{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:13:03Z","timestamp":1793657583478,"version":"4.5.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["no. ZR2021ZD40"],"award-info":[{"award-number":["no. ZR2021ZD40"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["no. ZR2020MH179"],"award-info":[{"award-number":["no. ZR2020MH179"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["no. ZR2021MH385"],"award-info":[{"award-number":["no. ZR2021MH385"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["no. ts20130913"],"award-info":[{"award-number":["no. ts20130913"]}],"id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no. 82171150"],"award-info":[{"award-number":["no. 82171150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["no. 82271172"],"award-info":[{"award-number":["no. 82271172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>M\u00e9ni\u00e8re\u2019s disease (MD), a common disease in the inner ear, is characterized by an increase in endolymph in the cochlear duct and vestibular labyrinth. The pathophysiology of the condition appears to be the immune response. Studies have shown that basal levels of the IL-1\u03b2 increased in some MD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we used a murine model of endolymphatic hydrops (EH) to study the effect of anakinra on auditory and vestibular function. Mice were intraperitoneal injected with anakinra or saline before LPS by postauricular injection. Weight and disease severity were measured, histologic changes in auditory were assessed, and inflammation state was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that anakinra therapy reduced LPS-induced EH, alleviated LPS-induced hearing loss and vestibular dysfunction, and inhibited the expression of the inflammatory cytokines and macrophage infiltration in the cochlea of mice. We further demonstrated that anakinra ameliorated the disorganization and degeneration of myelin sheath, and reduced the neuron damage in cochlea of EH mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Consequently, anakinra contributes to a promising therapeutic approach to MD, by restricting EH, alleviating auditory and vestibular function, inhibiting inflammation of the inner ear and protecting the cochlear nerve. Further investigations are needed to assess the potential therapeutic benefits of anakinra in patients with MD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fncel.2022.1088099","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T08:56:36Z","timestamp":1671094596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops"],"prefix":"10.3389","volume":"16","author":[{"given":"Na","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaomin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daogong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","article-title":"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.","volume":"360","author":"Aksentijevich","year":"2009","journal-title":"N Engl J. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.otc.2010.05.001","article-title":"Current epidemiology of Meniere\u2019s syndrome.","volume":"43","author":"Alexander","year":"2010","journal-title":"Otolaryngol. Clin. North Am."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.7150\/thno.49121","article-title":"Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharide-induced inflammation.","volume":"11","author":"Bae","year":"2021","journal-title":"Theranostics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cca.2015.02.039","article-title":"Autoimmune peripheral neuropathies.","volume":"449","author":"Bourque","year":"2015","journal-title":"Clin. Chim. Acta."},{"key":"B5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.heares.2018.10.007","article-title":"Response of the inner ear to lipopolysaccharide introduced directly into scala media.","volume":"370","author":"Brown","year":"2018","journal-title":"Hear. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/ng.3089","article-title":"An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.","volume":"46","author":"Canna","year":"2014","journal-title":"Nat. Genet."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00148","article-title":"Anakinra Therapy for Non-cancer Inflammatory Diseases.","volume":"9","author":"Cavalli","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nn.4571","article-title":"PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.","volume":"20","author":"Chen","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"7203","DOI":"10.1523\/JNEUROSCI.2791-13.2014","article-title":"A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.","volume":"34","author":"Clopath","year":"2014","journal-title":"J. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.otc.2010.05.004","article-title":"Allergy and its relation to Meniere\u2019s disease.","volume":"43","author":"Derebery","year":"2010","journal-title":"Otolaryngol. Clin. North Am."