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GLP-1R agonist use is also associated with a reduced risk for glaucoma in patients with diabetes. In this study, we demonstrate that several commercially available GLP-1R agonists, administered either systemically or topically, hold protective potential in a mouse model of hypertensive glaucoma. Further, the resulting neuroprotection likely occurs through the same pathways previously shown for NLY01. This work contributes to a growing body of evidence suggesting that GLP-1R agonists represent a viable therapeutic option for glaucoma.<\/jats:p>","DOI":"10.3389\/fncel.2023.1156829","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T04:43:06Z","timestamp":1686285786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":41,"title":["Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma"],"prefix":"10.3389","volume":"17","author":[{"given":"Emily C. 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