{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:16:19Z","timestamp":1780467379766,"version":"3.54.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Mitochondrial homeostasis includes balancing organelle biogenesis with recycling (mitophagy). The ketogenic diet protects retinal ganglion cells (RGCs) from glaucoma-associated neurodegeneration, with a concomitant increase in mitochondrial biogenesis. This study aimed to determine if the ketogenic diet also promoted mitophagy. MitoQC mice that carry a pH-sensitive mCherry-GFP tag on the outer mitochondrial membrane were placed on a ketogenic diet or standard rodent chow for 5\u2009weeks; ocular hypertension (OHT) was induced via magnetic microbead injection in a subset of control or ketogenic diet animals 1\u2009week after the diet began. As a measure of mitophagy, mitolysosomes were quantified in sectioned retina immunolabeled with RBPMS for RGCs or vimentin for M\u00fcller glia. Mitolysosomes were significantly increased as a result of OHT and the ketogenic diet (KD) in RGCs. Interestingly, the ketogenic diet increased mitolysosome number significantly higher than OHT alone. In contrast, OHT and the ketogenic diet both increased mitolysosome number in M\u00fcller glia to a similar degree. To understand if hypoxia could be a stimulus for mitophagy, we quantified mitolysosomes after acute OHT, finding significantly greater mitolysosome number in cells positive for pimonidazole, an adduct formed in cells exposed to hypoxia. Retinal protein analysis for BNIP3 and NIX showed no differences across groups, suggesting that these receptors were equivocal for mitophagy in this model of OHT. Our data indicate that OHT and hypoxia stimulate mitophagy and that the ketogenic diet is an additive for mitophagy in RGCs. The different response across RGCs and M\u00fcller glia to the ketogenic diet may reflect the different metabolic needs of these cell types.<\/jats:p>","DOI":"10.3389\/fncel.2024.1409717","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T04:46:31Z","timestamp":1716353191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The ketogenic diet and hypoxia promote mitophagy in the context of glaucoma"],"prefix":"10.3389","volume":"18","author":[{"given":"Autumn B.","family":"Morgan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1167\/iovs.05-1639","article-title":"Mitochondrial abnormalities in patients with primary open-angle Glaucoma","volume":"47","author":"Abu-Amero","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"5644","DOI":"10.1523\/jneurosci.5956-09.2010","article-title":"Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration","volume":"30","author":"Baltan","year":"2010","journal-title":"J. Neurosci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1128\/MCB.00166-09","article-title":"Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains","volume":"29","author":"Bellot","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1038\/s41380-020-00988-w","article-title":"Hippocampal neurons respond to brain activity with functional hypoxia","volume":"26","author":"Butt","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"100881","DOI":"10.1016\/j.preteyeres.2020.100881","article-title":"Retinal energy metabolism in health and glaucoma","volume":"81","author":"Casson","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics\u2013fusion, fission, movement, and mitophagy\u2013in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.3389\/fnins.2017.00478","article-title":"Investigations into hypoxia and oxidative stress at the optic nerve head in a rat model of Glaucoma","volume":"11","author":"Chidlow","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"101703","DOI":"10.1016\/j.redox.2020.101703","article-title":"AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration","volume":"37","author":"Choi","year":"2020","journal-title":"Redox Biol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1167\/iovs.14-16126","article-title":"Mitochondrial morphology differences and Mitophagy deficit in murine glaucomatous optic nerve","volume":"56","author":"Coughlin","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-017-0146-9","article-title":"Overexpression of parkin protects retinal ganglion cells in experimental glaucoma","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnins.2019.00005","article-title":"Ketogenic diet and epilepsy: what we know so far","volume":"13","author":"D\u2019Andrea Meira","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/antiox10050794","article-title":"Mitophagy and oxidative stress: the role of aging","volume":"10","author":"De Gaetano","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3389\/fnins.2014.00290","article-title":"Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA\/2J mouse model of glaucoma","volume":"8","author":"Dengler-Crish","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1080\/02713683.2018.1454478","article-title":"Neuroprotective effects of Psalmotoxin-1, an acid-sensing Ion Channel (ASIC) inhibitor, in ischemia reperfusion in mouse eyes","volume":"43","author":"Dibas","year":"2018","journal-title":"Curr. Eye Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1515\/hsz-2012-0119","article-title":"Mitophagy: mechanisms, pathophysiological roles, and analysis","volume":"393","author":"Ding","year":"2012","journal-title":"Biol. Chem."