capable of spontaneous hair cell regeneration in the neonatal mouse cochlea","volume":"146","author":"McGovern","year":"2019","journal-title":"Development"},{"key":"B47","doi-asserted-by":"publisher","first-page":"16919","DOI":"10.1073\/pnas.1408064111","article-title":"Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse","volume":"111","author":"Mellado Lagarde","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B48","doi-asserted-by":"publisher","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","article-title":"PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways and data analysis tool enhancements","volume":"45","author":"Mi","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/nprot.2013.092","article-title":"Large-scale gene function analysis with the PANTHER classification system","volume":"8","author":"Mi","year":"2013","journal-title":"Nat. Protoc."},{"key":"B50","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1046\/j.1460-9568.1998.00070.x","article-title":"A role for BDNF in early postnatal rat vestibular epithelia maturation: implication of supporting cells","volume":"10","author":"Montcouquiol","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/cdd.2015.48","article-title":"Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death","volume":"22","author":"Monzack","year":"2015","journal-title":"Cell Death Differ."},{"key":"B52","doi-asserted-by":"publisher","first-page":"13649","DOI":"10.1038\/ncomms13649","article-title":"Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan","volume":"7","author":"Noormohammadi","year":"2016","journal-title":"Nat. Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/jnr.21625","article-title":"Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea","volume":"86","author":"Okano","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/mao.0000000000000879","article-title":"Anti CD163+, Iba1+, and CD68+ cells in the adult human inner ear: normal distribution of an unappreciated class of macrophages\/microglia and implications for inflammatory otopathology in humans","volume":"37","author":"O\u2019Malley","year":"2016","journal-title":"Otol. Neurotol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"3160.e3","DOI":"10.1016\/j.celrep.2019.02.053","article-title":"Insights into the biology of hearing and deafness revealed by single-cell RNA sequencing","volume":"26","author":"Ranum","year":"2019","journal-title":"Cell Rep."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e66179","DOI":"10.1371\/journal.pone.0066179","article-title":"RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo","volume":"8","author":"Sanz","year":"2013","journal-title":"PLoS One"},{"key":"B57","doi-asserted-by":"publisher","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B58","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10162-009-0198-3","article-title":"Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury","volume":"11","author":"Sato","year":"2010","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1523\/JNEUROSCI.5126-14.2015","article-title":"Gene expression by mouse inner ear hair cells during development","volume":"35","author":"Scheffer","year":"2015","journal-title":"J. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/1471-2105-7-302","article-title":"A new measure for functional similarity of gene products based on Gene Ontology","volume":"7","author":"Schlicker","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1073\/pnas.0910268107","article-title":"BBS6, BBS10, and BBS12 form a complex with CCT\/TRiC family chaperonins and mediate BBSome assembly","volume":"107","author":"Seo","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B62","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1002\/cne.22424","article-title":"Oncomodulin identifies different hair cell types in the mammalian inner ear","volume":"518","author":"Simmons","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/srep00026","article-title":"Intrinsic regenerative potential of murine cochlear supporting cells","volume":"1","author":"Sinkkonen","year":"2011","journal-title":"Sci. Rep."},{"key":"B64","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s10162-018-0676-6","article-title":"Characterization of adult vestibular organs in 11 CreER mouse lines","volume":"19","author":"Stone","year":"2018","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"key":"B65","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/cne.21227","article-title":"Dynamic patterns of neurotrophin 3 expression in the postnatal mouse inner ear","volume":"501","author":"Sugawara","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/s0306-4522(97)00025-0","article-title":"Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ","volume":"79","author":"Takumi","year":"1997","journal-title":"Neuroscience"},{"key":"B67","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s12192-008-0097-2","article-title":"Hsp70 inhibits aminoglycoside-induced hearing loss and cochlear hair cell death","volume":"14","author":"Taleb","year":"2009","journal-title":"Cell Stress Chaperones"},{"key":"B68","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10162-008-0122-2","article-title":"Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock","volume":"9","author":"Taleb","year":"2008","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3389\/fncel.2015.00190","article-title":"Early transcriptional response to aminoglycoside antibiotic suggests alternate pathways leading to apoptosis in sensory hair cells in the mouse inner ear","volume":"9","author":"Tao","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1038\/nmeth.4437","article-title":"Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations","volume":"14","author":"van den Brink","year":"2017","journal-title":"Nat. Methods."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1016\/j.celrep.2015.04.062","article-title":"Quantitative high-resolution cellular map of the organ of corti","volume":"11","author":"Waldhaus","year":"2015","journal-title":"Cell Rep."},{"key":"B72","doi-asserted-by":"publisher","first-page":"6613","DOI":"10.1038\/ncomms7613","article-title":"Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1016\/j.cell.2012.10.042","article-title":"Norrin\/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity","volume":"151","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/nature04849","article-title":"Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells","volume":"441","author":"White","year":"2006","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1042\/bcj20170378","article-title":"The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring","volume":"475","author":"Willison","year":"2018","journal-title":"Biochem. J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e1007552","DOI":"10.1371\/journal.pgen.1007552","article-title":"High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor","volume":"14","author":"Yamashita","year":"2018","journal-title":"PLoS Genet."},{"key":"B77","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/dvg.20632","article-title":"Gfi1-Cre knock-in mouse line: a tool for inner ear hair cell-specific gene deletion","volume":"48","author":"Yang","year":"2010","journal-title":"Genesis"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1101\/739680","article-title":"Development of the mouse and human cochlea at single cell resolution","author":"Yu","year":"2019","journal-title":"bioRxiv"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.00123\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T13:27:36Z","timestamp":1589808456000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.00123\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":80,"alternative-id":["10.3389\/fncel.2020.00123"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2020.00123","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]},"article-number":"123"}}