{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:14:12Z","timestamp":1788786852990,"version":"build-2803163510"},"reference-count":139,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Auditory dysfunction affects the vast majority of people with autism spectrum disorder (ASD) and can range from deafness to hypersensitivity. <jats:italic>In utero<\/jats:italic> exposure to the antiepileptic valproic acid (VPA) is associated with significant risk of an ASD diagnosis in humans and timed <jats:italic>in utero<\/jats:italic> exposure to VPA is utilized as an animal model of ASD. VPA-exposed rats have significantly fewer neurons in their auditory brainstem, thalamus and cortex, reduced ascending projections to the midbrain and thalamus and reduced descending projections from the cortex to the auditory midbrain. Consistent with these anatomical changes, VPA-exposed animals also have abnormal auditory brainstem responses. We have recently described a significant ascending projection from calbindin-positive neurons in the medial nucleus of the trapezoid body (MNTB) to the ventral division of the medial geniculate (vMG) in rats that bypasses the central nucleus of the inferior colliculus (CNIC). Since we found that axonal projections to the vMG in VPA-exposed rats are reduced beyond what is predicted from neuron loss alone, we hypothesize that VPA exposure would result in a significant reduction in the MNTB projection to the vMG. We examined this hypothesis by quantifying the proportion of retrogradely-labeled neurons in the MNTB of control and VPA-exposed animals after injections of retrograde tracers in the CNIC and vMG in control and VPA-exposed animals. Our results indicate that in control animals, the MNTB forms the largest projection from the superior olivary complex to the MG and that this projection is nearly abolished by <jats:italic>in utero<\/jats:italic> VPA exposure.<\/jats:p>","DOI":"10.3389\/fncel.2024.1465255","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:42:21Z","timestamp":1729140141000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Obliteration of a glycinergic projection to the medial geniculate in an animal model of autism"],"prefix":"10.3389","volume":"18","author":[{"given":"Yusra","family":"Mansour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Kulesza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/cne.901830305","article-title":"Ascending projections to the inferior colliculus","volume":"183","author":"Adams","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1152\/jn.1974.37.3.512","article-title":"Medial geniculate body: unit responses in the awake cat","volume":"37","author":"Aitkin","year":"1974","journal-title":"J. Neurophysiol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1111\/j.1469-7610.2004.t01-1-00303.x","article-title":"Speech-in-noise perception in high-functioning individuals with autism or Asperger\u2019s syndrome","volume":"45","author":"Alc\u00e1ntara","year":"2004","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"863","DOI":"10.5603\/FM.a2021.0098","article-title":"Brainstem motor neuron dysmorphology and excitatory\/inhibitory imbalance in an animal model of autism","volume":"81","author":"Alhelo","year":"2022","journal-title":"Folia Morphol. (Warsz)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"S48","DOI":"10.1177\/0883073888003001S10","article-title":"Austistic Spectrum disorders: clinical presentation in preschool children","volume":"3","author":"Allen","year":"1988","journal-title":"J. Child Neurol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3389\/fncir.2014.00109","article-title":"Development of glycinergic innervation to the murine LSO and SPN in the presence and absence of the MNTB","volume":"8","author":"Altieri","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"ref7","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1523\/JNEUROSCI.1652-15.2016","article-title":"Mind the gap: two dissociable mechanisms of temporal processing in the auditory system","volume":"36","author":"Anderson","year":"2016","journal-title":"J. Neurosci."},{"key":"ref9001","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1460-9568.2006.04930.x","article-title":"Evidence for a direct, short latency projection from the dorsal cochlear nucleus to the auditory thalamus in the guinea pig","volume":"24","author":"Anderson","year":"2006","journal-title":"Eur J Neurosci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/(SICI)1096-9861(19981026)400:3<417::AID-CNE10>3.0.CO;2-O","article-title":"Brainstem inputs to the ferret medial geniculate nucleus and the effect of early deafferentation on novel retinal projections to the auditory thalamus","volume":"400","author":"Angelucci","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/cne.903100105","article-title":"Immunohistochemical localization of calretinin in the rat hindbrain","volume":"310","author":"Arai","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref11","first-page":"195","article-title":"Thalamic and nonthalamic projections to association areas of the cat's cerebral cortex","volume-title":"Cortical Integration","author":"Avedafio","year":"1984"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1016\/j.ijporl.2014.10.039","article-title":"The correlation between central auditory processing in autistic children and their language processing abilities","volume":"78","author":"Azouz","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1523\/JNEUROSCI.12-07-02819.1992","article-title":"Intracellular recordings from neurobiotin-labeled cells in brain slices of the rat medial nucleus of the trapezoid body","volume":"12","author":"Banks","year":"1992","journal-title":"J. