{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T20:06:03Z","timestamp":1789329963608,"version":"build-2803163510"},"reference-count":198,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004398","name":"Mitsubishi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Immune cells play numerous roles in the host defense against the invasion of microorganisms and pathogens, which induces the release of inflammatory mediators (e.g., cytokines and chemokines). In the CNS, microglia is the major resident immune cell. Recent efforts have revealed the diversity of the cell types and the heterogeneity of their functions. The refinement of the synapse structure was a hallmark feature of the microglia, while they are also involved in the myelination and capillary dynamics. Another promising feature is the modulation of the synaptic transmission as synaptic plasticity and the intrinsic excitability of neurons as non-synaptic plasticity. Those modulations of physiological properties of neurons are considered induced by both transient and chronic exposures to inflammatory mediators, which cause behavioral disorders seen in mental illness. It is plausible for astrocytes and pericytes other than microglia and macrophage to induce the immune-triggered plasticity of neurons. However, current understanding has yet achieved to unveil what inflammatory mediators from what immune cells or glia induce a form of plasticity modulating pre-, post-synaptic functions and intrinsic excitability of neurons. It is still unclear what ion channels and intracellular signaling of what types of neurons in which brain regions of the CNS are involved. In this review, we introduce the ubiquitous modulation of the synaptic efficacy and the intrinsic excitability across the brain by immune cells and related inflammatory cytokines with the mechanism for induction. Specifically, we compare neuro-modulation mechanisms by microglia of the intrinsic excitability of cerebellar Purkinje neurons with cerebral pyramidal neurons, stressing the inverted directionality of the plasticity. We also discuss the suppression and augmentation of the extent of plasticity by inflammatory mediators, as the meta-plasticity by immunity. Lastly, we sum up forms of immune-triggered plasticity in the different brain regions with disease relevance. Together, brain immunity influences our cognition, sense, memory, and behavior<jats:italic>via<\/jats:italic>immune-triggered plasticity.<\/jats:p>","DOI":"10.3389\/fncel.2022.925493","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T02:48:59Z","timestamp":1658544539000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Immune-Triggered Forms of Plasticity Across Brain Regions"],"prefix":"10.3389","volume":"16","author":[{"given":"Momoka","family":"Hikosaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Ohtsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nrn2356","article-title":"Metaplasticity: tuning synapses and networks for plasticity","volume":"9","author":"Abraham","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"B2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0166-2236(96)80018-X","article-title":"Metaplasticity: the plasticity of synaptic plasticity","volume":"19","author":"Abraham","year":"1996","journal-title":"Trends Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nn778","article-title":"PGE(2) selectively blocks inhibitory glycinergic neurotransmission onto rat superficial dorsal horn neurons","volume":"5","author":"Ahmadi","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10209","DOI":"10.1523\/JNEUROSCI.3028-06.2006","article-title":"Bidirectional trafficking of prostaglandin E2 receptors involved in long-term potentiation in visual cortex","volume":"26","author":"Akaneya","year":"2006","journal-title":"J. Neurosci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.celrep.2016.12.041","article-title":"Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain","volume":"18","author":"Askew","year":"2017","journal-title":"Cell Rep."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1038\/s41593-018-0192-3","article-title":"Epigenetic regulation of brain region-specific microglia clearance activity","volume":"21","author":"Ayata","year":"2018","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e72981","DOI":"10.7554\/eLife.72981","article-title":"VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors","volume":"11","author":"Baek","year":"2022","journal-title":"Elife"},{"key":"B8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/cne.20598","article-title":"Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1\/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides","volume":"489","author":"Banisadr","year":"","journal-title":"J. Comput. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/cne.20729","article-title":"Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1\/CCL2 on calcium mobilization in primary cultured neurons","volume":"492","author":"Banisadr","year":"","journal-title":"J. Comput. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s12035-018-1048-2","article-title":"Long-term cognitive outcomes after sepsis: a translational systematic review","volume":"56","author":"Barichello","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1126\/science.1067859","article-title":"Control of synaptic strength by glial TNFalpha","volume":"295","author":"Beattie","year":"2002","journal-title":"Science"},{"key":"B12","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0006-8993(93)90959-Q","article-title":"Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus","volume":"628","author":"Bellinger","year":"1993","journal-title":"Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"13630","DOI":"10.1523\/JNEUROSCI.3226-10.2010","article-title":"Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells","volume":"30","author":"Belmeguenai","year":"2010","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.neuroimage.2007.04.060","article-title":"Accelerated