{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:43:25Z","timestamp":1793357005809,"version":"4.5.0"},"reference-count":272,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["POS_NAC_2016_1_129959"],"award-info":[{"award-number":["POS_NAC_2016_1_129959"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["POS_NAC_2016_1_129865"],"award-info":[{"award-number":["POS_NAC_2016_1_129865"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["POS_NAC_2013_1_11165"],"award-info":[{"award-number":["POS_NAC_2013_1_11165"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["POS_NAC_2012_1_8584"],"award-info":[{"award-number":["POS_NAC_2012_1_8584"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["INI_X_2011_1_3852"],"award-info":[{"award-number":["INI_X_2011_1_3852"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Functional genomics studies through transcriptomics, translatomics and proteomics have become increasingly important tools to understand the molecular basis of biological systems in the last decade. In most cases, when these approaches are applied to the nervous system, they are centered in cell bodies or somatodendritic compartments, as these are easier to isolate and, at least <jats:italic>in vitro<\/jats:italic>, contain most of the mRNA and proteins present in all neuronal compartments. However, key functional processes and many neuronal disorders are initiated by changes occurring far away from cell bodies, particularly in axons (axopathologies) and synapses (synaptopathies). Both neuronal compartments contain specific RNAs and proteins, which are known to vary depending on their anatomical distribution, developmental stage and function, and thus form the complex network of molecular pathways required for neuron connectivity. Modifications in these components due to metabolic, environmental, and\/or genetic issues could trigger or exacerbate a neuronal disease. For this reason, detailed profiling and functional understanding of the precise changes in these compartments may thus yield new insights into the still intractable molecular basis of most neuronal disorders. In the case of synaptic dysfunctions or synaptopathies, they contribute to dozens of diseases in the human brain including neurodevelopmental (i.e., autism, Down syndrome, and epilepsy) as well as neurodegenerative disorders (i.e., Alzheimer\u2019s and Parkinson\u2019s diseases). Histological, biochemical, cellular, and general molecular biology techniques have been key in understanding these pathologies. Now, the growing number of omics approaches can add significant extra information at a high and wide resolution level and, used effectively, can lead to novel and insightful interpretations of the biological processes at play. This review describes current approaches that use transcriptomics, translatomics and proteomic related methods to analyze the axon and presynaptic elements, focusing on the relationship that axon and synapses have with neurodegenerative diseases.<\/jats:p>","DOI":"10.3389\/fncel.2021.686722","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T07:05:35Z","timestamp":1624604735000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases"],"prefix":"10.3389","volume":"15","author":[{"given":"Andres","family":"Di Paolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Garat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Eastman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquina","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Dajas-Bailador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Smircich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Roberto","family":"Sotelo-Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104870","article-title":"Glial cells involvement in spinal muscular atrophy: could SMA be a neuroinflammatory disease?","volume":"140","author":"Abati","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1365-2990.2012.01308.x","article-title":"Review: axon pathology in age-related neurodegenerative disorders.","volume":"39","author":"Adalbert","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.ebiom.2019.06.013","article-title":"Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.","volume":"45","author":"Akiyama","year":"2019","journal-title":"EBioMedicine"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax2656","article-title":"Expansion sequencing: spatially precise in situ transcriptomics in intact biological systems.","volume":"371","author":"Alon","year":"2021","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/s0022-5193(85)80028-x","article-title":"Slow axoplasmic transport: a fiction?","volume":"112","author":"Alvarez","year":"1985","journal-title":"J. Theor. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/nn.2486","article-title":"An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.","volume":"13","author":"Andreassi","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18956-x","article-title":"Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer.","volume":"11","author":"Ap\u00f3stolo","year":"2020","journal-title":"Nat. Commun."},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56908-8","article-title":"Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory.","volume":"9","author":"Arey","year":"2019","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuron.2020.12.010","article-title":"Single-cell sequencing of brain cell transcriptomes and epigenomes.","volume":"109","author":"Armand","year":"2021","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103413","article-title":"Emerging roles for 3\u2032 UTRs in neurons.","volume":"21","author":"Bae","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-4020-5943-8_6","article-title":"Synaptosome proteomics.","volume":"43","author":"Bai","year":"2007","journal-title":"Subcell. Biochem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.cell.2014.07.001","article-title":"Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.","volume":"158","author":"Baleriola","year":"2014","journal-title":"Cell"},{"key":"B13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1523\/jneurosci.18-01-00251.1998","article-title":"Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.","volume":"18","author":"Bassell","year":"1998","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.celrep.2016.12.093","article-title":"miR-182 regulates Slit2-mediated axon guidance by modulating the local translation of a specific mRNA.","volume":"18","author":"Bellon","year":"2017","journal-title":"Cell Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/embj.201386120","article-title":"Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.","volume":"33","author":"Biesemann","year":"2014","journal-title":"EMBO J."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay4991","article-title":"Monosomes actively translate synaptic mRNAs in neuronal processes.","volume":"367","author":"Biever","year":"2020","journal-title":"Science"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00676-w","article-title":"Messenger RNAs localized to distal projections of human stem cell derived neurons.","volume":"7","author":"Bigler","year":"2017","journal-title":"Sci. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00401-019-02063-3","article-title":"Early defects in translation elongation factor 1\u03b1 levels at excitatory synapses in \u03b1-synucleinopathy.","volume":"138","author":"Blumenstock","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1073\/pnas.53.2.418","article-title":"A suggestive relationship of nerve cell rna with specific synaptic sites.","volume":"53","author":"Bodian","year":"1965","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1042\/bj1760365","article-title":"A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain.","volume":"176","author":"Booth","year":"1978","journal-title":"Biochem. J"},{"key":"B21","doi-asserted-by":"crossref","DOI":"10.1002\/wdev.392","article-title":"Proximity-dependent labeling methods for proteomic profiling in living cells: an update.","volume":"10","author":"Bosch","year":"2021","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1084\/jem.115.3.453","article-title":"The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.","volume":"115","author":"Boyden","year":"1962","journal-title":"J. Exp. