{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:25:57Z","timestamp":1788881157591,"version":"build-2803163510"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>More than 5% of the global population suffers from disabling hearing loss, primarily sensorineural hearing loss (SNHL). SNHL is often caused by factors such as vascular disorders, viral infections, ototoxic drugs, systemic inflammation, age-related labyrinthine membrane degeneration, and noise-induced hearing loss (NIHL). NIHL, in particular, leads to changes in blood-labyrinth-barrier (BLB) physiology, increased permeability, and various health issues, including cardiovascular disease, hypertension, diabetes, neurological disorders, and adverse reproductive outcomes. Recent advances in neuromodulation and vector-based approaches offer hope for overcoming biological barriers such as the BLB in the development of innovative treatments. Computational methods, including molecular docking, molecular dynamics simulations, QSAR\/QSPR analysis with machine\/deep learning algorithms, and network pharmacology, hold potential for identifying drug candidates and optimizing their interactions with BLB transporters, such as the glutamate transporter. This paper provides an overview of NIHL, focusing on its pathophysiology; its impact on membrane transporters, ion channels, and BLB structures; and associated symptoms, comorbidities, and emerging therapeutic approaches. Recent advancements in neuromodulation and vector-based strategies show great promise in overcoming biological barriers such as BLB, facilitating the development of innovative treatment options. The primary aim of this review is to examine NIHL in detail and explore its underlying mechanisms, physiological effects, and cutting-edge therapeutic strategies for its effective management and prevention.<\/jats:p>","DOI":"10.3389\/fncel.2025.1523149","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:20:20Z","timestamp":1744003220000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Interplay between noise-induced sensorineural hearing loss and hypertension: pathophysiological mechanisms and therapeutic prospects"],"prefix":"10.3389","volume":"19","author":[{"given":"Carola Y.","family":"F\u00f6rster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Shityakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Stavrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Scheper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.neuron.2012.05.019","article-title":"Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy","volume":"75","author":"Akil","year":"2012","journal-title":"Neuron"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3109\/00016487909126417","article-title":"Occupational hearing loss. The significance of asymmetrical hearing thresholds","volume":"87","author":"Alberti","year":"1979","journal-title":"Acta Otolaryngol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3389\/fphys.2019.00025","article-title":"Chronic low-level Vagus nerve stimulation improves long-term survival in Salt-sensitive hypertensive rats","volume":"10","author":"Annoni","year":"2019","journal-title":"Front. Physiol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e12476","DOI":"10.14814\/phy2.12476","article-title":"Intermittent electrical stimulation of the right cervical vagus nerve in salt-sensitive hypertensive rats: effects on blood pressure, arrhythmias, and ventricular electrophysiology","volume":"3","author":"Annoni","year":"2015","journal-title":"Physiol. Rep."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/joa.13122","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J. Anat."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"242","DOI":"10.2471\/BLT.21.285643","article-title":"(2021) the world report on hearing","volume":"99","author":"Chadha","year":"2021","journal-title":"Bull. World Health Organ."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1289\/ehp.10346","article-title":"Effects of occupational noise exposure on 24-hour ambulatory vascular properties in male workers","volume":"115","author":"Chang","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"H276","DOI":"10.1152\/ajpheart.00043.2016","article-title":"Chronic vagal nerve stimulation prevents high-salt diet-induced endothelial dysfunction and aortic stiffening in stroke-prone spontaneously hypertensive rats","volume":"311","author":"Chapleau","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"778197","DOI":"10.3389\/fnins.2021.778197","article-title":"Detecting noise-induced Cochlear Synaptopathy by auditory brainstem response in tinnitus patients with Normal hearing thresholds: a Meta-analysis","volume":"15","author":"Chen","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature09656","article-title":"Reversing pathological neural activity using targeted plasticity","volume":"470","author":"Engineer","year":"2011","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.15761\/OHNS.1000221","article-title":"Hearing loss and strial microvascular pathology towards unravelling the functional contribution of the blood-labyrinth barrier","author":"F\u00f6rster","year":"2019","journal-title":"Otorhinolaryngol. Head Neck Surg."},{"key":"ref12","first-page":"4","article-title":"Hearing loss and strial microvascular pathology \u2013 towards unravelling the functional contribution of the blood-labyrinth barrier","author":"F\u00f6rster","year":"2020","journal-title":"Otorhinolaryngol. Head Neck Surg."