{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:28:36Z","timestamp":1793644116208,"version":"4.5.1"},"reference-count":161,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Schwann cells (SCs) have a critical role in the peripheral nervous system. These cells are able to support axons during homeostasis and after injury. However, mutations in genes associated with the SCs repair program or myelination result in dysfunctional SCs. Several neuropathies such as Charcot\u2013Marie\u2013Tooth (CMT) disease, diabetic neuropathy and Guillain\u2013Barr\u00e9 syndrome show abnormal SC functions and an impaired regeneration process. Thus, understanding SCs-axon interaction and the nerve environment in the context of homeostasis as well as post-injury and disease onset is necessary. Several neurotrophic factors, cytokines, and regulators of signaling pathways associated with proliferation, survival and regeneration are involved in this process. Preclinical studies have focused on the discovery of therapeutic targets for peripheral neuropathies and injuries. To study the effect of new therapeutic targets, modeling neuropathies and peripheral nerve injuries (PNIs) <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> are useful tools. Furthermore, several <jats:italic>in vitro<\/jats:italic> protocols have been designed using SCs and neuron cell lines to evaluate these targets in the regeneration process. SCs lines have been used to generate effective myelinating SCs without success. Alternative options have been investigated using direct conversion from somatic cells to SCs or SCs derived from pluripotent stem cells to generate functional SCs. This review will go over the advantages of these systems and the problems associated with them. In addition, there have been challenges in establishing adequate and reproducible protocols <jats:italic>in vitro<\/jats:italic> to recapitulate repair SC-neuron interactions observed <jats:italic>in vivo<\/jats:italic>. So, we also discuss the mechanisms of repair SCs-axon interactions in the context of peripheral neuropathies and nerve injury (PNI) <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. Finally, we summarize current preclinical studies evaluating transgenes, drug, and novel compounds with translational potential into clinical studies.<\/jats:p>","DOI":"10.3389\/fncel.2023.1248922","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:55:16Z","timestamp":1697093716000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Neuron-Schwann cell interactions in peripheral nervous system homeostasis, disease, and preclinical treatment"],"prefix":"10.3389","volume":"17","author":[{"given":"Julia Teixeira","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yanick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Wein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Elisabeth","family":"Gomez Limia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"102786","DOI":"10.1016\/j.scr.2022.102786","article-title":"Generation of a human induced pluripotent stem cell (iPSC) line (JUCTCi019-A) from a patient with Charcot\u2013Marie\u2013Tooth disease type 2A2 (CMT2A2) due to a heterozygous missense substitution c.2119C>T (p.Arg707Trp) in MFN2 gene","volume":"62","author":"Ababneh","year":"2022","journal-title":"Stem Cell Res."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"886","DOI":"10.3390\/microorganisms10050886","article-title":"Preclinical evidence for the role of botulinum neurotoxin A (BoNT\/A) in the treatment of peripheral nerve injury","volume":"10","author":"Adler","year":"2022","journal-title":"Microorganisms"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/fcp.12827","article-title":"Enhancement of nerve regeneration with nimodipine treatment after sciatic nerve injury","volume":"37","author":"Al-Saedi","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1038\/s41593-020-0689-4","article-title":"A glycolytic shift in Schwann cells supports injured axons","volume":"23","author":"Babetto","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9","article-title":"Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB","volume":"177","author":"Badache","year":"1998","journal-title":"J. Cell. Physiol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"608442","DOI":"10.3389\/fnmol.2020.608442","article-title":"Insights into the role and potential of Schwann cells for peripheral nerve repair from studies of development and injury","volume":"13","author":"Balakrishnan","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/j.1460-2075.1987.tb04835.x","article-title":"Cellular localization of nerve growth factor synthesis by in situ hybridization","volume":"6","author":"Bandtlow","year":"1987","journal-title":"EMBO J."