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.neuron.2013.02.027","article-title":"Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.","volume":"78","author":"Boyken","year":"2013","journal-title":"Neuron"},{"key":"B24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/cm.970050203","article-title":"Video microscopy of fast axonal transport in extruded axoplasm: a new model for study of molecular mechanisms.","volume":"5","author":"Brady","year":"1985","journal-title":"Cell Motil."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: causes and treatment.","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1027","article-title":"Whole transcriptome profiling reveals the RNA content of motor axons.","volume":"44","author":"Briese","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/neu.480230303","article-title":"Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles.","volume":"23","author":"Buchheit","year":"1992","journal-title":"J. Neurobiol."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174895","article-title":"A novel synaptic junction preparation for the identification and characterization of cleft proteins.","volume":"12","author":"Burch","year":"2017","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"crossref","first-page":"29.e4","DOI":"10.1016\/j.neuron.2018.06.004","article-title":"Rapid cue-specific remodeling of the nascent axonal proteome.","volume":"99","author":"Cagnetta","year":"2018","journal-title":"Neuron"},{"key":"B30","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.neuron.2012.02.036","article-title":"The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging.","volume":"74","author":"Cajigas","year":"2012","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/s0896-6273(01)00551-7","article-title":"Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.","volume":"32","author":"Campbell","year":"2001","journal-title":"Neuron"},{"key":"B32","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.74.10.4516","article-title":"Local control of neurite development by nerve growth factor.","volume":"74","author":"Campenot","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/neu.10322","article-title":"Retrograde transport of neurotrophins: fact and function.","volume":"58","author":"Campenot","year":"2004","journal-title":"J. Neurobiol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233651","article-title":"Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve.","volume":"15","author":"Canclini","year":"2020","journal-title":"PLoS One"},{"key":"B35","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3233\/bpl-140001","article-title":"Synaptic failure: focus in an integrative view of ALS.","volume":"1","author":"Casas","year":"2016","journal-title":"Brain Plast."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s12035-019-01835-y","article-title":"Deregulated local protein synthesis in the brain synaptosomes of a mouse model for Alzheimer\u2019s disease.","volume":"57","author":"Cefaliello","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B37","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jalz.2012.04.009","article-title":"The synaptic proteome in Alzheimer\u2019s disease.","volume":"9","author":"Chang","year":"2013","journal-title":"Alzheimers Dement."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1007\/s00018-018-2849-1","article-title":"The role of survival motor neuron protein (SMN) in protein homeostasis.","volume":"75","author":"Chaytow","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s11055-017-0440-0","article-title":"Local protein synthesis in dendritic terminals and its regulation in normal conditions and during plastic changes.","volume":"47","author":"Chesnokova","year":"2017","journal-title":"Neurosci. Behav. Physiol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0815-882d","article-title":"Erratum: a mass-tolerant database search identifies a large proportion of unassigned spectra in shotgun proteomics as modified peptides.","volume":"33","author":"Chick","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1021\/acs.jproteome.8b00069","article-title":"Unbiased proteomic study of the axons of cultured rat cortical neurons.","volume":"17","author":"Chuang","year":"2018","journal-title":"J. Proteome Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228726","article-title":"In the right place at the right time: miRNAs as key regulators in developing axons.","volume":"21","author":"Corradi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B43","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102513","article-title":"Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits.","volume":"39","author":"Corradi","year":"2020","journal-title":"EMBO J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"11024","DOI":"10.1523\/jneurosci.2429-08.2008","article-title":"Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system.","volume":"28","author":"Court","year":"2008","journal-title":"J. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1111\/j.1471-4159.1993.tb03632.x","article-title":"Neurofilament proteins are synthesized in nerve endings from squid brain.","volume":"61","author":"Crispino","year":"1993","journal-title":"J. Neurochem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/dneu.22109","article-title":"Local gene expression in nerve endings.","volume":"74","author":"Crispino","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"7694","DOI":"10.1523\/jneurosci.17-20-07694.1997","article-title":"Active polysomes are present in the large presynaptic endings of the synaptosomal fraction from squid brain.","volume":"17","author":"Crispino","year":"1997","journal-title":"J. Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s12031-010-9467-1","article-title":"The \u201cdying-back\u201d phenomenon of motor neurons in ALS.","volume":"43","author":"Dadon-Nachum","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nn.3082","article-title":"microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons.","volume":"15","author":"Dajas-Bailador","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41583-020-00407-7","article-title":"The functional organization of axonal mRNA transport and translation.","volume":"22","author":"Dalla Costa","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00117","article-title":"Response: commentary: analysis of SUMO1-conjugation at synapses.","volume":"12","author":"Daniel","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B52","first-page":"1255","article-title":"Laser capture microdissection: big data from small samples.","volume":"30","author":"Datta","year":"2015","journal-title":"Histol. Histopathol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1083\/jcb.96.5.1355","article-title":"Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. II. Its specific association with synaptic vesicles demonstrated by immunocytochemistry in agarose-embedded synaptosomes.","volume":"96","author":"De Camilli","year":"1983","journal-title":"J. Cell Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1083\/jcb.1.1.47","article-title":"Some features of the submicroscopic morphology of synapses in frog and earthworm.","volume":"1","author":"de Robertis","year":"1955","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1083\/jcb.9.1.229","article-title":"On the isolation of nerve endings and synaptic vesicles.","volume":"9","author":"de Robertis","year":"1961","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/194794a0","article-title":"Isolation of synaptic vesicles from nerve endings of the rat brain.","volume":"194","author":"de Robertis","year":"1962","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1471-4159.1963.tb05038.x","article-title":"Isolation of synaptic vesicles and structural organization of the acetycholine system within brain nerve endings.","volume":"10","author":"de Robertis","year":"1963","journal-title":"J. Neurochem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.neuron.2009.12.019","article-title":"LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation.","volume":"64","author":"de Wit","year":"2009","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS.","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1021\/acs.jproteome.0c00980","article-title":"Rat sciatic nerve axoplasm proteome is enriched with ribosomal proteins during regeneration processes.","volume":"20","author":"Di Paolo","year":"2021","journal-title":"J. Proteome Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1074\/mcp.r115.051482","article-title":"Proteomics of the synapse\u2013a quantitative approach to neuronal plasticity.","volume":"15","author":"Dieterich","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017578118","article-title":"Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression.","volume":"118","author":"Donlin-Asp","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/j.1600-0854.2010.01118.x","article-title":"Subcellular communication through RNA transport and localized protein synthesis.","volume":"12","author":"Donnelly","year":"2010","journal-title":"Traffic"},{"key":"B64","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-1-4939-8739-9_3","article-title":"Synaptosome preparations: which procedure should i use?","author":"Dunkley","year":"2018","journal-title":"Neuromethods"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1038\/nprot.2008.171","article-title":"A rapid Percoll gradient procedure for preparation of synaptosomes.","volume":"3","author":"Dunkley","year":"2008","journal-title":"Nat. Protoc."