{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:20:56Z","timestamp":1793049656070,"version":"4.5.0"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The choroid plexus is located in the cerebral ventricles. It consists of a stromal core and a single layer of cuboidal epithelial cells that forms the blood-cerebrospinal barrier. The main function of the choroid plexus is to produce cerebrospinal fluid. Subarachnoid hemorrhage due to aneurysm rupture is a devastating type of hemorrhagic stroke. Following subarachnoid hemorrhage, blood and the blood degradation products that disperse into the cerebrospinal fluid come in direct contact with choroid plexus epithelial cells. The aim of the current study was to elucidate the pathophysiological cascades responsible for the inflammatory reaction that is seen in the choroid plexus following subarachnoid hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subarachnoid hemorrhage was induced in rats by injecting non-heparinized autologous blood to the cisterna magna. Increased intracranial pressure following subarachnoid hemorrhage was modeled by using artificial cerebrospinal fluid instead of blood. Subarachnoid hemorrhage and artificial cerebrospinal fluid animals were left to survive for 1, 3, 7 and 14 days. Immunohistochemical staining of TLR4, TLR9, FPR2, CCL2, TNF\u03b1, IL-1\u03b2, CCR2 and CX3CR1 was performed on the cryostat sections of choroid plexus tissue. The level of TLR4, TLR9, FPR2, CCL2, TNF\u03b1, IL-1\u03b2 was detected by measuring immunofluorescence intensity in randomly selected epithelial cells. The number of CCR2 and CX3CR1 positive cells per choroid plexus area was manually counted. Immunohistochemical changes were confirmed by Western blot analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Immunohistochemical methods and Western blot showed increased levels of TLR9 and a slight increase in TLR4 and FRP2 following both subarachnoid hemorrhage as well as the application of artificial cerebrospinal fluid over time, although the individual periods were different. The levels of TNF\u03b1 and IL-1\u03b2 increased, while CCL2 level decreased slightly. Accumulation of macrophages positive for CCR2 and CX3CR1 was found in all periods after subarachnoid hemorrhage as well as after the application of artificial cerebrospinal fluid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our results suggest that the inflammation develops in the choroid plexus and blood-cerebrospinal fluid barrier in response to blood components as well as acutely increased intracranial pressure following subarachnoid hemorrhage. These pro-inflammatory changes include accumulation in the choroid plexus of pro-inflammatory cytokines, innate immune receptors, and monocyte-derived macrophages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fncel.2024.1525415","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T02:45:36Z","timestamp":1736217936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules"],"prefix":"10.3389","volume":"18","author":[{"given":"Peter","family":"Sol\u00e1r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Br\u00e1zda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bare\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemeh","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"EmamiAref","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Joukal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Kub\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Kro\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaudia","family":"Ha\u0161anov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Joukal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s004410051042","article-title":"Broad immunocytochemical localization of the formylpeptide receptor in human organs, tissues, and cells","volume":"292","author":"Becker","year":"1998","journal-title":"Cell Tissue Res."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00006123-199802000-00091","article-title":"Acute vasoconstriction after subarachnoid hemorrhage","volume":"42","author":"Bederson","year":"1998","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e2006859","DOI":"10.1371\/journal.pbio.2006859","article-title":"Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation","volume":"17","author":"Benbenishty","year":"2019","journal-title":"PLoS Biol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.bbrc.2006.10.065","article-title":"Restoring wild-type conformation and DNA-binding activity of mutant p53 is insufficient for restoration of transcriptional activity","volume":"351","author":"Brazda","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1471-4159.2010.06736.x","article-title":"Toll-like receptor 4 in CNS pathologies","volume":"114","author":"Buchanan","year":"2010","journal-title":"J. Neurochem."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s11658-023-00416-1","article-title":"Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia-reperfusion injury","volume":"28","author":"Cao","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/1742-2094-11-132","article-title":"Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2\/CCL2 signaling","volume":"11","author":"Cazareth","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"23799","DOI":"10.1074\/jbc.273.37.23799","article-title":"Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1","volume":"273","author":"Combadiere","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jneuroim.2010.05.010","article-title":"The role of monocyte chemoattractant protein MCP1\/CCL2 in neuroinflammatory diseases","volume":"224","author":"Conductier","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","article-title":"Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/american Stroke Association","volume":"43","author":"Connolly","year":"2012","journal-title":"Stroke"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/BF01411481","article-title":"Brain energy metabolism in the acute stage of experimental subarachnoid haemorrhage: local changes in cerebral glucose utilization","volume":"138","author":"d\u2019Avella","year":"1996","journal-title":"Acta Neurochir."