maturation of white matter in young children with autism: a high b value DWI study","volume":"37","author":"Ben Bashat","year":"2007","journal-title":"Neuroimage"},{"key":"B15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/385729a0","article-title":"A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells","volume":"385","author":"Black","year":"1997","journal-title":"Nature"},{"key":"B16","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrn1475","article-title":"Short-term synaptic plasticity: a comparison of two synapses","volume":"5","author":"Blitz","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neuropharm.2012.11.007","article-title":"Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression","volume":"67","author":"Bray","year":"2013","journal-title":"Neuropharmacology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1093\/molbev\/msy050","article-title":"Evolutionary origins of toll-like receptor signaling","volume":"35","author":"Brennan","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"B19","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"Campbell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.1083\/jcb.201607048","article-title":"Microglia control the glycinergic but not the GABAergic synapses via prostaglandin E2 in the spinal cord","volume":"216","author":"Cantaut-Belarif","year":"2017","journal-title":"J. Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"11252","DOI":"10.1038\/srep11252","article-title":"A key role for TGF-\u03b21 in hippocampal synaptic plasticity and memory","volume":"5","author":"Caraci","year":"2015","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1073\/pnas.72.9.3666","article-title":"An endotoxin-induced serum factor that causes necrosis of tumors","volume":"72","author":"Carswell","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1152\/jn.2002.87.6.2851","article-title":"Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity","volume":"87","author":"Chen","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41531-021-00182-x","article-title":"Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson's disease","volume":"7","author":"Chen","year":"2021","journal-title":"NPJ Parkinsons Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nn.4571","article-title":"PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1","volume":"20","author":"Chen","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuroscience.2020.06.008","article-title":"Losing the beat: contribution of purkinje cell firing dysfunction to disease, and its reversal","volume":"462","author":"Cook","year":"2021","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuron.2004.09.007","article-title":"Spike timing-dependent plasticity of neural circuits","volume":"44","author":"Dan","year":"2004","journal-title":"Neuron"},{"key":"B32","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.neuron.2017.06.020","article-title":"Local cues establish and maintain region-specific phenotypes of Basal Ganglia Microglia","volume":"95","author":"De Biase","year":"2017","journal-title":"Neuron"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-associated microglia: a universal immune sensor of neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"B34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1101\/lm.6.3.284","article-title":"BDNF regulates the intrinsic excitability of cortical neurons","volume":"6","author":"Desai","year":"1999","journal-title":"Learn. Mem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"110094","DOI":"10.1016\/j.celrep.2021.110094","article-title":"Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis","volume":"37","author":"Di Filippo","year":"2021","journal-title":"Cell Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41586-020-03151-1","article-title":"STING controls nociception via type I interferon signalling in sensory neurons","volume":"591","author":"Donnelly","year":"2021","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4622","DOI":"10.1523\/JNEUROSCI.2339-19.2020","article-title":"Similar microglial cell densities across brain structures and mammalian species: implications for brain tissue function","volume":"40","author":"Dos Santos","year":"2020","journal-title":"J. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.neuron.2018.08.030","article-title":"PDGFR\u03b2 cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2","volume":"100","author":"Duan","year":"2018","journal-title":"Neuron"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1111\/bpa.12909","article-title":"The use and limitations of single-cell mass cytometry for studying human microglia function","volume":"30","author":"Fern\u00e1ndez-Zapata","year":"2020","journal-title":"Brain Pathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.3389\/fimmu.2019.01412","article-title":"Structural basis of IL-1 family cytokine signaling","volume":"10","author":"Fields","year":"2019","journal-title":"Front. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1172\/JCI83844","article-title":"Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice","volume":"126","author":"Fritz","year":"2016","journal-title":"J. Clin. Invest"},{"key":"B43","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/nrendo.2010.194","article-title":"Stress responses: the contribution of prostaglandin E(2) and its receptors","volume":"7","author":"Furuyashiki","year":"2011","journal-title":"Nat. Rev. Endocrinol"},{"key":"B44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0304-3940(94)90807-9","article-title":"Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats","volume":"182","author":"Gadient","year":"","journal-title":"Neurosci. Lett."},{"key":"B45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0006-8993(94)91211-4","article-title":"Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development","volume":"637","author":"Gadient","year":"","journal-title":"Brain. