{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T21:08:27Z","timestamp":1794517707231,"version":"4.9.1"},"reference-count":186,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Spinal cord ischemia\/reperfusion injury (SCIRI) is a serious disease that leads to the loss of sensory and motor functions and is a common complication after spinal cord injury, spinal cord degeneration or thoracic and abdominal aortic surgery. At present, the spinal cord is mainly protected from ischemic injury through treatment strategies such as hypothermia, surgery and drug assistance, but these intervention measures cannot effectively improve these conditions. SCIRI is a complex process that leads to cell damage and death. Among them, oxidative stress is an important pathological event of ischemia\/reperfusion injury. Oxidative stress can initiate multiple inflammatory and apoptotic pathways, triggering a series of destructive events such as inflammatory responses and cell death, further deteriorating the microenvironment at the injured site, and leading to neurological dysfunction. Based on the important role of oxidative stress in SCIRI, we believe that targeted inhibition of oxidative stress responses can effectively reduce secondary injuries caused by trauma, which has a certain positive effect on the rehabilitation and prognosis of patients with SCIRI. This review systematically expounds the spatiotemporal dynamic characteristics of oxidative stress during the SCIRI process and its molecular regulatory network, with a focus on analyzing the multivariate generation mechanism of ROS. To deeply explore the regulatory effects of ROS on pathological processes such as neuronal death, inflammatory response and blood-spinal barrier disruption under SCIRI conditions, as well as its interaction patterns with signaling pathways. In order to form a systematic treatment for SCIRI caused by oxidative stress and promote the recovery of neurological function after injury. This review is helpful for us to understand the effect of oxidative stress on SCIRI and provides a theoretical basis for the treatment of SCIRI based on oxidative stress.<\/jats:p>","DOI":"10.3389\/fncel.2025.1590493","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T11:21:58Z","timestamp":1750764118000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications"],"prefix":"10.3389","volume":"19","author":[{"given":"Yu","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-zhang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-lin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.reprotox.2020.06.015","article-title":"Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2\/ho-1 pathway and the inhibition of oxidative stress and apoptosis in male rats","volume":"96","author":"Abdel-Wahab","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jare.2020.08.004","article-title":"Role of pyroptosis in spinal cord injury and its therapeutic implications","volume":"28","author":"Al Mamun","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"282","DOI":"10.3389\/fneur.2019.00282","article-title":"Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms","volume":"10","author":"Alizadeh","year":"2019","journal-title":"Front. Neurol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1747-4949.2009.00387.x","article-title":"Oxidative stress and its role in the pathogenesis of ischaemic stroke","volume":"4","author":"Allen","year":"2009","journal-title":"Int. J. Stroke"},{"key":"ref6","first-page":"353","article-title":"Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia\/reperfusion injury and correlation with tissue damage","volume":"19","author":"Altinors","year":"2009","journal-title":"Turk. Neurosurg."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.cdd.4401025","article-title":"Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis","volume":"9","author":"Angkeow","year":"2002","journal-title":"Cell Death Differ."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/jcbfm.2012.158","article-title":"The dynamics of the mitochondrial organelle as a potential therapeutic target","volume":"33","author":"Anne Stetler","year":"2013","journal-title":"J. Cereb. Blood Flow Metabol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1532\/hsf.1590","article-title":"Remote ischemic preconditioning attenuates oxidative stress during cardiopulmonary bypass","volume":"19","author":"Arvola","year":"2016","journal-title":"Heart Surg. Forum"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1742-2094-8-79","article-title":"Microglial p38\u03b1 Mapk is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (Tlr) ligands or beta-amyloid (A\u03b2)","volume":"8","author":"Bachstetter","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.biopha.2016.10.007","article-title":"Tetrandrine protects against oxygen-glucose-serum deprivation\/reoxygenation-induced injury via Pi3K\/Akt\/Nf-\u03baB signaling pathway in rat spinal cord astrocytes","volume":"84","author":"Bao","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"S152","DOI":"10.1161\/CIRCULATIONAHA.112.000024","article-title":"Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury","volume":"128","author":"Bell","year":"2013","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"ref14","first-page":"20313","article-title":"Protein oxidation in aging, disease, and oxidative stress","author":"Berlett","year":"1997"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1152\/physrev.00001.2015","article-title":"The mitochondrial permeability transition pore: channel formation by F-Atp synthase, integration in signal transduction, and role in pathophysiology","volume":"95","author":"Bernardi","year":"2015","journal-title":"Physiol. Rev."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.cellsig.2012.01.018","article-title":"The macrophage response towards Lps and its control through the p38(Mapk)-Stat3 axis","volume":"24","author":"Bode","year":"2012","journal-title":"Cell. Signal."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/S0003-4975(99)01033-4","article-title":"Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription","volume":"68","author":"Boyle","year":"1999","journal-title":"Ann. Thorac. Surg."