{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:09Z","timestamp":1787068269003,"version":"build-2736575974"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143210, MOP-84437, FDN-154278"],"award-info":[{"award-number":["FDN-143210, MOP-84437, FDN-154278"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"DOI":"10.3389\/fncel.2020.590569","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:51:56Z","timestamp":1604537516000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Mandi E.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Caron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirah E.","family":"Aly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny L.","family":"Lemari\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Dal Cengio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Lazic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ana.410310412","article-title":"Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington\u2019s disease","volume":"31","author":"Albin","year":"1992","journal-title":"Ann. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1084\/jem.20161673","article-title":"Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations","volume":"214","author":"Bading","year":"2017","journal-title":"J. Exp. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.nbd.2015.12.009","article-title":"Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington\u2019s disease","volume":"87","author":"Buren","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/sj.emboj.7600510","article-title":"Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK","volume":"24","author":"Chen","year":"2005","journal-title":"EMBO J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"10248","DOI":"10.1523\/JNEUROSCI.0546-04.2004","article-title":"Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand","volume":"24","author":"Chung","year":"2004","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1093\/emboj\/16.5.998","article-title":"DAP-kinase is a Ca2+\/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity","volume":"16","author":"Cohen","year":"1997","journal-title":"EMBO J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/aps.2011.68","article-title":"CaMKII in cerebral ischemia","volume":"32","author":"Coultrap","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"B8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.nbd.2013.11.013","article-title":"Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice","volume":"62","author":"Dau","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1101\/gad.9.1.15","article-title":"Identification of a novel serine\/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death","volume":"9","author":"Deiss","year":"1995","journal-title":"Genes Dev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nprot.2007.52","article-title":"Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging","volume":"2","author":"Dieterich","year":"2007","journal-title":"Nat. Protoc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"10928","DOI":"10.1523\/JNEUROSCI.2491-09.2009","article-title":"Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington\u2019s disease","volume":"29","author":"Fan","year":"2009","journal-title":"J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3768","DOI":"10.1523\/JNEUROSCI.4356-06.2007","article-title":"Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington\u2019s disease","volume":"27","author":"Fan","year":"2007","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nn.3637","article-title":"Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation","volume":"17","author":"Fan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1523\/JNEUROSCI.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington\u2019s disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry","volume":"11","author":"Ferrante","year":"1991","journal-title":"J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.neurobiolaging.2014.09.006","article-title":"A\u03b2 and NMDAR activation cause mitochondrial dysfunction involving ER calcium release","volume":"36","author":"Ferreira","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/jnc.12700","article-title":"Alterations in striatal-enriched protein tyrosine phosphatase (STEP) expression, activation and downstream signaling in early and late stages of the YAC128 Huntington\u2019s disease mouse model","volume":"130","author":"Gladding","year":"2014","journal-title":"J. Neurochem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.1093\/hmg\/dds154","article-title":"Calpain and striatal-enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington\u2019s disease mouse model","volume":"21","author":"Gladding","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.celrep.2017.05.068","article-title":"DAPK1 mediates LTD by making CaMKII\/GluN2B binding LTP specific","volume":"19","author":"Goodell","year":"2017","journal-title":"Cell Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1523\/JNEUROSCI.5473-08.2009","article-title":"Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease","volume":"29","author":"Graham","year":"2009","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington\u2019s disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-e","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s disease collaborative research group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/s1474-4422(02)00164-3","article-title":"Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?","volume":"1","author":"Ikonomidou","year":"2002","journal-title":"Lancet Neurol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1113\/jphysiol.2006.105510","article-title":"Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal-regulated kinases (ERK) activity in cultured rat hippocampal neurons","volume":"572","author":"Ivanov","year":"2006","journal-title":"J. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"39033","DOI":"10.1074\/jbc.M605097200","article-title":"Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation","volume":"281","author":"Jin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1523\/JNEUROSCI.5687-08.2009","article-title":"Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease","volume":"29","author":"Joshi","year":"2009","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1237","DOI":"10.1038\/cddis.2014.216","article-title":"Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function","volume":"5","author":"Kim","year":"2014","journal-title":"Cell Death Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.3390\/ijms20133131","article-title":"Death-associated protein kinase 1 phosphorylation in neuronal cell death and neurodegenerative disease","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","article-title":"Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington\u2019s disease transgenic mice","volume":"86","author":"Klapstein","year":"2001","journal-title":"J. Neurophysiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"9112","DOI":"10.1523\/JNEUROSCI.21-23-09112.2001","article-title":"Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington\u2019s disease","volume":"21","author":"Laforet","year":"2001","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/s0028-3908(03)00308-3","article-title":"Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression","volume":"45","author":"Lavezzari","year":"2003","journal-title":"Neuropharmacology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.brainresbull.2012.01.012","article-title":"Striatal atrophy and dendritic alterations in a knock-in mouse model of Huntington\u2019s disease","volume":"87","author":"Lerner","year":"2012","journal-title":"Brain Res. Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/mp.2017.85","article-title":"Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects","volume":"23","author":"Li","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.expneurol.2017.10.005","article-title":"Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain","volume":"299","author":"Lu","year":"2018","journal-title":"Exp. Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"28596","DOI":"10.1074\/jbc.R115.652750","article-title":"Dynamic regulation of N-methyl-D-aspartate (NMDA) and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications","volume":"290","author":"Lussier","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/nm.3246","article-title":"Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington\u2019s disease models","volume":"19","author":"Marco","year":"2013","journal-title":"Nat. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0306-4522(89)90128-0","article-title":"The organization of the projection from the cerebral cortex to the striatum in the rat","volume":"29","author":"McGeorge","year":"1989","journal-title":"Neuroscience"},{"key":"B40","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuron.2010.01.008","article-title":"Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington\u2019s disease mice","volume":"65","author":"Milnerwood","year":"2010","journal-title":"Neuron"},{"key":"B41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.nbd.2012.05.013","article-title":"Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington\u2019s disease mice","volume":"48","author":"Milnerwood","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"B42","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1074\/jbc.M008085200","article-title":"Characterization of fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor","volume":"276","author":"Nakazawa","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"31670","DOI":"10.1074\/jbc.271.49.31670","article-title":"Identification of a phosphorylation site for calcium\/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor","volume":"271","author":"Omkumar","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/jnnp.2009.171926","article-title":"Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease","volume":"81","author":"Orth","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","article-title":"Extrasynaptic NMDA receptor involvement in central nervous system disorders","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"B47","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1093\/cercor\/bhv096","article-title":"A novel mechanism of spine damages in stroke via DAPK1 and tau","volume":"25","author":"Pei","year":"2015","journal-title":"Cereb. Cortex"},{"key":"B48","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.neuron.2005.08.016","article-title":"The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2","volume":"47","author":"Prybylowski","year":"2005","journal-title":"Neuron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/j.1471-4159.2009.06108.x","article-title":"Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium\/calmodulin-dependent protein kinase II","volume":"110","author":"Raveendran","year":"2009","journal-title":"J. Neurochem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.bbrc.2016.07.058","article-title":"Striatal synaptic dysfunction and altered calcium regulation in Huntington disease","volume":"483","author":"Raymond","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B51","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington\u2019s disease: time-dependent alterations in synaptic and receptor function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"B52","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","article-title":"Differential loss of striatal projection neurons in Huntington disease","volume":"85","author":"Reiner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/ana.410380605","article-title":"Preferential loss of preproenkephalin vs. preprotachykinin neurons from the striatum of Huntington\u2019s disease patients","volume":"38","author":"Richfield","year":"1995","journal-title":"Ann. Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.nbd.2015.10.016","article-title":"Synaptic scaling up in medium spiny neurons of aged BACHD mice: a slow-progression model of Huntington\u2019s disease","volume":"86","author":"Rocher","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: a clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet J. Rare Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases: structure, function and regulation","volume":"66","author":"Roskoski","year":"2012","journal-title":"Pharmacol. Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington\u2019s disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"R\u00fcb","year":"2016","journal-title":"Brain Pathol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ceca.2009.08.005","article-title":"Endoplasmic reticulum Ca2+ release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity","volume":"46","author":"Ruiz","year":"2009","journal-title":"Cell Calcium"},{"key":"B59","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.celrep.2013.02.011","article-title":"Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors","volume":"3","author":"Sanz-Clemente","year":"2013","journal-title":"Cell Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"B61","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.biopsych.2008.12.026","article-title":"Abnormal motor cortex excitability in preclinical and very early Huntington\u2019s disease","volume":"65","author":"Schippling","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12915-018-0526-3","article-title":"Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease","volume":"16","author":"Schmidt","year":"2018","journal-title":"BMC Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/B978-0-12-420170-5.00003-9","article-title":"CaMKII: a molecular substrate for synaptic plasticity and memory","volume":"122","author":"Shonesy","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"10843","DOI":"10.1523\/JNEUROSCI.2258-16.2016","article-title":"Selective degeneration of entorhinal-CA1 synapses in Alzheimer\u2019s disease via activation of DAPK1","volume":"36","author":"Shu","year":"2016","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1111\/j.0953-816X.2004.03374.x","article-title":"Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6\/1 Huntington\u2019s disease transgenic mice","volume":"19","author":"Spires","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"23798","DOI":"10.1074\/jbc.M001471200","article-title":"Mechanism and regulation of calcium\/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor","volume":"275","author":"Strack","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.biopsych.2018.12.008","article-title":"MicroRNA-26a\/death-associated protein kinase 1 signaling induces synucleinopathy and dopaminergic neuron degeneration in Parkinson\u2019s disease","volume":"85","author":"Su","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"B68","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1101\/gad.8.21.2527","article-title":"Differential activation of CREB by Ca2+\/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity","volume":"8","author":"Sun","year":"1994","journal-title":"Genes Dev."},{"key":"B69","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e95777","DOI":"10.1371\/journal.pone.0095777","article-title":"Protection of pyruvate against glutamate excitotoxicity is mediated by regulating DAPK1 protein complex","volume":"9","author":"Tian","year":"2014","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.cell.2009.12.055","article-title":"DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke","volume":"140","author":"Tu","year":"2010","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pneurobio.2017.03.008","article-title":"Synaptopathic mechanisms of neurodegeneration and dementia: insights from Huntington\u2019s disease","volume":"153","author":"Tyebji","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.1038\/nprot.2014.150","article-title":"Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans","volume":"9","author":"Ullrich","year":"2014","journal-title":"Nat. Protoc."},{"key":"B75","first-page":"599","article-title":"Neuropathology of Huntington\u2019s disease","volume-title":"Handbook of Clinical Neurology Dementias","author":"Vonsattel","year":"2008"},{"key":"B76","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington\u2019s disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/7854_2014_354","article-title":"The neuropathology of Huntington\u2019s disease","volume":"22","author":"Waldvogel","year":"2015","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B78","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nprot.2016.160","article-title":"Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling","volume":"12","author":"Wang","year":"2017","journal-title":"Nat. Protoc."},{"key":"B79","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1523\/JNEUROSCI.1038-15.2016","article-title":"Enhanced store-operated calcium entry leads to striatal synaptic loss in a Huntington\u2019s disease mouse model","volume":"36","author":"Wu","year":"2016","journal-title":"J. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jns.2018.01.003","article-title":"DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells","volume":"387","author":"Xiong","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/(sici)1097-4547(19991201)58:5<674::aid-jnr8>3.0.co;2-3","article-title":"Developmental changes in distribution of death-associated protein kinase mRNAs","volume":"58","author":"Yamamoto","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e0162784","DOI":"10.1371\/journal.pone.0162784","article-title":"CaMKII-mediated CREB phosphorylation is involved in Ca2+-induced BDNF mRNA transcription and neurite outgrowth promoted by electrical stimulation","volume":"11","author":"Yan","year":"2016","journal-title":"PLoS One"},{"key":"B83","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/cdd.2016.114","article-title":"Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death","volume":"24","author":"You","year":"2017","journal-title":"Cell Death Differ."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2020.590569\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:52:01Z","timestamp":1604537521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2020.590569\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,5]]},"references-count":83,"alternative-id":["10.3389\/fncel.2020.590569"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2020.590569","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,5]]},"article-number":"590569"}}