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0006-8993(78)90858-2","article-title":"Afferent projections to the central nucleus of the inferior colliculus in the rat","volume":"145","author":"Beyerl","year":"1978","journal-title":"Brain Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jaac.2011.12.009","article-title":"Autism spectrum disorder and autistic traits in the Avon longitudinal study of parents and children: precursors and early signs","volume":"51","author":"Bolton","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/jnnp-2012-304270","article-title":"The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs","volume":"84","author":"Bromley","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1002\/cne.901970410","article-title":"HRP study of the organization of auditory afferents ascending to central nucleus of inferior colliculus in cat","volume":"197","author":"Brunso-Bechtold","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1007\/s00221-022-06489-2","article-title":"Leveling up: a long-range olivary projection to the medial geniculate without collaterals to the central nucleus of the inferior colliculus in rats","volume":"240","author":"Burchell","year":"2022","journal-title":"Exp. Brain Res."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/cne.20888","article-title":"Organization of the inferior colliculus of the gerbil (Meriones unguiculatus): differences in distribution of projections from the cochlear nuclei and the superior olivary complex","volume":"495","author":"Cant","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref20","year":"2024"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/cne.10164","article-title":"Cell types and response properties of neurons in the ventral division of the medial geniculate body of the rabbit","volume":"445","author":"Cetas","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/cne.902970103","article-title":"Anatomy of the rat medial geniculate body: I. Cytoarchitecture, myeloarchitecture, and neocortical connectivity","volume":"297","author":"Clerici","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/cne.902620204","article-title":"Sources of projections to subdivisions of the inferior colliculus in the rat","volume":"262","author":"Coleman","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1007\/s10803-021-05126-1","article-title":"Newborn auditory brainstem responses in children with developmental disabilities","volume":"53","author":"Delgado","year":"2023","journal-title":"J. Autism Dev. Disord."},{"key":"ref9002","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/(SICI)1096-9861(19990927)412:3<383::AID-CNE2>3.0.CO;2-5","article-title":"Organization of projections to the lateral amygdala from auditory and visual areas of the thalamus in the rat","volume":"412","author":"Doron","year":"1999","journal-title":"J Comp Neurol."},{"key":"ref27","first-page":"31","article-title":"Ascending and descending projections to the inferior colliculus in the rat","volume":"33","author":"Druga","year":"1984","journal-title":"Physiol. Bohemoslov."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.neuroscience.2016.01.030","article-title":"Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem","volume":"324","author":"Dubiel","year":"2016","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/BF00248219","article-title":"Divergent projections of physiologically characterized rat ventral cochlear nucleus neurons as shown by intra-axonal injection of horseradish peroxidase","volume":"73","author":"Friauf","year":"1988","journal-title":"Exp. Brain Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF01531818","article-title":"Auditory brainstem responses in childhood psychosis","volume":"13","author":"Gillberg","year":"1983","journal-title":"J. Autism Dev. Disord."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/0378-5955(91)90184-B","article-title":"Divergent projections of projecting neurons of the inferior colliculus to the medial geniculate body and the contralateral inferior colliculus in the rat","volume":"52","author":"Gonz\u00e1lez-Hern\u00e1ndez","year":"1991","journal-title":"Hear. Res."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/01.aud.0000215979.65645.22","article-title":"Peripheral audition of children on the autistic spectrum","volume":"27","author":"Gravel","year":"2006","journal-title":"Ear Hear."},{"key":"ref33","first-page":"87","article-title":"Developmental patterns and outcomes in infants and children with disorders in relating and communicating: a chart review of 200 cases of children with autistic spectrum diagnoses","volume":"1","author":"Greenspan","year":"1997","journal-title":"J. Dev. Learn. Disord."