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1073\/pnas.0307823100","article-title":"Erythropoietin both protects from and reverses experimental diabetic neuropathy","volume":"101","author":"Bianchi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1093\/hmg\/10.24.2783","article-title":"Human connexin 32, a gap junction protein altered in the X-linked form of Charcot\u2013Marie\u2013Tooth disease, is directly regulated by the transcription factor SOX10","volume":"10","author":"Bondurand","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1002\/mus.880110408","article-title":"Schwann cell-conditioned medium supports neurite outgrowth and survival of spinal cord neurons in culture","volume":"11","author":"Bosch","year":"1988","journal-title":"Muscle Nerve"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1007\/s12035-018-1172-z","article-title":"Effect of exosomes from rat adipose-derived mesenchymal stem cells on neurite outgrowth and sciatic nerve regeneration after crush injury","volume":"56","author":"Bucan","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.stemcr.2019.01.001","article-title":"Reprogramming captures the genetic and tumorigenic properties of neurofibromatosis type 1 plexiform neurofibromas","volume":"12","author":"Carri\u00f3","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/aja.1001940306","article-title":"Neuroblastoma \u00d7 spinal cord (NSC) hybrid cell lines resemble developing motor neurons","volume":"194","author":"Cashman","year":"1992","journal-title":"Dev. Dyn."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1523\/JNEUROSCI.2255-17.2017","article-title":"Sustained MAPK\/ERK activation in adult Schwann cells impairs nerve repair","volume":"38","author":"Cervellini","year":"2018","journal-title":"J. Neurosci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.4103\/1673-5374.357914","article-title":"Potential application of let-7a antagomir in injured peripheral nerve regeneration","volume":"18","author":"Chen","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","article-title":"Peripheral regeneration","volume":"30","author":"Chen","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13287-018-1017-8","article-title":"Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer","volume":"9","author":"Ching","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/s41419-018-1192-7","article-title":"Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy","volume":"9","author":"Chung","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1093\/brain\/awx012","article-title":"Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination","volume":"140","author":"Clark","year":"2017","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"11024","DOI":"10.1523\/JNEUROSCI.2429-08.2008","article-title":"Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system","volume":"28","author":"Court","year":"2008","journal-title":"J. Neurosci."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/0092-8674(94)90378-6","article-title":"Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons","volume":"76","author":"Crowley","year":"1994","journal-title":"Cells"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/jns.12373","article-title":"Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain\u2013Barr\u00e9 syndrome","volume":"25","author":"Cunningham","year":"2020","journal-title":"J. Peripher. Nerv. Syst."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"R15","DOI":"10.1016\/S0960-9822(98)70009-0","article-title":"Neuronal survival: early dependence on Schwann cells","volume":"8","author":"Davies","year":"1998","journal-title":"Curr. Biol."},{"key":"ref1001","doi-asserted-by":"publisher","first-page":"e0272097","DOI":"10.1371\/journal.pone.0272097","article-title":"Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells","volume":"17","author":"Deck","year":"2022","journal-title":"PLOS ONE"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0092-8674(92)90183-D","article-title":"Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells","volume":"68","author":"de Waegh","year":"1992","journal-title":"Cells"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/1566524011307010024","article-title":"Functions of S100 proteins","volume":"13","author":"Donato","year":"2013","journal-title":"Curr Mol Med"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"e6458237","DOI":"10.1155\/2019\/6458237","article-title":"MSC-derived exosomes-based therapy for peripheral nerve injury: a novel therapeutic strategy","volume":"2019","author":"Dong","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1090738","DOI":"10.3389\/fnana.2023.1090738","article-title":"Comparative neuroprotective effects of Cerebrolysin, dexamethasone, and ascorbic acid on sciatic nerve injury model: behavioral and histopathological study","volume":"17","author":"Elhessy","year":"2023","journal-title":"Front. Neuroanat."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"113694","DOI":"10.1016\/j.expneurol.2021.113694","article-title":"Treatment of diabetic peripheral neuropathy with engineered mesenchymal stromal cell-derived exosomes enriched with microRNA-146a provide amplified therapeutic efficacy","volume":"341","author":"Fan","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11064-022-03721-x","article-title":"Effect of azithromycin on sciatic nerve injury in the Wistar rats","volume":"48","author":"Ferdowsi","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1186\/s12864-020-06963-7","article-title":"SOX10-regulated promoter use defines isoform-specific gene expression in Schwann cells","volume":"21","author":"Fogarty","year":"2020","journal-title":"BMC Genomics"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1177\/1545968318790020","article-title":"Botulinum toxin conditioning enhances motor axon regeneration in mouse and human preclinical models","volume":"32","author":"Franz","year":"2018","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"809","DOI":"10.2217\/fnl.11.45","article-title":"The role of neuregulin-1 in the response to nerve injury","volume":"6","author":"Fricker","year":"2011","journal-title":"Future Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1002\/cpz1.78","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"1","author":"Furman","year":"2021","journal-title":"Curr. Protoc."