{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:14:50Z","timestamp":1792818890405,"version":"4.5.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Depression is a mental disorder that significantly impairs both physical and mental health. Recent studies have shown that reactive astrogliosis have gained significant attention for their involvement in the pathophysiology of depression. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots regarding the role of astrocytes in the mechanisms and treatment of depression through bibliometric analysis. The scope of the literature review encompasses both basic and clinical research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publications related to astrocytes in depression and treatment from 2014 to 2023 were searched in the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and the R package \u201cbibliometrix\u201d were used to conduct this bibliometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2014 to 2023, a total of 1,502 documents from 78 countries on astrocytes in depression and treatment were analyzed from 169 journals, with the most co-cited journals being the Journal of Neuroscience and PNAS. China Medical University was the most productive institution. The analysis identified key authors like Verkhratsky Alexei and Baoman Li, and major co-cited references by Rajkowska and Liddelow. Keywords such as \u201csynaptic plasticity,\u201d \u201castrocytes,\u201d and \u201cneuroinflammation\u201d revealed research trends focusing on molecular mechanisms, gut microbiota, and inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first bibliometric study to comprehensively summarize the research trends and advancements regarding astrocytes in depression and its treatment. Through this bibliometric analysis, we aim to enhance the understanding of the significance of astrocytes in depression research and provide new perspectives and insights for future investigations. We hope that this study will facilitate a broader integration of basic and clinical research, offering novel approaches for the treatment of depression.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fncel.2024.1521398","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T10:51:52Z","timestamp":1736938312000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Bibliometric insights into astrocytic roles in depression and treatment"],"prefix":"10.3389","volume":"18","author":[{"given":"Linsun","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peigang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s11192-011-0406-x","article-title":"The field-standardized average impact of national research systems compared to world average: The case of Italy","volume":"88","author":"Abramo","year":"2011","journal-title":"Scientometrics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1007\/s11192-022-04344-3","article-title":"Citation burst prediction in a bibliometric network","volume":"127","author":"Amjad","year":"2022","journal-title":"Scientometrics"},{"key":"ref1006","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/ijms24010350","article-title":"Depression Pathophysiology: Astrocyte Mitochondrial Melatonergic Pathway as Crucial Hub","volume":"24","author":"Anderson","year":"2022","journal-title":"Int J Mol Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"5880","DOI":"10.1111\/ejn.14969","article-title":"The effects of microglia- and astrocyte-derived factors on neurogenesis in health and disease","volume":"54","author":"Araki","year":"2021","journal-title":"Eur. 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Biol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1007\/s11064-020-03225-6","article-title":"The association between antidepressant effect of SSRIs and astrocytes: conceptual overview and Meta-analysis of the literature","volume":"46","author":"Chen","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10802-020-00715-7","article-title":"Social media and depression symptoms: a Meta-analysis","volume":"49","author":"Cunningham","year":"2021","journal-title":"Res. Child. Adolesc. Psychopathol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jad.2020.03.022","article-title":"Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression","volume":"268","author":"De Tomaz","year":"2020","journal-title":"J. Affect. 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Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: an overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J. Bus. Res."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1001\/jama.2017.3826","article-title":"Depression is the leading cause of disability around the world","volume":"317","author":"Friedrich","year":"2017","journal-title":"JAMA"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jphs.2020.11.002","article-title":"Perisynaptic astrocytes as a potential target for novel antidepressant drugs","volume":"145","author":"Frizzo","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmed.2023.1135592","article-title":"A bibliometric analysis of systematic reviews and meta-analyses in ophthalmology","volume":"10","author":"Fu","year":"2023","journal-title":"Front. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3934\/Neuroscience.2024001","article-title":"Brain-derived neurotrophic factor (BDNF) in chronic pain research: a decade of bibliometric analysis and network visualization","volume":"11","author":"Ismail","year":"2024","journal-title":"AIMSN"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"e14576","DOI":"10.1111\/cns.14576","article-title":"Mitochondria in depression: the dysfunction of mitochondrial energy metabolism and quality control systems","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3301","DOI":"10.1007\/s10571-023-01386-w","article-title":"Astrocytes in post-stroke depression: roles in inflammation, neurotransmission, and Neurotrophin signaling","volume":"43","author":"Jing","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Rev. 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Disord."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1017\/S1461145711001386","article-title":"Acute d-serine treatment produces antidepressant-like effects in rodents","volume":"15","author":"Malkesman","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1007\/s11064-012-0967-y","article-title":"The pro-inflammatory cytokine TNF-\u03b1 regulates the activity and expression of the serotonin transporter (SERT) in astrocytes","volume":"38","author":"Malynn","year":"2013","journal-title":"Neurochem. 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Soft Comput."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3390\/brainsci11101298","article-title":"HPA Axis in the Pathomechanism of depression and schizophrenia: new therapeutic strategies based on its participation","volume":"11","author":"Mikulska","year":"2021","journal-title":"Brain Sci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41380-018-0017-5","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Milaneschi","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"3833","DOI":"10.1038\/s41380-022-01730-4","article-title":"Does the change in glutamate to GABA ratio correlate with change in depression severity? A randomized, double-blind clinical trial","volume":"27","author":"Narayan","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.bbadis.2017.11.004","article-title":"Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration","volume":"1864","author":"Neal","year":"2018","journal-title":"Biochim. Biophys. Acta. Mol. Basis Dis."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson\u2019s disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1002\/glia.23994","article-title":"Implication of cerebral astrocytes in major depression: a review of fine neuroanatomical evidence in humans","volume":"69","author":"O\u2019Leary","year":"2021","journal-title":"Glia"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.5498\/wjp.v11.i7.297","article-title":"Glutamate and depression: reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule","volume":"11","author":"Onaolapo","year":"2021","journal-title":"World J. Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.30773\/pi.2019.0171","article-title":"Understanding the complex of suicide in depression: from research to clinics","volume":"17","author":"Orsolini","year":"2020","journal-title":"Psychiatry Investig."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"ref1007","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/14737175.2018.1458612","article-title":"Depression and obesity: evidence of shared biological mechanisms","volume":"24","author":"Peng","year":"2018","journal-title":"Mol. 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Drug Targets"},{"key":"ref1004","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1126\/science.adp3269","article-title":"Rodent tests for psychiatric drugs get a rethink","volume":"383","author":"Reardon","year":"2024","journal-title":"Science."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.celrep.2015.07.051","article-title":"Astrocyte depletion impairs redox homeostasis and triggers neuronal loss in the adult CNS","volume":"12","author":"Schreiner","year":"2015","journal-title":"Cell Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/515180a","article-title":"Mental health: a world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.3390\/ijms25105135","article-title":"Kinetic properties and pharmacological modulation of high- and low-affinity dopamine transport in striatal astrocytes of adult rats","volume":"25","author":"So\u010dan","year":"2024","journal-title":"IJMS"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.neuron.2015.10.037","article-title":"Synaptic integration of adult-born hippocampal neurons is locally controlled by astrocytes","volume":"88","author":"Sultan","year":"2015","journal-title":"Neuron"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.euroneuro.2007.03.010","article-title":"Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression","volume":"17","author":"Taler","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1126\/science.aal3589","article-title":"Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development","volume":"359","author":"Vainchtein","year":"2018","journal-title":"Science"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2009","journal-title":"Scientometrics"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1504\/IJBBM.2017.082422","article-title":"Analytical evaluation of emerging scientific trends in business intelligence through the utilisation of burst detection algorithm","volume":"1","author":"Vanani","year":"2017","journal-title":"Int. J. Bibliomet. Busi. 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