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1152\/jn.1994.71.2.706","article-title":"Interaction of excitation and inhibition in processing of pure tone and amplitude-modulated stimuli in the medial superior olive of the mustached bat","volume":"71","author":"Grothe","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1152\/jn.1993.69.4.1192","article-title":"Bilateral inhibition by glycinergic afferents in the medial superior olive","volume":"69","author":"Grothe","year":"1993","journal-title":"J. Neurophysiol."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.143.3605.473","article-title":"Nucleus of the trapezoid body: dual afferent innervation","volume":"143","author":"Harrison","year":"1964","journal-title":"Science"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.neuroscience.2003.12.027","article-title":"Topography of corticothalamic projections from the auditory cortex of the rat","volume":"124","author":"Hazama","year":"2004","journal-title":"Neuroscience"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0006-8993(89)90644-6","article-title":"GABA and glycine immunoreactivity in the guinea pig superior olivary complex","volume":"501","author":"Helfert","year":"1989","journal-title":"Brain Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1056\/NEJMoa2309359","article-title":"Risk of autism after prenatal Topiramate, valproate, or lamotrigine exposure","volume":"390","author":"Hern\u00e1ndez-D\u00edaz","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fnana.2010.00135","article-title":"Origins of glutamatergic terminals in the inferior colliculus identified by retrograde transport and expression of VGLUT1 and VGLUT2 genes","volume":"4","author":"Ito","year":"2010","journal-title":"Front. Neuroanat."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fncir.2012.00048","article-title":"The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus","volume":"6","author":"Ito","year":"2012","journal-title":"Front. Neural Circuits"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"15044","DOI":"10.1523\/JNEUROSCI.2604-13.2013","article-title":"Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body","volume":"33","author":"Jalabi","year":"2013","journal-title":"J. Neurosci."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/j.neuroscience.2007.11.008","article-title":"Encoding of temporal features of auditory stimuli in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat","volume":"151","author":"Kadner","year":"2008","journal-title":"Neuroscience"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1152\/jn.00902.2005","article-title":"Neurons in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat may play a role in sound duration coding","volume":"95","author":"Kadner","year":"2006","journal-title":"J. Neurophysiol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nn810","article-title":"Experience-dependent refinement of inhibitory inputs to auditory coincidence-detector neurons","volume":"5","author":"Kapfer","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0378-5955(97)00195-0","article-title":"Projections from the superior olive and lateral lemniscus to tonotopic regions of the rat's inferior colliculus","volume":"116","author":"Kelly","year":"1998","journal-title":"Hear. Res."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/cne.21929","article-title":"Anatomical projections of the nuclei of the lateral lemniscus in the albino rat (Rattus norvegicus)","volume":"512","author":"Kelly","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1046\/j.1460-9568.2001.01423.x","article-title":"Peripheral auditory asymmetry in infantile autism","volume":"13","author":"Khalfa","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0306-4522(02)00949-1","article-title":"Auditory thalamic nuclei projections to the temporal cortex in the rat","volume":"117","author":"Kimura","year":"2003","journal-title":"Neuroscience"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.neuroscience.2008.01.088","article-title":"The medial nucleus of the trapezoid body: comparative physiology","volume":"154","author":"Kopp-Scheinpflug","year":"2008","journal-title":"Neuroscience"},{"key":"ref51","first-page":"444","article-title":"Major malformations with valproic acid","volume":"52","author":"Koren","year":"2006","journal-title":"Can. Fam. Physician"},{"key":"ref52","first-page":"146","volume-title":"Cortical dysmorphology and reduced cortico-collicular projections in an animal model of autism spectrum disorderCereb. Cortex","author":"Kosmer","year":"2024"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/cne.902980403","article-title":"Auditory brainstem in the mole (Mogera): nuclear configurations and the projections to the inferior colliculus","volume":"298","author":"Kudo","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.heares.2006.12.006","article-title":"Cytoarchitecture of the human superior olivary complex: medial and lateral superior olive","volume":"225","author":"Kulesza","year":"2007","journal-title":"Hear. Res."