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.3390\/biom12111717","article-title":"Linking cerebrovascular dysfunction to age-related hearing loss and Alzheimer's disease-are systemic approaches for diagnosis and therapy required?","volume":"12","author":"Forster","year":"2022","journal-title":"Biomolecules"},{"key":"ref14","article-title":"Linking neurovascular dysfunction to age-related hearing loss and Alzheimer\u2019s disease- are systemic approaches for diagnostic and treatment required?","author":"F\u00f6rster","year":"2022","journal-title":"Front. Deaf. Aging Alzheimers Dis."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1113\/jphysiol.2005.084038","article-title":"Occludin as direct target for glucocorticoid-induced improvement of blood-brain barrier properties in a murine in vitro system","volume":"565","author":"Forster","year":"2005","journal-title":"J. Physiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1097\/HJH.0000000000001504","article-title":"Association between exposure to noise and risk of hypertension: a meta-analysis of observational epidemiological studies","volume":"35","author":"Fu","year":"2017","journal-title":"J. Hypertens."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"e35250","DOI":"10.7759\/cureus.35250","article-title":"Evaluation of lung functions, blood pressure, and hearing deterioration in tile setters","volume":"15","author":"Gangwar","year":"2023","journal-title":"Cureus"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.3390\/antiox10121880","article-title":"Impulse noise induced hidden hearing loss, hair cell ciliary changes and oxidative stress in mice","volume":"10","author":"Gratias","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1093\/cvr\/cvab172","article-title":"Neuroscientific therapies for atrial fibrillation","volume":"117","author":"Hanna","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1001619","DOI":"10.3389\/fnins.2023.1001619","article-title":"Using an appetitive operant conditioning paradigm to screen rats for tinnitus induced by intense sound exposure: experimental considerations and interpretation","volume":"17","author":"Hayes","year":"2023","journal-title":"Front. Neurosci."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"684706","DOI":"10.3389\/fncel.2021.684706","article-title":"Cochlear synaptic degeneration and regeneration after noise: effects of age and neuronal subgroup","volume":"15","author":"Hickman","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1007\/s10162-014-0476-6","article-title":"Systemic lipopolysaccharide compromises the blood-labyrinth barrier and increases entry of serum fluorescein into the perilymph","volume":"15","author":"Hirose","year":"2014","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"7494","DOI":"10.1073\/pnas.1222295110","article-title":"ATP-gated ion channels mediate adaptation to elevated sound levels","volume":"110","author":"Housley","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/cbdd.13894","article-title":"In silico prediction of drug-induced ototoxicity using machine learning and deep learning methods","volume":"98","author":"Huang","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"286","DOI":"10.12968\/hmed.2017.78.5.286","article-title":"Noise-induced hearing loss: a modern epidemic?","volume":"78","author":"Imam","year":"2017","journal-title":"Br. J. Hosp. Med. (Lond.)"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00455891","article-title":"The blood-perilymph barrier","volume":"228","author":"Jahnke","year":"1980","journal-title":"Arch. Otorhinolaryngol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1289\/ehp.10775","article-title":"Hypertension and exposure to noise near airports: the HYENA study","volume":"116","author":"Jarup","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3760\/cma.j.cn112150-20210917-00905","article-title":"A case-control study on the relationship between DNA methylation and occupational noise hearing loss","volume":"56","author":"Jiao","year":"2022","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"108682","DOI":"10.1016\/j.heares.2022.108682","article-title":"The role of the stria vascularis in neglected otologic disease","volume":"428","author":"Johns","year":"2023","journal-title":"Hear. Res."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1177\/000348948109000208","article-title":"Nature of blood-labyrinth barrier in experimental conditions","volume":"90","author":"Juhn","year":"1981","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/S0006-8993(01)02164-3","article-title":"Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat","volume":"904","author":"Kastenbauer","year":"2001","journal-title":"Brain Res."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"7190","DOI":"10.1523\/JNEUROSCI.1314-19.2020","article-title":"The neural bases of tinnitus: lessons from deafness and Cochlear implants","volume":"40","author":"Knipper","year":"2020","journal-title":"J. Neurosci. Res."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/lio2.364","article-title":"Vagus nerve stimulation paired with tones for tinnitus suppression: effects on voice and hearing","volume":"5","author":"Kochilas","year":"2020","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \"temporary\" noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J. Neurosci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.heares.2016.11.013","article-title":"Cellular mechanisms of noise-induced hearing loss","volume":"349","author":"Kurabi","year":"2017","journal-title":"Hear. Res."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1093\/geront\/gnz009","article-title":"Hearing loss and depression in older adults: a systematic review and Meta-analysis","volume":"60","author":"Lawrence","year":"2020","journal-title":"Gerontologist"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s40463-017-0245-8","article-title":"Mannitol and the blood-labyrinth barrier","volume":"46","author":"Le","year":"2017","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.heares.2006.10.006","article-title":"Mechanisms of noise-induced hearing loss indicate multiple methods of prevention","volume":"226","author":"Le Prell","year":"2007","journal-title":"Hear. Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"e19130","DOI":"10.1371\/journal.pone.0019130","article-title":"Acoustic trauma increases Cochlear and hair cell uptake of gentamicin","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"620921","DOI":"10.3389\/fphar.2021.620921","article-title":"The role of Nrf 2 in hearing loss","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-2981-8_1","article-title":"Noise-induced hearing loss: permanent versus temporary threshold shifts and the effects of hair cell versus neuronal degeneration","volume":"875","author":"Liberman","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e0142341","DOI":"10.1371\/journal.pone.0142341","article-title":"Chronic conductive hearing loss leads to Cochlear degeneration","volume":"10","author":"Liberman","year":"2015","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.21037\/atm-21-2508","article-title":"Experimental animal models of drug-induced sensorineural hearing loss: a narrative review","volume":"9","author":"Lin","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"746","DOI":"10.3760\/cma.j.cn121094-20210913-00453","article-title":"A case-control study of occupational noise exposure induced high-frequency hearing loss and the risk of hypertension","volume":"40","author":"Liu","year":"2022","journal-title":"Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1007\/s10072-022-05948-6","article-title":"Noise as a cause of neurodegenerative disorders: molecular and cellular mechanisms","volume":"43","author":"Manukyan","year":"2022","journal-title":"Neurol. Sci."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/4784385","article-title":"Noise-induced hearing loss: updates on molecular targets and potential interventions","volume":"2021","author":"Mao","year":"2021","journal-title":"Neural Plast."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1111\/jgs.12429","article-title":"Hearing loss and depression in older adults","volume":"61","author":"Mener","year":"2013","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s11302-015-9473-4","article-title":"Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells","volume":"11","author":"Morton-Jones","year":"2015","journal-title":"Purinergic Signal"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1093\/eurheartj\/ehx081","article-title":"Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice","volume":"38","author":"Munzel","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jacc.2017.12.015","article-title":"Environmental noise and the cardiovascular system","volume":"71","author":"Munzel","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1038\/s41440-023-01272-4","article-title":"Denervation or stimulation? Role of sympatho-vagal imbalance in HFpEF with hypertension","volume":"46","author":"Nagai","year":"2023","journal-title":"Hypertens. Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s10286-020-00744-8","article-title":"The insular cortex as a vestibular area in relation to autonomic function","volume":"31","author":"Nagai","year":"2021","journal-title":"Clin. Auton. Res."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"12, 2347","DOI":"10.3390\/jcm13040944","article-title":"Correction: Natarajan et al. noise-induced hearing loss","volume":"13","author":"Natarajan","year":"2024","journal-title":"J. Clin. Med."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1017\/S0022215120000663","article-title":"The World Health Organization's world report on hearing: a call to action for hearing care providers","volume":"134","author":"Nieman","year":"2020","journal-title":"J. Laryngol. Otol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0378-5955(99)00163-X","article-title":"Histopathological differences between temporary and permanent threshold shift","volume":"139","author":"Nordmann","year":"2000","journal-title":"Hear. Res."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/s0006-8993(00)02733-5","article-title":"Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea","volume":"878","author":"Ohinata","year":"2000","journal-title":"Brain Res."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41514-020-00053-4","article-title":"Activation of the NRF2 pathway in Keap 1-knockdown mice attenuates progression of age-related hearing loss","volume":"6","author":"Oishi","year":"2020","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1097\/00001756-199806220-00037","article-title":"Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss","volume":"9","author":"Puel","year":"1998","journal-title":"Neuroreport"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1136\/bjophthalmol-2014-306093","article-title":"Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells","volume":"99","author":"Quill","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1080\/14992027.2023.2177894","article-title":"Effectiveness of transcutaneous vagus nerve stimulation for the treatment of tinnitus: an interventional prospective controlled study","volume":"63","author":"Raj-Koziak","year":"2023","journal-title":"Int. J. Audiol."