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.2147\/NDT.S65695","article-title":"Acute lipopolysaccharide exposure facilitates epileptiform activity via enhanced excitatory synaptic transmission and neuronal excitability in vitro","volume":"10","author":"Gao","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"B47","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.pain.2007.01.011","article-title":"Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain","volume":"131","author":"Gao","year":"2007","journal-title":"Pain"},{"key":"B48","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.biopsych.2011.11.018","article-title":"The stress-induced cytokine interleukin-6 decreases the inhibition\/excitation ratio in the rat temporal cortex via trans-signaling","volume":"71","author":"Garcia-Oscos","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1111\/ejn.13191","article-title":"Microglia-derived purines modulate mossy fibre synaptic transmission and plasticity through P2X4 and A1 receptors","volume":"43","author":"George","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1038\/sj.npp.1300446","article-title":"Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development","volume":"29","author":"Gilmore","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"B52","first-page":"a020537","article-title":"Origin of microglia: current concepts and past controversies","volume-title":"Cold Spring Harb. Perspect. Biol","author":"Ginhoux","year":"2015"},{"key":"B53","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0165-5728(98)00192-1","article-title":"CXC chemokines interleukin-8 (IL-8) and growth-related gene product alpha (GROalpha) modulate Purkinje neuron activity in mouse cerebellum","volume":"92","author":"Giovannelli","year":"1998","journal-title":"J. Neuroimmunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1471-4159.2005.03431.x","article-title":"Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1\/CCL2 of GABA-induced currents in spinal cord neurones","volume":"95","author":"Gosselin","year":"2005","journal-title":"J. Neurochem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nn.4222","article-title":"Microglial brain region-dependent diversity and selective regional sensitivities to aging","volume":"19","author":"Grabert","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"Grace","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1038\/mp.2017.156","article-title":"Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia","volume":"23","author":"Greene","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B58","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s12311-012-0445-8","article-title":"Neuroimmune regulation of neurophysiology in the cerebellum","volume":"12","author":"Gruol","year":"2013","journal-title":"Cerebellum"},{"key":"B59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF02740665","article-title":"Physiological and pathological roles of interleukin-6 in the central nervous system","volume":"15","author":"Gruol","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1152\/jn.00652.2014","article-title":"The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-\u03b1-mediated increase in nociceptors excitability","volume":"113","author":"Gudes","year":"2015","journal-title":"J. Neurophysiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3389\/fnins.2019.00303","article-title":"Chronic microglial activation in the GFAP-IL6 mouse contributes to age-dependent cerebellar volume loss and impairment in motor function","volume":"13","author":"Gyengesi","year":"2019","journal-title":"Front. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","article-title":"Neuroinflammatory TNF\u03b1 impairs memory via astrocyte signaling","volume":"163","author":"Habbas","year":"2015","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1126\/science.1094925","article-title":"GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization","volume":"304","author":"Harvey","year":"2004","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/glia.22445","article-title":"G protein-coupled receptor 30 contributes to improved remyelination after cuprizone-induced demyelination","volume":"61","author":"Hirahara","year":"2013","journal-title":"Glia"},{"key":"B65","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-2236(95)80029-2","article-title":"Cytokines and the nervous system. I: expression and recognition","volume":"18","author":"Hopkins","year":"1995","journal-title":"Trends Neurosci."},{"key":"B66","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.tins.2013.03.007","article-title":"Emerging roles of metaplasticity in behaviour and disease","volume":"36","author":"Hulme","year":"2013","journal-title":"Trends Neurosci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1038\/s41380-022-01458-1","volume":"27","author":"Hwang","year":"2022","journal-title":"Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice"},{"key":"B69","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"key":"B70","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12974-020-1722-y","article-title":"Interferon-\u03b3 acutely augments inhibition of neocortical layer 5 pyramidal neurons","volume":"17","author":"Janach","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"B71","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbi.2021.09.017","article-title":"Systemic LPS-induced microglial activation results in increased GABAergic tone: a mechanism of protection against neuroinflammation in the medial prefrontal cortex in mice","volume":"99","author":"Jiang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.neuron.2006.09.032","article-title":"Synaptic memories upside down: bidirectional plasticity at cerebellar parallel fiber-Purkinje cell synapses","volume":"52","author":"J\u00f6rntell","year":"2006","journal-title":"Neuron"},{"key":"B73","doi-asserted-by":"publisher","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1771-06.2006","article-title":"Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury","volume":"26","author":"Katsura","year":"2006","journal-title":"J. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s00429-012-0491-5","article-title":"Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain","volume":"219","author":"Kaur","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"B75","doi-asserted-by":"publisher","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J. Neurosci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/S2215-0366(14)00122-9","article-title":"Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment","volume":"2","author":"Khandaker","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"B77","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s004240050915","article-title":"Bicuculline block of small-conductance calcium-activated potassium channels","volume":"438","author":"Khawaled","year":"1999","journal-title":"Pflugers Arch."},{"key":"B78","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/intimm\/dxq030","article-title":"IL-6: from its discovery to clinical applications","volume":"22","author":"Kishimoto","year":"2010","journal-title":"Int. Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fneur.2016.00044","article-title":"Changes in neuronal excitability by activated microglia: differential Na(+) current upregulation in pyramid-shaped and bipolar neurons by TNF-\u03b1 and IL-18","volume":"7","author":"Klapal","year":"2016","journal-title":"Front. Neurol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.immuni.2020.12.016","article-title":"Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons","volume":"54","author":"Klawonn","year":"2021","journal-title":"Immunity"},{"key":"B81","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.bbi.2007.07.009","article-title":"IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2","volume":"22","author":"Kleibeuker","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"B82","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"B83","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(88)90486-2","article-title":"A novel form of TNF\/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF","volume":"53","author":"Kriegler","year":"1988","journal-title":"Cell"},{"key":"B84","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s43018-021-00301-w","article-title":"Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment","volume":"3","author":"Kuett","year":"2022","journal-title":"Nat. Cancer"},{"key":"B85","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0306-4522(90)90229-W","article-title":"Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain","volume":"39","author":"Lawson","year":"1990","journal-title":"Neuroscience"},{"key":"B86","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1073\/pnas.0915020107","article-title":"Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning","volume":"107","author":"Le","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B87","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.neuron.2016.03.030","article-title":"Microglial TNF-\u03b1 suppresses cocaine-induced plasticity and behavioral sensitization","volume":"90","author":"Lewitus","year":"2016","journal-title":"Neuron"},{"key":"B88","doi-asserted-by":"publisher","first-page":"6146","DOI":"10.1523\/JNEUROSCI.3481-13.2014","article-title":"An adaptive role of TNF\u03b1 in the regulation of striatal synapses","volume":"34","author":"Lewitus","year":"2014","journal-title":"J. Neurosci."},{"key":"B89","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0006-8993(96)01283-8","article-title":"Interleukin-6 inhibits long-term potentiation in rat hippocampal slices","volume":"748","author":"Li","year":"1997","journal-title":"Brain Res."},{"key":"B90","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/glia.440070105","article-title":"The origin and nature of ramified and amoeboid microglia: a historical review and current concepts","volume":"7","author":"Ling","year":"1993","journal-title":"Glia"},{"key":"B91","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1093\/gbe\/evz266","article-title":"Evolutionary history of the toll-like receptor gene family across vertebrates","volume":"12","author":"Liu","year":"2020","journal-title":"Genome Biol. Evol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1016\/j.celrep.2019.10.085","article-title":"Interleukin-17 regulates neuron-glial communications, synaptic transmission, and neuropathic pain after chemotherapy","volume":"29","author":"Luo","year":"2019","journal-title":"Cell Rep"},{"key":"B93","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13041-020-00701-6","article-title":"CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals","volume":"13","author":"Ma","year":"2020","journal-title":"Mol. Brain"},{"key":"B94","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s12576-012-0215-x","article-title":"Interleukin-6 inhibits L-type calcium channel activity of cultured cerebellar granule neurons","volume":"62","author":"Ma","year":"2012","journal-title":"J. Physiol. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"12105","DOI":"10.1523\/JNEUROSCI.5369-12.2013","article-title":"Interleukin-1\u03b2 alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis","volume":"33","author":"Mandolesi","year":"2013","journal-title":"J. Neurosci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41586-019-0924-x","article-title":"Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution","volume":"566","author":"Masuda","year":"2019","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 family of cytokines in health and disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"key":"B98","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1523\/JNEUROSCI.4810-07.2008","article-title":"Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons","volume":"28","author":"Medvedeva","year":"2008","journal-title":"J. Neurosci."