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1111\/j.1469-7580.2009.01078.x","article-title":"Myelin basic protein-positive nerve fibres in human Meissner corpuscles","volume":"214","author":"Garc\u00eda-Su\u00e1rez","year":"2009","journal-title":"J. Anat."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1038\/s41467-021-22593-3","article-title":"AAV2\/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot\u2013Marie\u2013Tooth disease 1 A","volume":"12","author":"Gautier","year":"2021","journal-title":"Nat. Commun."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1083\/jcb.201503019","article-title":"Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves","volume":"210","author":"Gomez-Sanchez","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.3390\/ijms23062996","article-title":"Emerging role of HDACs in regeneration and ageing in the peripheral nervous system: repair Schwann cells as pivotal targets","volume":"23","author":"Gomez-Sanchez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1002\/glia.23881","article-title":"Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy","volume":"68","author":"Gon\u00e7alves","year":"2020","journal-title":"Glia"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1172\/JCI92100","article-title":"Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies","volume":"127","author":"Gonzalez","year":"2017","journal-title":"J. Clin. Invest."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrneurol.2016.172","article-title":"Guillain\u2013Barr\u00e9 syndrome: a century of progress","volume":"12","author":"Goodfellow","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.2147\/IJN.S71951","article-title":"Nanotechnology versus stem cell engineering: in vitro comparison of neurite inductive potentials","volume":"9","author":"Haastert-Talini","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/jnr.10327","article-title":"Comparative analysis of Schwann cell lines as model systems for myelin gene transcription studies","volume":"69","author":"Hai","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nm.4483","article-title":"A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration","volume":"24","author":"He","year":"2018","journal-title":"Nat. Med."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"9646","DOI":"10.1523\/JNEUROSCI.1620-06.2006","article-title":"Schwann cells express motor and sensory phenotypes that regulate axon regeneration","volume":"26","author":"H\u00f6ke","year":"2006","journal-title":"J. Neurosci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.3390\/cells11233753","article-title":"Development and in vitro differentiation of Schwann cells","volume":"11","author":"H\u00f6rner","year":"2022","journal-title":"Cells"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1002\/glia.23122","article-title":"BACE1 regulates the proliferation and cellular functions of Schwann cells: HU et al","volume":"65","author":"Hu","year":"2017","journal-title":"Glia"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1077071","DOI":"10.3389\/fncel.2022.1077071","article-title":"Schwann cells-derived exosomes promote functional recovery after spinal cord injury by promoting angiogenesis","volume":"16","author":"Huang","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"19727","DOI":"10.1038\/srep19727","article-title":"Generating trunk neural crest from human pluripotent stem cells","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.35248\/2471-9552.19.5.156","article-title":"Neuroprotective effect of glial cell-derived exosomes on neurons","volume":"5","author":"Hyung","year":"2019","journal-title":"Immunotherapy"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"15122","DOI":"10.1038\/srep15122","article-title":"Coculture of primary motor neurons and Schwann cells as a model for in vitro myelination","volume":"5","author":"Hyung","year":"2015","journal-title":"Sci. Rep."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1570159X14666160825160421","article-title":"Exosomes: the messengers of health and disease","volume":"15","author":"Isola","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair Schwann cell and its function in regenerating nerves: repair Schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"J. Physiol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fncel.2019.00033","article-title":"The success and failure of the Schwann cell response to nerve injury","volume":"13","author":"Jessen","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"a020487","DOI":"10.1101\/cshperspect.a020487","article-title":"Schwann cells: development and role in nerve repair","volume":"7","author":"Jessen","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/cells8101173","article-title":"Wnt signaling in neural crest ontogenesis and oncogenesis","volume":"8","author":"Ji","year":"2019","journal-title":"Cells"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"6911","DOI":"10.1096\/fj.201800597R","article-title":"Exosomes derived from high-glucose-stimulated Schwann cells promote development of diabetic peripheral neuropathy","volume":"32","author":"Jia","year":"2018","journal-title":"FASEB J."