},{"key":"B11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity.","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/jlb.59.4.489","article-title":"The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice.","volume":"59","author":"Fantuzzi","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.biopha.2018.09.161","article-title":"Luteolin inhibits IL-1beta-induced in fl ammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model.","volume":"109","author":"Fei","year":"2019","journal-title":"Biomed Pharmacother."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23911-4","article-title":"Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease.","volume":"8","author":"Frejo","year":"2018","journal-title":"Sci. Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1744-313X.2011.01004.x","article-title":"Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere\u2019s disease.","volume":"38","author":"Furuta","year":"2011","journal-title":"Int. J. Immunogenet."},{"key":"B16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nrrheum.2010.4","article-title":"IL-1 pathways in inflammation and human diseases.","volume":"6","author":"Gabay","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.rdc.2004.01.005","article-title":"Anakinra: Interleukin-1 receptor antagonist therapy for rheumatoid arthritis.","volume":"30","author":"Garces","year":"2001","journal-title":"Issues Emerg. Health Technol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026759","article-title":"High prevalence of systemic autoimmune diseases in patients with Meni\u00e8re\u2019s disease.","volume":"6","author":"Gazquez","year":"2011","journal-title":"PLoS One."},{"key":"B19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.autrev.2012.01.004","article-title":"Meniere\u2019s disease might be an autoimmune condition?","volume":"11","author":"Greco","year":"2012","journal-title":"Autoimmun. Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1177\/003591573803101112","article-title":"Observations on the pathology of Meniere\u2019s syndrome: (Section of Otology).","volume":"31","author":"Hallpike","year":"1938","journal-title":"Proc. R. Soc. Med."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.","volume":"28","author":"He","year":"2020","journal-title":"Redox Biol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau7426","article-title":"VSIG4 mediates transcriptional inhibition of and \u03b2 in macrophages.","volume":"5","author":"Huang","year":"2019","journal-title":"Sci. Adv."},{"key":"B23","doi-asserted-by":"publisher","first-page":"10480","DOI":"10.1073\/pnas.1201836109","article-title":"NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.","volume":"109","author":"Inoue","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1093\/rheumatology\/key402","article-title":"Anakinra for the treatment of acute gout flares: A randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial.","volume":"58","author":"Janssen","year":"2019","journal-title":"Rheumatology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1469-7580.2004.00250.x","article-title":"Prenatal growth and development of the modern human labyrinth.","volume":"204","author":"Jeffery","year":"2004","journal-title":"J. Anat."},{"key":"B26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-med-061512-150641","article-title":"IL-1 blockade in autoinflammatory syndromes.","volume":"65","author":"Jesus","year":"2014","journal-title":"Annu. Rev. Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03181","article-title":"The human endolymphatic sac and inner ear immunity: Macrophage interaction and molecular expression.","volume":"9","author":"Kampfe Nordstrom","year":"2018","journal-title":"Front. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3109\/00016489.2014.902989","article-title":"Long-term administration of vasopressin can cause Meniere\u2019s disease in mice.","volume":"134","author":"Katagiri","year":"2014","journal-title":"Acta Otolaryngol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.amjcard.2020.03.041","article-title":"Usefulness of interleukin-1 receptor antagonists in patients with recurrent pericarditis.","volume":"127","author":"Khayata","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03364-w","article-title":"Anakinra treatment in critically ill COVID-19 patients: A prospective cohort study.","volume":"24","author":"Kooistra","year":"2020","journal-title":"Crit. Care"},{"key":"B31","doi-asserted-by":"publisher","first-page":"734","DOI":"10.18502\/ijaai.v20i6.8024","article-title":"Association of pro-inflammatory cytokine gene polymorphism with Meniere\u2019s disease in an iranian sample.","volume":"20","author":"Kouhi","year":"2021","journal-title":"Iran. J. Allergy Asthma Immunol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001227","article-title":"Systematic literature review of efficacy\/effectiveness and safety of current therapies for the treatment of cryopyrin-associated periodic syndrome, hyperimmunoglobulin D syndrome and tumour necrosis factor receptor-associated periodic syndrome.","volume":"6","author":"Kuemmerle-Deschner","year":"2020","journal-title":"RMD Open"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1002\/acn3.51229","article-title":"Anakinra usage in febrile infection related epilepsy syndrome: An international cohort.","volume":"7","author":"Lai","year":"2020","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146347","article-title":"Microarray analysis of lipopolysaccharide-induced endotoxemia in the cochlea.","volume":"823","author":"Lee","year":"2022","journal-title":"Gene."