{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:25:12Z","timestamp":1793237112212,"version":"4.5.0"},"reference-count":236,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in Parkinson\u2019s disease (PD), a major neurodegenerative disease, has been indicated using animal models. Although PD is associated with both genetic and environmental factors, sporadic forms of PD account for more than 90% of total PD. Following the importance of environmental factors, various neurotoxins are used as chemical inducers of PD both <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. In contrast to other neurodegenerative diseases such as Alzheimer\u2019s and Huntington\u2019s diseases (AD and HD), many of the characteristics of PD can be reproduced <jats:italic>in vivo<\/jats:italic> by the use of specific neurotoxins. Given the indication of ferroptosis in PD pathology, several studies have been conducted to examine whether ferroptosis plays role in the loss of dopaminergic neurons in PD. However, there are still few reports showing an authentic form of ferroptosis in neuronal cells during exposure to the neurotoxins used as PD inducers. In this review article, we summarize the history of the uses of chemicals to create PD models <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Besides, we also survey recent reports examining the possible involvement of ferroptosis in chemical models of PD.<\/jats:p>","DOI":"10.3389\/fncel.2020.581191","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T07:20:40Z","timestamp":1608708040000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["Chemically Induced Models of Parkinson\u2019s Disease: History and Perspectives for the Involvement of Ferroptosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Shuheng","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Aki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Unuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1289\/ehp.85-1568326","article-title":"An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin","volume":"85","author":"Adam","year":"1990","journal-title":"Environ. 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