},{"key":"B99","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Innate immunity","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1038\/s41593-017-0010-3","article-title":"Social stress induces neurovascular pathology promoting depression","volume":"20","author":"Menard","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B101","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pain.2012.10.022","article-title":"Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model","volume":"154","author":"Meng","year":"2013","journal-title":"Pain"},{"key":"B102","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bbrc.2009.03.133","article-title":"Impairment of long-term depression induced by chronic brain inflammation in rats","volume":"383","author":"Min","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B103","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s004010000284","article-title":"Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude","volume":"101","author":"Mittelbronn","year":"2001","journal-title":"Acta Neuropathol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1038\/mp.2017.106","article-title":"Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls","volume":"23","author":"Moberget","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0960-8966(01)00250-4","article-title":"Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease","volume":"12","author":"Moore","year":"2002","journal-title":"Neuromuscul. Disord."},{"key":"B106","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S0306-4522(00)00302-X","article-title":"Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells","volume":"100","author":"Morikawa","year":"2000","journal-title":"Neuroscience"},{"key":"B107","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/385733a0","article-title":"Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha","volume":"385","author":"Moss","year":"1997","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.bbrc.2008.12.023","article-title":"The direct excitatory effect of IL-1beta on cerebellar Purkinje cell","volume":"379","author":"Motoki","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B109","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0168-0102(93)90047-T","article-title":"Functional roles of microglia in the brain","volume":"17","author":"Nakajima","year":"1993","journal-title":"Neurosci. Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"e57380","DOI":"10.1371\/journal.pone.0057380","article-title":"Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model","volume":"8","author":"Naviaux","year":"2013","journal-title":"PLoS ONE"},{"key":"B111","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0306-4522(98)00316-9","article-title":"Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6","volume":"89","author":"Nelson","year":"1999","journal-title":"Neuroscience"},{"key":"B112","doi-asserted-by":"publisher","first-page":"S106","DOI":"10.1016\/j.bbi.2011.02.013","article-title":"Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression","volume":"25","author":"Nelson","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1111\/j.1460-9568.2004.03706.x","article-title":"Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons","volume":"20","author":"Nelson","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1152\/jn.2002.88.1.475","article-title":"Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar purkinje neurons in culture","volume":"88","author":"Nelson","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/j.bbrc.2019.08.072","article-title":"Interleukin-10 and transforming growth factor-\u03b21 facilitate long-term potentiation in CA1 region of hippocampus","volume":"518","author":"Nenov","year":"2019","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"B116","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1523\/JNEUROSCI.18-06-02239.1998","article-title":"Exposure to acute stress induces brain interleukin-1beta protein in the rat","volume":"18","author":"Nguyen","year":"1998","journal-title":"J. Neurosci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.neuron.2018.06.035","article-title":"The innate immune receptors TLR2\/4 mediate repeated social defeat stress-induced social avoidance through prefrontal microglial activation","volume":"99","author":"Nie","year":"2018","journal-title":"Neuron"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1038\/mp.2017.151","article-title":"The complement system: a gateway to gene-environment interactions in schizophrenia pathogenesis","volume":"22","author":"Nimgaonkar","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"B120","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.neuroscience.2013.05.023","article-title":"Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels","volume":"247","author":"Nishio","year":"2013","journal-title":"Neuroscience"},{"key":"B121","doi-asserted-by":"publisher","first-page":"e54666","DOI":"10.1371\/journal.pone.0054666","article-title":"Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis","volume":"8","author":"Nistic\u00f2","year":"2013","journal-title":"PLoS ONE"},{"key":"B122","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.0105-2896.2004.00118.x","article-title":"Primitive complement system of invertebrates","volume":"198","author":"Nonaka","year":"2004","journal-title":"Immunol. Rev."},{"key":"B123","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1523\/JNEUROSCI.3211-18.2019","article-title":"Modification of synaptic-input clustering by intrinsic excitability plasticity on cerebellar Purkinje cell dendrites","volume":"40","author":"Ohtsuki","year":"2020","journal-title":"J. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.isci.2018.02.001","article-title":"Synaptic potential and plasticity of an SK2 channel gate regulate spike burst activity in cerebellar Purkinje cells","volume":"1","author":"Ohtsuki","year":"2018","journal-title":"iScience"},{"key":"B125","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1111\/j.1460-9568.2008.06539.x","article-title":"Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses","volume":"28","author":"Ohtsuki","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neuron.2012.05.025","article-title":"SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells","volume":"75","author":"Ohtsuki","year":"2012","journal-title":"Neuron"},{"key":"B127","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3389\/neuro.03.004.2009","article-title":"Climbing fiber signaling and cerebellar gain control","volume":"3","author":"Ohtsuki","year":"2009","journal-title":"Front. Cell Neurosci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1111\/febs.15355","article-title":"Synergistic excitability plasticity in cerebellar functioning","volume":"287","author":"Ohtsuki","year":"2020","journal-title":"FEBS J."},{"key":"B129","doi-asserted-by":"publisher","first-page":"512","DOI":"10.4103\/1673-5374.293148","article-title":"Psychosis symptoms following aberrant immunity in the brain","volume":"16","author":"Ozaki","year":"2021","journal-title":"Neural. Regen. Res."},{"key":"B130","doi-asserted-by":"publisher","first-page":"a016246","DOI":"10.1101\/cshperspect.a016246","article-title":"Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors","volume":"7","author":"Pandey","year":"2014","journal-title":"Cold Spring Harb. Perspect Biol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41582-019-0174-4","article-title":"Immunoneuropsychiatry: novel perspectives on brain disorders","volume":"15","author":"Pape","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"15072","DOI":"10.1523\/JNEUROSCI.2443-11.2011","article-title":"Resolving TRPV1- and TNF-\u03b1-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1","volume":"31","author":"Park","year":"","journal-title":"J. Neurosci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"18433","DOI":"10.1523\/JNEUROSCI.4192-11.2011","article-title":"Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1\/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1","volume":"31","author":"Park","year":"","journal-title":"J. Neurosci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000319828","article-title":"Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway","volume":"18","author":"Parker-Athill","year":"2010","journal-title":"Neurosignals"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"B136","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3390\/brainsci12030367","article-title":"Acute cerebellar inflammation and related ataxia: mechanisms and pathophysiology","volume":"12","author":"Parvez","year":"2022","journal-title":"Brain Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.1073\/pnas.1111098109","article-title":"Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission","volume":"109","author":"Pascual","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B138","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1152\/jn.00251.2021","article-title":"Tumor necrosis factor-\u03b1 modulates GABAergic and dopaminergic neurons in the ventrolateral periaqueductal gray of female mice","volume":"126","author":"Pati","year":"2021","journal-title":"J. Neurophysiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neulet.2004.10.069","article-title":"Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity","volume":"374","author":"Peng","year":"2005","journal-title":"Neurosci. Lett."},{"key":"B140","doi-asserted-by":"publisher","first-page":"5586","DOI":"10.1038\/ncomms6586","article-title":"Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism","volume":"5","author":"Piochon","year":"2014","journal-title":"Nat. Commun."},{"key":"B141","doi-asserted-by":"publisher","first-page":"15879","DOI":"10.1523\/JNEUROSCI.0530-13.2013","article-title":"TNF-\u03b1 downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors","volume":"33","author":"Pribiag","year":"2013","journal-title":"J. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1021\/acschemneuro.8b00511","article-title":"Inhibition of LTP-induced translation by IL-1\u03b2 reduces the level of newly synthesized proteins in hippocampal dendrites","volume":"10","author":"Prieto","year":"","journal-title":"ACS Chem. Neurosci."},{"key":"B143","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s11064-018-2517-8","article-title":"TNF\u03b1 and IL-1\u03b2 but not IL-18 suppresses hippocampal long-term potentiation directly at the synapse","volume":"44","author":"Prieto","year":"","journal-title":"Neurochem. Res."},{"key":"B144","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1523\/JNEUROSCI.15-10-06688.1995","article-title":"Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons","volume":"15","author":"Qiu","year":"1995","journal-title":"J. Neurosci."},{"key":"B145","doi-asserted-by":"crossref","first-page":"10445","DOI":"10.1523\/JNEUROSCI.18-24-10445.1998","article-title":"Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons","volume":"18","author":"Qiu","year":"1998","journal-title":"J. Neurosci."},{"key":"B146","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0165-5728(94)90188-0","article-title":"Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide","volume":"49","author":"Quan","year":"1994","journal-title":"J. Neuroimmunol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"10488","DOI":"10.1523\/JNEUROSCI.3192-06.2006","article-title":"Chemokine fractalkine\/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons","volume":"26","author":"Ragozzino","year":"2006","journal-title":"J. Neurosci."