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Emphasizing the importance of targeting underlying disease mechanisms beyond traditional neuron-focused therapies, the review delves into the role of astroglia in epilepsy progression. We detail how astroglia transitions from a normal to a pathological state, leading to epileptogenic seizures and cognitive decline. Astroglia activity is correlated with epileptiform activity in both animal models and human tissue, indicating their potential role in seizure induction and modulation. Understanding astroglia\u2019s dual beneficial and detrimental roles could lead to novel treatments for epilepsy and other neurological disorders with aberrant neuronal activity as the underlying disease substrate.<\/jats:p>","DOI":"10.3389\/fncel.2025.1544460","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:13:36Z","timestamp":1742368416000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Astroglia\u2019s role in synchronized spontaneous neuronal activity: from physiology to pathology"],"prefix":"10.3389","volume":"19","author":[{"given":"Aswathy","family":"Ammothumkandy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Cayce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Bonaguidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.cell.2018.05.002","article-title":"Astrocytic activation generates de novo neuronal potentiation and memory enhancement.","volume":"174","author":"Adamsky","year":"2018","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1073\/pnas.0800946105","article-title":"NMDA receptors inhibit synapse unsilencing during brain development.","volume":"105","author":"Adesnik","year":"2008","journal-title":"Proc. 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