{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:50Z","timestamp":1789570970760,"version":"build-2803163510"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2020.566712","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T14:45:10Z","timestamp":1601045110000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Rod and Cone Coupling Modulates Photopic ERG Responses in the Mouse Retina"],"prefix":"10.3389","volume":"14","author":[{"given":"Yichao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1152\/jn.00142.2009","article-title":"Genetic dissection of rod and cone pathways in the dark-adapted mouse retina","volume":"102","author":"Abd-El-Barr","year":"2009","journal-title":"J. Neurophysiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1016\/j.visres.2006.04.015","article-title":"Cone phototransduction and growth of the ERG b-wave during light adaptation","volume":"46","author":"Alexander","year":"2006","journal-title":"Vision Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0896-6273(00)00062-3","article-title":"The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning","volume":"27","author":"Applebury","year":"2000","journal-title":"Neuron"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/h0044572","article-title":"Long-term light adaptation of the human electroretinogram","volume":"51","author":"Armington","year":"1958","journal-title":"J. Comp. Physiol. Psychol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"E006","DOI":"10.1017\/S0952523817000037","article-title":"Connexin 36 expression is required for electrical coupling between mouse rods and cones","volume":"34","author":"Asteriti","year":"2017","journal-title":"Vis. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s10633-011-9292-z","article-title":"An extended 15 Hz ERG protocol (1): the contributions of primary and secondary rod pathways and the cone pathway","volume":"123","author":"Bijveld","year":"2011","journal-title":"Doc. Ophthalmol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrn2636","article-title":"The diverse functional roles and regulation of neuronal gap junctions in the retina","volume":"10","author":"Bloomfield","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s12031-015-0654-y","article-title":"Expression and localization of connexins in the outer retina of the mouse","volume":"58","author":"Bolte","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1017\/s0952523806232024","article-title":"Origin of electroretinogram amplitude growth during light adaptation in pigmented rats","volume":"23","author":"Bui","year":"2006","journal-title":"Vis. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1001\/archopht.1954.00920040519010","article-title":"Electric responses of the human visual system","volume":"51","author":"Burian","year":"1954","journal-title":"AMA Arch. Ophthalmol."},{"key":"B11","first-page":"635","article-title":"A proximal retinal component in the primate photopic ERG a-wave","volume":"35","author":"Bush","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1167\/iovs.19-27242","article-title":"Cone ERG changes during light adaptation in two all-cone mutant mice: implications for rod-cone pathway interactions","volume":"60","author":"Bush","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B13","first-page":"2209","article-title":"Influence of the rod photoresponse on light adaptation and circadian rhythmicity in the cone ERG","volume":"15","author":"Cameron","year":"2009","journal-title":"Mol. Vis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/s0042-6989(01)00146-8","article-title":"Retinal degeneration mutants in the mouse","volume":"42","author":"Chang","year":"2002","journal-title":"Vision Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/s0896-6273(01)00373-7","article-title":"Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36","volume":"31","author":"Deans","year":"2001","journal-title":"Neuron"},{"key":"B16","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/s0896-6273(02)01046-2","article-title":"Connexin36 is essential for transmission of rod-mediated visual signals in the mammalian retina","volume":"36","author":"Deans","year":"2002","journal-title":"Neuron"},{"key":"B17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1023\/A:1001869212639","article-title":"Cone properties of the light-adapted murine ERG","volume":"97","author":"Ekesten","year":"1999","journal-title":"Doc. Ophthalmol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.14412.1","article-title":"Rod and cone interactions in the retina","volume":"7","author":"Fain","year":"2018","journal-title":"F1000Res"},{"key":"B19","first-page":"139","article-title":"Origins of the electroretinogram","volume-title":"Principles and Practice of Clinical Electrophysiology of Vision","author":"Frishman","year":"2006"},{"key":"B20","first-page":"625","article-title":"Growth in amplitude of the human cone electroretinogram with light adaptation","volume":"30","author":"Gouras","year":"1989","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"6036","DOI":"10.1523\/JNEUROSCI.21-16-06036.2001","article-title":"Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36","volume":"21","author":"G\u00fcldenagel","year":"2001","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.brainres.2012.05.060","article-title":"Electrical synapses between AII amacrine cells in the retina: function and modulation","volume":"1487","author":"Hartveit","year":"2012","journal-title":"Brain Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.1523\/JNEUROSCI.1117-05.2005","article-title":"The primordial, blue-cone color system of the mouse retina","volume":"25","author":"Haverkamp","year":"2005","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.7551\/mitpress\/5557.001.0001","volume-title":"Principles and Practice of Clinical Electrophysiology of Vision.","author":"Heckenlively","year":"2006"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1152\/jn.00536.2010","article-title":"Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling","volume":"105","author":"Heikkinen","year":"2011","journal-title":"J. Neurophysiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/s0896-6273(01)00387-7","article-title":"Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice","volume":"31","author":"Hormuzdi","year":"2001","journal-title":"Neuron"},{"key":"B27","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.1523\/JNEUROSCI.0711-12.2012","article-title":"Retinal dopamine mediates multiple dimensions of light-adapted vision","volume":"32","author":"Jackson","year":"2012","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1523\/JNEUROSCI.3301-15.2016","article-title":"Direct evidence for daily plasticity of electrical coupling between rod photoreceptors in the mammalian retina","volume":"36","author":"Jin","year":"2016","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e43856","DOI":"10.1371\/journal.pone.0043856","article-title":"Rod-driven OFF pathway responses in the distal retina: dark-adapted flicker electroretinogram in mouse","volume":"7","author":"Lei","year":"2012","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1523\/JNEUROSCI.2807-12.2013","article-title":"Adenosine and dopamine receptors coregulate photoreceptor coupling via gap junction phosphorylation in mouse retina","volume":"33","author":"Li","year":"2013","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1167\/iovs.17-23011","article-title":"Light-Dependent OCT structure changes in photoreceptor degenerative rd 10 mouse retina","volume":"59","author":"Li","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1523\/JNEUROSCI.19-01-00442.1999","article-title":"UV- and midwave-sensitive cone-driven retinal responses of the mouse: a possible phenotype for coexpression of cone photopigments","volume":"19","author":"Lyubarsky","year":"1999","journal-title":"J. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cne.901720106","article-title":"Cat cones have rod input: a comparison of the response properties of cones and horizontal cell bodies in the retina of the cat","volume":"172","author":"Nelson","year":"1977","journal-title":"J. Comp. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1085\/jgp.200409208","article-title":"Photoreceptors of Nrl\u2212\/\u2212 mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms","volume":"125","author":"Nikonov","year":"2005","journal-title":"J. Gen. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.neulet.2017.09.003","article-title":"Design principles of electrical synaptic plasticity","volume":"695","author":"O\u2019Brien","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1146\/annurev-vision-091517-034133","article-title":"Plasticity of retinal gap junctions: roles in synaptic physiology and disease","volume":"4","author":"O\u2019Brien","year":"2018","journal-title":"Annu. Rev. Vis. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10633-015-9480-3","article-title":"Rod and cone contributions to the dark-adapted 15-Hz flicker electroretinogram","volume":"130","author":"Park","year":"2015","journal-title":"Doc. Ophthalmol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1017\/s0952523800009305","article-title":"Light adaptation, rods and the human cone flicker Erg","volume":"8","author":"Peachey","year":"","journal-title":"Vis. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1016\/0042-6989(92)90066-r","article-title":"Rapid and slow changes in the human cone electroretinogram during light and dark-adaptation","volume":"32","author":"Peachey","year":"","journal-title":"Vision Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0304-3940(93)90547-x","article-title":"Properties of the mouse cone-mediated electroretinogram during light adaptation","volume":"162","author":"Peachey","year":"1993","journal-title":"Neurosci. Lett."},{"key":"B41","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10633-007-9064-y","article-title":"Interpretation of the mouse electroretinogram","volume":"115","author":"Pinto","year":"2007","journal-title":"Doc. Ophthalmol."},{"key":"B42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5772\/22817","article-title":"Comparison of rat cone ERG elicited by a pulse flicker and sine-wave modulated light stimuli","volume-title":"Electroretinograms","author":"Qian","year":"2011"},{"key":"B43","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.exer.2008.04.011","article-title":"Two distinct processes are evident in rat cone flicker ERG responses at low and high temporal frequencies","volume":"87","author":"Qian","year":"2008","journal-title":"Exp. Eye Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"5116","DOI":"10.1167\/iovs.06-0364","article-title":"An electrophysiological study of retinal function in the diabetic female rat","volume":"47","author":"Ramsey","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e24483","DOI":"10.1371\/journal.pone.0024483","article-title":"Localization of melatonin receptor 1 in mouse retina and its role in the circadian regulation of the electroretinogram and dopamine levels","volume":"6","author":"Sengupta","year":"2011","journal-title":"PLoS One"},{"key":"B46","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.exer.2009.10.006","article-title":"Characteristics of period doubling in the rat cone flicker ERG","volume":"90","author":"Shah","year":"2010","journal-title":"Exp. Eye Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"11182","DOI":"10.1523\/JNEUROSCI.3096-04.2004","article-title":"Convergence and segregation of the multiple rod pathways in mammalian retina","volume":"24","author":"V\u00f6lgyi","year":"2004","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/s1350-9462(98)00006-8","article-title":"Oscillatory potentials in the retina: what do they reveal","volume":"17","author":"Wachtmeister","year":"1998","journal-title":"Prog. Retin. Eye Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/s0079-6123(01)31037-3","article-title":"Some aspects of the oscillatory response of the retina","volume":"131","author":"Wachtmeister","year":"2001","journal-title":"Prog. Brain Res."},{"key":"B50","first-page":"1176","article-title":"The oscillatory potentials of the mudpuppy retina","volume":"17","author":"Wachtmeister","year":"1978","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.exer.2015.07.002","article-title":"In vivo electroretinographic studies of the role of GABAC receptors in retinal signal processing","volume":"139","author":"Wang","year":"2015","journal-title":"Exp. Eye Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2007.09.003","article-title":"Rodent electroretinography: methods for extraction and interpretation of rod and cone responses","volume":"27","author":"Weymouth","year":"2008","journal-title":"Prog. Retin. Eye Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"E009","DOI":"10.1017\/S0952523815000061","article-title":"Circadian clock control of connexin36 phosphorylation in retinal photoreceptors of the CBA\/CaJ mouse strain","volume":"32","author":"Zhang","year":"2015","journal-title":"Vis. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.15252\/emmm.201505298","article-title":"Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration","volume":"7","author":"Zhao","year":"2015","journal-title":"EMBO Mol. Med."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.566712\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T05:42:44Z","timestamp":1617514964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fncel.2020.566712\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":54,"alternative-id":["10.3389\/fncel.2020.566712"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2020.566712","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"566712"}}