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.survophthal.2015.01.004","article-title":"The interactions of genes, age, and environment in glaucoma pathogenesis","volume":"60","author":"Doucette","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"33619","DOI":"10.1073\/pnas.2014213117","article-title":"Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin","volume":"117","author":"Harder","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1186\/s12974-018-1346-7","article-title":"Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma","volume":"15","author":"Harun-Or-Rashid","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1523\/jneurosci.3652-17.2018","article-title":"Structural and functional Rescue of Chronic Metabolically Stressed Optic Nerves through respiration","volume":"38","author":"Harun-Or-Rashid","year":"2018","journal-title":"J. Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1523\/jneurosci.2702-18.2019","article-title":"Mitochondrial uncoupling protein 2 Knock-out promotes Mitophagy to decrease retinal ganglion cell death in a mouse model of Glaucoma","volume":"39","author":"Hass","year":"2019","journal-title":"J. Neurosci."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41419-022-05418-z","article-title":"BNIP3 phosphorylation by JNK1\/2 promotes mitophagy via enhancing its stability under hypoxia","volume":"13","author":"He","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fnmol.2018.00350","article-title":"Overexpression of optic atrophy type 1 protects retinal ganglion cells and upregulates Parkin expression in experimental Glaucoma","volume":"11","author":"Hu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/jnr.23583","article-title":"Glucose, lactate, and shuttling of metabolites in vertebrate retinas","volume":"93","author":"Hurley","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnins.2017.00146","article-title":"Metabolic vulnerability in the neurodegenerative disease Glaucoma","volume":"11","author":"Inman","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1089\/ars.2020.8180","article-title":"Oxidative stress and hypoxia modify mitochondrial homeostasis during Glaucoma","volume":"35","author":"Jassim","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1167\/iovs.18-24977","article-title":"Evidence of hypoxic glial cells in a model of ocular hypertension","volume":"60","author":"Jassim","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3390\/antiox11050888","article-title":"Ocular hypertension results in hypoxia within glia and neurons throughout the visual projection","volume":"11","author":"Jassim","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"101205","DOI":"10.1016\/j.preteyeres.2023.101205","article-title":"Mitophagy in the retina: viewing mitochondrial homeostasis through a new lens","volume":"96","author":"Jim\u00e9nez-Loygorri","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.1167\/iovs.07-1661","article-title":"Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve","volume":"49","author":"Ju","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"8215","DOI":"10.1167\/iovs.15-17885","article-title":"Decreased energy capacity and increased Autophagic activity in optic nerve axons with defective anterograde transport","volume":"56","author":"Kleesattel","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"27628","DOI":"10.1074\/jbc.M805711200","article-title":"SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation","volume":"283","author":"Lan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"424","DOI":"10.5483\/bmbrep.2016.49.8.081","article-title":"Role of the mammalian ATG8\/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy","volume":"49","author":"Lee","year":"2016","journal-title":"BMB Rep."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.neuroscience.2006.11.065","article-title":"Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation","volume":"145","author":"Maalouf","year":"2007","journal-title":"Neuroscience"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.mehy.2015.08.002","article-title":"Ketosis may promote brain macroautophagy by activating Sirt1 and hypoxia-inducible factor-1","volume":"85","author":"McCarty","year":"2015","journal-title":"Med. Hypotheses"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1083\/jcb.201603039","article-title":"Mito-QC illuminates mitophagy and mitochondrial architecture in vivo","volume":"214","author":"McWilliams","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10555-007-9080-0","article-title":"The role of the hypoxia-inducible BH3-only proteins BNIP3 and BNIP3L in cancer","volume":"26","author":"Mellor","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"111196","DOI":"10.1016\/j.mad.2019.111196","article-title":"Semi-automated quantitation of mitophagy in cells and tissues","volume":"185","author":"Montava-Garriga","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.cub.2007.12.038","article-title":"Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers","volume":"18","author":"Neuspiel","year":"2008","journal-title":"Curr. Biol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.3390\/cells11233756","article-title":"Destabilizing COXIV in M\u00fcller glia increases retinal glycolysis and alters scotopic Electroretinogram","volume":"11","author":"Nsiah","year":"2022","journal-title":"Cells"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"20541","DOI":"10.1038\/s41598-023-47942-8","article-title":"Long-term HIF-1\u03b1 stabilization reduces respiration, promotes mitophagy, and results in retinal cell death","volume":"13","author":"Nsiah","year":"2023","journal-title":"Sci. Rep."