},{"key":"B148","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1097\/00001756-199811160-00011","article-title":"Modulation of the neurotransmitter release in rat cerebellar neurons by GRO beta","volume":"9","author":"Ragozzino","year":"1998","journal-title":"Neuroreport"},{"key":"B149","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-019-1843-6","article-title":"IL-17a promotes sociability in mouse models of neurodevelopmental disorders","volume":"577","author":"Reed","year":"2020","journal-title":"Nature"},{"key":"B150","doi-asserted-by":"publisher","first-page":"17151","DOI":"10.1073\/pnas.0806682105","article-title":"Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation","volume":"105","author":"Riazi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B151","doi-asserted-by":"publisher","first-page":"eaay5199","DOI":"10.1126\/sciimmunol.aay5199","article-title":"Meningeal \u03b3\u03b4 T cell-derived IL-17 controls synaptic plasticity and short-term memory","volume":"4","author":"Ribeiro","year":"2019","journal-title":"Sci. Immunol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jneuroim.2003.08.030","article-title":"A dual role for interleukin-1 in LTP in mouse hippocampal slices","volume":"144","author":"Ross","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"B153","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.4049\/jimmunol.150.12.5445","article-title":"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene","volume":"150","author":"Rouvier","year":"1993","journal-title":"J. Immunol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.neuron.2011.02.003","article-title":"TNF\u03b1 controls glutamatergic gliotransmission in the hippocampal dentate gyrus","volume":"69","author":"Santello","year":"2011","journal-title":"Neuron"},{"key":"B155","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1176\/jnp.16.3.367","article-title":"Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome","volume":"16","author":"Schmahmann","year":"2004","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B156","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1460-9568.1993.tb00210.x","article-title":"Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain","volume":"5","author":"Sch\u00f6bitz","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"B157","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/biology10010034","article-title":"A destruction model of the vascular and lymphatic systems in the emergence of psychiatric symptoms","volume":"10","author":"Segawa","year":"2021","journal-title":"Biology"},{"key":"B158","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1523\/JNEUROSCI.2079-16.2016","article-title":"Hebbian spike-timing dependent plasticity at the cerebellar input stage","volume":"37","author":"Sgritta","year":"2017","journal-title":"J. Neurosci."},{"key":"B159","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bbi.2008.07.012","article-title":"Activation of the maternal immune system alters cerebellar development in the offspring","volume":"23","author":"Shi","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"B160","doi-asserted-by":"publisher","first-page":"11589","DOI":"10.1038\/s41598-018-29786-9","article-title":"TNF-\u03b1 increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia","volume":"8","author":"Shim","year":"2018","journal-title":"Sci. Rep."},{"key":"B161","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1002\/glia.23458","article-title":"Microglia heterogeneity along a spatio-temporal axis: more questions than answers","volume":"66","author":"Silvin","year":"2018","journal-title":"Glia"},{"key":"B162","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.neuron.2006.06.017","article-title":"A cooperative switch determines the sign of synaptic plasticity in distal dendrites of neocortical pyramidal neurons","volume":"51","author":"Sj\u00f6str\u00f6m","year":"2006","journal-title":"Neuron"},{"key":"B163","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1152\/physrev.00016.2007","article-title":"Dendritic excitability and synaptic plasticity","volume":"88","author":"Sj\u00f6str\u00f6m","year":"2008","journal-title":"Physiol. Rev."},{"key":"B164","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.it.2020.07.003","article-title":"The role of TGF\u03b2 signaling in microglia maturation and activation","volume":"41","author":"Spittau","year":"2020","journal-title":"Trends Immunol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1523\/JNEUROSCI.4486-04.2005","article-title":"Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha","volume":"25","author":"Stellwagen","year":"2005","journal-title":"J. Neurosci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"B167","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuint.2016.11.006","article-title":"Neutrophil granulocytes in cerebral ischemia: evolution from killers to key players","volume":"107","author":"Strecker","year":"2017","journal-title":"Neurochem. Int."},{"key":"B168","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1016\/j.celrep.2020.02.109","article-title":"Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system","volume":"30","author":"S\u00fc\u00df","year":"2020","journal-title":"Cell Rep."},{"key":"B169","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.neuron.2016.10.022","article-title":"Timing rules for synaptic plasticity matched to behavioral function","volume":"92","author":"Suvrathan","year":"2016","journal-title":"Neuron"},{"key":"B170","doi-asserted-by":"publisher","first-page":"e2297","DOI":"10.1371\/journal.pone.0002297","article-title":"Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin","volume":"3","author":"Takeuchi","year":"2008","journal-title":"PLoS ONE"},{"key":"B171","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"key":"B172","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.celrep.2018.09.039","article-title":"Sensitive periods for cerebellar-mediated autistic-like behaviors","volume":"25","author":"Tsai","year":"2018","journal-title":"Cell Rep."},{"key":"B173","doi-asserted-by":"publisher","first-page":"eaav4520","DOI":"10.1126\/sciadv.aav4520","article-title":"Awake functional MRI detects neural circuit dysfunction in a mouse model of autism","volume":"6","author":"Tsurugizawa","year":"2020","journal-title":"Sci. Adv."