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s101620010054","article-title":"Superior paraolivary nucleus of the rat is a GABAergic nucleus","volume":"1","author":"Kulesza","year":"2000","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1152\/jn.00547.2002","article-title":"Physiological response properties of neurons in the superior paraolivary nucleus of the rat","volume":"89","author":"Kulesza","year":"2003","journal-title":"J. Neurophysiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.brainres.2010.10.015","article-title":"Malformation of the human superior olive in autistic spectrum disorders","volume":"1367","author":"Kulesza","year":"2011","journal-title":"Brain Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.brainres.2008.01.009","article-title":"Morphological features of the medial superior olive in autism","volume":"1200","author":"Kulesza","year":"2008","journal-title":"Brain Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0378-5955(02)00374-X","article-title":"Unbiased stereological estimates of neuron number in subcortical auditory nuclei of the rat","volume":"168","author":"Kulesza","year":"2002","journal-title":"Hear. Res."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/cne.903140405","article-title":"Afferents to the medial nucleus of the trapezoid body and their collateral projections","volume":"314","author":"Kuwabara","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/cne.903240406","article-title":"Projections to the medial superior olive from the medial and lateral nuclei of the trapezoid body in rodents and bats","volume":"324","author":"Kuwabara","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3346\/jkms.2007.22.4.656","article-title":"Electrophysiologic assessment of central auditory processing by auditory brainstem responses in children with autism spectrum disorders","volume":"22","author":"Kwon","year":"2007","journal-title":"J. Korean Med. Sci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cne.902640110","article-title":"Topographic organization of convergent projections to the thalamus from the inferior colliculus and spinal cord in the rat","volume":"264","author":"LeDoux","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/j.1749-6632.1985.tb37611.x","article-title":"Auditory emotional memories, establishment by projections from the medial geniculate nucleus to the posterior neostriatum and\/or dorsal amygdala","volume":"444","author":"LeDoux","year":"1985","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/(SICI)1096-9861(19960325)367:1<90::AID-CNE7>3.0.CO;2-E","article-title":"Distribution of the calcium-binding proteins parvalbumin and calretinin in the auditory brainstem of adult and developing rats","volume":"367","author":"Lohmann","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neuroscience.2014.11.033","article-title":"Organization of the human superior olivary complex in 15q duplication syndromes and autism spectrum disorders","volume":"286","author":"Lukose","year":"2015","journal-title":"Neuroscience"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.brainres.2011.05.013","article-title":"Malformation of the superior olivary complex in an animal model of autism","volume":"1398","author":"Lukose","year":"2011","journal-title":"Brain Res."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"285","DOI":"10.5607\/en.2015.24.4.285","article-title":"Exploring the validity of valproic acid animal model of autism","volume":"24","author":"Mabunga","year":"2015","journal-title":"Exp. Neurobiol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neuroscience.2016.10.052","article-title":"Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia","volume":"340","author":"Main","year":"2017","journal-title":"Neuroscience"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"108816","DOI":"10.1016\/j.heares.2023.108816","article-title":"Abnormal auditory brainstem responses in an animal model of autism spectrum disorder","volume":"436","author":"Malhotra","year":"2023","journal-title":"Hear. Res."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"10891","DOI":"10.1523\/JNEUROSCI.22-24-10891.2002","article-title":"Direct projections from cochlear nuclear complex to auditory thalamus in the rat","volume":"22","author":"Malmierca","year":"2002","journal-title":"J. Neurosci."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00221-020-05982-w","article-title":"Abnormal morphology and subcortical projections to the medial geniculate in an animal model of autism","volume":"239","author":"Mansour","year":"","journal-title":"Exp. Brain Res."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"743561","DOI":"10.3389\/fnint.2021.743561","article-title":"Central auditory and vestibular dysfunction are key features of autism spectrum disorder","volume":"15","author":"Mansour","year":"","journal-title":"Front. Integr. Neurosci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"148056","DOI":"10.1016\/j.brainres.2022.148056","article-title":"Abnormal vestibular brainstem structure and function in an animal model of autism spectrum disorder","volume":"1793","author":"Mansour","year":"2022","journal-title":"Brain Res."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"107974","DOI":"10.1016\/j.heares.2020.107974","article-title":"Three dimensional reconstructions of the superior olivary complex from children with autism spectrum disorder","volume":"393","author":"Mansour","year":"2020","journal-title":"Hear. Res."