},{"key":"B66","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.arr.2014.03.004","article-title":"Non-coding RNA regulation of synaptic plasticity and memory: implications for aging.","volume":"17","author":"Earls","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"B67","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.bbadis.2014.07.024","article-title":"Molecular mechanisms and animal models of spinal muscular atrophy.","volume":"1852","author":"Edens","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B68","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1471-4159.1969.tb10344.x","article-title":"Protein synthesis in the isolated Mauthner nerve fibre of goldfish.","volume":"16","author":"Edstr\u00f6m","year":"1969","journal-title":"J. Neurochem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41586-019-1049-y","article-title":"Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH.","volume":"568","author":"Eng","year":"2019","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1080\/21678421.2016.1245757","article-title":"Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis.","volume":"18","author":"Engelen-Lee","year":"2017","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.1007\/s12035-021-02296-y","article-title":"The coding and small non-coding hippocampal synaptic RNAome.","volume":"58","author":"Epple","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1021\/acs.jproteome.9b00159","article-title":"Pathologic alterations in the proteome of synaptosomes from a mouse model of spinal muscular atrophy.","volume":"18","author":"Eshraghi","year":"2019","journal-title":"J. Proteome Res."},{"key":"B73","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1460-9568.2007.05304.x","article-title":"Local synthesis of axonal and presynaptic RNA in squid model systems.","volume":"25","author":"Eyman","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainres.2012.01.044","article-title":"Spinal muscular atrophy: the role of SMN in axonal mRNA regulation.","volume":"1462","author":"Fallini","year":"2012","journal-title":"Brain Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/dvdy.24665","article-title":"Compartmentalized devices as tools for investigation of human brain network dynamics.","volume":"248","author":"Fantuzzo","year":"2019","journal-title":"Dev. Dyn."},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1186\/s13064-018-0104-y","article-title":"Astrocytes, neurons, synapses: a tripartite view on cortical circuit development.","volume":"13","author":"Farhy-Tselnicker","year":"2018","journal-title":"Neural Dev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1261\/rna.073700.119","article-title":"Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons.","volume":"26","author":"Farias","year":"2020","journal-title":"RNA"},{"key":"B78","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201900054","article-title":"Toward axonal system biology: genome wide views of local mRNA translation.","volume":"19","author":"Farias","year":"2019","journal-title":"Proteomics"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2019.00030","article-title":"Molecular systems biology of neurodevelopmental disorders, rett syndrome as an archetype.","volume":"13","author":"Faundez","year":"2019","journal-title":"Front. Integr. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123702","article-title":"Imaging and molecular mechanisms of Alzheimer\u2019s disease: a review.","volume":"19","author":"Femminella","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41593-020-00785-2","article-title":"RNA transport and local translation in neurodevelopmental and neurodegenerative disease.","volume":"24","author":"Fernandopulle","year":"2021","journal-title":"Nat. Neurosci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man.","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/nn.4561","article-title":"Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.","volume":"20","author":"Fletcher","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/1673-5374.244782","article-title":"Amyotrophic lateral sclerosis as a synaptopathy.","volume":"14","author":"Fogarty","year":"2019","journal-title":"Neural Regen. Res."},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00578","article-title":"Biological significance of microRNA biomarkers in ALS-innocent bystanders or disease culprits?","volume":"10","author":"Foggin","year":"2019","journal-title":"Front. Neurol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1074\/mcp.m115.049965","article-title":"Proteomic analysis of dynein-interacting proteins in amyotrophic lateral sclerosis synaptosomes reveals alterations in the RNA-binding protein staufen1.","volume":"15","author":"Gershoni-Emek","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"B87","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/newbio237195a0","article-title":"Helical structure of Myxicola axoplasm.","volume":"237","author":"Gilbert","year":"1972","journal-title":"Nat. New Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1152\/physrev.00051.2006","article-title":"Local gene expression in axons and nerve endings: the glia-neuron unit.","volume":"88","author":"Giuditta","year":"2008","journal-title":"Physiol. Rev."},{"key":"B89","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1073\/pnas.59.4.1284","article-title":"Protein synthesis in the isolated giant axon of the squid.","volume":"59","author":"Giuditta","year":"1968","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax5783","article-title":"Stitching the synapse: cross-linking mass spectrometry into resolving synaptic protein interactions.","volume":"6","author":"Gonzalez-Lozano","year":"2020","journal-title":"Sci. Adv."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1523\/jneurosci.4074-09.2010","article-title":"Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein.","volume":"30","author":"Gr\u00f8nborg","year":"2010","journal-title":"J. Neurosci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s00726-020-02912-6","article-title":"Proteomic comparison of different synaptosome preparation procedures.","volume":"52","author":"Guly\u00e1ssy","year":"2020","journal-title":"Amino Acids"},{"key":"B93","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.expneurol.2009.06.004","article-title":"The role of local protein synthesis and degradation in axon regeneration.","volume":"223","author":"Gumy","year":"2010","journal-title":"Exp. Neurol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1261\/rna.2386111","article-title":"Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.","volume":"17","author":"Gumy","year":"2011","journal-title":"RNA"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00391-7","article-title":"Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s disease.","volume":"15","author":"Guo","year":"2020","journal-title":"Mol. Neurodegen."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau3644","article-title":"Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments.","volume":"364","author":"Hafner","year":"2019","journal-title":"Science"},{"key":"B97","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13658-5","article-title":"Mapping axon initial segment structure and function by multiplexed proximity biotinylation.","volume":"11","author":"Hamdan","year":"2020","journal-title":"Nat. Commun."