},{"key":"B35","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1017\/S0022215113000017","article-title":"Postauricular hypodermic injection to treat inner ear disorders: Experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison.","volume":"127","author":"Li","year":"2013","journal-title":"J. Laryngol. Otol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182592","article-title":"A network-based method using a random walk with restart algorithm and screening tests to identify novel genes associated with Meniere\u2019s disease.","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One."},{"key":"B37","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/MAO.0b013e31819a8827","article-title":"Spiral ganglion cell loss is unrelated to segmental cochlear sensory system degeneration in humans.","volume":"30","author":"Linthicum","year":"2009","journal-title":"Otol. Neurotol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.781702","article-title":"Distribution of immune cells including macrophages in the human cochlea.","volume":"12","author":"Liu","year":"","journal-title":"Front. Neurol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00223","article-title":"Macrophages in the human cochlea: Saviors or predators-a study using super-resolution immunohistochemistry.","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.1080\/15548627.2021.1905466","article-title":"PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.","volume":"17","author":"Liu","year":"","journal-title":"Autophagy"},{"key":"B41","doi-asserted-by":"publisher","first-page":"E7766","DOI":"10.1073\/pnas.1702946114","article-title":"NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.","volume":"114","author":"Nakanishi","year":"","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.28","article-title":"Meniere\u2019s disease.","volume":"2","author":"Nakashima","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"key":"B43","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s10495-014-1073-1","article-title":"Toll\/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.","volume":"20","author":"Narayanan","year":"2015","journal-title":"Apoptosis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/JCMA.0000000000000036","article-title":"Elevated matrix metalloproteinase-3 level may affect hearing function in patients with rheumatoid arthritis.","volume":"82","author":"Nasution","year":"2019","journal-title":"J. Chin. Med. Assoc."},{"key":"B45","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.neuro.30.051606.094309","article-title":"Axon-glial signaling and the glial support of axon function.","volume":"31","author":"Nave","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08264-w","article-title":"Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.","volume":"10","author":"Nist-Lund","year":"2019","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1177\/000348948709600418","article-title":"Localization, frequency, and severity of endolymphatic hydrops and the pathology of the labyrinthine membrane in Meniere\u2019s disease.","volume":"96","author":"Okuno","year":"1987","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1158\/2159-8290.CD-21-1115","article-title":"A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8. TNFalpha, and IL-1beta.","volume":"12","author":"Olivera","year":"2022","journal-title":"Cancer Discov."},{"key":"B49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/MAO.0000000000000879","article-title":"Anti CD163+, Iba1+, and CD68+ Cells in the adult human inner ear: Normal distribution of an unappreciated class of macrophages\/microglia and implications for inflammatory otopathology in humans.","volume":"37","author":"O\u2019Malley","year":"2016","journal-title":"Otol. Neurotol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/cge.12150","article-title":"Familial clustering and genetic heterogeneity in Meniere\u2019s disease.","volume":"85","author":"Requena","year":"2014","journal-title":"Clin. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1002\/art.41699","article-title":"A Randomized, phase II study evaluating the efficacy and safety of anakinra in the treatment of gout flares.","volume":"73","author":"Saag","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/S0140-6736(08)61161-7","article-title":"Meniere\u2019s disease.","volume":"372","author":"Sajjadi","year":"2008","journal-title":"Lancet."