{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:27:43Z","timestamp":1769074063195,"version":"3.49.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Stroke, resulting in hypoxia and glucose deprivation, is a leading cause of death and disability worldwide. Presently, there are no treatments that reduce neuronal damage and preserve function aside from tissue plasminogen activator administration and rehabilitation therapy. Interestingly, <jats:italic>Drosophila melanogaster<\/jats:italic>, the common fruit fly, demonstrates robust hypoxic tolerance, characterized by minimal effects on survival and motor function following systemic hypoxia. Due to its organized brain, conserved neurotransmitter systems, and genetic similarity to humans and other mammals, uncovering the mechanisms of <jats:italic>Drosophila\u2019s<\/jats:italic> tolerance could be a promising approach for the development of new therapeutics. Interestingly, a key facet of hypoxic tolerance in <jats:italic>Drosophila<\/jats:italic> is organism-wide metabolic suppression, a response involving multiple genes and pathways. Specifically, studies have demonstrated that pathways associated with oxidative stress, insulin, hypoxia-inducible factors, NF\u03baB, Wnt, Hippo, and Notch, all potentially contribute to <jats:italic>Drosophila<\/jats:italic> hypoxic tolerance. While manipulating the oxidative stress response and insulin signaling pathway has similar outcomes in <jats:italic>Drosophila<\/jats:italic> hypoxia and the mammalian middle cerebral artery occlusion (MCAO) model of ischemia, effects of Notch pathway manipulation differ between <jats:italic>Drosophila<\/jats:italic> and mammals. Additional research is warranted to further explore how other pathways implicated in hypoxic tolerance in <jats:italic>Drosophila<\/jats:italic>, such as NF\u03baB, and Hippo, may be utilized to benefit mammalian response to ischemia. Together, these studies demonstrate that exploration of the hypoxic response in <jats:italic>Drosophila<\/jats:italic> may lead to new avenues of research for stroke treatment in humans.<\/jats:p>","DOI":"10.3389\/fncel.2024.1347980","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T04:20:39Z","timestamp":1711081239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["What can the common fruit fly teach us about stroke?: lessons learned from the hypoxic tolerant Drosophila melanogaster"],"prefix":"10.3389","volume":"18","author":[{"given":"Princy S.","family":"Quadros-Mennella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt M.","family":"Lucin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin E.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9756429","DOI":"10.1155\/2017\/9756429","article-title":"To use or not to use metformin in cerebral ischemia: a review of the application of metformin in stroke rodents","volume":"2017","author":"Arbel\u00e1ez-Quintero","year":"2017","journal-title":"Stroke Res. Treat."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1146\/annurev-ento-112408-085356","article-title":"Insect fat body: energy, metabolism, and regulation","volume":"55","author":"Arrese","year":"2010","journal-title":"Annu. Rev. Entomol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pneurobio.2018.03.002","article-title":"Notch signaling and neuronal death in stroke","author":"Arumugam","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1534\/g3.112.003681","article-title":"Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen","volume":"2","author":"Azad","year":"2012","journal-title":"G3 (Bethesda, Md.)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"bio053629","DOI":"10.1242\/bio.053629","article-title":"Compartment and cell-type specific hypoxia responses in the developing Drosophila brain","volume":"9","author":"Baccino-Calace","year":"2020","journal-title":"Biol. Open."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e00127","DOI":"10.1042\/BSR20140095","article-title":"Hypoxia activates IKK-NF-\u03baB and the immune response in Drosophila melanogaster","volume":"34","author":"Bandarra","year":"2014","journal-title":"Biosci. Rep."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1534\/genetics.120.303219","article-title":"Tolerance to hypoxia is promoted by FOXO regulation of the innate immunity transcription factor NF-\u03baB\/relish in Drosophila","volume":"215","author":"Barretto","year":"2020","journal-title":"Genetics"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1002\/mrd.22228","article-title":"Wingless\/Wnt signaling in Drosophila: the pattern and the pathway","volume":"80","author":"Bejsovec","year":"2013","journal-title":"Mol. Reprod. Dev."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signaling: a simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"jeb177147","DOI":"10.1242\/jeb.177147","article-title":"Paralytic hypo-energetic state facilitates anoxia tolerance despite ionic imbalance in adult Drosophila melanogaster","volume":"221","author":"Campbell","year":"2018","journal-title":"J. Exp. Biol."