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1038\/cdd.2015.86","article-title":"Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis","volume":"22","author":"Palikaras","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1007\/s11064-013-1017-0","article-title":"Immunohistochemical localization of glycogen synthase and GSK3\u03b2: control of glycogen content in retina","volume":"38","author":"P\u00e9rezLe\u00f3n","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.ajo.2013.05.027","article-title":"Lifetime risk of blindness in open-angle glaucoma","volume":"156","author":"Peters","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu14091952","article-title":"The therapeutic role of ketogenic diet in neurological disorders","volume":"14","author":"Pietrzak","year":"2022","journal-title":"Nutrients"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1038\/jcbfm.2008.79","article-title":"Neuroprotection in diet-induced Ketotic rat brain after focal ischemia","volume":"28","author":"Puchowicz","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria","volume":"113","author":"Richter","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"465","DOI":"10.3389\/fopht.2023.1290465","article-title":"Glial metabolic alterations during glaucoma pathogenesis","volume":"3","author":"Rombaut","year":"2023","journal-title":"Front. Ophthalmol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1089\/ars.2020.8058","article-title":"Mitochondrial reactive oxygen species and Mitophagy: a complex and nuanced relationship","volume":"34","author":"Schofield","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"6284","DOI":"10.1096\/fj.201903051R","article-title":"AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner","volume":"34","author":"Seabright","year":"2020","journal-title":"FASEB J."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.bbamcr.2010.08.006","article-title":"Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning","volume":"1813","author":"Semenza","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"749","DOI":"10.4103\/1673-5374.249218","article-title":"Mitophagy links oxidative stress conditions and neurodegenerative diseases","volume":"14","author":"Shefa","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"33830","DOI":"10.1038\/srep33830","article-title":"Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration","volume":"6","author":"Shim","year":"2016","journal-title":"Sci. Rep."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S0306-4522(96)00600-8","article-title":"Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells","volume":"78","author":"Silver","year":"1997","journal-title":"Neuroscience"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cub.2011.11.057","article-title":"A vesicular transport pathway shuttles cargo from mitochondria to lysosomes","volume":"22","author":"Soubannier","year":"2012","journal-title":"Curr. Biol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1001\/archopht.122.9.1348","article-title":"Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head","volume":"122","author":"Tezel","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1007\/s12035-017-0760-7","article-title":"A perspective on the M\u00fcller cell-neuron metabolic partnership in the inner retina","volume":"55","author":"Toft-Kehler","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1016\/j.devcel.2021.06.003","article-title":"Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy","volume":"56","author":"Towers","year":"2021","journal-title":"Dev. Cell"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: Mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol. Cell"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia\u2013neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2337\/diab.42.6.801","article-title":"Hyperglycemic pseudohypoxia and diabetic complications","volume":"42","author":"Williamson","year":"1993","journal-title":"Diabetes"},{"key":"ref63","first-page":"3183","article-title":"Energy metabolism in human retinal M\u00fcller cells","volume":"41","author":"Winkler","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-1-4419-1241-1_9","article-title":"Diet-induced ketosis improves cognitive performance in aged rats","volume":"662","author":"Xu","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01280-y","article-title":"Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species","author":"Yamashita","year":"2024","journal-title":"Cell Death Different."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"8315","DOI":"10.7150\/thno.45922","article-title":"Mitochondrial Sirtuin 3: new emerging biological function and therapeutic target","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"811","DOI":"10.18240\/ijo.2023.05.20","article-title":"Mitochondrial dysfunction in glaucomatous degeneration","volume":"16","author":"Zhang","year":"2023","journal-title":"Int. J. Ophthalmol."}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1409717\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T04:46:33Z","timestamp":1716353193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2024.1409717\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":67,"alternative-id":["10.3389\/fncel.2024.1409717"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2024.1409717","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]},"article-number":"1409717"}}