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1016\/j.devcel.2021.09.013","article-title":"Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability","volume":"56","author":"Jia","year":"2021","journal-title":"Dev. Cell"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.3390\/biom10121657","article-title":"In vitro differentiation of human placenta-derived multipotent cells into Schwann-Like cells","volume":"10","author":"Juan","year":"2020","journal-title":"Biomol. Ther."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1136\/jnnp-2018-318834","article-title":"Challenges in modelling the Charcot\u2013Marie\u2013Tooth neuropathies for therapy development","volume":"90","author":"Juneja","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/s41434-021-00250-0","article-title":"AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy","volume":"28","author":"Kagiava","year":"2021","journal-title":"Gene Ther."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/emboj\/19.6.1290","article-title":"BDNF regulates eating behavior and locomotor activity in mice","volume":"19","author":"Kernie","year":"2000","journal-title":"EMBO J."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1002\/ana.20285","article-title":"A novel endogenous erythropoietin mediated pathway prevents axonal degeneration","volume":"56","author":"Keswani","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13287-020-01772-x","article-title":"Directly induced human Schwann cell precursors as a valuable source of Schwann cells","volume":"11","author":"Kim","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1016\/j.stemcr.2017.04.011","article-title":"Schwann cell precursors from human pluripotent stem cells as a potential therapeutic target for myelin repair","volume":"8","author":"Kim","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/348257a0","article-title":"Structure, expression and function of a schwannoma derived growth factor","volume":"348","author":"Kimura","year":"1990","journal-title":"Nature"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/glia.23582","article-title":"Direct conversion of adult human skin fibroblasts into functional Schwann cells that achieve robust recovery of the severed peripheral nerve in rats","volume":"67","author":"Kitada","year":"2019","journal-title":"Glia"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12964-019-0383-x","article-title":"YAP promotes neural crest emigration through interactions with BMP and Wnt activities","volume":"17","author":"Kumar","year":"2019","journal-title":"Cell Commun. Signal"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1093\/brain\/awg030","article-title":"Autoimmunoreactivity to Schwann cells in patients with inflammatory neuropathies","volume":"126","author":"Kwa","year":"2003","journal-title":"Brain J. Neurol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1128\/MCB.01689-06","article-title":"Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10","volume":"27","author":"LeBlanc","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2174\/1570159X19666210407155543","article-title":"In vitro, in vivo and ex vivo models for peripheral nerve injury and regeneration","volume":"20","author":"Li","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0165-0270(96)00028-3","article-title":"Establishment of Schwann cell lines from normal adult and embryoni","volume":"67","author":"Li","year":"1995","journal-title":"J. Neurosci. Methods"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1136\/jnnp.61.3.279","article-title":"Experimental Campylobacter jejuni infection in the chicken: an animal model of axonal Guillain\u2013Barr\u00e9 syndrome","volume":"61","author":"Li","year":"1996","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1126\/science.180605","article-title":"Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus","volume":"193","author":"Like","year":"1976","journal-title":"Science"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1080\/21645515.2018.1493415","article-title":"Immunotherapy of Guillain\u2013Barr\u00e9 syndrome","volume":"14","author":"Liu","year":"2018","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.4103\/1673-5374.253510","article-title":"Role of macrophages in peripheral nerve injury and repair","volume":"14","author":"Liu","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"266","DOI":"10.5966\/sctm.2011-0042","article-title":"Human neural crest stem cells derived from human ESCs and induced pluripotent stem cells: induction, maintenance, and differentiation into functional Schwann cells","volume":"1","author":"Liu","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"105141","DOI":"10.1016\/j.isci.2022.105141","article-title":"Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth","volume":"25","author":"Liu","year":"2022","journal-title":"iScience"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/1673-5374.265540","article-title":"Peripheral nerve injury induced changes in the spinal cord and strategies to counteract\/enhance the changes to promote nerve regeneration","volume":"15","author":"Liu","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e10223","DOI":"10.1002\/btm2.10223","article-title":"Preclinical study of peripheral nerve regeneration using nerve guidance conduits based on polyhydroxyalkanaotes","volume":"6","author":"Lizarraga-Valderrama","year":"2021","journal-title":"Bioeng. Transl. Med."