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"730439","DOI":"10.3389\/fnint.2021.730439","article-title":"The untouchable ventral nucleus of the trapezoid body: preservation of a nucleus in an animal model of autism spectrum disorder","volume":"15","author":"Mansour","year":"2021","journal-title":"Front. Integr. Neurosci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuroscience.2018.11.016","article-title":"Auditory midbrain hypoplasia and Dysmorphology after prenatal Valproic acid exposure","volume":"396","author":"Mansour","year":"2019","journal-title":"Neuroscience"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1001\/archpsyc.57.11.1077","article-title":"Prolongation of brainstem auditory-evoked responses in autistic probands and their unaffected relatives","volume":"57","author":"Maziade","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/aur.1886","article-title":"Auditory brainstem response in infants and children with autism spectrum disorder: a meta-analysis of wave V","volume":"11","author":"Miron","year":"2018","journal-title":"Autism Res."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1523\/JNEUROSCI.03-01-00237.1983","article-title":"Strychnine blocks binaural inhibition in lateral superior olivary neurons","volume":"3","author":"Moore","year":"1983","journal-title":"J. Neurosci."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1136\/jmg.37.7.489","article-title":"A clinical study of 57 children with fetal anticonvulsant syndromes","volume":"37","author":"Moore","year":"2000","journal-title":"J. Med. Genet."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/0006-8993(68)90235-7","article-title":"The collateral system of the medial nucleus of the trapezoid body of the cat, its neuronal architecture and relation to the olivo-cochlear bundle","volume":"9","author":"Morest","year":"","journal-title":"Brain Res."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/BF00526129","article-title":"The growth of synaptic endings in the mammalian brain: a study of the calyces of the trapezoid body","volume":"127","author":"Morest","year":"","journal-title":"Z. Anat. Entwicklungsgesch."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/cne.902140203","article-title":"Ascending auditory projections to the inferior colliculus in the adult gerbil,Meriones unguiculatus","volume":"214","author":"Nordeen","year":"1983","journal-title":"J. Comp. Neurol. Psychol."},{"key":"ref9003","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0010-440X(69)90002-9","article-title":"Disorders of perception common to early infantile autism and schizophrenia","volume":"10","author":"Ornitz","year":"1969","journal-title":"Compr Psychiatry."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/cne.901870209","article-title":"Afferent connections to the amygdaloid complex of the rat and cat.I.Projections from the thalamus","volume":"187","author":"Ottersen","year":"1979","journal-title":"J. Comp. Neurol."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1002\/cne.902290308","article-title":"Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique","volume":"229","author":"Ottersen","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"e209279","DOI":"10.1212\/WNL.0000000000209279","article-title":"Teratogenesis, perinatal, and neurodevelopmental outcomes after in utero exposure to Antiseizure medication: practice guideline from the AAN, AES, and SMFM","volume":"102","author":"Pack","year":"2024","journal-title":"Neurology"},{"key":"ref89","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2007"},{"key":"ref90","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.brainres.2009.09.051","article-title":"Valproate reversibly reduces neurite outgrowth by human SY5Y neuroblastoma cells","volume":"1302","author":"Qian","year":"2009","journal-title":"Brain Res."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10072-018-3594-9","article-title":"Auditory brainstem response to speech in children with high functional autism spectrum disorder","volume":"40","author":"Ramezani","year":"2019","journal-title":"Neurol. Sci."},{"key":"ref9004","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0306-4522(96)00278-3","article-title":"Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain","volume":"75","author":"Rampon","year":"1996","journal-title":"Neuroscience."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0306-4522(92)90012-Q","article-title":"Calretinin in rat brain: an immunohistochemical study","volume":"46","author":"R\u00e9sibois","year":"1992","journal-title":"Neuroscience"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fncir.2014.00049","article-title":"The relative contributions of MNTB and LNTB neurons to inhibition in the medial superior olive assessed through single and paired recordings","volume":"8","author":"Roberts","year":"2014","journal-title":"Front. Neural Circuits"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","article-title":"Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei","volume":"370","author":"Rodier","year":"1996","journal-title":"J. Comp. Neurol."