},{"key":"B98","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.conb.2017.10.015","article-title":"Proximity labeling: spatially resolved proteomic mapping for neurobiology.","volume":"50","author":"Han","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/s0896-6273(03)00770-0","article-title":"Axoplasmic importins enable retrograde injury signaling in lesioned nerve.","volume":"40","author":"Hanz","year":"2003","journal-title":"Neuron"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00374","article-title":"The nanoworld of the tripartite synapse: insights from super-resolution microscopy.","volume":"11","author":"Heller","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B101","doi-asserted-by":"crossref","first-page":"E3827","DOI":"10.1073\/pnas.1720956115","article-title":"Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover.","volume":"115","author":"Heo","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B102","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-019-0847-7","article-title":"Comparative profiling of the synaptic proteome from Alzheimer\u2019s disease patients with focus on the APOE genotype.","volume":"7","author":"Hesse","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes7030030","article-title":"Network analysis of a membrane-enriched brain proteome across stages of Alzheimer\u2019s disease.","volume":"7","author":"Higginbotham","year":"2019","journal-title":"Proteomes"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1523\/jneurosci.05-08-02240.1985","article-title":"Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3\u2032:5\u2032-monophosphate-generating systems, receptors, and enzymes.","volume":"5","author":"Hollingsworth","year":"1985","journal-title":"J. Neurosci."},{"key":"B105","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41594-019-0263-5","article-title":"Local translation in neurons: visualization and function.","volume":"26","author":"Holt","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1083\/jcb.96.5.1374","article-title":"Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.","volume":"96","author":"Huttner","year":"1983","journal-title":"J. Cell Biol."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00735","article-title":"Targeting the synapse in Alzheimer\u2019s disease.","volume":"13","author":"Jackson","year":"2019","journal-title":"Front. Neurosci."},{"key":"B108","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910722","article-title":"Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS\/FTD is rescued by SV2 replenishment.","volume":"12","author":"Jensen","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s40120-017-0070-z","article-title":"The study of postmortem human synaptosomes for understanding Alzheimer\u2019s disease and other neurological disorders: a review.","volume":"6","author":"Jhou","year":"2017","journal-title":"Neurol. Ther."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.038109","article-title":"Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function.","volume":"12","author":"Jiang","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"B111","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa053","article-title":"Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis.","volume":"2","author":"Joilin","year":"2020","journal-title":"Brain Commun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/0005-2736(74)90268-5","article-title":"Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation.","volume":"356","author":"Jones","year":"1974","journal-title":"Biochim. Biophys. Acta"},{"key":"B113","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.mex.2014.08.002","article-title":"Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain.","volume":"1","author":"Kamat","year":"2014","journal-title":"MethodsX"},{"key":"B114","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.expneurol.2012.06.003","article-title":"Axonal degeneration in Alzheimer\u2019s disease: when signaling abnormalities meet the axonal transport system.","volume":"246","author":"Kanaan","year":"2013","journal-title":"Exp. Neurol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/1044-7431(92)90017-v","article-title":"beta-Actin and beta-Tubulin are components of a heterogeneous mRNA population present in the squid giant axon.","volume":"3","author":"Kaplan","year":"1992","journal-title":"Mol. Cell. Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1177\/1073858417712668","article-title":"Expanding axonal transcriptome brings new functions for axonally synthesized proteins in health and disease.","volume":"24","author":"Kar","year":"2018","journal-title":"Neuroscientist"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.stemcr.2017.09.021","article-title":"Generation of a motor nerve organoid with human stem cell-derived neurons.","volume":"9","author":"Kawada","year":"2017","journal-title":"Stem Cell Rep."},{"key":"B118","doi-asserted-by":"publisher","first-page":"33627","DOI":"10.18632\/oncotarget.9092","article-title":"An integrated proteomics approach shows synaptic plasticity changes in an APP\/PS1 Alzheimer\u2019s mouse model.","volume":"7","author":"Kempf","year":"2016","journal-title":"Oncotarget"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092972","article-title":"Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo.","volume":"9","author":"Kennard","year":"2014","journal-title":"PLoS One"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00031","article-title":"Tau: the center of a signaling nexus in Alzheimer\u2019s disease.","volume":"10","author":"Khan","year":"2016","journal-title":"Front. Neurosci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1242\/jeb.00298","article-title":"Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.","volume":"206","author":"Kholodenko","year":"2003","journal-title":"J. Exp. Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5483\/bmbrep.2015.48.3.010","article-title":"Local protein synthesis in neuronal axons: why and how we study.","volume":"48","author":"Kim","year":"2015","journal-title":"BMB Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-3-7091-0932-8_13","article-title":"Dendritic mRNA targeting and translation.","volume":"970","author":"Kindler","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1471-4159.1965.tb04236.x","article-title":"Synthetic mechanisms in the axon iirna in myelin-free axons of the cat.","volume":"12","author":"Koenig","year":"1965","journal-title":"J. Neurochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1471-4159.1967.tb09542.x","article-title":"Synthetic mechanisms in the axon iv. In vitro incorporation of [3H]precursors into axonal protein and rna.","volume":"14","author":"Koenig","year":"1967","journal-title":"J. Neurochem."},{"key":"B126","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/0006-8993(86)91488-5","article-title":"Isolation of native Mauthner cell axoplasm and an analysis of organelle movement in non-aqueous and aqueous media.","volume":"398","author":"Koenig","year":"1986","journal-title":"Brain Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/1044-7431(91)90025-j","article-title":"Evaluation of local synthesis of axonal proteins in the goldfish Mauthner cell axon and axons of dorsal and ventral roots of the rat in vitro.","volume":"2","author":"Koenig","year":"1991","journal-title":"Mol. Cell. Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1126\/science.132.3435.1249","article-title":"Acetylcholinesterase regeneration in peripheral nerve after irreversible inactivation.","volume":"132","author":"Koenig","year":"1960","journal-title":"Science"},{"key":"B129","doi-asserted-by":"publisher","first-page":"8390","DOI":"10.1523\/jneurosci.20-22-08390.2000","article-title":"Cryptic peripheral ribosomal domains distributed intermittently along mammalian myelinated axons.","volume":"20","author":"Koenig","year":"2000","journal-title":"J. Neurosci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1523\/jneurosci.4434-08.2009","article-title":"Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice.","volume":"29","author":"Kong","year":"2009","journal-title":"J. Neurosci."},{"key":"B131","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1039\/c8mo00172c","article-title":"Omics approaches for subcellular translation studies.","volume":"14","author":"Koppel","year":"2018","journal-title":"Mol. Omics"},{"key":"B132","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.copbio.2019.03.001","article-title":"Beyond bulk: a review of single cell transcriptomics methodologies and applications.","volume":"58","author":"Kulkarni","year":"2019","journal-title":"Curr. Opin. Biotechnol"},{"key":"B133","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948882","article-title":"Mitochondrial protein biogenesis in the synapse is supported by local translation.","volume":"21","author":"Kuzniewska","year":"2020","journal-title":"EMBO Rep."