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"jcs239004","DOI":"10.1242\/jcs.239004","article-title":"Schwann cell reprogramming into repair cells increases exosome-loaded miRNA-21 promoting axonal growth","volume":"133","author":"L\u00f3pez-Leal","year":"2020","journal-title":"J. Cell Sci."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1056\/NEJMoa0908094","article-title":"Whole-genome sequencing in a patient with Charcot\u2013Marie\u2013Tooth neuropathy","volume":"362","author":"Lupski","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.cub.2005.02.030","article-title":"erbb3 and erbb2 are essential for Schwann cell migration and myelination in zebrafish","volume":"15","author":"Lyons","year":"2005","journal-title":"Curr. Biol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.stem.2023.04.006","article-title":"Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy","volume":"30","author":"Majd","year":"2023","journal-title":"Cell Stem Cell"},{"key":"ref85","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1089\/ten.tea.2018.0176","article-title":"Gingiva-derived mesenchymal stem cell-extracellular vesicles activate Schwann cell repair phenotype and promote nerve regeneration","volume":"25","author":"Mao","year":"2019","journal-title":"Tissue Eng. A"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2337\/diab.47.2.224","article-title":"Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide","volume":"47","author":"Masiello","year":"1998","journal-title":"Diabetes"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"14088","DOI":"10.1038\/ncomms14088","article-title":"Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells","volume":"8","author":"Mazzara","year":"2017","journal-title":"Nat. Commun."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e158524","DOI":"10.1172\/JCI158524","article-title":"Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain\u2013Barr\u00e9 syndrome mouse model","volume":"132","author":"McGonigal","year":"2022","journal-title":"J. Clin. Invest."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.nbd.2006.08.014","article-title":"Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration","volume":"24","author":"Melli","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"78","DOI":"10.21037\/atm-22-81","article-title":"Endothelial cells promote the proliferation and migration of Schwann cells","volume":"10","author":"Meng","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1083\/jcb.119.1.45","article-title":"Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA","volume":"119","author":"Meyer","year":"1992","journal-title":"J. Cell Biol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1073\/pnas.0603243104","article-title":"Pleiotrophin is a neurotrophic factor for spinal motor neurons","volume":"104","author":"Mi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.celrep.2013.03.025","article-title":"Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs","volume":"3","author":"Mica","year":"2013","journal-title":"Cell Rep."},{"key":"ref94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-7506-9552-7.50010-7","article-title":"Schwann cells and myelin in the peripheral nervous system","volume-title":"Biopsy diagnosis of peripheral neuropathy","author":"Midroni","year":"1995"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"7300","DOI":"10.1523\/JNEUROSCI.0900-21.2021","article-title":"Schwann cells provide Iron to axonal mitochondria and its role in nerve regeneration","volume":"41","author":"Mietto","year":"2021","journal-title":"J. Neurosci."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"e1700220","DOI":"10.1126\/sciadv.1700220","article-title":"Peripheral myelin protein 22 alters membrane architecture","volume":"3","author":"Mittendorf","year":"2017","journal-title":"Sci. Adv."},{"key":"ref97","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/glia.23793","article-title":"The properties of human Schwann cells: lessons from in vitro culture and transplantation studies","volume":"68","author":"Monje","year":"2020","journal-title":"Glia"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"6637","DOI":"10.1007\/s12035-017-0837-3","article-title":"Phenotypic and functional characteristics of human Schwann cells as revealed by cell-based assays and RNA-SEQ","volume":"55","author":"Monje","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jneuroim.2005.04.013","article-title":"Antibodies induced by ganglioside-mimicking Campylobacter jejuni lipooligosaccharides recognise epitopes at the nodes of Ranvier","volume":"165","author":"Moran","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.expneurol.2014.10.018","article-title":"Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush","volume":"263","author":"Morrison","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"9932","DOI":"10.1523\/JNEUROSCI.2483-12.2013","article-title":"Activation of NF-B in Schwann cells is dispensable for myelination in vivo","volume":"33","author":"Morton","year":"2013","journal-title":"J. Neurosci."