},{"key":"ref96","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/13623613030073002","article-title":"Co-occurrence of autism and deafness: diagnostic considerations","volume":"7","author":"Roper","year":"2003","journal-title":"Autism"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/BF02408472","article-title":"Auditory brainstem evoked responses in autistic children","volume":"10","author":"Rosenblum","year":"1980","journal-title":"J. Autism Dev. Disord."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1469-8749.2011.04149.x","article-title":"Evidence for atypical auditory brainstem responses in young children with suspected autism spectrum disorders","volume":"54","author":"ROTH","year":"2012","journal-title":"Dev. Med. Child Neurol."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/BF00237048","article-title":"Ascending vestibular projections, further results at cortical and thalamic levels in the cat","volume":"29","author":"Roucoux-Hanus","year":"1977","journal-title":"Exp. Brain Res."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s10803-009-0737-0","article-title":"Effects of background noise on cortical encoding of speech in autism spectrum disorders","volume":"39","author":"Russo","year":"2009","journal-title":"J. Autism Dev. Disord."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0006-8993(74)90903-2","article-title":"Differential telencephalic projections of the medial and ventral divisions of the medial geniculate body of the rat","volume":"82","author":"Ryugo","year":"1974","journal-title":"Brain Res."},{"key":"ref102","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuroscience.2009.06.030","article-title":"Connections of the superior paraolivary nucleus of the rat: projections to the inferior colliculus","volume":"163","author":"Salda\u00f1a","year":"2009","journal-title":"Neuroscience"},{"key":"ref103","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref104","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"ref105","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/cne.903440107","article-title":"Projections to the cochlear nuclei from principal cells in the medial nucleus of the trapezoid body in guinea pigs","volume":"344","author":"Schofield","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"ref106","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/cne.903170409","article-title":"Organization of the superior olivary complex in the guinea pig: II. Patterns of projection from the periolivary nuclei to the inferior colliculus","volume":"317","author":"Schofield","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"ref107","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fnana.2014.00070","article-title":"Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus","volume":"8","author":"Schofield","year":"","journal-title":"Front. Neuroanat."},{"key":"ref108","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnana.2014.00010","article-title":"Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body","volume":"8","author":"Schofield","year":"","journal-title":"Front. Neuroanat."},{"key":"ref109","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/0006-3223(90)90464-D","article-title":"Brainstem auditory-evoked responses with and without sedation in autism and Down's syndrome","volume":"27","author":"Sersen","year":"1990","journal-title":"Biol. Psychiatry"},{"key":"ref110","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/cne.903040305","article-title":"Projections of physiologically characterized globular bushy cell axons from the cochlear nucleus of the cat","volume":"304","author":"Smith","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref111","doi-asserted-by":"publisher","first-page":"3127","DOI":"10.1152\/jn.1998.79.6.3127","article-title":"Anatomy and physiology of principal cells of the medial nucleus of the trapezoid body (MNTB) of the cat","volume":"79","author":"Smith","year":"1998","journal-title":"J. Neurophysiol."},{"key":"ref112","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/cne.22682","article-title":"Thalamocortical projections to rat auditory cortex from the ventral and dorsal divisions of the medial geniculate nucleus","volume":"520","author":"Smith","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"ref113","first-page":"315","article-title":"Auditory nerve-brain stem responses (ABR) in children with developmental brain disorders and in high risk neonates","volume":"36","author":"Sohmer","year":"1982","journal-title":"Electroencephalogr. Clin. Neurophysiol. Suppl."},{"key":"ref114","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/BF00229781","article-title":"Principal cells of the rat medial nucleus of the trapezoid body: an intracellular in vivo study of their physiology and morphology","volume":"95","author":"Sommer","year":"1993","journal-title":"Exp. Brain Res."},{"key":"ref115","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/cne.902380302","article-title":"The projections of principal cells of the medial nucleus of the trapezoid body in the cat","volume":"238","author":"Spangler","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"ref116","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/cne.902030107","article-title":"Thalamic projections to the primary and secondary somatosensory cortices in cat, single and double retrograde tracer studies","volume":"203","author":"Spreafico","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"ref117","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF01550274","article-title":"Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits","volume":"8","author":"Student","year":"1978","journal-title":"J. Autism Child. Schizophr."