},{"key":"B134","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","first-page":"486","DOI":"10.2174\/138920207783769530","article-title":"Advances on the understanding of the origins of synaptic pathology in AD.","volume":"8","author":"Lacor","year":"2007","journal-title":"Curr. Genomics"},{"key":"B136","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/newbio244162a0","article-title":"Analysis of axoplasmic RNA from invertebrate giant axons.","volume":"244","author":"Lasek","year":"1973","journal-title":"Nat. New Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1083\/jcb.74.2.501","article-title":"Cell-to-cell transfer of glial proteins to the squid giant axon: the glia- neuron protein transfer hypothesis.","volume":"74","author":"Lasek","year":"1977","journal-title":"J. Cell Biol."},{"key":"B138","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/jnc.12358","article-title":"Amyloid precursor proteins are constituents of the presynaptic active zone.","volume":"127","author":"La\u00dfek","year":"2013","journal-title":"J. Neurochem."},{"key":"B139","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00441-014-1943-4","article-title":"The synaptic proteome.","volume":"359","author":"La\u00dfek","year":"2015","journal-title":"Cell Tissue Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.pharmthera.2006.06.003","article-title":"Synaptic plasticity and phosphorylation.","volume":"112","author":"Lee","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1126\/science.1250212","article-title":"Highly multiplexed subcellular RNA sequencing in situ.","volume":"343","author":"Lee","year":"2014","journal-title":"Science"},{"key":"B142","doi-asserted-by":"publisher","first-page":"676.e8","DOI":"10.1016\/j.neuron.2020.08.011","article-title":"APP family regulates neuronal excitability and synaptic plasticity but not neuronal survival.","volume":"108","author":"Lee","year":"2020","journal-title":"Neuron"},{"key":"B143","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1126\/science.aan6827","article-title":"The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing.","volume":"358","author":"Lein","year":"2017","journal-title":"Science"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/nn1775","article-title":"Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1.","volume":"9","author":"Leung","year":"2006","journal-title":"Nat. Neurosci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"3120","DOI":"10.15252\/embj.201797724","article-title":"Somatodendritic accumulation of Tau in Alzheimer\u2019s disease is promoted by Fyn-mediated local protein translation.","volume":"36","author":"Li","year":"2017","journal-title":"EMBO J."},{"key":"B146","article-title":"Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA).","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf6716","article-title":"Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.","volume":"9","author":"Li","year":"2016","journal-title":"Sci. Signal"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2020.1822638","article-title":"Axonal mRNA translation in neurological disorders.","author":"Lin","year":"2020","journal-title":"RNA Biol."},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00193","article-title":"Emerging roles of astrocytes in neuro-vascular unit and the tripartite synapse with emphasis on reactive gliosis in the context of Alzheimer\u2019s disease.","volume":"12","author":"Liu","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B150","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nmeth.3603","article-title":"Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.","volume":"12","author":"Liu","year":"2015","journal-title":"Nat. Methods"},{"key":"B151","doi-asserted-by":"crossref","first-page":"1295.e21","DOI":"10.1016\/j.cell.2016.07.041","article-title":"Proteomic analysis of unbounded cellular compartments: synaptic clefts.","volume":"166","author":"Loh","year":"2016","journal-title":"Cell"},{"key":"B152","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies.","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00205","article-title":"Transfer of vesicles from schwann cells to axons: a novel mechanism of communication in the peripheral nervous system.","volume":"3","author":"Lopez-Verrilli","year":"2012","journal-title":"Front. Physiol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/nmeth.2892","article-title":"Single-cell in situ RNA profiling by sequential hybridization.","volume":"11","author":"Lubeck","year":"2014","journal-title":"Nat. Methods"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1242\/dev.180232","article-title":"Spatiotemporal regulation of GSK3\u03b2 levels by miRNA-26a controls axon development in cortical neurons.","volume":"147","author":"Lucci","year":"2020","journal-title":"Development"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20188746","article-title":"Current best practices in single-cell RNA-seq analysis: a tutorial.","volume":"15","author":"Luecken","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-1-4939-6688-2_10","article-title":"Purification of synaptosome populations using fluorescence-activated synaptosome sorting.","volume":"1538","author":"Luquet","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.neuron.2014.10.019","article-title":"Axonal transport: cargo-specific mechanisms of motility and regulation.","volume":"84","author":"Maday","year":"2014","journal-title":"Neuron"},{"key":"B159","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/j.1471-4159.1974.tb10763.x","article-title":"Studies of axon permeability utilizing axoplasm extrusion techniques with single isolated axons from the circumesophageal connectives of Homarus americanus.","volume":"23","author":"Marquis","year":"1974","journal-title":"J. Neurochem."},{"key":"B160","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1002\/path.4080","article-title":"Synaptic defects in type I spinal muscular atrophy in human development.","volume":"229","author":"Mart\u00ednez-Hern\u00e1ndez","year":"2013","journal-title":"J. Pathol."},{"key":"B161","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-20684-8","article-title":"Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation.","volume":"8","author":"Mathur","year":"2018","journal-title":"Sci. Rep."},{"key":"B162","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1074\/mcp.m900369-mcp200","article-title":"Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve.","volume":"9","author":"Michaelevski","year":"","journal-title":"Mol. Cell. Proteomics"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000952","article-title":"Signaling to transcription networks in the neuronal retrograde injury response.","volume":"3","author":"Michaelevski","year":"","journal-title":"Sci. Signal."},{"key":"B164","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-1-4939-6688-2_9","article-title":"Isolation of synaptosomes, synaptic plasma membranes, and synaptic junctional complexes.","volume":"1538","author":"Michaelis","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.583811","article-title":"High-resolution transcriptomic and proteomic profiling of heterogeneity of brain-derived microglia in multiple sclerosis.","volume":"13","author":"Miedema","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/dneu.22140","article-title":"Subcellular transcriptomics-dissection of the mRNA composition in the axonal compartment of sensory neurons.","volume":"74","author":"Minis","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5324","article-title":"Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region.","volume":"362","author":"Moffitt","year":"2018","journal-title":"Science"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00252","article-title":"ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease.","volume":"8","author":"Moloney","year":"2014","journal-title":"Front. Neurosci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/j.1471-4159.2008.05824.x","article-title":"The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.","volume":"108","author":"Morciano","year":"2009","journal-title":"J. Neurochem."