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1037\/0003-066X.51.11.1109","article-title":"National research agenda for prevention research. The National Institute of Mental Health report","volume":"51","author":"Reiss","year":"1996","journal-title":"Am. Psychol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/ohn.163","article-title":"Cardiovascular risk factors in patients with sudden sensorineural hearing loss: A systematic review and meta-analysis","volume":"168","author":"Saba","year":"2023","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.3390\/ijerph20064903","article-title":"Traffic-related high sleep disturbance in the LIFE-adult cohort study: a comparison to the WHO exposure-response-curves","volume":"20","author":"Schubert","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1749-6632.1999.tb08644.x","article-title":"Mechanisms of alterations in the microcirculation of the cochlea","volume":"884","author":"Seidman","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.3390\/ijerph7103730","article-title":"Noise and quality of life","volume":"7","author":"Seidman","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0006-8993(02)04090-8","article-title":"Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress","volume":"967","author":"Shi","year":"2003","journal-title":"Brain Res."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1504\/IJCBDD.2013.056801","article-title":"Multidrug resistance protein P-gp interaction with nanoparticles (fullerenes and carbon nanotube) to assess their drug delivery potential: a theoretical molecular docking study","volume":"6","author":"Shityakov","year":"2013","journal-title":"Int. J. Comput. Biol. Drug Des."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2147\/AABC.S63749","article-title":"In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter","volume":"7","author":"Shityakov","year":"","journal-title":"Adv. Appl. Bioinform. Chem."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/AABC.S56046","article-title":"In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions","volume":"7","author":"Shityakov","year":"","journal-title":"Adv. Appl. Bioinform. Chem."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"900","DOI":"10.3390\/biom11060900","article-title":"The conspicuous link between ear, brain and heart-could Neurotrophin-treatment of age-related hearing loss help prevent Alzheimer's disease and associated amyloid cardiomyopathy?","volume":"11","author":"Shityakov","year":"","journal-title":"Biomol. Ther."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1504\/IJCBDD.2013.052195","article-title":"Analysing molecular polar surface descriptors to predict blood-brain barrier permeation","volume":"6","author":"Shityakov","year":"2013","journal-title":"Int. J. Comput. Biol. Drug Des."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1021\/acs.jcim.6b00215","article-title":"Characterization, in vivo evaluation, and molecular modeling of different Propofol-Cyclodextrin complexes to assess their drug delivery potential at the blood-brain barrier level","volume":"56","author":"Shityakov","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"736509","DOI":"10.3389\/fchem.2021.736509","article-title":"Scaffold searching of FDA and EMA-approved drugs identifies Lead candidates for drug repurposing in Alzheimer's disease","volume":"9","author":"Shityakov","year":"","journal-title":"Front. Chem."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1177\/0194599820910377","article-title":"Hearing loss, loneliness, and social isolation: a systematic review","volume":"162","author":"Shukla","year":"2020","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0378-5955(86)90107-3","article-title":"Overview of mechanical damage to the inner ear: noise as a tool to probe cochlear function","volume":"22","author":"Slepecky","year":"1986","journal-title":"Hear. Res."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jacep.2023.10.015","article-title":"Noninvasive Vagus nerve stimulation in postural tachycardia syndrome: a randomized clinical trial","volume":"10","author":"Stavrakis","year":"2024","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"e023582","DOI":"10.1161\/JAHA.121.023582","article-title":"Neuromodulation of inflammation to treat heart failure with preserved ejection fraction: a pilot randomized clinical trial","volume":"11","author":"Stavrakis","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jacep.2019.11.008","article-title":"TREAT AF (transcutaneous electrical Vagus nerve stimulation to suppress atrial fibrillation): a randomized clinical trial","volume":"6","author":"Stavrakis","year":"2020","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref80","doi-asserted-by":"publisher","first-page":"e115","DOI":"10.1111\/j.1528-1167.2012.03492.x","article-title":"Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial","volume":"53","author":"Stefan","year":"2012","journal-title":"Epilepsia"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"267","DOI":"10.5152\/iao.2018.3977","article-title":"Characteristics of stimulus intensity in transcutaneous Vagus nerve stimulation for chronic tinnitus","volume":"14","author":"Suk","year":"2018","journal-title":"J. Int. Adv. Otol."},{"key":"ref82","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0378-5955(01)00397-5","article-title":"Effect of noise exposure on blood-labyrinth barrier in guinea pigs","volume":"164","author":"Suzuki","year":"2002","journal-title":"Hear. Res."},{"key":"ref83","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s00418-016-1436-5","article-title":"Characterisation of cochlear inflammation in mice following acute and chronic noise exposure","volume":"146","author":"Tan","year":"2016","journal-title":"Histochem. Cell Biol."},{"key":"ref84","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s10162-007-0105-8","article-title":"Rapid hair cell loss: a mouse model for cochlear lesions","volume":"9","author":"Taylor","year":"2008","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref85","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1121\/1.5134465","article-title":"Occupational noise exposure: a review of its effects, epidemiology, and impact with recommendations for reducing its burden","volume":"146","author":"Themann","year":"2019","journal-title":"J. Acoust. Soc. Am."