{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:09:10Z","timestamp":1792595350173,"version":"4.5.0"},"reference-count":291,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>DNA methylation plays a crucial role in development, aging, degeneration of various tissues and dedifferentiated cells. This review explores the multifaceted impact of DNA methylation on the retina and brain during development and pathological processes. First, we investigate the role of DNA methylation in retinal development, and then focus on retinal diseases, detailing the changes in DNA methylation patterns in diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. Since the retina is considered an extension of the brain, its unique structure allows it to exhibit similar immune response mechanisms to the brain. We further extend our exploration from the retina to the brain, examining the role of DNA methylation in brain development and its associated diseases, such as Alzheimer\u2019s disease (AD) and Huntington\u2019s disease (HD) to better understand the mechanistic links between retinal and brain diseases, and explore the possibility of communication between the visual system and the central nervous system (CNS) from an epigenetic perspective. Additionally, we discuss neurodevelopmental brain diseases, including schizophrenia (SZ), autism spectrum disorder (ASD), and intellectual disability (ID), focus on how DNA methylation affects neuronal development, synaptic plasticity, and cognitive function, providing insights into the molecular mechanisms underlying neurodevelopmental disorders.<\/jats:p>","DOI":"10.3389\/fncel.2024.1499719","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T04:31:50Z","timestamp":1732854710000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Traversing the epigenetic landscape: DNA methylation from retina to brain in development and disease"],"prefix":"10.3389","volume":"18","author":[{"given":"Chunxiu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1093\/hmg\/ddl253","article-title":"Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder","volume":"15","author":"Abdolmaleky","year":"2006","journal-title":"Hum. 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Sq."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.14336\/AD.2014.050052","article-title":"New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer","volume":"5","author":"Afanas'ev","year":"2014","journal-title":"Aging Dis."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","article-title":"The dynamic epigenetic landscape of the retina during development, reprogramming, and tumorigenesis","volume":"94","author":"Aldiri","year":"2017","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13148-019-0672-7","article-title":"DNA methylation signature of human hippocampus in Alzheimer's disease is linked to neurogenesis","volume":"11","author":"Altuna","year":"2019","journal-title":"Clin. 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Eye Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"11762","DOI":"10.1038\/s41598-017-12084-1","article-title":"DNA Methylomes reveal biological networks involved in human eye development, Functions and Associated Disorders","volume":"7","author":"Berdasco","year":"2017","journal-title":"Sci. Rep."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1080\/15592294.2020.1748917","article-title":"Early epigenetic changes of Alzheimer's disease in the human hippocampus","volume":"15","author":"Blanco-Luquin","year":"2020","journal-title":"Epigenetics"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.bbi.2011.01.017","article-title":"DNA methylation in repetitive elements and Alzheimer disease","volume":"25","author":"Bollati","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref19","first-page":"483","article-title":"Differential DNA methylation patterns in human Schlemm's canal endothelial cells with glaucoma","volume":"26","author":"Cai","year":"2020","journal-title":"Mol. 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Ophthalmol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"9171536","DOI":"10.1155\/2018\/9171536","article-title":"DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E, and HERV-K in trabeculectomy specimens from Glaucoma eyes","volume":"2018","author":"Chansangpetch","year":"2018","journal-title":"J. Ophthalmol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/genes8010014","article-title":"mRNA expression and DNA methylation analysis of serotonin receptor 2A (HTR2A) in the human schizophrenic brain","volume":"8","author":"Cheah","year":"2017","journal-title":"Genes (Basel)"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.kint.2019.02.020","article-title":"Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease","volume":"96","author":"Chen","year":"2019","journal-title":"Kidney Int."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3389\/fncel.2015.00451","article-title":"Advancements in the underlying pathogenesis of schizophrenia: implications of DNA methylation in glial cells","volume":"9","author":"Chen","year":"2015","journal-title":"Front. Cell. 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A."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1515\/tnsci-2018-0028","article-title":"Age-related disturbances in DNA (hydroxy)methylation in APP\/PS1 mice","volume":"9","author":"Chouliaras","year":"2018","journal-title":"Transl. Neurosci."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients","volume":"34","author":"Chouliaras","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"397","DOI":"10.12659\/MSM.895896","article-title":"DNA methylation of BDNF gene in schizophrenia","volume":"22","author":"\u00c7\u00f6po\u011flu","year":"2016","journal-title":"Med. Sci. 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A."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.3390\/biomedicines11123258","article-title":"Bridging retinal and cerebral neurodegeneration: a focus on crosslinks between Alzheimer-Perusini's disease and retinal dystrophies","volume":"11","author":"Donato","year":"2023","journal-title":"Biomedicines."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"4831","DOI":"10.1167\/iovs.18-24548","article-title":"Epigenetics and regulation of oxidative stress in diabetic retinopathy","volume":"59","author":"Duraisamy","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.bbadis.2019.03.013","article-title":"Mitochondrial fusion and maintenance of mitochondrial homeostasis in diabetic retinopathy","volume":"1865","author":"Duraisamy","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"827274","DOI":"10.3389\/fgene.2022.827274","article-title":"The potential role of epigenetic mechanisms in the development of retinitis Pigmentosa and related photoreceptor dystrophies","volume":"13","author":"Dvoriantchikova","year":"2022","journal-title":"Front. Genet."