},{"key":"B170","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1111\/j.1471-4159.2005.03506.x","article-title":"Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.","volume":"95","author":"Morciano","year":"2005","journal-title":"J. Neurochem."},{"key":"B171","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1083\/jcb.98.6.2064","article-title":"Monomer-polymer equilibria in the axon: direct measurement of tubulin and actin as polymer and monomer in axoplasm.","volume":"98","author":"Morris","year":"1984","journal-title":"J. Cell Biol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.gpb.2018.07.007","article-title":"Deciphering brain complexity using single-cell sequencing.","volume":"17","author":"Mu","year":"2019","journal-title":"Genomics Proteomics Bioinform."},{"key":"B173","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1093\/hmg\/ddm367","article-title":"Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.","volume":"17","author":"Murray","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B174","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/s0015-3796(84)80093-1","article-title":"A rapid method for separation of thylakoid membranes by density gradient centrifugation in percoll.","volume":"179","author":"Nagy","year":"1984","journal-title":"Biochem. Physiol. Pflanzen"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1261\/rna.1833310","article-title":"Identification and quantitative analyses of microRNAs located in the distal axons of sympathetic neurons.","volume":"16","author":"Natera-Naranjo","year":"2010","journal-title":"RNA"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.stemcr.2018.11.005","article-title":"Axon-Seq decodes the motor axon transcriptome and its modulation in response to ALS.","volume":"11","author":"Nijssen","year":"2018","journal-title":"Stem Cell Rep."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav2642","article-title":"The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep.","volume":"366","author":"Noya","year":"2019","journal-title":"Science"},{"key":"B178","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.coph.2011.10.005","article-title":"Axonal protein synthesis: a potential target for pain relief?","volume":"12","author":"Obara","year":"2012","journal-title":"Curr. Opin. Pharmacol."},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51607","article-title":"Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.","volume":"8","author":"Ostroff","year":"2019","journal-title":"eLife"},{"key":"B180","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.neuron.2005.01.023","article-title":"Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve.","volume":"45","author":"Perlson","year":"2005","journal-title":"Neuron"},{"key":"B181","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1074\/mcp.m400004-mcp200","article-title":"Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury.","volume":"3","author":"Perlson","year":"2004","journal-title":"Mol. Cell. Proteomics"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137461","article-title":"Dynamic change and target prediction of axon-specific micrornas in regenerating sciatic nerve.","volume":"10","author":"Phay","year":"2015","journal-title":"PLoS One"},{"key":"B183","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/bfgp\/ell013","article-title":"Organization of brain complexity\u2013synapse proteome form and function.","volume":"5","author":"Pocklington","year":"2006","journal-title":"Brief. Funct. Genomics Proteomics"},{"key":"B184","doi-asserted-by":"publisher","first-page":"13390","DOI":"10.1523\/jneurosci.3432-06.2006","article-title":"Identification of process-localized mRNAs from cultured rodent hippocampal neurons.","volume":"26","author":"Poon","year":"2006","journal-title":"J. Neurosci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41586-018-0847-y","article-title":"Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex.","volume":"565","author":"Poulopoulos","year":"2019","journal-title":"Nature"},{"key":"B186","author":"Purves","year":"2018","journal-title":"Neuroscience."},{"key":"B187","doi-asserted-by":"publisher","first-page":"693","DOI":"10.15252\/embr.201744045","article-title":"Local translation in neuronal compartments: how local is local?","volume":"18","author":"Rangaraju","year":"2017","journal-title":"EMBO Rep."},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001933","article-title":"Cellular strategies of axonal pathfinding.","volume":"2","author":"Raper","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.pnpbp.2017.09.011","article-title":"Synaptic proteomics as a means to identify the molecular basis of mental illness: are we getting there?","volume":"84","author":"Reig-Viader","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B190","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/dneu.20755","article-title":"Axoplasm isolation from peripheral nerve.","volume":"2","author":"Rishal","year":"","journal-title":"Dev. Neurobiol."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.3791\/2087","article-title":"Axoplasm isolation from rat sciatic nerve.","volume":"2087","author":"Rishal","year":"","journal-title":"J. Vis. Exp."},{"key":"B192","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/364362c0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.","volume":"364","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1038\/srep44500","article-title":"ALS along the axons \u2013 expression of coding and noncoding RNA differs in axons of ALS models.","volume":"7","author":"Rotem","year":"2017","journal-title":"Sci. Rep."},{"key":"B194","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-004-0952-x","article-title":"Axonal transport defects: a common theme in neurodegenerative diseases.","volume":"109","author":"Roy","year":"2005","journal-title":"Acta Neuropathol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1261\/rna.047373.114","article-title":"Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation.","volume":"20","author":"Saal","year":"2014","journal-title":"RNA"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00451","article-title":"Axonal degeneration during aging and its functional role in neurodegenerative disorders.","volume":"11","author":"Salvadores","year":"2017","journal-title":"Front. Neurosci."},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050668","article-title":"Local translation in growth cones and presynapses, two axonal compartments for local neuronal functions.","volume":"10","author":"Sasaki","year":"2020","journal-title":"Biomolecules"},{"key":"B198","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/dneu.22113","article-title":"Identification of axon-enriched microRNAs localized to growth cones of cortical neurons.","volume":"74","author":"Sasaki","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B199","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-65377-3","article-title":"Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.","volume":"10","author":"Scaduto","year":"2020","journal-title":"Sci. Rep."},{"key":"B200","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.neuron.2016.10.001","article-title":"In situ transcription profiling of single cells reveals spatial organization of cells in the mouse hippocampus.","volume":"92","author":"Shah","year":"2016","journal-title":"Neuron"},{"key":"B201","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/jnr.490410305","article-title":"Glia-to-axon communication: enrichment of glial proteins transferred to the squid giant axon.","volume":"41","author":"Sheller","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005777","article-title":"Synapses and Alzheimer\u2019s disease.","volume":"4","author":"Sheng","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B203","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cell.2016.05.029","article-title":"Dynamic axonal translation in developing and mature visual circuits.","volume":"166","author":"Shigeoka","year":"2016","journal-title":"Cell"},{"key":"B204","doi-asserted-by":"crossref","first-page":"360510.e","DOI":"10.1016\/j.celrep.2019.11.025","article-title":"On-site ribosome remodeling by locally synthesized ribosomal proteins in axons.","volume":"29","author":"Shigeoka","year":"2019","journal-title":"Cell Rep."