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant Protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J. Interf. Cytokine Res."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1742-2094-10-55","article-title":"Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve","volume":"10","author":"Dubov\u00fd","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00418-002-0411-5","article-title":"A quantitative immunohistochemical study of the endoneurium in the rat dorsal and ventral spinal roots","volume":"117","author":"Dubov\u00fd","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.pharmthera.2010.04.010","article-title":"Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists","volume":"127","author":"Dufton","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1001\/jamaneurol.2019.0006","article-title":"Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population: A systematic review and Meta-analysis","volume":"76","author":"Etminan","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"20221","DOI":"10.1074\/jbc.M610737200","article-title":"Characterization of heme as activator of toll-like receptor 4","volume":"282","author":"Figueiredo","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1038\/s41467-021-23683-y","article-title":"TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection","volume":"12","author":"Geng","year":"2021","journal-title":"Nat. Commun."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12974-014-0200-9","article-title":"Extracellular hemoglobin - mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage","volume":"11","author":"Gram","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"C525","DOI":"10.1152\/ajpcell.00026.2018","article-title":"Genetic and pharmacological inactivation of apical Na+-K+-2Cl- cotransporter 1 in choroid plexus epithelial cells reveals the physiological function of the cotransporter","volume":"316","author":"Gregoriades","year":"2019","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/STROKEAHA.115.011223","article-title":"Lipoxin A4 reduces inflammation through formyl peptide receptor 2\/p38 MAPK signaling pathway in subarachnoid hemorrhage rats","volume":"47","author":"Guo","year":"2016","journal-title":"Stroke"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12974-016-0508-8","article-title":"CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model","volume":"13","author":"Hernang\u00f3mez","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","article-title":"Intrathecal morphine in mice: a new technique","volume":"67","author":"Hylden","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/jcbfm.1990.140","article-title":"The time course of intracranial pathophysiological changes following experimental subarachnoid haemorrhage in the rat","volume":"10","author":"Jackowski","year":"1990","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1080\/14728222.2020.1752182","article-title":"Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury","volume":"24","author":"Karimy","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nm.4361","article-title":"Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus","volume":"23","author":"Karimy","year":"2017","journal-title":"Nat. Med."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1093\/jnen\/nlv030","article-title":"The choroid plexus in healthy and diseased brain","volume":"75","author":"Kaur","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s10571-019-00767-4","article-title":"Inflammatory pathways following subarachnoid hemorrhage","volume":"40","author":"Khey","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.3390\/ijms16035028","article-title":"Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage","volume":"16","author":"Kwon","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01748-x","article-title":"Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury","volume":"17","author":"Li","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1086\/654929","article-title":"Synergistic inflammation is induced by blood degradation products with microbial toll-like receptor agonists and is blocked by Hemopexin","volume":"202","author":"Lin","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/(SICI)1097-0029(19980401)41:1<43::AID-JEMT5>3.0.CO;2-V","article-title":"Origin, nature, and some functional considerations of intraventricular macrophages, with special reference to the epiplexus cells","volume":"41","author":"Ling","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3171\/jns.1984.61.3.0486","article-title":"Morphological changes of the basilar artery, ventricles, and choroid plexus after experimental SAH","volume":"61","author":"Liszczak","year":"1984","journal-title":"J. Neurosurg."