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The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barr\u00e9 syndrome. This article discusses a relationship between development of the nervous system diseases and the functional single nucleotide polymorphism (SNP) at position -1562C\/T within the MMP-9 gene. A pathogenic influence of MMP-9-1562C\/T SNP was observed both in neurological and psychiatric disorders. The presence of the allele T often increases the activity of the MMP-9 gene promoter and consequently the expression of MMP-9 when compared to the allele C. This leads to a change in the likelihood of an occurrence of diseases and modifies the course of certain brain diseases in humans, as discussed below. The presented data indicates that the MMP-9-1562C\/T functional polymorphism influences the course of many neuropsychiatric disorders in humans suggesting a significant pathological role of the MMP-9 metalloproteinase in pathologies of the human central nervous system.<\/jats:p>","DOI":"10.3389\/fncel.2023.1110967","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T04:40:51Z","timestamp":1683088851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Does the functional polymorphism-1562C\/T of MMP-9 gene influence brain disorders?"],"prefix":"10.3389","volume":"17","author":[{"given":"Sylwia","family":"Pabian-Jewu\u0142a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Rylski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1093\/AJCP\/AQV008","article-title":"Matrix metalloproteinase 3 gene polymorphism and its level predict morbidity after acute myocardial infarction.","volume":"145","author":"Abd El-Aziz","year":"2016","journal-title":"Am. 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