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41551-019-0381-8","article-title":"Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder","volume":"3","author":"Mukherjee-Clavin","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.actbio.2018.10.011","article-title":"Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells","volume":"82","author":"Muller","year":"2018","journal-title":"Acta Biomater."},{"key":"ref104","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/s41434-021-00231-3","article-title":"AAV1.NT-3 gene therapy for X-linked Charcot\u2013Marie\u2013Tooth neuropathy type 1","volume":"29","author":"Ozes","year":"2022","journal-title":"Gene Ther."},{"key":"ref105","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.3390\/cells11111786","article-title":"CD200R1 contributes to successful functional Reinnervation after a sciatic nerve injury","volume":"11","author":"Pannunzio","year":"2022","journal-title":"Cells"},{"key":"ref106","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.3390\/molecules26082141","article-title":"Dabrafenib promotes Schwann cell differentiation by inhibition of the MEK-ERK pathway","volume":"26","author":"Park","year":"2021","journal-title":"Molecules"},{"key":"ref107","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nm1023","article-title":"Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot\u2013Marie\u2013Tooth disease","volume":"10","author":"Passage","year":"2004","journal-title":"Nat. Med."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/glia.22922","article-title":"Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking: PLP in peripheral myelin","volume":"64","author":"Patzig","year":"2016","journal-title":"Glia"},{"key":"ref109","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1038\/s41598-020-66266-5","article-title":"Energy metabolism and mitochondrial defects in X-linked Charcot\u2013Marie\u2013Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation","volume":"10","author":"Perez-Siles","year":"2020","journal-title":"Sci. Rep."},{"key":"ref110","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ymgme.2018.08.005","article-title":"Identification of a pathogenic PMP2 variant in a multi-generational family with CMT type 1: clinical gene panels versus genome-wide approaches to molecular diagnosis","volume":"125","author":"Punetha","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/ar.23918","article-title":"Developing an in vitro model to screen drugs for nerve regeneration: in vitro model to screen drugs for nerve regeneration","volume":"301","author":"Rayner","year":"2018","journal-title":"Anat. Rec."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metabolism"},{"key":"ref113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-023-05607-4","article-title":"Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury","volume":"14","author":"Ren","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1126\/science.aao1785","article-title":"MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot\u2013Marie\u2013Tooth disease type 2A","volume":"360","author":"Rocha","year":"2018","journal-title":"Science"},{"key":"ref115","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.expneurol.2008.04.015","article-title":"Neurotrophin-3 deficient Schwann cells impair nerve regeneration","volume":"212","author":"Sahenk","year":"2008","journal-title":"Exp. Neurol."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.expneurol.2014.10.005","article-title":"Axonal Charcot\u2013Marie\u2013Tooth disease patient-derived motor neurons demonstrate disease-specific phenotypes including abnormal electrophysiological properties","volume":"263","author":"Saporta","year":"2015","journal-title":"Exp. Neurol."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1093\/brain\/awx048","article-title":"A human cellular model to study peripheral myelination and demyelinating neuropathies","volume":"140","author":"Saporta","year":"2017","journal-title":"Brain"},{"key":"ref118","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1093\/hmg\/ddy411","article-title":"Enhanced axonal neuregulin-1 type-III signaling ameliorates neurophysiology and hypomyelination in a Charcot\u2013Marie\u2013Tooth type 1B mouse model","volume":"28","author":"Scapin","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S0896-6273(00)80128-2","article-title":"A transgenic rat model of Charcot\u2013Marie\u2013Tooth disease","volume":"16","author":"Sereda","year":"1996","journal-title":"Neuron"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1517\/14656566.2011.564160","article-title":"The role of immunotherapy in Guillain\u2013Barr\u00e9 syndrome: understanding the mechanism of action","volume":"12","author":"Shahrizaila","year":"2011","journal-title":"Expert. Opin. Pharmacother."},{"key":"ref121","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.stemcr.2017.11.013","article-title":"Modeling the pathogenesis of Charcot\u2013Marie\u2013Tooth disease type 1A using patient-specific iPSCs","volume":"10","author":"Shi","year":"2018","journal-title":"Stem Cell Rep."