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"816149","DOI":"10.3389\/fimmu.2022.816149","article-title":"Piezo1 channels as force sensors in mechanical force-related chronic inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.4049\/jimmunol.1701118","article-title":"Cutting edge: Piezo1 Mechanosensors optimize human T cell activation","volume":"200","author":"Liu","year":"2018","journal-title":"J. Immunol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00401-017-1758-y","article-title":"The choroid plexus is a key cerebral invasion route for T cells after stroke","volume":"134","author":"Llovera","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/brain\/awh655","article-title":"Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis","volume":"129","author":"Mahad","year":"2006","journal-title":"Brain"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0006-8993(95)01511-6","article-title":"Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage","volume":"713","author":"Matz","year":"1996","journal-title":"Brain Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3389\/fimmu.2020.01117","article-title":"Revising CX3CR1 expression on murine classical and non-classical monocytes","volume":"11","author":"Meghraoui-Kheddar","year":"2020","journal-title":"Front. Immunol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1093\/brain\/awp144","article-title":"CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system","volume":"132","author":"Mildner","year":"2009","journal-title":"Brain"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/384342","article-title":"Inflammation, vasospasm, and brain injury after subarachnoid hemorrhage","volume":"2014","author":"Miller","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.smim.2006.12.002","article-title":"Innate immune sensing of pathogens and danger signals by cell surface toll-like receptors","volume":"19","author":"Miyake","year":"2007","journal-title":"Semin. Immunol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4103\/1673-5374.200795","article-title":"Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage","volume":"12","author":"Okada","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3389\/fnins.2020.00685","article-title":"A review of hematoma components clearance mechanism after subarachnoid hemorrhage","volume":"14","author":"Pan","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jneuroim.2016.03.019","article-title":"TLR4 induces CCR7-dependent monocytes transmigration through the blood\u2013brain barrier","author":"Paradis","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2010\/672395","article-title":"DAMPening inflammation by modulating TLR Signalling","volume":"2010","author":"Piccinini","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jneuroim.2010.05.015","article-title":"Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS","volume":"224","author":"Prinz","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-3-7091-1192-5_42","article-title":"Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: A review","volume":"115","author":"Provencio","year":"2013","journal-title":"Acta Neurochir. Suppl."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/00006123-200301000-00022","article-title":"Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models","volume":"52","author":"Prunell","year":"2003","journal-title":"Neurosurgery"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1097\/00001756-200212200-00034","article-title":"A new experimental model in rats for study of the pathophysiology of subarachnoid hemorrhage","volume":"13","author":"Prunell","year":"2002","journal-title":"Neuroreport"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.1523\/JNEUROSCI.23-13-05607.2003","article-title":"Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus","volume":"23","author":"Reyes","year":"2003","journal-title":"J. Neurosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"e13693","DOI":"10.1371\/journal.pone.0013693","article-title":"Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice","volume":"5","author":"Saederup","year":"2010","journal-title":"PLoS One"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1161\/01.STR.0000127425.47266.20","article-title":"Role of p38 mitogen-activated protein kinase on cerebral vasospasm after subarachnoid hemorrhage","volume":"35","author":"Sasaki","year":"2004","journal-title":"Stroke"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"307231","DOI":"10.1155\/2010\/307231","article-title":"TNF\u03b1 induces choroid plexus epithelial cell barrier alterations by apoptotic and nonapoptotic mechanisms","volume":"2010","author":"Schwerk","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12035-010-8155-z","article-title":"Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury","volume":"43","author":"Sehba","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.toxrep.2021.03.002","article-title":"Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice","volume":"8","author":"Shimada","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10495-008-0187-8","article-title":"Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications","volume":"13","author":"Silva","year":"2008","journal-title":"Apoptosis"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s12975-011-0070-8","article-title":"Inflammation of the choroid plexus and ependymal layer of the ventricle following intraventricular hemorrhage","volume":"2","author":"Simard","year":"2011","journal-title":"Transl. Stroke Res."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1556\/AVet.2014.027","article-title":"Profile of toll-like receptor mRNA expression in the choroid plexus in adult ewes","volume":"63","author":"Skipor","year":"2015","journal-title":"Acta Vet. Hung."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"593305","DOI":"10.3389\/fncel.2020.593305","article-title":"Subarachnoid hemorrhage increases level of Heme Oxygenase-1 and Biliverdin reductase in the choroid plexus","volume":"14","author":"Sol\u00e1r","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1080\/02688697.2022.2151563","article-title":"Impact of analgesic regimen on patient outcome following subarachnoid hemorrhage: positive adjuvant effects of metamizole","volume":"38","author":"Solar","year":"2022","journal-title":"Br. J. Neurosurg."