{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:21:33Z","timestamp":1787026893802,"version":"build-2736575974"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Intracerebral hemorrhage (ICH) is a major cerebrovascular illness that causes substantial neurological sequelae and dysfunction caused by secondary brain injury (SBI), and there are no effective therapies to mitigate the disability. Microglia, the brain-resident macrophage, participates in the primary inflammatory response, and activation of microglia to an M1-like phenotype largely takes place in the acute phase following ICH. A growing body of research suggests that the pathophysiology of SBI after ICH is mediated by an inflammatory response mediated by microglial-pyroptotic inflammasomes, while inhibiting the activation of microglial pyroptosis could suppress the inflammatory cascade reaction, thus attenuating the brain injury after ICH. Pyroptosis is characterized by rapid plasma membrane disruption, followed by the release of cellular contents and pro-inflammatory mediators. In this review, we outline the molecular mechanism of microglial pyroptosis and summarize the up-to-date evidence of its involvement in the pathological process of ICH, and highlight microglial pyroptosis-targeted strategies that have the potential to cure intracerebral hemorrhage. This review contributes to a better understanding of the function of microglial pyroptosis in ICH and assesses it as a possible therapeutic target.<\/jats:p>","DOI":"10.3389\/fncel.2022.971469","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T14:06:24Z","timestamp":1662732384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage"],"prefix":"10.3389","volume":"16","author":[{"given":"Lingui","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81334-3","article-title":"Human ICE\/CED-3 protease nomenclature.","volume":"87","author":"Alnemri","year":"1996","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5853\/jos.2016.00864","article-title":"Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: An update.","volume":"19","author":"An","year":"2017","journal-title":"J. Stroke"},{"key":"B3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/bpa.12476","article-title":"A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?","volume":"27","author":"Barrington","year":"2017","journal-title":"Brain Pathol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: Host cell death and inflammation.","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1042\/BCJ20170257","article-title":"P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization.","volume":"474","author":"Boyce","year":"2017","journal-title":"Biochem. J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: Mechanism of assembly, regulation and signalling.","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02519","article-title":"Caspase-11 mediates neutrophil chemotaxis and extracellular trap formation during acute gouty arthritis through alteration of cofilin phosphorylation.","volume":"10","author":"Caution","year":"2019","journal-title":"Front. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"E1128","DOI":"10.1073\/pnas.1616783114","article-title":"Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.","volume":"114","author":"Chao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1111\/bph.14639","article-title":"The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1\/JNK\/p38 MAPK pathway in a mouse model of intracerebral haemorrhage.","volume":"176","author":"Chen","year":"","journal-title":"Br. J. Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101638","article-title":"Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.","volume":"38","author":"Chen","year":"","journal-title":"EMBO J."},{"key":"B11","doi-asserted-by":"publisher","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs.","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"B12","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/jmcb\/mjy056","article-title":"GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.","volume":"11","author":"Chen","year":"","journal-title":"J. Mol. Cell Biol."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3462530","article-title":"ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis.","volume":"2019","author":"Chen","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.cbpb.2008.05.010","article-title":"Caspases - an update.","volume":"151","author":"Chowdhury","year":"2008","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/s0966-842x(00)01936-3","article-title":"Pro-inflammatory programmed cell death.","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-020-00084-2","article-title":"Gasdermin D inhibitor protects against sepsis.","volume":"19","author":"Crunkhorn","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"B17","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/ng1829","article-title":"Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.","volume":"38","author":"Delmaghani","year":"2006","journal-title":"Nat. Genet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41586-021-04384-4","article-title":"Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.","volume":"602","author":"Deng","year":"2022","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1074\/jbc.M509110200","article-title":"Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism.","volume":"281","author":"Di Sano","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027396","article-title":"CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.","volume":"6","author":"D\u2019Osualdo","year":"2011","journal-title":"PLoS One"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1046\/j.1523-1747.2000.00205.x","article-title":"Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.","volume":"115","author":"Eckhart","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00068","article-title":"Programmed cell deaths and potential crosstalk with blood-brain barrier dysfunction after hemorrhagic stroke.","volume":"14","author":"Fang","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12017-020-08623-1","article-title":"CD137 Ligand-CD137 interaction is required for inflammasome-associated brain injury following ischemic stroke.","volume":"22","author":"Fann","year":"2020","journal-title":"Neuromolecular. Med."