},{"key":"ref11","first-page":"2989","article-title":"Genome-wide association analysis of anoxia tolerance in drosophila melanogaster","author":"Campbell","year":""},{"key":"ref12","doi-asserted-by":"publisher","first-page":"R442","DOI":"10.1152\/ajpregu.00389.2018","article-title":"Metabolomics of anoxia tolerance in Drosophila melanogaster: evidence against substrate limitation and for roles of protective metabolites and paralytic hypometabolism","volume":"317","author":"Campbell","year":"","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/sj.embor.7400528","article-title":"Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha\/Sima","volume":"6","author":"Centanin","year":"2005","journal-title":"EMBO Rep."},{"key":"ref14","year":"2023"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1007980","DOI":"10.1371\/journal.pgen.1007980","article-title":"Glial response to hypoxia in mutants of NPAS1\/3 homolog Trachealess through Wg signaling to modulate synaptic Bouton organization","volume":"15","author":"Chen","year":"2019","journal-title":"PLoS Genet."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejphar.2019.05.010","article-title":"Inhibition of p70 ribosomal S6 kinase 1 (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability","volume":"855","author":"Chi","year":"2019","journal-title":"Eur. J. Pharm."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fcell.2018.00175","article-title":"Hypoxia mimetic agents for ischemic stroke","volume":"6","author":"Davis","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5431","DOI":"10.1242\/jcs.02648","article-title":"The insulin-PI3K\/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha\/Sima","volume":"118","author":"Dekanty","year":"2005","journal-title":"J. Cell Sci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"11131","DOI":"10.3390\/ijms222011131","article-title":"Hypoxia tolerant species: the wisdom of nature translated into targets for stroke therapy","volume":"22","author":"Del R\u00edo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1242\/bio.026294","article-title":"Investigation of protein synthesis in Drosophila larvae using puromycin labelling","volume":"6","author":"Deliu","year":"2017","journal-title":"Biol. Open."},{"key":"ref9001","first-page":"jkac263","article-title":"Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila","author":"Ding","year":"2022"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1242\/dev.126.17.3937","article-title":"The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila","volume":"126","author":"Emmons","year":"1999","journal-title":"Development"},{"key":"ref9002","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"ref9003","doi-asserted-by":"publisher","first-page":"13648","DOI":"10.3390\/ijms232113648","article-title":"E3 ubiquitin ligase FBXO3 drives neuroinflammation to aggravate cerebral ischemia\/reperfusion injury","volume":"23","author":"Gao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e103292","DOI":"10.1371\/journal.pone.0103292","article-title":"Wnt pathway activation increases hypoxia tolerance during development","volume":"9","author":"Gersten","year":"2014","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1086\/648581","article-title":"Hypoxia tolerance in animals: biology and application","volume":"83","author":"Gorr","year":"2010","journal-title":"Physiol. Biochem. Zool."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1139\/bcb-2016-0233","article-title":"Osthole prevents cerebral ischemia-reperfusion injury via the notch signaling pathway","volume":"95","author":"Guan","year":"2017","journal-title":"Biochem. Cell Biol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s12276-021-00565-3","article-title":"Posthypoxic behavioral impairment and mortality of Drosophila melanogaster are associated with high temperatures, enhanced predeath activity and oxidative stress","volume":"53","author":"Habib","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"10809","DOI":"10.1073\/pnas.94.20.10809","article-title":"Genetic basis of tolerance to O2 deprivation in Drosophila melanogaster","volume":"94","author":"Haddad","year":"","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0022-1910(96)00084-4","article-title":"Behavioral and Electrophysiologic responses of Drosophila melanogaster to prolonged periods of anoxia","volume":"43","author":"Haddad","year":"","journal-title":"J. Insect Physiol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1749-6632.2010.05735.x","article-title":"NF-\u03baB and innate immunity in ischemic stroke","volume":"1207","author":"Harari","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"801985","DOI":"10.3389\/fimmu.2021.801985","article-title":"Biological functions and regulatory mechanisms of hypoxia-inducible factor-1\u03b1 in ischemic stroke","volume":"12","author":"He","year":"2021","journal-title":"Front. Immunol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.4049\/jimmunol.169.4.2069","article-title":"Hypoxia diminishes toll-like receptor 4 expression through reactive oxygen species generated by mitochondria in endothelial cells","volume":"169","author":"Ishida","year":"2002","journal-title":"J. Immunol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2174\/1570159X13666150205143555","article-title":"Neuropharmacological actions of metformin in stroke","volume":"13","author":"Jia","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"101634","DOI":"10.1016\/j.xpro.2022.101634","article-title":"Standardized hypoxia-reoxygenation protocol to assess posthypoxic neurobehavioral impairments and molecular mechanisms in Drosophila melanogaster","volume":"3","author":"Jung","year":"2022","journal-title":"STAR Protoc."