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fncel.2020.00018","article-title":"Subarachnoid hemorrhage induces dynamic immune cell reactions in the choroid plexus","volume":"14","author":"Sol\u00e1r","year":"","journal-title":"Front. Cell. Neurosci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12987-020-00196-2","article-title":"Choroid plexus and the blood\u2013cerebrospinal fluid barrier in disease","volume":"17","author":"Sol\u00e1r","year":"","journal-title":"Fluids Barriers CNS"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12987-022-00312-4","article-title":"The blood\u2013brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments","volume":"19","author":"Sol\u00e1r","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1161\/01.str.16.1.58","article-title":"Decrease in cerebral blood flow in rats after experimental subarachnoid hemorrhage: a new animal model","volume":"16","author":"Solomon","year":"1985","journal-title":"Stroke"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s12975-012-0248-8","article-title":"Regulation of toll-like receptors in the choroid plexus in the immature brain after systemic inflammatory stimuli","volume":"4","author":"Stridh","year":"2013","journal-title":"Transl. Stroke Res."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12974-022-02497-9","article-title":"The primary macrophage chemokine, CCL2, is not necessary after a peripheral nerve injury for macrophage recruitment and activation or for conditioning lesion enhanced peripheral regeneration","volume":"19","author":"Talsma","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/cne.1187","article-title":"Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines","volume":"434","author":"Thibeault","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12987-022-00372-6","article-title":"The choroid plexus and its role in the pathogenesis of neurological infections","volume":"19","author":"Thompson","year":"2022","journal-title":"Fluids Barriers CNS"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1007\/s43440-021-00271-x","article-title":"Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology","volume":"73","author":"Tylek","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/glia.20266","article-title":"Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord","volume":"53","author":"Valli\u00e8res","year":"2006","journal-title":"Glia"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1007\/s10143-017-0827-y","article-title":"An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage","volume":"41","author":"van Lieshout","year":"2018","journal-title":"Neurosurg. Rev."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1161\/01.str.26.7.1279","article-title":"The Sheffield model of subarachnoid hemorrhage in rats","volume":"26","author":"Veelken","year":"1995","journal-title":"Stroke"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1111\/cns.13203","article-title":"Activation of epiplexus macrophages in hydrocephalus caused by subarachnoid hemorrhage and thrombin","volume":"25","author":"Wan","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1111\/cns.13919","article-title":"Protective role of TLR9-induced macrophage\/microglia phagocytosis after experimental intracerebral hemorrhage in mice","volume":"28","author":"Wei","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"610734","DOI":"10.3389\/fphar.2020.610734","article-title":"Resolvin D1 ameliorates inflammation-mediated blood-brain barrier disruption after subarachnoid hemorrhage in rats by modulating A20 and NLRP3 Inflammasome","volume":"11","author":"Wei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.pupt.2016.02.005","article-title":"Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation","volume":"37","author":"Wenceslau","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1172\/JCI41911","article-title":"Trafficking of immune cells in the central nervous system","volume":"120","author":"Wilson","year":"2010","journal-title":"J. Clin. Invest."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00401-009-0627-8","article-title":"Choroid plexus: biology and pathology","volume":"119","author":"Wolburg","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.toxlet.2009.08.025","article-title":"Lipopolysaccharide triggers macrophage activation of inflammatory cytokine expression, chemotaxis, phagocytosis, and oxidative ability via a toll-like receptor 4-dependent pathway: validated by RNA interference","volume":"191","author":"Wu","year":"2009","journal-title":"Toxicol. Lett."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12987-017-0056-3","article-title":"The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury","volume":"14","author":"Xiang","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"ref86","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s10787-022-00942-y","article-title":"Lipoxin A4 regulates M1\/M2 macrophage polarization via FPR2-IRF pathway","volume":"30","author":"Yuan","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref87","unstructured":"Buffered picric acid-formaldehyde: A new rapid fixation for electron microscopy\n          \n          148A\n          \n            \n              Zamboni\n              L\n            \n          \n          J. Cell Biol.\n          35\n          1967"},{"key":"ref88","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.2174\/1570159X19666211101103646","article-title":"New mechanisms and targets of subarachnoid hemorrhage: A focus on mitochondria","volume":"20","author":"Zhang","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.4049\/jimmunol.1900961","article-title":"CCR2-mediated uptake of constitutively produced CCL2: A mechanism for regulating chemokine levels in the blood","volume":"203","author":"Zhao","year":"2019","journal-title":"J. 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