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fnmol.2019.00182","article-title":"DNA methylation dynamics during the differentiation of retinal progenitor cells into retinal neurons reveal a role for the DNA demethylation pathway","volume":"12","author":"Dvoriantchikova","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"175909141456210","DOI":"10.1177\/1759091414562107","article-title":"Connecting the retina to the brain","volume":"6","author":"Erskine","year":"2014","journal-title":"ASN Neuro"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41419-020-03359-z","article-title":"Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish","volume":"12","author":"Facchinello","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"e1558","DOI":"10.1038\/cddis.2014.512","article-title":"DNA methylation and differential gene regulation in photoreceptor cell death","volume":"5","author":"Farinelli","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref52","first-page":"528","article-title":"Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting","volume":"50","author":"Farrer","year":"1992","journal-title":"Am. J. Hum. Genet."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"8355","DOI":"10.1093\/nar\/gkr528","article-title":"The USP7\/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1","volume":"39","author":"Felle","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nn.2514","article-title":"Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons","volume":"13","author":"Feng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jns.2016.02.004","article-title":"Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease","volume":"362","author":"Ferri","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"eaaw2880","DOI":"10.1126\/sciadv.aaw2880","article-title":"Epigenetic signatures of methylated DNA cytosine in Alzheimer's disease","volume":"5","author":"Fetahu","year":"2019","journal-title":"Sci. Adv."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"583687","DOI":"10.3389\/fimmu.2020.583687","article-title":"The role of inflammation in diabetic retinopathy","volume":"11","author":"Forrester","year":"2020","journal-title":"Front. Immunol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.tig.2007.05.008","article-title":"Epigenetics and aging: the targets and the marks","volume":"23","author":"Fraga","year":"2007","journal-title":"Trends Genet."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"564277","DOI":"10.3389\/fpsyt.2020.564277","article-title":"BDNF Gene's role in schizophrenia: from risk allele to methylation implications","volume":"11","author":"Fu","year":"2020","journal-title":"Front. Psych."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.neuint.2012.07.014","article-title":"SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer's disease","volume":"61","author":"Furuya","year":"2012","journal-title":"Neurochem. Int."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.eurpsy.2017.03.002","article-title":"Catechol-O-methyltransferase gene promoter methylation as a peripheral biomarker in male schizophrenia","volume":"44","author":"Gao","year":"2017","journal-title":"Eur. Psychiatry"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/ajmg.b.31192","article-title":"Hypomethylation of the serotonin receptor type-2A gene (HTR2A) at T102C polymorphic site in DNA derived from the saliva of patients with schizophrenia and bipolar disorder","author":"Ghadirivasfi","year":"2011","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/s41398-024-03102-8","article-title":"Longitudinal changes in DNA methylation associated with clozapine use in treatment-resistant schizophrenia from two international cohorts","volume":"14","author":"Gillespie","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Goll","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"144","DOI":"10.4161\/epi.4.3.8534","article-title":"From trans-methylation to cytosine methylation: evolution of the methylation hypothesis of schizophrenia","volume":"4","author":"Grayson","year":"2009","journal-title":"Epigenetics"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/npp.2012.125","article-title":"The dynamics of DNA methylation in schizophrenia and related psychiatric disorders","volume":"38","author":"Grayson","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"108349","DOI":"10.1016\/j.exer.2020.108349","article-title":"Differential Lysyl oxidase like 1 expression in pseudoexfoliation glaucoma is orchestrated via DNA methylation","volume":"201","author":"Greene","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature10443","article-title":"The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes","volume":"477","author":"Gu","year":"2011","journal-title":"Nature"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"103737","DOI":"10.1016\/j.ejmg.2019.103737","article-title":"DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation","volume":"63","author":"Guerra","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.preteyeres.2017.06.002","article-title":"On phagocytes and macular degeneration","volume":"61","author":"Guillonneau","year":"2017","journal-title":"Prog. Retin. 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Sci."},{"key":"ref247","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/pcn.13282","article-title":"Cell type-specific DNA methylation analysis of the prefrontal cortex of patients with schizophrenia","volume":"75","author":"Ueda","year":"2021","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref248","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.pharmthera.2018.11.001","article-title":"The role of DNA methylation in epigenetics of aging","volume":"195","author":"Unnikrishnan","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref249","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3109\/15622975.2015.1085597","article-title":"Excitatory\/inhibitory imbalance in autism spectrum disorders: implications for interventions and therapeutics","volume":"17","author":"Uzunova","year":"2016","journal-title":"World J. Biol. 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