{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:00:08Z","timestamp":1793314808754,"version":"4.5.0"},"reference-count":180,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>M\u00fcller cells are the most abundant glial cells in the mammalian retina. Their morphology and metabolism enable them to be in close contact and interact biochemically and physically with almost all retinal cell types, including neurons, pericytes, endothelial cells, and other glial cells, influencing their physiology by releasing bioactive molecules. Studies indicate that M\u00fcller glial cells are the primary source of angiogenic growth factor secretion in the neuroretina. Because of this, over the past decade, it has been postulated that M\u00fcller glial cells play a significant role in maintaining retinal vascular homeostasis, with potential implications in vasoproliferative retinopathies. This review aims to summarize the current understanding of the mechanisms by which M\u00fcller glial cells influence retinal angiogenesis in health and disease, with a particular emphasis on three of the retinopathies with the most significant impact on visual health worldwide: diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration.<\/jats:p>","DOI":"10.3389\/fncel.2024.1513686","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:36:20Z","timestamp":1733794580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["M\u00fcller cells and retinal angiogenesis: critical regulators in health and disease"],"prefix":"10.3389","volume":"18","author":[{"given":"Alan E.","family":"Medina-Arellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Silvestre","family":"Albert-Garay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Medina-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Hern\u00e1ndez","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Ruiz-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenin","family":"Ochoa-de la Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref1","first-page":"451","article-title":"Modulation of retinal capillary endothelial cells by M\u00fcller glial cell-derived factors","volume":"15","author":"Abukawa","year":"2009","journal-title":"Mol. Vis."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.sjopt.2018.05.002","article-title":"Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy","volume":"32","author":"Al-Kharashi","year":"2018","journal-title":"Saudi J. Ophthalmol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1167\/iovs.16-19285","article-title":"VEGF as a survival factor in ex vivo models of early diabetic retinopathy","volume":"57","author":"Amato","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref5","first-page":"298","article-title":"Transgenic expression of leukemia inhibitory factor (LIF) blocks normal vascular development but not pathological neovascularization in the eye","volume":"11","author":"Ash","year":"2005","journal-title":"Mol. Vis."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"E3030","DOI":"10.1073\/pnas.1423765112","article-title":"Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy","volume":"112","author":"Babapoor-Farrokhran","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/path.2611","article-title":"M\u00fcller cell-derived VEGF is a significant contributor to retinal neovascularization","volume":"219","author":"Bai","year":"2009","journal-title":"J. Pathol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.phrs.2015.05.013","article-title":"Exploring the various aspects of the pathological role of vascular endothelial growth factor (VEGF) in diabetic retinopathy","volume":"99","author":"Behl","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"dev182279","DOI":"10.1242\/dev.182279","article-title":"Neuronal and glial regulation of CNS angiogenesis and barriergenesis","volume":"147","author":"Biswas","year":"2020","journal-title":"Development"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.62.3.20","article-title":"The long non-coding RNA HOTAIR is a critical epigenetic mediator of angiogenesis in diabetic retinopathy","volume":"62","author":"Biswas","year":"2021","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s00125-003-1040-9","article-title":"Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy","volume":"46","author":"Boehm","year":"2003","journal-title":"Diabetologia"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1001\/jamaophthalmol.2013.4154","article-title":"Exploratory analysis of the effect of intravitreal Ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial","volume":"131","author":"Bressler","year":"2013","journal-title":"JAMA Ophthalmol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.1097\/00001756-199712220-00001","article-title":"Heterogeneous expression of Ca2+\u2212 dependent K+ currents by M\u00fcller glial cells","volume":"8","author":"Bringmann","year":"1997","journal-title":"Neuroreport"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.preteyeres.2018.03.006","article-title":"The primate fovea: structure, function and development","volume":"66","author":"Bringmann","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1167\/iovs.01-1193","article-title":"Role for extracellular signal-responsive Kinase-1 and -2 in retinal angiogenesis","volume":"44","author":"Bullard","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-vision-093019-113719","article-title":"Imaging the retinal vasculature","volume":"7","author":"Burns","year":"2021","journal-title":"Ann. Rev. Vis. Sci."