{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:22:58Z","timestamp":1768684978645,"version":"3.49.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca<jats:sup>2+<\/jats:sup>. However, the manner in which Ca<jats:sup>2+<\/jats:sup> in dorsal striatum astrocytes impacts neuronal signaling after exposure to self-administered cocaine remains unclear. We addressed this question following over-expression of the Ca<jats:sup>2+<\/jats:sup> extrusion pump, hPMCA2w\/b, in dorsal striatum astrocytes and the Ca<jats:sup>2+<\/jats:sup> indicator, GCaMP6f, in dorsal striatum neurons of rats that were trained to self-administer cocaine. Following extinction of cocaine-seeking behavior, the rats over-expressing hMPCA2w\/b showed a significant increase in cue-induced reinstatement of cocaine seeking. Suppression of astrocyte Ca<jats:sup>2+<\/jats:sup> increased the amplitude of neuronal Ca<jats:sup>2+<\/jats:sup> transients in brain slices, but only after cocaine self-administration. This was accompanied by decreased duration of neuronal Ca<jats:sup>2+<\/jats:sup> events in the cocaine group and no changes in Ca<jats:sup>2+<\/jats:sup> event frequency. Acute administration of cocaine to brain slices decreased amplitude of neuronal Ca<jats:sup>2+<\/jats:sup> in both the control and cocaine self-administration groups regardless of hPMCA2w\/b expression. These results indicated that astrocyte Ca<jats:sup>2+<\/jats:sup> control over neuronal Ca<jats:sup>2+<\/jats:sup> transients was enhanced by cocaine self-administration experience, although sensitivity to acutely applied cocaine remained comparable across all groups. To explore this further, we found that neither the hMPCA2w\/b expression nor the cocaine self-administration experience altered regulation of neuronal Ca<jats:sup>2+<\/jats:sup> events by NPS-2143, a Ca<jats:sup>2+<\/jats:sup> sensing receptor (CaSR) antagonist, suggesting that plasticity of neuronal signaling after hPMCA2w\/b over-expression was unlikely to result from elevated extracellular Ca<jats:sup>2+<\/jats:sup>. We conclude that astrocyte Ca<jats:sup>2+<\/jats:sup> in the dorsal striatum impacts neurons via cell-intrinsic mechanisms (e.g., gliotransmission, metabolic coupling, etc.) and impacts long-term neuronal plasticity after cocaine self-administration differently from neuronal response to acute cocaine. Overall, astrocyte Ca<jats:sup>2+<\/jats:sup> influences neuronal output in the dorsal striatum to promote resistance to cue-induced reinstatement of cocaine seeking.<\/jats:p>","DOI":"10.3389\/fncel.2024.1347491","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T04:35:39Z","timestamp":1724906139000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Astrocyte Ca2+ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking"],"prefix":"10.3389","volume":"18","author":[{"given":"Navid S.","family":"Tavakoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha G.","family":"Malone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanner L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryson E.","family":"Neeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artin","family":"Asadipooya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Bardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel I.","family":"Ortinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1530\/JME-21-0058","article-title":"Heterogeneity of G protein activation by the calcium-sensing receptor","volume":"67","author":"Abid","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"13819","DOI":"10.1523\/JNEUROSCI.2601-12.2012","article-title":"Optimization of a GCaMP calcium indicator for neural activity imaging","volume":"32","author":"Akerboom","year":"2012","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"011402","DOI":"10.1117\/1.NPh.7.1.011402","article-title":"Interpreting in vivo calcium signals from neuronal cell bodies, axons, and dendrites: a review","volume":"7","author":"Ali","year":"2020","journal-title":"Neurophotonics"},{"key":"B4","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1523\/JNEUROSCI.1554-07.2007","article-title":"The role of the dorsal striatum in reward and decision-making","volume":"27","author":"Balleine","year":"2007","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bbr.2008.10.034","article-title":"The integrative function of the basal ganglia in instrumental conditioning","volume":"199","author":"Balleine","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1113\/JP270988","article-title":"Role of astrocyte-synapse interactions in CNS disorders","volume":"595","author":"Blanco-Suarez","year":"2017","journal-title":"J. Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1038\/npp.2014.135","article-title":"Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence","volume":"39","author":"Bull","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1073\/pnas.1521238113","article-title":"In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward","volume":"113","author":"Calipari","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13293-023-00525-8","article-title":"Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex","volume":"14","author":"Catalfio","year":"2023","journal-title":"Biol. Sex Differ."