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/14728222.2018.1439477","article-title":"The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke","volume":"22","author":"Kim","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"11586","DOI":"10.3390\/ijms222111586","article-title":"Increased post-hypoxic oxidative stress and activation of the PERK branch of the UPR in Trap1-deficient Drosophila melanogaster is abrogated by metformin","volume":"22","author":"Kokott-Vuong","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Komiya","year":"2008","journal-title":"Organogenesis"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3389\/fncel.2015.00056","article-title":"Compensatory mechanisms in genetic models of neurodegeneration: are the mice better than humans?","volume":"9","author":"Kreiner","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1038\/s41467-019-09643-7","article-title":"TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila","volume":"10","author":"Lee","year":"2019","journal-title":"Nat. Commun."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"113645","DOI":"10.1016\/j.expneurol.2021.113645","article-title":"Lipoxin A4 regulates microglial M1\/M2 polarization after cerebral ischemia-reperfusion injury via the notch signaling pathway","volume":"339","author":"Li","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/jnc.14790","article-title":"Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment","volume":"150","author":"Li","year":"2019","journal-title":"J. Neurochem."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.brainres.2008.06.130","article-title":"Cell death and proliferation in NF-kappaB p50 knockout mouse after cerebral ischemia","volume":"1230","author":"Li","year":"2008","journal-title":"Brain Res."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1152\/physiolgenomics.00262.2005","article-title":"Identification and function of hypoxia-response genes in Drosophila melanogaster","volume":"25","author":"Liu","year":"2006","journal-title":"Physiol. Genomics"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0169-328X(99)00224-7","article-title":"Isolation and characterization of the hypoxia-inducible factor 1beta in Drosophila melanogaster","volume":"73","author":"Ma","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"6749","DOI":"10.1038\/sj.onc.1209940","article-title":"Nuclear factor-kappa B pathways in Drosophila","volume":"25","author":"Minakhina","year":"2006","journal-title":"Oncogene"},{"key":"ref9004","first-page":"296","article-title":"A genetically encoded biosensor for visualising hypoxia responses in vivo","volume":"6","author":"Misra","year":"2017","journal-title":"Biology Open."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"914537","DOI":"10.3389\/fphar.2022.914537","article-title":"Activation of Wnt\/beta-catenin signaling pathway as a promising therapeutic candidate for cerebral ischemia\/reperfusion injury","volume":"13","author":"Mo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref45","first-page":"658","article-title":"Metformin: current knowledge","volume":"19","author":"Nasri","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/gtc.12913","article-title":"Sima, a Drosophila homolog of HIF-1\u03b1, in fat body tissue inhibits larval body growth by inducing tribbles gene expression","volume":"27","author":"Noguchi","year":"2022","journal-title":"Genes Cells"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3390\/life12030437","article-title":"Notch signaling and cross-talk in hypoxia: a candidate pathway for high-altitude adaptation","volume":"12","author":"O'Brien","year":"2022","journal-title":"Life (Basel)."