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4614-0631-0_32","article-title":"Neovascularization: ocular diseases, animal models and therapies","volume-title":"Retinal degenerative diseases, advances in experimental medicine and biology","author":"Cai","year":"2012"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"112470","DOI":"10.1016\/j.yexcr.2021.112470","article-title":"Lymphocytic microparticles suppress retinal angiogenesis via targeting M\u00fcller cells in the ischemic retinopathy mouse model","volume":"399","author":"Cai","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/hgtb.2015.169","article-title":"pEPito-driven PEDF expression ameliorates diabetic retinopathy hallmarks","volume":"27","author":"Calado","year":"2016","journal-title":"Human Gene Therapy Methods"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<789::AID-JNR4>3.0.CO;2-M","article-title":"Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death","volume":"57","author":"Cao","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"ref22","first-page":"1646","article-title":"In vivo protection of photoreceptors from light damage by pigment epithelium-derived factor","volume":"42","author":"Cao","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"718","DOI":"10.4172\/2155-6156.1000718","article-title":"Linoleic acid is a diabetes-relevant stimulator of retinal inflammation in human retinal Muller cells and microvascular endothelial cells","volume":"7","author":"Capozzi","year":"2016","journal-title":"J. Diabetes Metab"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"107885","DOI":"10.1016\/j.exer.2019.107885","article-title":"The peroxisome proliferator-activated receptor-\u03b2\/\u03b4 antagonist GSK0660 mitigates retinal cell inflammation and leukostasis","volume":"190","author":"Capozzi","year":"2020","journal-title":"Exp. Eye Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1002\/jcp.30116","article-title":"Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis","volume":"236","author":"Cappelli","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/380435a0","article-title":"Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele","volume":"380","author":"Carmeliet","year":"1996","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/glia.20733","article-title":"In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: differentiation, proliferation, and apoptosis","volume":"57","author":"Chan-Ling","year":"2009","journal-title":"Glia"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e30203","DOI":"10.1371\/journal.pone.0030203","article-title":"Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/j.bbrc.2006.07.188","article-title":"PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases","volume":"348","author":"Chen","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.neuron.2017.02.043","article-title":"Gradual suppression of transcytosis governs functional blood-retinal barrier formation","volume":"93","author":"Chow","year":"2017","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.visres.2017.03.013","article-title":"M\u00fcller cells and diabetic retinopathy","volume":"139","author":"Coughlin","year":"2017","journal-title":"Vision Res. Diabetic Retinopathy"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5301\/EJO.2010.6049","article-title":"Blood-retinal barrier","volume":"21","author":"Cunha-Vaz","year":"2011","journal-title":"Eur. J. Ophthalmol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s40001-024-01847-y","article-title":"Deciphering M\u00fcller cell heterogeneity signatures in diabetic retinopathy across species: an integrative single-cell analysis","volume":"29","author":"Deng","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.drudis.2019.01.023","article-title":"M\u00fcller cells as a target for retinal therapy","volume":"24","author":"Devoldere","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1016\/0042-6989(96)00005-3","article-title":"Glia cells of the monkey retina\u2014II. M\u00fcller Cells","volume":"36","author":"Distler","year":"1996","journal-title":"Vision Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1172\/JCI35977","article-title":"Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress","volume":"119","author":"Dorrell","year":"2009","journal-title":"J. Clin. Invest."},{"key":"ref40","first-page":"821","article-title":"Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth","volume":"43","author":"Duh","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.yexcr.2004.05.020","article-title":"PEDF derived from glial M\u00fcller cells: a possible regulator of retinal angiogenesis","volume":"299","author":"Eichler","year":"","journal-title":"Exp. Cell Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"4103","DOI":"10.1097\/00001756-200112210-00048","article-title":"Hypoxia: modulation of endothelial cell proliferation by soluble factors released by retinal cells","volume":"12","author":"Eichler","year":"2001","journal-title":"Neuroreport"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1097\/01.wnr.0000133071.00786.a4","article-title":"Angiogenesis-related factors derived from retinal glial (M\u00fcller) cells in hypoxia","volume":"15","author":"Eichler","year":"","journal-title":"Neuroreport"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/bph.14507","article-title":"Bioactive lipids and pathological retinal