{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:15:59Z","timestamp":1790370959722,"version":"4.1.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M3A9B4061407"],"award-info":[{"award-number":["NRF-2017M3A9B4061407"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2020.546659","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T06:36:50Z","timestamp":1601015810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model"],"prefix":"10.3389","volume":"14","author":[{"given":"Jeong-Eun","family":"Noh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Hyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/nm747","article-title":"Neuronal replacement from endogenous precursors in the adult brain after stroke","volume":"8","author":"Arvidsson","year":"2002","journal-title":"Nat. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1093\/brain\/awp174","article-title":"Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms","volume":"132","author":"Bacigaluppi","year":"2009","journal-title":"Brain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"144","DOI":"10.2174\/1574888x11308020005","article-title":"Mesenchymal stem cells derived from Wharton\u2019s Jelly of the umbilical cord: biological properties and emerging clinical applications","volume":"8","author":"Batsali","year":"2013","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"B5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/jnr.490380402","article-title":"Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis","volume":"38","author":"Bauer","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1007\/s12015-012-9418-z","article-title":"The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton\u2019s jelly of the human umbilical cord","volume":"9","author":"Bongso","year":"2013","journal-title":"Stem Cell Rev. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1634\/stemcells.2007-0417","article-title":"Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells","volume":"25","author":"Can","year":"2007","journal-title":"Stem Cells"},{"key":"B8","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.biocel.2012.12.001","article-title":"Proangiogenic features of Wharton\u2019s jelly-derived mesenchymal stromal\/stem cells and their ability to form functional vessels","volume":"45","author":"Choi","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/s1474-4422(02)00040-6","article-title":"Treatment of neural injury with marrow stromal cells","volume":"1","author":"Chopp","year":"2002","journal-title":"Lancet Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"146362","DOI":"10.1016\/j.brainres.2019.146362","article-title":"Efficacy of stem cell-based therapies for stroke","volume":"1722","author":"Chrostek","year":"2019","journal-title":"Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fncel.2012.00011","article-title":"Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation","volume":"6","author":"Denham","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1089\/ten.TEB.2013.0664","article-title":"Umbilical cord mesenchymal stem cells: the new gold standard for mesenchymal stem cell-based therapies?","volume":"20","author":"El Omar","year":"2014","journal-title":"Tissue Eng. Part B Rev."},{"key":"B13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1046\/j.1365-2141.2000.01986.x","article-title":"Mesenchymal progenitor cells in human umbilical cord blood","volume":"109","author":"Erices","year":"2000","journal-title":"Br. J. Haematol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.cell.2014.01.044","article-title":"Neurogenesis in the striatum of the adult human brain","volume":"156","author":"Ernst","year":"2014","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.acthis.2015.02.005","article-title":"Wharton\u2019s jelly derived mesenchymal stromal cells: biological properties, induction of neuronal phenotype and current applications in neurodegeneration research","volume":"117","author":"Frausin","year":"2015","journal-title":"Acta Histochem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1038\/nn.2963","article-title":"Perivascular instruction of cell genesis and fate in the adult brain","volume":"14","author":"Goldman","year":"2011","journal-title":"Nat. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"468748","DOI":"10.1155\/2014\/468748","article-title":"Stem cell-based therapies for ischemic stroke","volume":"2014","author":"Hao","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B19","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/01.WCB.0000041283.53351.CB","article-title":"Temporal profile of angiogenesis and expression of related genes in the brain after ischemia","volume":"23","author":"Hayashi","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S1474-4422(17)30046-7","article-title":"Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial","volume":"16","author":"Hess","year":"2017","journal-title":"Lancet Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1002\/stem.584","article-title":"Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation and vascular repair","volume":"29","author":"Horie","year":"2011","journal-title":"Stem Cells"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1089\/scd.2009.0485","article-title":"Functional module analysis reveals differential osteogenic and stemness potentials in human mesenchymal stem cells from bone marrow and Wharton\u2019s jelly of umbilical cord","volume":"19","author":"Hsieh","year":"2010","journal-title":"Stem Cells Dev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e72604","DOI":"10.1371\/journal.pone.0072604","article-title":"Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis and angiogenesis","volume":"8","author":"Hsieh","year":"2013","journal-title":"PLoS One"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"B26","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1161\/STROKEAHA.112.677328","article-title":"Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after stroke","volume":"44","author":"Ishizaka","year":"2013","journal-title":"Stroke"},{"key":"B29","doi-asserted-by":"publisher","first-page":"918280","DOI":"10.4061\/2011\/918280","article-title":"Comparison of vascular perturbations in an abeta-injected animal model and in AD brain","volume":"2011","author":"Jantaratnotai","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1161\/STR.0b013e318284056a","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the american heart association\/american stroke association","volume":"44","author":"Jauch","year":"2013","journal-title":"Stroke"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1161\/01.STR.0000083698.20199.1F","article-title":"Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage","volume":"34","author":"Jeong","year":"2003","journal-title":"Stroke"},{"key":"B32","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.nbd.2004.10.010","article-title":"Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat","volume":"18","author":"Jin","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1227\/01.NEU.0000377859.06219.78","article-title":"Isolation and perivascular localization of mesenchymal stem cells from mouse brain","volume":"67","author":"Kang","year":"2010","journal-title":"Neurosurgery"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e47559","DOI":"10.1371\/journal.pone.0047559","article-title":"Safety of cell therapy with mesenchymal stromal cells (safecell): a systematic review and meta-analysis of clinical trials","volume":"7","author":"Lalu","year":"2012","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1002\/stem.430","article-title":"A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"B39","doi-asserted-by":"publisher","first-page":"98","DOI":"10.5582\/irdr.2015.01010","article-title":"Functional recovery after acute intravenous administration of human umbilical cord mesenchymal stem cells in rats with cerebral ischemia-reperfusion injury","volume":"4","author":"Li","year":"2015","journal-title":"Intractable Rare Dis. Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"9682757","DOI":"10.1155\/2016\/9682757","article-title":"How to improve the survival of transplanted mesenchymal stem cell in ischemic heart?","volume":"2016","author":"Li","year":"2016","journal-title":"Stem Cells Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/jcbfm.2009.238","article-title":"Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study","volume":"30","author":"Li","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B42","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/scrt79","article-title":"Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia","volume":"2","author":"Lim","year":"2011","journal-title":"Stem Cell Res. Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1161\/STROKEAHA.110.603621","article-title":"Human umbilical mesenchymal stem cells promote recovery after ischemic stroke","volume":"42","author":"Lin","year":"2011","journal-title":"Stroke"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1161\/STROKEAHA.110.599654","article-title":"Stem cell research in stroke: how far from the clinic?","volume":"42","author":"Lindvall","year":"2011","journal-title":"Stroke"},{"key":"B45","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.pneurobio.2013.11.007","article-title":"Cell based therapies for ischemic stroke: from basic science to bedside","volume":"115","author":"Liu","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.str.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/j.jcyt.2015.04.007","article-title":"Early neuroprotective effect with lack of long-term cell replacement effect on experimental stroke after intra-arterial transplantation of adipose-derived mesenchymal stromal cells","volume":"17","author":"Oh","year":"2015","journal-title":"Cytotherapy"},{"key":"B50","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s12276-018-0041-1","article-title":"Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model","volume":"50","author":"Oh","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J. Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1523\/JNEUROSCI.15-05-03863.1995","article-title":"Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test","volume":"15","author":"Olsson","year":"1995","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e35577","DOI":"10.1371\/journal.pone.0035577","article-title":"The adult human brain harbors multipotent perivascular mesenchymal stem cells","volume":"7","author":"Paul","year":"2012","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1161\/STROKEAHA.109.575993","article-title":"Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia","volume":"41","author":"Pendharkar","year":"2010","journal-title":"Stroke"},{"key":"B55","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1161\/STR.0000000000000074","article-title":"2015 American heart association\/american stroke association focused update of the 2013 guidelines for the early management of patients with acute ischemic stroke regarding endovascular treatment: a guideline for healthcare professionals from the american heart association\/american stroke association","volume":"46","author":"Powers","year":"2015","journal-title":"Stroke"},{"key":"B58","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.stem.2012.02.005","article-title":"Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease","volume":"10","author":"Ranganath","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/s0361-9230(02)00962-0","article-title":"Examination of sensorimotor performance following middle cerebral artery occlusion in rats","volume":"59","author":"Reglodi","year":"2003","journal-title":"Brain Res Bull."},{"key":"B60","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s12975-016-0482-6","article-title":"Stem cell therapy and administration routes after stroke","volume":"7","author":"Rodr\u00edguez-Frutos","year":"2016","journal-title":"Transl. Stroke Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2174\/157488808785740352","article-title":"Adult stem cell transplantation in stroke: its limitations and prospects","volume":"3","author":"Roh","year":"2008","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"B62","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1634\/stemcells.21-1-105","article-title":"Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord","volume":"21","author":"Romanov","year":"2003","journal-title":"Stem Cells"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1111\/j.1582-4934.2008.00434.x","article-title":"A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer\u2019s disease brain","volume":"13","author":"Ryu","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1161\/STROKEAHA.116.012995","article-title":"Clinical outcomes of transplanted modified bone marrow-derived mesenchymal stem cells in stroke: a phase 1\/2a study","volume":"47","author":"Steinberg","year":"2016","journal-title":"Stroke"},{"key":"B66","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.nbd.2011.09.018","article-title":"New striatal neurons form projections to substantia nigra in adult rat brain after stroke","volume":"45","author":"Sun","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1093\/brain\/awt278","article-title":"Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery","volume":"136","author":"Tornero","year":"2013","journal-title":"Brain"},{"key":"B68","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.expneurol.2008.11.010","article-title":"Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia","volume":"216","author":"Toyama","year":"2009","journal-title":"Exp. Neurol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1089\/neu.2006.0161","article-title":"Mesenchymal stem cells derived from peripheral blood protects against ischemia","volume":"24","author":"Ukai","year":"2007","journal-title":"J. Neurotrauma"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1161\/STROKEAHA.107.502047","article-title":"Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia","volume":"39","author":"Walczak","year":"2008","journal-title":"Stroke"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1634\/stemcells.2007-1028","article-title":"Immune properties of human umbilical cord Wharton\u2019s jelly-derived cells","volume":"26","author":"Weiss","year":"2008","journal-title":"Stem Cells"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1161\/STROKEAHA.110.593129","article-title":"Delayed administration of human umbilical tissue-derived cells improved neurological functional recovery in a rodent model of focal ischemia","volume":"42","author":"Zhang","year":"2011","journal-title":"Stroke"},{"key":"B76","doi-asserted-by":"publisher","first-page":"4279","DOI":"10.1091\/mbc.E02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol. Biol. Cell."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.546659\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T06:37:41Z","timestamp":1601015861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.546659\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":65,"alternative-id":["10.3389\/fncel.2020.546659"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2020.546659","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"546659"}}