},{"key":"B10","doi-asserted-by":"publisher","first-page":"5757","DOI":"10.1523\/JNEUROSCI.2369-19.2020","article-title":"Astrocyte signaling gates long-term depression at corticostriatal synapses of the direct pathway","volume":"40","author":"Cavaccini","year":"2020","journal-title":"J. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"Chen","year":"2013","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/sj.npp.1300789","article-title":"Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: role of drug-environment conditioning","volume":"31","author":"Chinen","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/npp.2013.229","article-title":"Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP","volume":"39","author":"Chiodi","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1111\/ejn.12904","article-title":"Electrophysiological evidence of alterations to the nucleus accumbens and dorsolateral striatum during chronic cocaine self-administration","volume":"41","author":"Coffey","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/s41386-020-0721-0","article-title":"Cortical astrocytes regulate ethanol consumption and intoxication in mice","volume":"46","author":"Erickson","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pnpbp.2018.01.002","article-title":"Modeling cocaine relapse in rodents: behavioral considerations and circuit mechanisms","volume":"87","author":"Farrell","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1471-2202-11-29","article-title":"Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration","volume":"11","author":"Freeman","year":"2010","journal-title":"BMC Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1523\/JNEUROSCI.5146-05.2006","article-title":"Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen","volume":"26","author":"Fuchs","year":"2006","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.brainres.2011.08.030","article-title":"Lesions and reversible inactivation of the dorsolateral caudate-putamen impair cocaine-primed reinstatement to cocaine-seeking in rats","volume":"1417","author":"Gabriele","year":"2011","journal-title":"Brain Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1523\/JNEUROSCI.3349-17.2018","article-title":"Dopamine triggers CTCF-dependent morphological and genomic remodeling of astrocytes","volume":"38","author":"Galloway","year":"2018","journal-title":"J. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0038-16.2016","article-title":"Voltage dependence of a neuromodulator-activated ionic current","author":"Gray","year":"2016","journal-title":"eNeuro"},{"key":"B22","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fncel.2017.00427","article-title":"Functional roles of astrocyte calcium elevations: from synapses to behavior","volume":"11","author":"Guerra-Gomes","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00213-012-2713-1","article-title":"Development of stereotyped behaviors during prolonged escalation of methamphetamine self-administration in rats","volume":"223","author":"Hadamitzky","year":"2012","journal-title":"Psychopharmacology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1146\/annurev-physiol-021909-135843","article-title":"Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior","volume":"72","author":"Halassa","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41386-023-01580-w","article-title":"Membrane excitability of nucleus accumbens neurons gates the incubation of cocaine craving","volume":"48","author":"He","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1042\/EBC20220136","article-title":"Astrocyte heterogeneity and interactions with local neural circuits","volume":"67","author":"Holt","year":"2023","journal-title":"Essays Biochem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5079","DOI":"10.1523\/JNEUROSCI.23-12-05079.2003","article-title":"Cooperative activation of dopamine D1 and D2 receptors increases spike firing of nucleus accumbens neurons via G-protein betagamma subunits","volume":"23","author":"Hopf","year":"2003","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1176\/appi.ajp.162.8.1403","article-title":"The neural basis of addiction: a pathology of motivation and choice","volume":"162","author":"Kalivas","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.biopsych.2020.04.023","article-title":"Activation of astrocytes in the dorsomedial striatum facilitates transition from habitual to goal-directed reward-seeking behavior","volume":"88","author":"Kang","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.coph.2008.12.003","article-title":"Glutamate and reinstatement","volume":"9","author":"Knackstedt","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1038\/s41380-021-01333-5","article-title":"Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals","volume":"27","author":"Kruyer","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.biopsych.2022.12.024","article-title":"Rewiring of prelimbic inputs to the nucleus accumbens core underlies cocaine-induced behavioral sensitization","volume":"94","author":"Kwon","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/ADM.0b013e318199d863","article-title":"Gene expression profiling reveals distinct cocaine-responsive genes in human fetal CNS cell types","volume":"3","author":"Lee","year":"2009","journal-title":"J. Addict. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-3-030-81147-1_4","article-title":"The brain's reward system in health and disease","volume":"1344","author":"Lewis","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnsys.2019.00028","article-title":"Dorsal striatal circuits for habits, compulsions and addictions","volume":"13","author":"Lipton","year":"2019","journal-title":"Front. Syst. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"20130609","DOI":"10.1098\/rstb.2013.0609","article-title":"GABAergic interneuron to astrocyte signalling: a neglected form of cell communication in the brain","volume":"369","author":"Losi","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond,. B,. Biol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.neuron.2010.09.014","article-title":"Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex","volume":"68","author":"Lu","year":"2010","journal-title":"Neuron"},{"key":"B39","doi-asserted-by":"publisher","first-page":"13180","DOI":"10.1523\/JNEUROSCI.2369-11.2011","article-title":"Acute cocaine induces fast activation of D1 receptor and progressive deactivation of D2 receptor striatal neurons: in vivo optical microprobe [Ca2+]i imaging","volume":"31","author":"Luo","year":"2011","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1126\/science.aaa7945","article-title":"Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways","volume":"349","author":"Mart\u00edn","year":"2015","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.brainres.2009.08.074","article-title":"Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain","volume":"1298","author":"Mud\u00f2","year":"2009","journal-title":"Brain Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.cell.2019.03.019","article-title":"Hyperactivity with disrupted attention by activation of an astrocyte synaptogenic cue","volume":"177","author":"Nagai","year":"2019","journal-title":"Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"620869","DOI":"10.3389\/fnins.2021.620869","article-title":"Comparative effects of event detection methods on the analysis and interpretation of Ca(2+) imaging data","volume":"15","author":"Neugornet","year":"2021","journal-title":"Front. Neurosci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev.neuro.23.1.185","article-title":"Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens","volume":"23","author":"Nicola","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e13042","DOI":"10.1111\/adb.13042","article-title":"Cocaine experience induces functional adaptations in astrocytes: Implications for synaptic plasticity in the nucleus accumbens shell","volume":"26","author":"O'Donovan","year":"2021","journal-title":"Addict. Biol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/s12035-014-8636-6","article-title":"Cocaine-induced changes in NMDA receptor signaling","volume":"50","author":"Ortinski","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.neuropharm.2015.01.002","article-title":"Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons","volume":"92","author":"Ortinski","year":"2015","journal-title":"Neuropharmacology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"104651","DOI":"10.1016\/j.neubiorev.2022.104651","article-title":"Control of complex behavior by astrocytes and microglia","volume":"137","author":"Ortinski","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"9451","DOI":"10.1523\/JNEUROSCI.5730-12.2013","article-title":"Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration","volume":"33","author":"Ortinski","year":"2013","journal-title":"J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41386-022-01429-8","article-title":"Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice","volume":"48","author":"Pascoli","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1074\/mcp.RA118.000922","article-title":"Identification of novel protein targets of dimethyl fumarate modification in neurons and astrocytes reveals actions independent of Nrf2 stabilization","volume":"18","author":"Piroli","year":"2019","journal-title":"Mol. Cell. Proteomics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.beem.2013.03.001","article-title":"Roles of the calcium sensing receptor in the central nervous system","volume":"27","author":"Ruat","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"B53","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1523\/JNEUROSCI.0017-17.2017","article-title":"Gliotransmission: beyond black-and-white","volume":"38","author":"Savtchouk","year":"2018","journal-title":"J. Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1038\/sj.npp.1300918","article-title":"Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell","volume":"31","author":"Schramm-Sapyta","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.biopsych.2015.02.016","article-title":"Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking","volume":"78","author":"Scofield","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"B56","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.biopsych.2015.12.022","article-title":"Cocaine self-administration and extinction leads to reduced glial fibrillary acidic protein expression and morphometric features of astrocytes in the nucleus accumbens core","volume":"80","author":"Scofield","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1101\/lm.81404","article-title":"Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration","volume":"11","author":"Self","year":"2004","journal-title":"Learn. Mem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1085\/jgp.201210949","article-title":"Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses","volume":"141","author":"Shigetomi","year":"2013","journal-title":"J. Gen. Physiol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s11920-011-0224-0","article-title":"New findings on biological factors predicting addiction relapse vulnerability","volume":"13","author":"Sinha","year":"2011","journal-title":"Curr. Psychiatry Rep."},{"key":"B60","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.conb.2013.01.026","article-title":"Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)","volume":"23","author":"Smith","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3389\/fncel.2018.00246","article-title":"Region-specific reductions in morphometric properties and synaptic colocalization of astrocytes following cocaine self-administration and extinction","volume":"12","author":"Testen","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"S213","DOI":"10.4103\/2230-8210.104041","article-title":"Calcium-sensing receptor: Role in health and disease","volume":"16","author":"Thakker","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"key":"B63","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/bjp.2008.77","article-title":"Neuroplasticity in the mesolimbic dopamine system and cocaine addiction","volume":"154","author":"Thomas","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"53825","DOI":"10.3791\/53825-v","article-title":"Preparation of acute brain slices using an optimized N-methyl-D-glucamine protective recovery method","volume":"26","author":"Ting","year":"2018","journal-title":"J. Vis. Exp"},{"key":"B65","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1476-5381.1990.tb12999.x","article-title":"Actions of cocaine on rat nucleus accumbens neurones in vitro","volume":"99","author":"Uchimura","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e49536","DOI":"10.7554\/eLife.49536.028","article-title":"Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training","volume":"8","author":"Vandaele","year":"2019","journal-title":"Elife"},{"key":"B67","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1523\/JNEUROSCI.0925-05.2005","article-title":"Involvement of the dorsal striatum in cue-controlled cocaine seeking","volume":"25","author":"Vanderschuren","year":"2005","journal-title":"J. Neurosci."},{"key":"B68","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.biopsych.2018.04.009","article-title":"Cocaine self-administration alters transcriptome-wide responses in the brain's reward circuitry","volume":"84","author":"Walker","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B69","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41380-021-01080-7","article-title":"Astrocytes in cocaine addiction and beyond","volume":"27","author":"Wang","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.biopsych.2020.08.012","article-title":"Cocaine triggers astrocyte-mediated synaptogenesis","volume":"89","author":"Wang","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1038\/s41467-023-37045-3","article-title":"Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"3152","DOI":"10.1038\/s41380-020-00921-1","article-title":"Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal","volume":"26","author":"Wang","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e37673","DOI":"10.1371\/journal.pone.0037673","article-title":"Differences in rat dorsal striatal NMDA and AMPA receptors following acute and repeated cocaine-induced locomotor activation","volume":"7","author":"Yamamoto","year":"2012","journal-title":"PLoS ONE"},{"key":"B74","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1101\/lm.81004","article-title":"Contributions of striatal subregions to place and response learning","volume":"11","author":"Yin","year":"2004","journal-title":"Learn. Mem."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/s41586-023-05828-9","article-title":"Fast and sensitive GCaMP calcium indicators for imaging neural populations","volume":"615","author":"Zhang","year":"2023","journal-title":"Nature"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1347491\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T04:35:53Z","timestamp":1724906153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1347491\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":76,"alternative-id":["10.3389\/fncel.2024.1347491"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2024.1347491","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"article-number":"1347491"}}