angiogenesis","volume":"176","author":"Elmasry","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0006-8993(02)03766-6","article-title":"Immunocytochemical localization of vascular endothelial growth factor in neurons and glial cells of human retina","volume":"969","author":"Famiglietti","year":"2003","journal-title":"Brain Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/380439a0","article-title":"Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene","volume":"380","author":"Ferrara","year":"1996","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00739","article-title":"New lipid mediators in retinal angiogenesis and retinopathy","volume":"10","author":"Fleming","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.2174\/138161207781662920","article-title":"Neuronal and glial cell abnormality as predictors of progression of diabetic retinopathy","volume":"13","author":"Fletcher","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer, vascular, rheumatoid and other disease","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.med.57.121304.131306","article-title":"Angiogenesis","volume":"57","author":"Folkman","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10456-007-9065-1","article-title":"Development of the retinal vasculature","volume":"10","author":"Fruttiger","year":"2007","journal-title":"Angiogenesis"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.2337\/db15-0180","article-title":"M\u00fcller glia are a major cellular source of survival signals for retinal neurons in diabetes","volume":"64","author":"Fu","year":"2015","journal-title":"Diabetes"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1167\/iovs.04-0649","article-title":"Transforming growth factor-\u03b22 modulated extracellular matrix component expression in cultured human optic nerve head astrocytes","volume":"46","author":"Fuchshofer","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/aos.15226","article-title":"Lipid metabolism and retinal diseases","volume":"100","author":"Gabrielle","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13578-024-01217-5","article-title":"The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy","volume":"14","author":"Gandhi","year":"2024","journal-title":"Cell Biosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0014-5793(01)02110-X","article-title":"Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization","volume":"489","author":"Gao","year":"2001","journal-title":"FEBS Lett."},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-2541-6_16","article-title":"Role of M\u00fcller glia in neuroprotection and regeneration in the retina","author":"Garc\u00eda","year":"2003","journal-title":"Histol. Histopathol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1083\/jcb.200302047","article-title":"VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia","volume":"161","author":"Gerhardt","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s10571-011-9779-x","article-title":"Protective effects of adeno-associated virus mediated brain-derived neurotrophic factor expression on retinal ganglion cells in diabetic rats","volume":"32","author":"Gong","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1080\/02713683.2020.1712730","article-title":"Diabetes-induced inflammation and vascular alterations in the Goto\u2013Kakizaki rat retina","volume":"45","author":"Hachana","year":"2020","journal-title":"Curr. Eye Res."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and Management of Retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"10666","DOI":"10.1523\/JNEUROSCI.1944-11.2011","article-title":"Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells","volume":"31","author":"Hayakawa","year":"2011","journal-title":"J. Neurosci."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/jcbfm.2009.100","article-title":"Implications of vascular endothelial growth factor for Postischemic neurovascular remodeling","volume":"29","author":"Hermann","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s00417-004-0879-x","article-title":"Characterization of the basic fibroblast growth factor-evoked proliferation of the human M\u00fcller cell line, MIO-M1","volume":"242","author":"Hollborn","year":"2004","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"544170","DOI":"10.3389\/fcell.2020.00488","article-title":"Rank order of Small molecule induced Hypoxiamimesis to prevent retinopathy of prematurity","volume":"8","author":"Hoppe","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"200","DOI":"10.2337\/db14-0016","article-title":"Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1\u03b1-VEGF pathway inhibition","volume":"64","author":"Huang","year":"2015","journal-title":"Diabetes"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1182\/blood-2011-01-328716","article-title":"ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters","volume":"118","author":"Huang","year":"2011","journal-title":"Blood"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF00176889","article-title":"Basic fibroblast growth factor mRNA, bFGF peptide and FGF receptor in epiretinal membranes of intraocular proliferative disorders (PVR and PDR)","volume":"20","author":"Hueber","year":"1997","journal-title":"Int. Ophthalmol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/S0006-291X(02)00548-X","article-title":"Pigment epithelium-derived factor exerts opposite effects on endothelial cells of different phenotypes","volume":"294","author":"Hutchings","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1159\/000264803","article-title":"Electron microscope study on astrocytes in the human retina using ruthenium red","volume":"8","author":"Ikui","year":"1976","journal-title":"Ophthalmic Res."