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0409-2","article-title":"P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: Involvement of peroxynitrite.","volume":"12","author":"Feng","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1016\/j.jmb.2018.07.002","article-title":"Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.","author":"Feng","year":"2018","journal-title":"J. Mol. Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense.","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.immuni.2016.01.020","article-title":"Caspases connect cell-death signaling to organismal homeostasis.","volume":"44","author":"Galluzzi","year":"2016","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1038\/s12276-021-00702-y","article-title":"The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats.","volume":"53","author":"Gan","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16357.1","article-title":"Recent advances in spontaneous intracerebral hemorrhage.","volume":"8","author":"Garg","year":"2019","journal-title":"F1000Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00249","article-title":"Microglia versus myeloid cell nomenclature during brain inflammation.","volume":"6","author":"Greter","year":"2015","journal-title":"Front. Immunol."},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.810582","article-title":"Didymin suppresses microglia pyroptosis and neuroinflammation through the Asc\/Caspase-1\/GSDMD pathway following experimental intracerebral hemorrhage.","volume":"13","author":"Gu","year":"2022","journal-title":"Front. Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S0002-9440(10)63317-2","article-title":"Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer\u2019s disease.","volume":"165","author":"Guo","year":"2004","journal-title":"Am. J. Pathol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"56295","DOI":"10.18632\/oncotarget.10787","article-title":"Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.","volume":"7","author":"Hergueta-Redondo","year":"2016","journal-title":"Oncotarget"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1083\/jcb.200309161","article-title":"A Salmonella protein causes macrophage cell death by inducing autophagy.","volume":"163","author":"Hernandez","year":"2003","journal-title":"J. Cell Biol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-00599-1","article-title":"Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.","volume":"22","author":"Hou","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1146\/annurev-physiol-021115-105229","article-title":"Inflammasomes: Key mediators of lung immunity.","volume":"79","author":"Howrylak","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"8813","DOI":"10.7150\/thno.62521","article-title":"Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment.","volume":"11","author":"Hsu","year":"2021","journal-title":"Theranostics"},{"key":"B38","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00370","article-title":"The many alternative faces of macrophage activation.","volume":"6","author":"Hume","year":"2015","journal-title":"Front. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1126\/science.abb9818","article-title":"Succination inactivates gasdermin D and blocks pyroptosis.","volume":"369","author":"Humphries","year":"2020","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1084\/jem.192.7.1035","article-title":"Salmonella-induced caspase-2 activation in macrophages: A novel mechanism in pathogen-mediated apoptosis.","volume":"192","author":"Jesenberger","year":"2000","journal-title":"J. Exp. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1083\/jcb.200303157","article-title":"Regulation of the expression and processing of caspase-12.","volume":"162","author":"Kalai","year":"2003","journal-title":"J. Cell Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/imr.12906","article-title":"Molecular mechanisms activating the NAIP-NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer.","volume":"297","author":"Kay","year":"2020","journal-title":"Immunol. Rev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1126\/science.1240248","article-title":"Noncanonical inflammasome activation by intracellular LPS independent of TLR4.","volume":"341","author":"Kayagaki","year":"2013","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/intimm\/dxx018","article-title":"Mechanisms governing inflammasome activation, assembly and pyroptosis induction.","volume":"29","author":"Kesavardhana","year":"2017","journal-title":"Int. Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1266\/ggs.85.75","article-title":"Alu-derived cis-element regulates tumorigenesis-dependent gastric expression of GASDERMIN B (GSDMB).","volume":"85","author":"Komiyama","year":"2010","journal-title":"Genes Genet. Syst."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes.","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/nrneurol.2017.69","article-title":"Modulators of microglial activation and polarization after intracerebral haemorrhage.","volume":"13","author":"Lan","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-98","article-title":"Methyl salicylate 2-O-beta-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes.","volume":"8","author":"Lan","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death.","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-6579","article-title":"The pannexin-1 channel regulates pyroptosis through autophagy in a mouse model of sepsis-associated encephalopathy.","volume":"9","author":"Lei","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.neuropharm.2018.09.015","article-title":"Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.","volume":"141","author":"Li","year":"2018","journal-title":"Neuropharmacology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00011-020-01315-3","article-title":"The advances in pyroptosis initiated by inflammasome in inflammatory and immune diseases.","volume":"69","author":"Liang","year":"2020","journal-title":"Inflamm. Res."