},{"key":"ref122","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/00005072-198007000-00003","article-title":"Charcot\u2013Marie\u2013Tooth disease associated with hypertrophic neuropathy: a neuropathologic study of two cases","volume":"39","author":"Smith","year":"1980","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref123","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0092-8674(94)90048-5","article-title":"Functions of the neurotrophins during nervous system development: what the knockouts are teaching us","volume":"77","author":"Snider","year":"1994","journal-title":"Cells"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/WNR.0000000000001435","article-title":"Exosomes derived from differentiated Schwann cells inhibit Schwann cell migration via microRNAs","volume":"31","author":"Sohn","year":"2020","journal-title":"Neuroreport"},{"key":"ref125","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1002\/sctm.16-0122","article-title":"Direct conversion of human fibroblasts into Schwann cells that facilitate regeneration of injured peripheral nerve in vivo","volume":"6","author":"Sowa","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref126","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/1471-2199-8-117","article-title":"Differential regulation of NAB corepressor genes in Schwann cells","volume":"8","author":"Srinivasan","year":"2007","journal-title":"BMC Mol. Biol."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"6048","DOI":"10.3390\/ijms22116048","article-title":"Emerging therapies for Charcot\u2013Marie\u2013Tooth inherited neuropathies","volume":"22","author":"Stavrou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1212\/WNL.60.1.22","article-title":"Mutation of a putative protein degradation gene LITAF\/SIMPLE in Charcot\u2013Marie\u2013Tooth disease 1C","volume":"60","author":"Street","year":"2003","journal-title":"Neurology"},{"key":"ref129","doi-asserted-by":"publisher","first-page":"A105","DOI":"10.1227\/01.NEU.0000358537.30354.63","article-title":"Role of chronic Schwann cell denervation in poor functional recovery after nerve injuries and experimental strategies to combat it","volume":"65","author":"Sulaiman","year":"2009","journal-title":"Neurosurgery"},{"key":"ref130","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/356241a0","article-title":"Trembler mouse carries a point mutation in a myelin gene","volume":"356","author":"Suter","year":"1992","journal-title":"Nature"},{"key":"ref131","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1523\/JNEUROSCI.19-06-02059.1999","article-title":"A role for insulin-like growth factor-I in the regulation of Schwann cell survival","volume":"19","author":"Syroid","year":"1999","journal-title":"J. Neurosci."},{"key":"ref132","doi-asserted-by":"publisher","first-page":"ENEURO.0353-22.2023","DOI":"10.1523\/ENEURO.0353-22.2023","article-title":"Glycolytic system in axons supplement decreased ATP levels after axotomy of the peripheral nerve","volume":"10","author":"Takenaka","year":"2023","journal-title":"eNeuro"},{"key":"ref133","doi-asserted-by":"publisher","first-page":"23151","DOI":"10.1074\/jbc.M212986200","article-title":"Nerve growth factor blocks the glucose-induced down-regulation of caveolin-1 expression in Schwann cells via p75 Neurotrophin receptor signaling","volume":"278","author":"Tan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1159\/000489373","article-title":"Expression of Nrf2 promotes Schwann cell-mediated sciatic nerve recovery in diabetic peripheral neuropathy","volume":"46","author":"Tang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-62703-444-9_9","article-title":"Isolation and culture of Schwann cells","volume-title":"Neural development","author":"Tao","year":"2013"},{"key":"ref136","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.stemcr.2014.07.014","article-title":"Chemical conversion of human fibroblasts into functional Schwann cells","volume":"3","author":"Thoma","year":"2014","journal-title":"Stem Cell Rep."},{"key":"ref137","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1046\/j.1471-4159.1994.63051646.x","article-title":"Biochemical and cellular properties of three immortalized Schwann cell lines expressing different levels of the myelin-associated glycoprotein","volume":"63","author":"Toda","year":"2002","journal-title":"J. Neurochem."},{"key":"ref138","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/371796a0","article-title":"Krox-20 controls myelination in the peripheral nervous system","volume":"371","author":"Topilko","year":"1994","journal-title":"Nature"},{"key":"ref139","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1080\/01616412.2018.1504157","article-title":"Thymoquinone protects DRG neurons from axotomy-induced cell death","volume":"40","author":"\u00dcst\u00fcn","year":"2018","journal-title":"Neurol. Res."},{"key":"ref140","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1093\/brain\/awab226","article-title":"Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction","volume":"144","author":"Van Lent","year":"2021","journal-title":"Brain"},{"key":"ref141","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41592-021-01206-3","article-title":"The power of imaging to understand extracellular vesicle biology in vivo","volume":"18","author":"Verweij","year":"2021","journal-title":"Nat. Methods"},{"key":"ref142","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1749-6632.2002.tb02108.x","article-title":"Oxidative stress and programmed cell death in diabetic neuropathy","volume":"959","author":"Vincent","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref143","first-page":"369","article-title":"Experiments on the section of the glosso-pharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres","volume":"76","author":"Waller","year":"1985","journal-title":"Edinb. Med. Surg. J."