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"108490","DOI":"10.1016\/j.exer.2021.108490","article-title":"Microglia increase tight-junction permeability in coordination with M\u00fcller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier","volume":"205","author":"Inada","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1001\/archophthalmol.2012.1043","article-title":"Long-term effects of Ranibizumab on diabetic retinopathy severity and progression","volume":"130","author":"Ip","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1167\/iovs.13-13755","article-title":"Targeting M\u00fcller cell-derived VEGF164 to reduce intravitreal neovascularization in the rat model of retinopathy of prematurity","volume":"55","author":"Jiang","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/71517","article-title":"Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1","volume":"6","author":"Jim\u00e9nez","year":"2000","journal-title":"Nat. Med."},{"key":"ref75","first-page":"154","article-title":"Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues","volume":"7","author":"Karakousis","year":"2001","journal-title":"Mol. Vis."},{"key":"ref76","first-page":"2115","article-title":"Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in Normal eyes","volume":"40","author":"Kim","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1620\/tjem.137.453","article-title":"Impaired insulin secretion in the spontaneous diabetes rats","volume":"137","author":"Kimura","year":"1982","journal-title":"Tohoku J. Exp. Med."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"100159","DOI":"10.1016\/j.gpeds.2024.100159","article-title":"Retinopathy of prematurity (ROP): from the perspective of the neonatologist","volume":"8","author":"Koc","year":"2024","journal-title":"Global Pediatrics"},{"key":"ref79","volume-title":"Webvision: The organization of the retina and visual system","author":"Kolb","year":"2018"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1167\/iovs.15-17901","article-title":"Quantification of oxygen consumption in retina ex vivo demonstrates limited reserve capacity of photoreceptor mitochondria","volume":"56","author":"Kooragayala","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref81","first-page":"1283","article-title":"Fatty acid composition of serum lipids in patients with type 2 diabetes","volume":"58","author":"Korani","year":"2012","journal-title":"Clin. 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Sci."},{"key":"ref171","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/glia.22694","article-title":"M\u00fcller glial cells inhibit proliferation of retinal endothelial cells via TGF-\u03b22 and Smad signaling","volume":"62","author":"Yafai","year":"2014","journal-title":"Glia"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"e68773","DOI":"10.1371\/journal.pone.0068773","article-title":"Basic fibroblast growth factor contributes to a shift in the Angioregulatory activity of retinal glial (M\u00fcller) cells","volume":"8","author":"Yafai","year":"2013","journal-title":"PLoS One"},{"key":"ref173","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1080\/10739680490503375","article-title":"Retinal endothelial Angiogenic activity: effects of hypoxia and glial (M\u00fcller) cells","volume":"11","author":"Yafai","year":"2004","journal-title":"Microcirculation"},{"key":"ref174","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1002\/glia.20495","article-title":"Pigment epithelium-derived factor acts as an opponent of growth-stimulatory factors in retinal glial\u2013endothelial cell interactions","volume":"55","author":"Yafai","year":"2007","journal-title":"Glia"},{"key":"ref175","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.65.13.8","article-title":"Single-cell multiomics profiling reveals heterogeneity of M\u00fcller cells in the oxygen-induced retinopathy model","volume":"65","author":"Yao","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref176","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cell.2009.07.047","article-title":"Norrin, Frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization","volume":"139","author":"Ye","year":"2009","journal-title":"Cell"},{"key":"ref177","doi-asserted-by":"publisher","first-page":"13213","DOI":"10.1074\/jbc.M900553200","article-title":"Genetic variation in ANGPTL4 provides insights into protein processing and function *","volume":"284","author":"Yin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref178","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/dmrr.1007","article-title":"Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy","volume":"25","author":"Yoshida","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref179","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1111\/jcmm.15739","article-title":"YAP is essential for TGF-\u03b2-induced retinal fibrosis in diabetic rats via promoting the fibrogenic activity of M\u00fcller cells","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref180","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1677\/jme.1.02008","article-title":"Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF\u2013VEGF receptor 2 binding in diabetic retinopathy","volume":"37","author":"Zhang","year":"2006","journal-title":"J. Mol. 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