},{"key":"ref118","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1348\/0007126041528167","article-title":"Temporal processing deficits in high-functioning children with autism","volume":"95","author":"Szelag","year":"2004","journal-title":"Br. J. Psychol."},{"key":"ref119","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1001\/archpsyc.1982.04290020040008","article-title":"Auditory brainstem evoked responses in autistic children","volume":"39","author":"Tanguay","year":"1982","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref120","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/1362361307070908","article-title":"Evaluation of hearing in children with autism by using TEOAE and ABR","volume":"11","author":"Tas","year":"2007","journal-title":"Autism"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.cogbrainres.2004.10.021","article-title":"Auditory spatial localization and attention deficits in autistic adults","volume":"23","author":"Teder-S\u00e4lej\u00e4rvi","year":"2005","journal-title":"Brain Res. Cogn. Brain Res."},{"key":"ref122","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/01.aud.0000224981.60575.d8","article-title":"Auditory characteristics of children with autism","volume":"27","author":"Tharpe","year":"2006","journal-title":"Ear Hear."},{"key":"ref123","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1176\/ajp.147.12.1609","article-title":"Brainstem auditory evoked response and subcortical abnormalities in autism","volume":"147","author":"Thivierge","year":"1990","journal-title":"Am. J. Psychiatry"},{"key":"ref124","doi-asserted-by":"publisher","first-page":"190","DOI":"10.5014\/ajot.61.2.190","article-title":"Sensory processing in children with and without autism: a comparative study using the short sensory profile","volume":"61","author":"Tomchek","year":"2007","journal-title":"Am. J. Occup. Ther."},{"key":"ref125","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/0306-4522(87)92968-X","article-title":"Glycine immunoreactivity localized in the cochlear nucleus and superior olivary complex","volume":"22","author":"Wenthold","year":"1987","journal-title":"Neuroscience"},{"key":"ref126","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/cne.902290210","article-title":"Topographical organization of the inferior collicular projection and other connections of the ventral nucleus of the lateral lemniscus in the cat","volume":"229","author":"Whitley","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"ref127","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1469-8749.2001.tb00188.x","article-title":"Fetal valproate syndrome and autism: additional evidence of an association","volume":"43","author":"Williams","year":"2001","journal-title":"Dev. Med. Child Neurol."},{"key":"ref128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-69634-3_1","article-title":"The medial geniculate body of the cat","volume":"86","author":"Winer","year":"1985","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref129","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/cne.902570212","article-title":"Patterns of reciprocity in auditory thalamocortical and corticothalamic connections, study with horseradish peroxidase and autoradiographic methods in the rat medial geniculate body","volume":"257","author":"Winer","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"ref130","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S0378-5955(98)00217-2","article-title":"Origins of medial geniculate body projections to physiologically defined zones of rat primary auditory cortex","volume":"130","author":"Winer","year":"1999","journal-title":"Hear. Res."},{"key":"ref131","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/S0140-6736(97)09218-0","article-title":"The autistic spectrum","volume":"350","author":"Wing","year":"1997","journal-title":"Lancet"},{"key":"ref132","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/BF02207329","article-title":"Brainstem auditory evoked potential study in children with autistic disorder","volume":"21","author":"Wong","year":"1991","journal-title":"J. Autism Dev. Disord."},{"key":"ref133","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1113\/jphysiol.2004.067678","article-title":"In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs","volume":"560","author":"Yu","year":"2004","journal-title":"J. Physiol."},{"key":"ref134","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1523\/JNEUROSCI.01-05-00532.1981","article-title":"Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine","volume":"1","author":"Zarbin","year":"1981","journal-title":"J. Neurosci."},{"key":"ref135","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/s41398-019-0608-1","article-title":"Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates","volume":"9","author":"Zhao","year":"2019","journal-title":"Transl. 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