},{"key":"ref144","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainres.2011.01.098","article-title":"Schwann-like mesenchymal stem cells within vein graft facilitate facial nerve regeneration and remyelination","volume":"1383","author":"Wang","year":"2011","journal-title":"Brain Res."},{"key":"ref145","doi-asserted-by":"publisher","first-page":"114059","DOI":"10.1016\/j.biopha.2022.114059","article-title":"Inhibiting apoptosis of Schwann cell under the high-glucose condition: a promising approach to treat diabetic peripheral neuropathy using Chinese herbal medicine","volume":"157","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref146","doi-asserted-by":"publisher","first-page":"10042","DOI":"10.1038\/s41598-018-28190-7","article-title":"Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref147","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1212\/WNL.44.12.2383","article-title":"Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot\u2013Marie\u2013Tooth disease type 1","volume":"44","author":"Watson","year":"1994","journal-title":"Neurology"},{"key":"ref148","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neuron.2020.03.031","article-title":"Macrophages expressing GALC improve peripheral Krabbe disease by a mechanism independent of cross-correction","volume":"107","author":"Weinstock","year":"2020","journal-title":"Neuron"},{"key":"ref149","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/stem.3287","article-title":"Fibulin 5, a human Wharton\u2019s jelly-derived mesenchymal stem cells-secreted paracrine factor, attenuates peripheral nervous system myelination defects through the integrin-RAC1 signaling axis","volume":"38","author":"Won","year":"2020","journal-title":"Stem Cells"},{"key":"ref150","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.atherosclerosis.2006.08.030","article-title":"Diabetic atherosclerosis mouse models","volume":"191","author":"Wu","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/cbin.11613","article-title":"Nerve conduit based on HAP\/PDLLA\/PRGD for peripheral nerve regeneration with sustained release of valproic acid","volume":"45","author":"Wu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref152","first-page":"547","article-title":"Neurotrophic effects of Schwann cells in culture on spinal anterior horn neurons","volume":"109","author":"Wu","year":"1996","journal-title":"Chin. Med. J."},{"key":"ref153","doi-asserted-by":"publisher","first-page":"8974","DOI":"10.7150\/thno.44912","article-title":"Mechanical stimulation of Schwann cells promote peripheral nerve regeneration via extracellular vesicle-mediated transfer of microRNA 23b-3p","volume":"10","author":"Xia","year":"2020","journal-title":"Theranostics"},{"key":"ref154","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.devcel.2021.02.022","article-title":"Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation","volume":"56","author":"Yang","year":"2021","journal-title":"Dev. Cell"},{"key":"ref155","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/2051-5960-2-5","article-title":"A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain\u2013Barr\u00e9 syndrome","volume":"2","author":"Yang","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"ref156","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.mcn.2008.01.017","article-title":"Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis","volume":"38","author":"Yang","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"ref157","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1096\/fj.03-0199fje","article-title":"Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease","volume":"17","author":"Zehntner","year":"2003","journal-title":"FASEB J."},{"key":"ref158","doi-asserted-by":"publisher","first-page":"103061","DOI":"10.1016\/j.ebiom.2020.103061","article-title":"SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice","volume":"61","author":"Zhu","year":"2020","journal-title":"EBioMedicine"},{"key":"ref159","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1091\/mbc.E12-07-0544","article-title":"Mutation of SIMPLE in Charcot\u2013Marie\u2013Tooth 1C alters production of exosomes","volume":"24","author":"Zhu","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref160","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s12015-010-9198-2","article-title":"Efficient generation of Schwann cells from human embryonic stem cell-derived Neurospheres","volume":"7","author":"Ziegler","year":"2011","journal-title":"Stem Cell Rev. Rep."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2023.1248922\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:55:21Z","timestamp":1697093721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2023.1248922\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":161,"alternative-id":["10.3389\/fncel.2023.1248922"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2023.1248922","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"article-number":"1248922"}}