{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:00:33Z","timestamp":1778702433503,"version":"3.51.4"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Early progression in neurodegenerative disease involves challenges to homeostatic processes, including those controlling axonal excitability and dendritic organization. In glaucoma, the leading cause of irreversible blindness, stress from intraocular pressure (IOP) causes degeneration of retinal ganglion cells (RGC) and their axons which comprise the optic nerve. Previously, we discovered that early progression induces axogenic, voltage-gated enhanced excitability of RGCs, even as dendritic complexity in the retina reduces. Here, we investigate a possible contribution of the transient receptor potential vanilloid type 1 (TRPV1) channel to enhanced excitability, given its role in modulating excitation in other neural systems. We find that genetic deletion of <jats:italic>Trpv1<\/jats:italic> (<jats:italic>Trpv1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) influences excitability differently for RGCs firing continuously to light onset (\u03b1ON-Sustained) vs. light offset (\u03b1OFF-Sustained). Deletion drives excitability in opposing directions so that <jats:italic>Trpv1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> RGC responses with elevated IOP equalize to that of wild-type (WT) RGCs without elevated IOP. Depolarizing current injections in the absence of light-driven presynaptic excitation to directly modulate voltage-gated channels mirrored these changes, while inhibiting voltage-gated sodium channels and isolating retinal excitatory postsynaptic currents abolished both the differences in light-driven activity between WT and <jats:italic>Trpv1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> RGCs and changes in response due to IOP elevation. Together, these results support a voltage-dependent, axogenic influence of <jats:italic>Trpv1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> with elevated IOP. Finally, <jats:italic>Trpv1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> slowed the loss of dendritic complexity with elevated IOP, opposite its effect on axon degeneration, supporting the idea that axonal and dendritic degeneration follows distinctive programs even at the level of membrane excitability.<\/jats:p>","DOI":"10.3389\/fncel.2020.603419","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T12:48:54Z","timestamp":1610455734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress"],"prefix":"10.3389","volume":"14","author":[{"given":"Michael L.","family":"Risner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolan R.","family":"McGrady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Boal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Calkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature16468","article-title":"The functional diversity of retinal ganglion cells in the mouse","volume":"529","author":"Baden","year":"2016","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5644","DOI":"10.1523\/JNEUROSCI.5956-09.2010","article-title":"Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration","volume":"30","author":"Baltan","year":"2010","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"11758","DOI":"10.1038\/ncomms11758","article-title":"Human glia can both induce and rescue aspects of disease phenotype in Huntington disease","volume":"7","author":"Benraiss","year":"2016","journal-title":"Nat. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.cub.2013.12.020","article-title":"Visual space is represented by nonmatching topographies of distinct mouse retinal ganglion cell types","volume":"24","author":"Bleckert","year":"2014","journal-title":"Curr. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1523\/JNEUROSCI.23-06-02306.2003","article-title":"Functional specialization of the axon initial segment by isoform-specific sodium channel targeting","volume":"23","author":"Boiko","year":"2003","journal-title":"J. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"12116","DOI":"10.1038\/s41598-020-68937-9","article-title":"Transient receptor potential vanilloid type 1 is expressed in the horizontal pathway of the vervet monkey retina","volume":"10","author":"Bouskila","year":"2020","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5616","DOI":"10.1073\/pnas.090034797","article-title":"Sodium channel Nav1.6 is localized at nodes of ranvier, dendrites, and synapses","volume":"97","author":"Caldwell","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B8","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","article-title":"Critical pathogenic events underlying progression of neurodegeneration in glaucoma","volume":"31","author":"Calkins","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e22331","DOI":"10.7554\/eLife.22331","article-title":"Activity-dependent regulation of T-type calcium channels by submembrane calcium ions","volume":"6","author":"Cazade","year":"2017","journal-title":"eLife"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/anae.13666","article-title":"Life is lognormal! What to do when your data does not follow a normal distribution","volume":"71","author":"Choi","year":"2016","journal-title":"Anaesthesia"},{"key":"B12","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/375061a0","article-title":"Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis","volume":"375","author":"Collard","year":"1995","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.neuroscience.2006.02.079","article-title":"Morphological properties of mouse retinal ganglion