},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2019.108456","article-title":"Monitoring translation in synaptic fractions using a ribosome profiling strategy.","volume":"329","author":"Simbriger","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0504","article-title":"The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity.","volume":"369","author":"Smalheiser","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B207","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/dneu.22125","article-title":"Glia to axon RNA transfer.","volume":"74","author":"Sotelo","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061905","article-title":"Myosin-Va-dependent cell-to-cell transfer of RNA from Schwann Cells to axons.","volume":"8","author":"Sotelo","year":"2013","journal-title":"PLoS One"},{"key":"B209","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/dneu.22163","article-title":"Introduction to the special issue on local protein synthesis in axons.","volume":"74","author":"Sotelo-Silveira","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/j.1471-4159.2007.04999.x","article-title":"Myelinated axons contain \u03b2-actin mRNA and ZBP-1 in periaxoplasmic ribosomal plaques and depend on cyclic AMP and F-actin integrity for in vitro translation.","volume":"104","author":"Sotelo-Silveira","year":"2007","journal-title":"J. Neurochem."},{"key":"B211","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1126\/science.aaf2403","article-title":"Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.","volume":"353","author":"St\u00e5hl","year":"2016","journal-title":"Science"},{"key":"B212","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1523\/jneurosci.03-01-00177.1983","article-title":"Alterations in polyribosomes associated with dendritic spines during the reinnervation of the dentate gyrus of the adult rat.","volume":"3","author":"Steward","year":"1983","journal-title":"J. Neurosci."},{"key":"B213","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/0166-2236(92)90170-d","article-title":"Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neurons.","volume":"15","author":"Steward","year":"1992","journal-title":"Trends Neurosci."},{"key":"B214","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1523\/jneurosci.06-02-00412.1986","article-title":"Protein-synthetic machinery at postsynaptic sites during synaptogenesis: a quantitative study of the association between polyribosomes and developing synapses.","volume":"6","author":"Steward","year":"1986","journal-title":"J. Neurosci."},{"key":"B215","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1523\/jneurosci.02-03-00284.1982","article-title":"Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus.","volume":"2","author":"Steward","year":"1982","journal-title":"J. Neurosci."},{"key":"B216","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev.neuro.24.1.299","article-title":"Protein synthesis at synaptic sites on dendrites.","volume":"24","author":"Steward","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00194","article-title":"Omics approach to axonal dysfunction of motor neurons in amyotrophic lateral sclerosis (ALS).","volume":"14","author":"Suzuki","year":"2020","journal-title":"Front. Neurosci."},{"key":"B218","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuroscience.2012.12.003","article-title":"Dendritic protein synthesis in the normal and diseased brain.","volume":"232","author":"Swanger","year":"2013","journal-title":"Neuroscience"},{"key":"B219","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/jpd-150769","article-title":"Retrograde axonal degeneration in Parkinson disease.","volume":"6","author":"Tagliaferro","year":"2016","journal-title":"J. Parkinsons. Dis."},{"key":"B220","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cell.2006.10.030","article-title":"Molecular anatomy of a trafficking organelle.","volume":"127","author":"Takamori","year":"2006","journal-title":"Cell"},{"key":"B221","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.molcel.2016.01.020","article-title":"Distal alternative last exons localize mRNAs to neural projections.","volume":"61","author":"Taliaferro","year":"2016","journal-title":"Mol. Cell"},{"key":"B222","doi-asserted-by":"publisher","first-page":"33586","DOI":"10.1073\/pnas.2011870117","article-title":"Hidden proteome of synaptic vesicles in the mammalian brain.","volume":"117","author":"Taoufiq","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B223","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/nen.0000000000000074","article-title":"Mechanisms involved in spinal cord central synapse loss in a mouse model of spinal muscular atrophy.","volume":"73","author":"Tarabal","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B224","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.1523\/jneurosci.6130-08.2009","article-title":"Axonal mRNA in uninjured and regenerating cortical mammalian axons.","volume":"29","author":"Taylor","year":"2009","journal-title":"J. Neurosci."},{"key":"B225","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nmeth777","article-title":"A microfluidic culture platform for CNS axonal injury, regeneration and transport.","volume":"2","author":"Taylor","year":"2005","journal-title":"Nat. Methods"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1126\/science.aan1053","article-title":"Locally translated mTOR controls axonal local translation in nerve injury.","volume":"359","author":"Terenzio","year":"2018","journal-title":"Science"},{"key":"B227","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2017.10.015","article-title":"Compartmentalized signaling in neurons: from cell biology to neuroscience.","volume":"96","author":"Terenzio","year":"2017","journal-title":"Neuron"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00161","article-title":"The role of RNA binding proteins for local mRNA translation: implications in neurological disorders.","volume":"6","author":"Thelen","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"B229","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0014-4886(75)90206-x","article-title":"Axonal protein synthesizing activity during the early outgrowth period following neurotomy.","volume":"49","author":"Tobias","year":"1975","journal-title":"Exp. Neurol."},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026164","article-title":"SMN requirement for synaptic vesicle, active zone and microtubule postnatal organization in motor nerve terminals.","volume":"6","author":"Torres-Benito","year":"2011","journal-title":"PLoS One"},{"key":"B231","doi-asserted-by":"publisher","first-page":"4940","DOI":"10.1074\/jbc.m117.800763","article-title":"Single-cell nanobiopsy reveals compartmentalization of mRNAs within neuronal cells.","volume":"293","author":"T\u00f3th","year":"2018","journal-title":"J. Biol. Chem."},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200177","article-title":"Molecular mechanisms behind mRNA localization in axons.","volume":"10","author":"Turner-Bridger","year":"2020","journal-title":"Open Biol."},{"key":"B233","doi-asserted-by":"crossref","first-page":"495.e6","DOI":"10.1016\/j.neuron.2018.03.030","article-title":"Alternative 3\u2019 UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments.","volume":"98","author":"Tushev","year":"2018","journal-title":"Neuron"},{"key":"B234","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.4103\/1673-5374.191193","article-title":"Intra-axonal protein synthesis - a new target for neural repair?","volume":"11","author":"Twiss","year":"2016","journal-title":"Neural Regen. Res."},{"key":"B235","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1006\/nbdi.2000.0293","article-title":"Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration.","volume":"7","author":"Twiss","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"B236","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1126\/science.aag0821","article-title":"Identification of an elaborate complex mediating postsynaptic inhibition.","volume":"353","author":"Uezu","year":"2016","journal-title":"Science"},{"key":"B237","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"B238","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1523\/jneurosci.3073-04.2005","article-title":"Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration.","volume":"25","author":"Verma","year":"2005","journal-title":"J. Neurosci."