},{"key":"B174","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1113\/JP272547","article-title":"KV 7\/M channels as targets for lipopolysaccharide-induced inflammatory neuronal hyperexcitability","volume":"595","author":"Tzour","year":"2017","journal-title":"J. Physiol."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41593-019-0421-4","article-title":"Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability","volume":"22","author":"Valentinova","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"5906","DOI":"10.1038\/s41467-021-26214-x","article-title":"Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry","volume":"12","author":"van Maldegem","year":"2021","journal-title":"Nat. Commun."},{"key":"B177","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Ann. Neurol."},{"key":"B178","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.pain.2007.02.010","article-title":"Interferon-gamma induced disruption of GABAergic inhibition in the spinal dorsal horn in vivo","volume":"133","author":"Vikman","year":"2007","journal-title":"Pain"},{"key":"B179","doi-asserted-by":"publisher","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J. Neurosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jneuroim.2004.01.011","article-title":"Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices","volume":"150","author":"Vlkolinsk\u00fd","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1038\/81792","article-title":"Coincidence detection in single dendritic spines mediated by calcium release","volume":"3","author":"Wang","year":"2000","journal-title":"Nat. Neurosci."},{"key":"B182","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1101\/2021.02.23.432495","article-title":"Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication","volume":"100","author":"Wang","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0896-6273(02)01189-3","article-title":"Bidirectional changes in spatial dendritic integration accompanying long-term synaptic modifications","volume":"37","author":"Wang","year":"2003","journal-title":"Neuron"},{"key":"B184","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","article-title":"Repopulating microglia promote brain repair in an IL-6-dependent manner","volume":"180","author":"Willis","year":"2020","journal-title":"Cell"},{"key":"B185","doi-asserted-by":"publisher","first-page":"2923","DOI":"10.1016\/j.celrep.2019.07.078","article-title":"Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation","volume":"28","author":"Yamamoto","year":"2019","journal-title":"Cell Rep."},{"key":"B186","doi-asserted-by":"publisher","first-page":"100028","DOI":"10.1016\/j.crneur.2022.100028","article-title":"Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex","volume":"3","author":"Yamawaki","year":"2022","journal-title":"Curr. Res. Neurobiol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.brainres.2004.11.018","article-title":"Interleukin-1beta enhances NMDA receptor-mediated current but inhibits excitatory synaptic transmission","volume":"1034","author":"Yang","year":"2005","journal-title":"Brain Res."},{"key":"B188","doi-asserted-by":"publisher","first-page":"7950","DOI":"10.1523\/JNEUROSCI.5250-14.2015","article-title":"Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18","volume":"35","author":"Yang","year":"2015","journal-title":"J. Neurosci."},{"key":"B189","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/bph.14530","article-title":"Prostaglandin-cytokine crosstalk in chronic inflammation","volume":"176","author":"Yao","year":"2019","journal-title":"Br. J. Pharmacol"},{"key":"B190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/CMR.8.1.131","article-title":"Viruses, schizophrenia, and bipolar disorder","volume":"8","author":"Yolken","year":"1995","journal-title":"Clin. Microbiol. Rev."},{"key":"B191","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nn.3641","article-title":"Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior","volume":"17","author":"Zhan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B192","doi-asserted-by":"publisher","first-page":"12844","DOI":"10.1523\/JNEUROSCI.2437-10.2010","article-title":"A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha","volume":"30","author":"Zhang","year":"2010","journal-title":"J. Neurosci."},{"key":"B193","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuron.2014.01.043","article-title":"Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase","volume":"82","author":"Zhang","year":"2014","journal-title":"Neuron"},{"key":"B194","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/25665","article-title":"A critical window for cooperation and competition among developing retinotectal synapses","volume":"395","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1016\/j.pain.2013.07.002","article-title":"Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons","volume":"154","author":"Zhang","year":"2013","journal-title":"Pain"},{"key":"B196","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1523\/JNEUROSCI.0138-07.2007","article-title":"Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury","volume":"27","author":"Zhao","year":"2007","journal-title":"J. Neurosci."},{"key":"B197","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.bbi.2020.11.007","article-title":"Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala","volume":"91","author":"Zheng","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"B198","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1471-4159.2010.07121.x","article-title":"Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices","volume":"116","author":"Zhou","year":"2011","journal-title":"J. Neurochem."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.925493\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T11:55:47Z","timestamp":1676202947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.925493\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":198,"alternative-id":["10.3389\/fncel.2022.925493"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2022.925493","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"925493"}}