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp. Gerontol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.redox.2014.02.005","article-title":"Hydrogen peroxide signaling in vascular endothelial cells","volume":"2","author":"Breton-Romero","year":"2014","journal-title":"Redox. Biol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1213\/ANE.0000000000004417","article-title":"Characteristics of Dexmedetomidine Postconditioning in the field of myocardial ischemia-reperfusion injury","volume":"130","author":"Bunte","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.3390\/nu10121920","article-title":"Effects of Millimolar steady-state hydrogen peroxide exposure on inflammatory and redox gene expression in immune cells from humans with metabolic syndrome","volume":"10","author":"Busquets-Cort\u00e9s","year":"2018","journal-title":"Nutrients"},{"key":"ref23","first-page":"483","article-title":"Ischemic preconditioning modulates Ros to confer protection in liver ischemia and reperfusion","volume":"16","author":"Bystrom","year":"2017","journal-title":"EXCLI J."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2018.01.024","article-title":"Ros and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection","volume":"117","author":"Cadenas","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1142\/S0192415X1850026X","article-title":"Anti-apoptotic mechanisms of acupuncture in neurological diseases: a review","volume":"46","author":"Cai","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the Nrf2-are pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"7199","DOI":"10.3390\/ijms12107199","article-title":"Roles of oxidative stress, apoptosis, Pgc-1\u03b1 and mitochondrial biogenesis in cerebral ischemia","volume":"12","author":"Chen","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s12035-014-8869-4","article-title":"Co induces Nrf2-dependent Heme Oxygenase-1 transcription by cooperating with Sp1 and c-Jun in rat brain astrocytes","volume":"52","author":"Chi","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e0118204","DOI":"10.1371\/journal.pone.0118204","article-title":"Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R. sachalinensis","volume":"10","author":"Cui","year":"2015","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1681\/ASN.2006010017","article-title":"Update on mechanisms of ischemic acute kidney injury","volume":"17","author":"Devarajan","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.toxlet.2010.04.011","article-title":"Emp-induced alterations of tight junction protein expression and disruption of the blood-brain barrier","volume":"196","author":"Ding","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an Iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1097\/00000542-200204000-00018","article-title":"Preconditioning with hyperbaric oxygen and Hyperoxia induces tolerance against spinal cord ischemia in rabbits","volume":"96","author":"Dong","year":"2002","journal-title":"Anesthesiology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1097\/ALN.0b013e3181d0486d","article-title":"Limb remote ischemic preconditioning protects the spinal cord from ischemia-reperfusion injury: a newly identified nonneuronal but reactive oxygen species-dependent pathway","volume":"112","author":"Dong","year":"2010","journal-title":"Anesthesiology"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"598","DOI":"10.4103\/NRR.NRR-D-24-00668","article-title":"Role of mitophagy in spinal cord ischemia-reperfusion injury","volume":"21","author":"Duan","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"120726","DOI":"10.1016\/j.lfs.2022.120726","article-title":"Neuroprotective effect of the Nrf2\/are\/mirna145-5p signaling pathway in the early phase of spinal cord injury","volume":"304","author":"Ebrahimy","year":"2022","journal-title":"Life Sci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/8100195","article-title":"Effects of polyphenols on oxidative stress, inflammation, and interconnected pathways during spinal cord injury","volume":"2022","author":"Fakhri","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.3390\/molecules24142640","article-title":"The neuroprotective effects of Astaxanthin: therapeutic targets and clinical perspective","volume":"24","author":"Fakhri","year":"2019","journal-title":"Molecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"966","DOI":"10.3390\/nu9090966","article-title":"Antioxidant therapeutic strategies for cardiovascular conditions associated with oxidative stress","volume":"9","author":"Far\u00edas","year":"2017","journal-title":"Nutrients"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"101984","DOI":"10.1016\/j.redox.2021.101984","article-title":"Iron overload in the motor cortex induces neuronal ferroptosis following spinal cord injury","volume":"43","author":"Feng","year":"2021","journal-title":"Redox Biol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1111\/j.1462-5822.2006.00751.x","article-title":"Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages","volume":"8","author":"Fink","year":"2006","journal-title":"Cell. Microbiol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s13018-020-01790-8","article-title":"Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of Pi3K\/Akt\/Gsk-3\u03b2 pathway in rats","volume":"15","author":"Fu","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1089\/jmf.2017.4021","article-title":"Neuroprotective effects of Luteolin against spinal cord ischemia-reperfusion injury by attenuation of oxidative stress, inflammation, and apoptosis","volume":"21","author":"Fu","year":"2018","journal-title":"J. Med. Food"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1681\/ASN.2013070708","article-title":"Remote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option?","volume":"25","author":"Gassanov","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm2240","article-title":"Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?","volume":"8","author":"Giorgio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"949","DOI":"10.3171\/2015.10.SPINE15612","article-title":"Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis","volume":"24","author":"G\u00f6kce","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1161\/01.HYP.20.1.118","article-title":"Oxygen free radicals and cardiac reperfusion abnormalities","volume":"20","author":"Goldhaber","year":"1992","journal-title":"Hypertension"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox. Biol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0092-8674(00)81728-6","article-title":"Apoptotic pathways: the roads to ruin","volume":"94","author":"Green","year":"1998","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13578-023-00999-4","article-title":"Remote ischemic preconditioning protects against spinal cord ischemia-reperfusion injury in mice by activating Nmdar\/Ampk\/Pgc-1\u03b1\/Sirt3 signaling","volume":"13","author":"Gu","year":"2023","journal-title":"Cell Biosci."