},{"key":"B53","doi-asserted-by":"publisher","first-page":"53","DOI":"10.7874\/jao.2020.00115","article-title":"Experimental animal models for Meniere\u2019s disease: A mini-review.","volume":"24","author":"Seo","year":"2020","journal-title":"J. Audiol. Otol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/MAO.0b013e31819bda13","article-title":"Vestibular evoked myogenic potentials in normal mice and Phex mice with spontaneous endolymphatic hydrops.","volume":"30","author":"Sheykholeslami","year":"2009","journal-title":"Otol. Neurotol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s00441-010-1040-2","article-title":"Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells.","volume":"342","author":"Shi","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jaci.2007.05.011","article-title":"Successful treatment of cutaneous mastocytosis and M\u00e9ni\u00e8re disease with anti-IgE therapy.","volume":"120","author":"Siebenhaar","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.conb.2007.08.003","article-title":"Wrapping it up: The cell biology of myelination.","volume":"17","author":"Simons","year":"2007","journal-title":"Curr. Opin. Neurobiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1096\/fj.201801513R","article-title":"Critical role of IL-1alpha in IL-1beta-induced inflammatory responses: Cooperation with NF-kappaBp65 in transcriptional regulation.","volume":"33","author":"Singh","year":"2019","journal-title":"FASEB J."},{"key":"B59","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1385\/CRIAI:28:3:239","article-title":"Pro-inflammatory cytokines in rheumatoid arthritis: Pathogenetic and therapeutic aspects.","volume":"28","author":"Smolen","year":"2005","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1053\/j.gastro.2013.09.030","article-title":"Postoperative ileus involves interleukin-1 receptor signaling in enteric glia.","volume":"146","author":"Stoffels","year":"2014","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/00016480701497436","article-title":"A new animal model for Meniere\u2019s disease.","volume":"128","author":"Takumida","year":"2008","journal-title":"Acta Otolaryngol."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108297","article-title":"MYSM1 represses innate immunity and autoimmunity through suppressing the cGAS-STING pathway.","volume":"33","author":"Tian","year":"2020","journal-title":"Cell Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1097\/AUD.0000000000000264","article-title":"The cost of Meniere\u2019s disease: A novel multisource approach.","volume":"37","author":"Tyrrell","year":"2016","journal-title":"Ear Hear."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3105cm1","article-title":"Interleukin-1 (IL-1) pathway.","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003847","article-title":"Single-center experience using anakinra for steroid-refractory immune effector cell-associated neurotoxicity syndrome (ICANS).","volume":"10","author":"Wehrli","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034500","article-title":"Age-related changes of myelin basic protein in mouse and human auditory nerve.","volume":"7","author":"Xing","year":"2012","journal-title":"PLoS One."},{"key":"B67","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.neulet.2018.12.036","article-title":"Surgery-free video-oculography in mouse models: Enabling quantitative and short-interval longitudinal assessment of vestibular function.","volume":"696","author":"Yang","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B68","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuro.2018.12.004","article-title":"Bilirubin-induced neurotoxic and ototoxic effects in rat cochlear and vestibular organotypic cultures.","volume":"71","author":"Ye","year":"2019","journal-title":"Neurotoxicology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10162-013-0403-2","article-title":"Characterization and inflammatory response of perivascular-resident macrophage-like melanocytes in the vestibular system.","volume":"14","author":"Zhang","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8851525","article-title":"Cisplatin-induced stria vascularis damage is associated with inflammation and fibrosis.","volume":"2020","author":"Zhang","year":"2020","journal-title":"Neural Plasticity"},{"key":"B71","doi-asserted-by":"publisher","first-page":"827","DOI":"10.4049\/jimmunol.2100745","article-title":"Bidirectional transport of IgE by CD23 in the inner ear of patients with Meniere\u2019s disease.","volume":"208","author":"Zhang","year":"2022","journal-title":"J. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"10388","DOI":"10.1073\/pnas.1205210109","article-title":"Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier.","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.1088099\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T08:56:40Z","timestamp":1671094600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.1088099\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":72,"alternative-id":["10.3389\/fncel.2022.1088099"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2022.1088099","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]},"article-number":"1088099"}}