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"jeb226027","DOI":"10.1242\/jeb.226027","article-title":"Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila","volume":"223","author":"Polan","year":"2020","journal-title":"J. Exp. Biol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1001\/jama.2015.3058","article-title":"Acute stroke intervention: a systematic review","volume":"313","author":"Prabhakaran","year":"2015","journal-title":"JAMA"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0076-6879(07)35007-6","article-title":"Cellular and developmental adaptations to hypoxia: a Drosophila perspective","volume":"435","author":"Romero","year":"2007","journal-title":"Method Enzymol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1016\/j.devcel.2022.05.015","article-title":"Damage-responsive neuro-glial clusters coordinate the recruitment of dormant neural stem cells in Drosophila","volume":"57","author":"Sim\u00f5es","year":"2022","journal-title":"Dev. Cell"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3389\/fcell.2019.00085","article-title":"Hippo signaling in cancer: lessons from Drosophila models","volume":"7","author":"Snigdha","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.3390\/ijms22041862","article-title":"Drosophila homeodomain-interacting protein kinase (Hipk) phosphorylates hippo\/warts signalling effector Yorkie","volume":"22","author":"Steinmetz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1471-2202-14-41","article-title":"Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis","volume":"14","author":"Str\u00f6m","year":"2013","journal-title":"BMC Neurosci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1038\/s41467-019-09943-y","article-title":"A fat-tissue sensor couples growth to oxygen availability by remotely controlling insulin secretion","volume":"10","author":"Texada","year":"2019","journal-title":"Nat. Commun."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"649","DOI":"10.4049\/jimmunol.1002302","article-title":"The Drosophila toll signaling pathway","volume":"186","author":"Valanne","year":"2011","journal-title":"J. Immunol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e5422","DOI":"10.1371\/journal.pone.0005422","article-title":"Strong dietary restrictions protect Drosophila against anoxia\/reoxygenation injuries","volume":"4","author":"Vigne","year":"2009","journal-title":"PLoS One"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1161\/STROKEAHA.120.030486","article-title":"Blowing up neural repair for stroke recovery: preclinical and clinical trial considerations","volume":"51","author":"Ward","year":"2020","journal-title":"Stroke"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"e115297","DOI":"10.1371\/journal.pone.0115297","article-title":"Insulin- and warts-dependent regulation of tracheal plasticity modulates systemic larval growth during hypoxia in Drosophila melanogaster","volume":"9","author":"Wong","year":"2014","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-0529-0_1","article-title":"Drosophila as a model organism","volume":"1076","author":"Yamaguchi","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1002\/iub.2357","article-title":"Inhibition of microRNA-9-5p and microRNA-128-3p can inhibit ischemic stroke-related cell death in vitro and in vivo","volume":"72","author":"Yan","year":"2020","journal-title":"IUBMB Life"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"R1347","DOI":"10.1152\/ajpregu.00164.2015","article-title":"Cardiac responses to hypoxia and reoxygenation in Drosophila","volume":"309","author":"Zarndt","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1007\/s11064-022-03697-8","article-title":"Cell death mechanisms in cerebral ischemia-reperfusion injury","volume":"47","author":"Zhang","year":"2022","journal-title":"Neurochem. Res."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-genom-091212-153439","article-title":"Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans","volume":"14","author":"Zhou","year":"2013","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"jkab038","DOI":"10.1093\/g3journal\/jkab038","article-title":"Genetic interactions regulate hypoxia tolerance conferred by activating notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster","volume":"11","author":"Zhou","year":"2021","journal-title":"G3 (Bethesda)"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1073\/pnas.1010643108","article-title":"Experimental selection of hypoxia-tolerant Drosophila melanogaster","volume":"108","author":"Zhou","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1080\/00207454.2018.1564290","article-title":"FoxO3 transcription factor promotes autophagy after transient cerebral ischemia\/reperfusion","volume":"129","author":"Zhou","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"113828","DOI":"10.1016\/j.expneurol.2021.113828","article-title":"Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats","volume":"345","author":"Zhu","year":"2021","journal-title":"Exp. Neurol."}],"updated-by":[{"DOI":"10.3389\/fncel.2024.1422866","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000}}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1347980\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:48:36Z","timestamp":1715345316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1347980\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":72,"alternative-id":["10.3389\/fncel.2024.1347980"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2024.1347980","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fncel.2024.1422866","asserted-by":"object"}]},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]},"article-number":"1347980"}}