},{"key":"B239","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jneumeth.2006.05.008","article-title":"Rapid isolation of synaptoneurosomes and postsynaptic densities from adult mouse hippocampus.","volume":"158","author":"Villasana","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201745435","article-title":"A\u03b2 triggers the generation of a retrograde signaling complex from sentinel mRNAs in axons.","volume":"19","author":"Walker","year":"2018","journal-title":"EMBO Rep."},{"key":"B241","article-title":"Multiplexed imaging of high-density libraries of RNAs with MERFISH and expansion microscopy.","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"B242","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease - insights from amyloid-\u03b2 metabolism beyond the brain.","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes6030030","article-title":"Uncovering discrete synaptic proteomes to understand neurological disorders.","volume":"6","author":"Wang","year":"2018","journal-title":"Proteomes"},{"key":"B244","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-01341-1","article-title":"From whole-mount to single-cell spatial assessment of gene expression in 3D.","volume":"3","author":"Waylen","year":"2020","journal-title":"Commun. Biol."},{"key":"B245","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/B978-008045046-9.02045-3","article-title":"Synaptosomes","author":"Weiler","year":"2009","journal-title":"Encyclopedia of Neuroscience"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00043","article-title":"APP\u2014a novel player within the presynaptic active zone proteome.","volume":"10","author":"Weingarten","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.3791\/3196","article-title":"Preparation of synaptoneurosomes from mouse cortex using a discontinuous percoll-sucrose density gradient.","volume":"55","author":"Westmark","year":"2011","journal-title":"J. Vis. Exp."},{"key":"B248","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/bf01181319","article-title":"Thirty years of synaptosome research.","volume":"22","author":"Whittaker","year":"1993","journal-title":"J. Neurocytol."},{"key":"B249","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1042\/bj0900293","article-title":"The separation of synaptic vesicles from nerve-ending particles (\u2018synaptosomes\u2019).","volume":"90","author":"Whittaker","year":"1964","journal-title":"Biochem. J."},{"key":"B250","doi-asserted-by":"publisher","first-page":"29621","DOI":"10.1074\/jbc.m701448200","article-title":"Diffusion and not active transport underlies and limits ERK1\/2 synapse-to-nucleus signaling in hippocampal neurons.","volume":"282","author":"Wiegert","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004936","article-title":"Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer\u2019s disease.","volume":"4","author":"Williams","year":"2009","journal-title":"PLoS One"},{"key":"B252","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/978-1-61779-005-8_21","article-title":"Profiling axonal mRNA transport.","volume":"714","author":"Willis","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"B253","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1083\/jcb.200703209","article-title":"Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs.","volume":"178","author":"Willis","year":"2007","journal-title":"J. Cell Biol."},{"key":"B254","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1523\/jneurosci.4235-04.2005","article-title":"Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons.","volume":"25","author":"Willis","year":"2005","journal-title":"J. Neurosci."},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.21769\/bioprotoc.2423","article-title":"Preparation of crude synaptosomal fractions from mouse brains and spinal cords.","volume":"7","author":"Wirths","year":"2017","journal-title":"Bio-Protocol"},{"key":"B256","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1523\/jneurosci.09-01-00094.1989","article-title":"Flow cytometric analysis of rat striatal nerve terminals.","volume":"9","author":"Wolf","year":"1989","journal-title":"J. Neurosci."},{"key":"B257","doi-asserted-by":"crossref","first-page":"852.e8","DOI":"10.1016\/j.neuron.2017.07.016","article-title":"RNA docking and local translation regulate site-specific axon remodeling in vivo.","volume":"95","author":"Wong","year":"2017","journal-title":"Neuron"},{"key":"B258","doi-asserted-by":"publisher","first-page":"19490","DOI":"10.1073\/pnas.1912459116","article-title":"Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression.","volume":"116","author":"Xia","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B259","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/jnc.12057","article-title":"Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways.","volume":"124","author":"Xu","year":"2013","journal-title":"J. Neurochem."},{"key":"B260","doi-asserted-by":"crossref","DOI":"10.1186\/s13041-021-00750-5","article-title":"Proteomic insights into synaptic signaling in the brain: the past, present and future.","volume":"14","author":"Xu","year":"2021","journal-title":"Mol. Brain"},{"key":"B261","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3233\/jad-130476","article-title":"Shotgun brain proteomics reveals early molecular signature in presymptomatic mouse model of Alzheimer\u2019s disease.","volume":"37","author":"Yang","year":"2013","journal-title":"J. Alzheimers. Dis."},{"key":"B262","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/b978-0-12-394308-8.00001-7","article-title":"Synaptic plasticity regulated by protein-protein interactions and posttranslational modifications.","volume":"297","author":"Yokoi","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"B263","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuron.2008.05.029","article-title":"Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.","volume":"59","author":"Yudin","year":"2008","journal-title":"Neuron"},{"key":"B264","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-00690-6","article-title":"RNA localization is a key determinant of neurite-enriched proteome.","volume":"8","author":"Zappulo","year":"2017","journal-title":"Nat. Commun."},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.169561","article-title":"A comprehensive review of amyotrophic lateral sclerosis.","volume":"6","author":"Zarei","year":"2015","journal-title":"Surg. Neurol. Int."},{"key":"B266","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41380-020-0721-9","article-title":"Biomarkers for Alzheimer\u2019s disease\u2014preparing for a new era of disease-modifying therapies.","volume":"26","author":"Zetterberg","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B267","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1471-4159.2011.07519.x","article-title":"Proteolytic processing of Alzheimer\u2019s \u03b2-amyloid precursor protein.","volume":"120","author":"Zhang","year":"2012","journal-title":"J. Neurochem."},{"key":"B268","doi-asserted-by":"publisher","first-page":"19348","DOI":"10.1073\/pnas.1319280110","article-title":"Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy.","volume":"110","author":"Zhang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B269","doi-asserted-by":"publisher","first-page":"9291","DOI":"10.1523\/jneurosci.21-23-09291.2001","article-title":"A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons.","volume":"21","author":"Zheng","year":"2001","journal-title":"J. Neurosci."},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-17","article-title":"Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons.","volume":"7","author":"Zhong","year":"2006","journal-title":"BMC Neurosci."},{"key":"B271","doi-asserted-by":"publisher","first-page":"15464","DOI":"10.1523\/jneurosci.1800-10.2010","article-title":"Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.","volume":"30","author":"Zivraj","year":"2010","journal-title":"J. Neurosci."},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009886","article-title":"Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities.","volume":"4","author":"Zoghbi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2021.686722\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T07:06:02Z","timestamp":1624604762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2021.686722\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":272,"alternative-id":["10.3389\/fncel.2021.686722"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2021.686722","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"article-number":"686722"}}