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Ischemic stroke may promote neuronal glycolysis, leading to lactate accumulation in brain tissue. This accumulation of lactate accumulation may heighten neuronal excitability by upregulating protein lactylation levels, potentially triggering post-stroke epilepsy. Although current clinical treatments for seizures have advanced significantly, approximately 30% of patients with epilepsy remain unresponsive to medication, and the prevalence of epilepsy continues to rise. This study explores the mechanisms of epilepsy-associated neuronal death mediated by lactate metabolism and protein lactylation. This study also examines the potential for histone deacetylase inhibitors to alleviate seizures by modifying lactylation levels, thereby offering fresh perspectives for future research into the pathogenesis and clinical treatment of epilepsy.<\/jats:p>","DOI":"10.3389\/fncel.2024.1464169","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:14:17Z","timestamp":1736835257000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["The lactate metabolism and protein lactylation in epilepsy"],"prefix":"10.3389","volume":"18","author":[{"given":"Xi","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s10020-023-00742-2","article-title":"Autophagy and autophagy signaling in epilepsy: possible role of autophagy activator","volume":"29","author":"Ali","year":"2023","journal-title":"Mol. 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Acta Mol. Basis Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev-physiol-021422-091035","article-title":"Metabolic recruitment in brain tissue","volume":"85","author":"Barros","year":"2023","journal-title":"Annu. Rev. Physiol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s40360-023-00692-9","article-title":"Butyrate alleviates renal inflammation and fibrosis in a rat model of polycystic ovarian syndrome by suppression of SDF-1","volume":"24","author":"Bashir","year":"2023","journal-title":"BMC Pharmacol. 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Chem."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"6628","DOI":"10.1038\/s41467-022-34399-y","article-title":"YiaC and CobB regulate lysine lactylation in Escherichia coli","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s12640-022-00524-4","article-title":"Catalpol ameliorates neurotoxicity in N2a\/APP695swe cells and APP\/PS1 transgenic mice","volume":"40","author":"Du","year":"2022","journal-title":"Neurotox. Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.3390\/nu14235003","article-title":"The role of ketogenic diet in the treatment of neurological diseases","volume":"14","author":"Dy\u0144ka","year":"2022","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1161\/CIRCRESAHA.121.319994","article-title":"Immune pathways in etiology, acute phase, and chronic sequelae of ischemic stroke","volume":"130","author":"Endres","year":"2022","journal-title":"Circ. Res."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.yjmcc.2015.05.018","article-title":"Heat-shock-protein 90 protects from downregulation of HIF-1\u03b1 in calcineurin-induced myocardial hypertrophy","volume":"85","author":"Eschricht","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3390\/antiox10091495","article-title":"Genetic polymorphisms, gene-gene interactions, and neurologic sequelae at two years follow-up in newborns with hypoxic-ischemic encephalopathy treated with hypothermia","volume":"10","author":"Esih","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/epi.14458","article-title":"Epilepsy in Asia: disease burden, management barriers, and challenges","volume":"60","author":"Eugen","year":"2019","journal-title":"Epilepsia"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"eadc9465","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"E330","DOI":"10.1152\/ajpendo.00159.2022","article-title":"Lactylation: novel epigenetic regulatory and therapeutic opportunities","volume":"324","author":"Fan","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3892\/or.2020.7541","article-title":"LOXL2 upregulates hypoxia-inducible factor-1\u03b1 signaling through snail-FBP1 axis in hepatocellular carcinoma cells","volume":"43","author":"Fan","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12035-021-02583-8","article-title":"Lactate and pyruvate activate autophagy and mitophagy that protect cells in toxic model of Parkinson's disease","volume":"59","author":"Fedotova","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1038\/s41467-022-32521-8","article-title":"Lactate increases stemness of CD8\u202f+\u202fT cells to augment anti-tumor immunity","volume":"13","author":"Feng","year":"2022","journal-title":"Nat. Commun."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1002\/glia.23616","article-title":"Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus","volume":"67","author":"Feng","year":"2019","journal-title":"Glia"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s12035-022-03107-8","article-title":"A novel mitochondria-targeting iron chelator neuroprotects multimodally via HIF-1 modulation against a mitochondrial toxin in a dopaminergic cell model of Parkinson's disease","volume":"60","author":"Fouch\u00e9","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"101671","DOI":"10.1016\/j.redox.2020.101671","article-title":"HIF-1\u03b1-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury","volume":"36","author":"Fu","year":"2020","journal-title":"Redox Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.7150\/thno.81406","article-title":"The STAT1\/HMGB1\/NF-\u03baB pathway in chronic inflammation and kidney injury after cisplatin exposure","volume":"13","author":"Fu","year":"2023","journal-title":"Theranostics"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s13059-022-02775-y","article-title":"H3K18 lactylation marks tissue-specific active enhancers","volume":"23","author":"Galle","year":"2022","journal-title":"Genome Biol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1097\/HEP.0000000000000279","article-title":"Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease","volume":"78","author":"Gao","year":"2023","journal-title":"Hepatology"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.3390\/nu15153411","article-title":"Hydroxysafflor yellow a alleviates acute myocardial ischemia\/reperfusion injury in mice by inhibiting ferroptosis via the activation of the HIF-1\u03b1\/SLC7A11\/GPX4 signaling pathway","volume":"15","author":"Ge","year":"2023","journal-title":"Nutrients"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"C404","DOI":"10.1152\/ajpcell.00214.2018","article-title":"A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes","volume":"316","author":"Genders","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"38095","DOI":"10.1074\/jbc.M111.257055","article-title":"HDAC4 protein regulates HIF1\u03b1 protein lysine acetylation and cancer cell response to hypoxia","volume":"286","author":"Geng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1080\/15548627.2021.1990515","article-title":"Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells","volume":"18","author":"Gong","year":"2021","journal-title":"Autophagy"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"342","DOI":"10.4103\/1673-5374.343910","article-title":"PANoptosis: new insights in regulated cell death in ischemia\/reperfusion models","volume":"18","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13578-023-00999-4","article-title":"Remote ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in mice by activating NMDAR\/AMPK\/PGC-1\u03b1\/SIRT3 signaling","volume":"13","author":"Gu","year":"2023","journal-title":"Cell Biosci."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.nbd.2015.02.025","article-title":"SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients","volume":"77","author":"Haenisch","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"109820","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2174\/1570159X20666220817140737","article-title":"Energy crisis links to autophagy and ferroptosis in Alzheimer's disease: current evidence and future avenues","volume":"21","author":"He","year":"2023","journal-title":"Curr. 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Microbiol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/biof.1320","article-title":"Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-a therapeutic implication in inflammatory bone resorption","volume":"43","author":"Hou","year":"2017","journal-title":"Biofactors"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"106881","DOI":"10.1016\/j.phrs.2023.106881","article-title":"Microglia sense and suppress epileptic neuronal hyperexcitability","volume":"195","author":"Hu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"116966","DOI":"10.1016\/j.lfs.2019.116966","article-title":"Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1\u03b1\/PFKFB3\/PFK1 pathway","volume":"239","author":"Hu","year":"2019","journal-title":"Life Sci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/biom13010050","article-title":"Hypoxia-inducible factor 1 and mitochondria: an intimate connection","volume":"13","author":"Huang","year":"2022","journal-title":"Biomol. Ther."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"20768","DOI":"10.1074\/jbc.M113.476903","article-title":"Sirtuin-7 inhibits the activity of hypoxia-inducible factors","volume":"288","author":"Hubbi","year":"2013","journal-title":"J. Biol. 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