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"109086","DOI":"10.1016\/j.envres.2019.109086","article-title":"Transportation noise impairs cardiovascular function without altering sleep: the importance of autonomic arousals","volume":"182","author":"Thiesse","year":"2020","journal-title":"Environ. Res."},{"key":"ref87","doi-asserted-by":"publisher","first-page":"106905","DOI":"10.1016\/j.envint.2021.106905","article-title":"Noise pollution and human cognition: an updated systematic review and meta-analysis of recent evidence","volume":"158","author":"Thompson","year":"2022","journal-title":"Environ. Int."},{"key":"ref88","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s10162-003-4003-4","article-title":"Purinergic modulation of cochlear partition resistance and its effect on the endocochlear potential in the Guinea pig","volume":"5","author":"Thorne","year":"2004","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"ref89","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0378-5955(87)90192-4","article-title":"Sound-induced artifact in cochlear blood flow measurements using the laser Doppler flowmeter","volume":"31","author":"Thorne","year":"1987","journal-title":"Hear. Res."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12265-018-9853-6","article-title":"Autonomic neuromodulation acutely ameliorates left ventricular strain in humans","volume":"12","author":"Tran","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref91","doi-asserted-by":"publisher","first-page":"11960","DOI":"10.1038\/s41598-017-12178-w","article-title":"Vagus nerve stimulation paired with tones for the treatment of tinnitus: a prospective randomized double-blind controlled pilot study in humans","volume":"7","author":"Tyler","year":"2017","journal-title":"Sci. Rep."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s003810050021","article-title":"Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept","volume":"16","author":"Ventureyra","year":"2000","journal-title":"Childs Nerv. Syst."},{"key":"ref93","doi-asserted-by":"publisher","first-page":"e 2245","DOI":"10.1038\/cddis.2016.156","article-title":"Toll-like receptor 4 modulates the cochlear immune response to acoustic injury","volume":"7","author":"Vethanayagam","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3390\/brainsci10100732","article-title":"Noise induced hearing loss and tinnitus-new research developments and remaining gaps in disease assessment, treatment, and prevention","volume":"10","author":"Wang","year":"2020","journal-title":"Brain Sci."},{"key":"ref95","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1161\/HYPERTENSIONAHA.121.17704","article-title":"Blood pressure and arterial stiffness in association with aircraft noise exposure: long-term observation and potential effect of COVID-19 lockdown","volume":"79","author":"Wojciechowska","year":"2022","journal-title":"Hypertension"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"e0207281","DOI":"10.1371\/journal.pone.0207281","article-title":"BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus","volume":"13","author":"Yakunina","year":"2018","journal-title":"PLoS One"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuroscience.2005.04.015","article-title":"Post-exposure treatment attenuates noise-induced hearing loss","volume":"134","author":"Yamashita","year":"2005","journal-title":"Neuroscience"},{"key":"ref98","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.brs.2018.01.034","article-title":"Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke","volume":"11","author":"Yang","year":"2018","journal-title":"Brain Stimul."},{"key":"ref99","doi-asserted-by":"publisher","first-page":"774585","DOI":"10.3389\/fnins.2021.774585","article-title":"Role of the Stria Vascularis in the pathogenesis of sensorineural hearing loss: a narrative review","volume":"15","author":"Yu","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tcm.2023.07.003","article-title":"Vagus nerve stimulation for cardiovascular diseases: is there light at the end of the tunnel?","volume":"34","author":"Zafeiropoulos","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"1037246","DOI":"10.3389\/fpubh.2022.1037246","article-title":"Relationship between occupational noise exposure and hypertension: cross-sectional evidence from real-world","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Public Health"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"181","DOI":"10.33549\/physiolres.934180","article-title":"Exposure to sodium salicylate disrupts VGLUT3 expression in cochlear inner hair cells and contributes to tinnitus","volume":"69","author":"Zhang","year":"2020","journal-title":"Physiol. Res."},{"key":"ref103","doi-asserted-by":"publisher","first-page":"1488065","DOI":"10.3389\/fpubh.2024.1488065","article-title":"Occupational epidemiological characteristics of noise-induced hearing loss and the impact of combined exposure to noise and dust on workers' hearing-a retrospective study","volume":"12","author":"Zhou","year":"2024","journal-title":"Front. Public Health"}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2025.1523149\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:20:24Z","timestamp":1744003224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2025.1523149\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":103,"alternative-id":["10.3389\/fncel.2025.1523149"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2025.1523149","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,7]]},"article-number":"1523149"}}