cells","volume":"140","author":"Coombs","year":"2006","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"18810","DOI":"10.1073\/pnas.2009425117","article-title":"Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress","volume":"117","author":"Cooper","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1167\/iovs.14-16126","article-title":"Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve","volume":"56","author":"Coughlin","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"5196","DOI":"10.1073\/pnas.0913141107","article-title":"Distal axonopathy with structural persistence in glaucomatous neurodegeneration","volume":"107","author":"Crish","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"17444","DOI":"10.1523\/JNEUROSCI.5461-12.2013","article-title":"Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma","volume":"33","author":"Della Santina","year":"2013","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1523\/JNEUROSCI.1419-14.2015","article-title":"Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types","volume":"35","author":"El-Danaf","year":"2015","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nrn3783","article-title":"Retinal bipolar cells: elementary building blocks of vision","volume":"15","author":"Euler","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.brainresbull.2018.05.023","article-title":"Driven to decay: excitability and synaptic abnormalities in amyotrophic lateral sclerosis","volume":"140","author":"Fogarty","year":"2018","journal-title":"Brain Res. Bull."},{"key":"B23","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.neuron.2007.12.027","article-title":"TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons","volume":"57","author":"Gibson","year":"2008","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1471-4159.2005.03551.x","article-title":"Rapid disassembly of dynamic microtubules upon activation of the capsaicin receptor TRPV1","volume":"96","author":"Goswami","year":"2006","journal-title":"J. Neurochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4144-08.2008","article-title":"Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin","volume":"28","author":"Her","year":"2008","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nn.2359","article-title":"Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation","volume":"12","author":"Hu","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnins.2017.00146","article-title":"Metabolic vulnerability in the neurodegenerative disease glaucoma","volume":"11","author":"Inman","year":"2017","journal-title":"Front. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6499","DOI":"10.1113\/JP274562","article-title":"Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways","volume":"595","author":"Jo","year":"2017","journal-title":"J. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"10981","DOI":"10.1523\/JNEUROSCI.0703-05.2005","article-title":"The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3","volume":"25","author":"Jones","year":"2005","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1523\/JNEUROSCI.4240-08.2009","article-title":"Coagonist release modulates NMDA receptor subtype contributions at synaptic inputs to retinal ganglion cells","volume":"29","author":"Kalbaugh","year":"2009","journal-title":"J. Neurosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1126\/science.152.3729.1637","article-title":"Input resistance, electrical excitability, and size of ventral horn cells in cat spinal cord","volume":"152","author":"Kernell","year":"1966","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.neuropharm.2013.09.004","article-title":"Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the A\u03b2-overproducing PDAPP mouse","volume":"79","author":"Kerrigan","year":"2014","journal-title":"Neuropharmacology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.bbadis.2013.01.017","article-title":"Specific functioning of Cav3.2 T-type calcium and TRPV1 channels under different types of STZ-diabetic neuropathy","volume":"1832","author":"Khomula","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e0180091","DOI":"10.1371\/journal.pone.0180091","article-title":"Four alpha ganglion cell types in mouse retina: function, structure, and molecular signatures","volume":"12","author":"Krieger","year":"2017","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fncel.2018.00353","article-title":"Polymodal TRPV1 and TRPV4 sensors colocalize but do not functionally interact in a subpopulation of mouse retinal ganglion cells","volume":"12","author":"Lakk","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1177\/1073858404266777","article-title":"Huntingtin and its role in neuronal degeneration","volume":"10","author":"Li","year":"2004","journal-title":"Neuroscientist"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1152\/jn.00589.2012","article-title":"Cross inhibition from ON to OFF pathway improves the efficiency of contrast encoding in the mammalian retina","volume":"108","author":"Liang","year":"2012","journal-title":"J. Neurophysiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"5994","DOI":"10.1523\/JNEUROSCI.0130-07.2007","article-title":"Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells","volume":"27","author":"Margolis","year":"2007","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"7127","DOI":"10.1523\/JNEUROSCI.5694-09.2010","article-title":"Dendritic calcium signaling in ON and OFF mouse retinal ganglion cells","volume":"30","author":"Margolis","year":"2010","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fphys.2020.00249","article-title":"TRPV1 tunes optic nerve axon excitability in glaucoma","volume":"11","author":"McGrady","year":"2020","journal-title":"Front. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1017\/S0952523807070101","article-title":"Normal and rebound impulse firing in retinal ganglion cells","volume":"24","author":"Mitra","year":"2007","journal-title":"Vis. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1523\/JNEUROSCI.3463-09.2009","article-title":"Axonal transport defects in neurodegenerative diseases","volume":"29","author":"Morfini","year":"2009","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"9240","DOI":"10.1523\/JNEUROSCI.0940-16.2016","article-title":"Selective vulnerability of specific retinal ganglion cell types and synapses after transient ocular hypertension","volume":"36","author":"Ou","year":"2016","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"6063","DOI":"10.1523\/JNEUROSCI.23-14-06063.2003","article-title":"Light-evoked excitatory and inhibitory synaptic inputs to ON and OFF alpha ganglion cells in the mouse retina","volume":"23","author":"Pang","year":"2003","journal-title":"J. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"H543","DOI":"10.1152\/ajpheart.00094.2018","article-title":"Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time","volume":"316","author":"Ren","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"107873","DOI":"10.1016\/j.exer.2019.107873","article-title":"Elevated ocular pressure reduces voltage-gated sodium channel NaV1.2 protein expression in retinal ganglion cell axons","volume":"190","author":"Risner","year":"2020","journal-title":"Exp. Eye Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"E2393","DOI":"10.1073\/pnas.1714888115","article-title":"Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma","volume":"115","author":"Risner","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B49","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1113\/jphysiol.2004.071746","article-title":"Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice","volume":"560","author":"Rong","year":"2004","journal-title":"J. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1113\/jphysiol.2005.083089","article-title":"Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones","volume":"564","author":"Rush","year":"2005","journal-title":"J. Physiol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"B52","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1167\/iovs.08-2321","article-title":"TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure","volume":"50","author":"Sappington","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1080\/19336950.2015.1009272","article-title":"Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress","volume":"9","author":"Sappington","year":"2015","journal-title":"Channels"},{"key":"B54","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.neuron.2014.03.022","article-title":"A role for melanopsin in alpha retinal ganglion cells and contrast detection","volume":"82","author":"Schmidt","year":"2014","journal-title":"Neuron"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1161\/01.RES.0000148633.93110.24","article-title":"Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction","volume":"95","author":"Scotland","year":"2004","journal-title":"Circ. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.brainres.2019.03.029","article-title":"Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1","volume":"1715","author":"Stanford","year":"2019","journal-title":"Brain Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1126\/science.1105681","article-title":"Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease","volume":"307","author":"Stokin","year":"2005","journal-title":"Science"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1152\/jn.00264.2012","article-title":"AMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors","volume":"108","author":"Sullivan","year":"2012","journal-title":"J. Neurophysiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"10864","DOI":"10.1523\/JNEUROSCI.1340-08.2008","article-title":"Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis","volume":"28","author":"van Zundert","year":"2008","journal-title":"J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1124\/mol.109.055624","article-title":"Pharmacology of vanilloid transient receptor potential cation channels","volume":"75","author":"Vriens","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3161","DOI":"10.1523\/JNEUROSCI.4089-13.2014","article-title":"Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection","volume":"34","author":"Ward","year":"2014","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nrn1497","article-title":"Parallel processing in the mammalian retina","volume":"5","author":"W\u00e4ssle","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"15369","DOI":"10.1523\/JNEUROSCI.3424-14.2014","article-title":"Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation","volume":"34","author":"Weitlauf","year":"2014","journal-title":"J. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"eabb6642","DOI":"10.1126\/sciadv.abb6642","article-title":"Tailoring of the axon initial segment shapes the conversion of synaptic inputs into spiking output in OFF-\u03b1 T retinal ganglion cells","volume":"6","author":"Werginz","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2020.603419\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:43:34Z","timestamp":1610585014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2020.603419\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"references-count":65,"alternative-id":["10.3389\/fncel.2020.603419"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2020.603419","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,11]]},"article-number":"603419"}}