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105771","article-title":"Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats.","volume":"75","author":"Liang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte Crosstalk in CNS Inflammation.","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1038\/sj.cdd.4400785","article-title":"Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.","volume":"7","author":"Lippens","year":"2000","journal-title":"Cell Death Differ."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-2590","article-title":"Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage.","volume":"9","author":"Liu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4504363","article-title":"Destructive effects of pyroptosis on homeostasis of neuron survival associated with the dysfunctional BBB-glymphatic system and amyloid-beta accumulation after cerebral ischemia\/reperfusion in rats.","volume":"2021","author":"Lyu","year":"2021","journal-title":"Neural. Plast."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1084\/jem.20071632","article-title":"Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.","volume":"205","author":"Maelfait","year":"2008","journal-title":"J. Exp. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/imr.12296","article-title":"Regulation of inflammasome activation.","volume":"265","author":"Man","year":"2015","journal-title":"Immunol. Rev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nri.2015.7","article-title":"Converging roles of caspases in inflammasome activation, cell death and innate immunity.","volume":"16","author":"Man","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: Master switches of inflammation.","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ."},{"key":"B64","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/s1097-2765(02)00599-3","article-title":"The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"B65","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.4049\/jimmunol.2000373","article-title":"Function and Regulation of Noncanonical Caspase-4\/5\/11 Inflammasome.","volume":"204","author":"Matikainen","year":"2020","journal-title":"J. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tins.2019.11.005","article-title":"Fiery cell death: Pyroptosis in the central nervous system.","volume":"43","author":"McKenzie","year":"2020","journal-title":"Trends Neurosci."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166422","article-title":"Gasdermin C is upregulated by inactivation of transforming growth factor beta receptor type II in the presence of mutated apc, promoting colorectal cancer proliferation.","volume":"11","author":"Miguchi","year":"2016","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells.","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1212\/CON.0000000000001018","article-title":"Intracerebral hemorrhage.","volume":"27","author":"Nobleza","year":"2021","journal-title":"Continuum (Minneap Minn"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor.","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/biology10100948","article-title":"Neuron-derived extracellular vesicles modulate microglia activation and function.","volume":"10","author":"Peng","year":"2021","journal-title":"Biology (Basel"},{"key":"B73","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s12031-011-9646-8","article-title":"P2X7 receptor-pannexin 1 hemichannel association: Effect of extracellular calcium on membrane permeabilization.","volume":"46","author":"Poornima","year":"2012","journal-title":"J. Mol. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im2002s39","article-title":"Mouse 4T1 breast tumor model.","author":"Pulaski","year":"2001","journal-title":"Curr. Protoc. Immunol."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03464","article-title":"TNFR1-dependent cell death drives inflammation in sharpin-deficient mice.","volume":"3","author":"Rickard","year":"2014","journal-title":"Elife"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death.","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/gcc.20636","article-title":"Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.","volume":"48","author":"Saeki","year":"2009","journal-title":"Genes Chromosomes. Cancer"},{"key":"B78","doi-asserted-by":"publisher","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during yersinia infection.","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.SA."},{"key":"B79","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes.","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105189","article-title":"Pannexin-1 channels as mediators of neuroinflammation.","volume":"22","author":"Seo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.coi.2008.06.001","article-title":"NOD-like receptors (NLRs): Bona fide intracellular microbial sensors.","volume":"20","author":"Shaw","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: Gasdermin-mediated programmed necrotic cell death.","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"B83","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS.","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"B84","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1593\/tlo.08112","article-title":"Expression of GSDML associates with tumor progression in uterine cervix cancer.","volume":"1","author":"Sun","year":"2008","journal-title":"Transl. Oncol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"16","DOI":"10.2174\/1389203711314010004","article-title":"Neuron-microglia interaction in neuroinflammation.","volume":"14","author":"Suzumura","year":"2013","journal-title":"Curr. Protein. Pept. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress.","volume":"13","author":"Tabas","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/746068","article-title":"Microglial responses after ischemic stroke and intracerebral hemorrhage.","volume":"2013","author":"Taylor","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5853\/jos.2019.02236","article-title":"Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets.","volume":"22","author":"Tschoe","year":"2020","journal-title":"J. Stroke"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09753-2","article-title":"Caspase-1 initiates apoptosis in the absence of gasdermin D.","volume":"10","author":"Tsuchiya","year":"2019","journal-title":"Nat. Commun."},{"key":"B90","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","article-title":"Astrocytes and microglia: In sickness and in health.","volume":"43","author":"Vainchtein","year":"2020","journal-title":"Trends Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/2503","article-title":"Nonsyndromic hearing impairment is associated with a mutation in DFNA5.","volume":"20","author":"Van Laer","year":"1998","journal-title":"Nat. Genet."},{"key":"B92","doi-asserted-by":"publisher","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis.","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr. Biol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.pneurobio.2010.08.001","article-title":"Preclinical and clinical research on inflammation after intracerebral hemorrhage.","volume":"92","author":"Wang","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","article-title":"A bioorthogonal system reveals antitumour immune function of pyroptosis.","volume":"579","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1146\/annurev-pharmtox-010814-124414","article-title":"Activation and regulation of caspase-6 and its role in neurodegenerative diseases.","volume":"55","author":"Wang","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"5071","DOI":"10.26355\/eurrev_202005_21200","article-title":"Nesfatin-1 alleviates acute lung injury through reducing inflammation and oxidative stress via the regulation of HMGB1.","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.2174\/1381612822666161027152234","article-title":"Epidemiology, prognosis and prevention of non-traumatic intracerebral hemorrhage.","volume":"23","author":"Weimar","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s00109-020-01962-3","article-title":"NLRP6 contributes to inflammation and brain injury following intracerebral haemorrhage by activating autophagy.","volume":"98","author":"Xiao","year":"2020","journal-title":"J. Mol. Med (Berl"},{"key":"B100","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1161\/STROKEAHA.120.032444","article-title":"IL33 (Interleukin 33)\/ST2 (Interleukin 1 Receptor-Like 1) axis drives protective microglial responses and promotes white matter integrity after stroke.","volume":"52","author":"Xie","year":"2021","journal-title":"Stroke"},{"key":"B101","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pneurobio.2016.05.001","article-title":"Functions and mechanisms of microglia\/macrophages in neuroinflammation and neurogenesis after stroke.","volume":"142","author":"Xiong","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s12975-020-00840-x","article-title":"TREM-1 exacerbates neuroinflammatory injury via nlrp3 inflammasome-mediated pyroptosis in experimental subarachnoid hemorrhage.","volume":"12","author":"Xu","year":"","journal-title":"Transl. Stroke Res."},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.269","article-title":"CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling.","volume":"11","author":"Xu","year":"","journal-title":"Clin. Transl. Med."},{"key":"B104","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1161\/STROKEAHA.120.033285","article-title":"CCR5 Activation Promotes NLRP1-dependent neuronal pyroptosis via CCR5\/PKA\/CREB pathway after intracerebral hemorrhage.","volume":"52","author":"Yan","year":"2021","journal-title":"Stroke"},{"key":"B105","doi-asserted-by":"publisher","first-page":"F75","DOI":"10.1152\/ajprenal.00117.2013","article-title":"Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway.","volume":"306","author":"Yang","year":"2014","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s12031-016-0874-9","article-title":"NLRP3 is required for complement-mediated caspase-1 and IL-1beta activation in ICH.","volume":"61","author":"Yao","year":"2017","journal-title":"J. Mol. Neurosci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/s41422-021-00506-9","article-title":"The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.","volume":"31","author":"Zhang","year":"2021","journal-title":"Cell Res."},{"key":"B108","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity.","volume":"579","author":"Zhang","year":"","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1007\/s12031-020-01608-6","article-title":"Biological effects of hydrogen sulfide and its protective role in intracerebral hemorrhage.","volume":"70","author":"Zhang","year":"","journal-title":"J. Mol. Neurosci."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00201","article-title":"Oligodendrogenesis after cerebral ischemia.","volume":"7","author":"Zhang","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s10072-014-1657-0","article-title":"NF-kappaB activation and cell death after intracerebral hemorrhage in patients.","volume":"35","author":"Zhang","year":"2014","journal-title":"Neurol. Sci."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0940-4","article-title":"Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats.","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12563","article-title":"Role of pyroptosis in cardiovascular disease.","volume":"52","author":"Zhaolin","year":"2019","journal-title":"Cell Prolif"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.971469\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T14:06:29Z","timestamp":1662732389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2022.971469\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":114,"alternative-id":["10.3389\/fncel.2022.971469"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2022.971469","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]},"article-number":"971469"}}