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/3549704","article-title":"Salidroside ameliorates mitochondria-dependent neuronal apoptosis after spinal cord ischemia-reperfusion injury partially through inhibiting oxidative stress and promoting Mitophagy","volume":"2020","author":"Gu","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"8975","DOI":"10.12659\/MSM.918665","article-title":"Biochanin a provides neuroprotection against cerebral ischemia\/reperfusion injury by Nrf2-mediated inhibition of oxidative stress and inflammation signaling pathway in rats","volume":"25","author":"Guo","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"646720","DOI":"10.3389\/fendo.2021.646720","article-title":"Biochanin a alleviates cerebral ischemia\/reperfusion injury by suppressing endoplasmic reticulum stress-induced apoptosis and p38MAPK signaling pathway in vivo and in vitro","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s13311-011-0026-4","article-title":"Antioxidant therapies for acute spinal cord injury","volume":"8","author":"Hall","year":"2011","journal-title":"Neurotherapeutics"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s10863-015-9600-5","article-title":"Lipid peroxidation in brain or spinal cord mitochondria after injury","volume":"48","author":"Hall","year":"2016","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref61","first-page":"B5054","article-title":"Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries","volume":"62","author":"Halladin","year":"2015","journal-title":"Dan. Med. J."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.celrep.2016.03.008","article-title":"Inflammation mediated by Jnk in myeloid cells promotes the development of hepatitis and hepatocellular carcinoma","volume":"15","author":"Han","year":"2016","journal-title":"Cell Rep."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"2178","DOI":"10.1016\/j.bbrc.2017.12.100","article-title":"Oxidative stress induced necroptosis activation is involved in the pathogenesis of hyperoxic acute lung injury","volume":"495","author":"Han","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.7150\/thno.37119","article-title":"Upregulation of neuronal Pgc-1\u03b1 ameliorates cognitive impairment induced by chronic cerebral hypoperfusion","volume":"10","author":"Han","year":"2020","journal-title":"Theranostics"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nrcardio.2011.85","article-title":"The therapeutic potential of ischemic conditioning: an update","volume":"8","author":"Hausenloy","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of Nlrp3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"662971","DOI":"10.3389\/fncel.2021.662971","article-title":"Functions and mechanisms of the voltage-gated Proton Channel Hv1 in brain and spinal cord injury","volume":"15","author":"He","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.jvs.2008.05.073","article-title":"Strategies to improve spinal cord ischemia in endovascular thoracic aortic repair: outcomes of a prospective cerebrospinal fluid drainage protocol","volume":"48","author":"Hnath","year":"2008","journal-title":"J. Vasc. Surg."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.biocel.2015.01.021","article-title":"Mitochondria: much ado about nothing? How dangerous is reactive oxygen species production?","volume":"63","author":"Holzerov\u00e1","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref70","first-page":"146","article-title":"Anti-oxidative stress actions and regulation mechanisms of Keap1-Nrf2\/are signal pathway","author":"Hu","year":"2016"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jsbmb.2018.03.001","article-title":"Glucocorticoids induce apoptosis and matrix metalloproteinase-13 expression in chondrocytes through the Nox4\/Ros\/p38 Mapk pathway","volume":"181","author":"Huang","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"7292","DOI":"10.3390\/ijms23137292","article-title":"Molecular mechanisms of Parthanatos and its role in diverse diseases","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1053\/j.jvca.2012.01.025","article-title":"Effect of pretreatment with simvastatin on spinal cord ischemia-reperfusion injury in rats","volume":"27","author":"Hwang","year":"2013","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.3390\/ijms24043772","article-title":"Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with micrornas","volume":"24","author":"Iantomasi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.pnpbp.2004.06.023","article-title":"The protective effect of nebivolol on ischemia\/reperfusion injury in rabbit spinal cord","volume":"28","author":"Ilhan","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. 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Med."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"7266","DOI":"10.3390\/molecules15107266","article-title":"The Nrf2 system as a potential target for the development of indirect antioxidants","volume":"15","author":"Jung","year":"2010","journal-title":"Molecules"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1016\/j.injury.2021.08.004","article-title":"Biochemical, pathological and ultrastructural investigation of whether lamotrigine has neuroprotective efficacy against spinal cord ischemia reperfusion injury","volume":"52","author":"Kahveci","year":"2021","journal-title":"Injury"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/cdd.2017.179","article-title":"Cell suicide as a Bcl-2 family business","volume":"25","author":"Kalkavan","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-1-60327-321-3_15","article-title":"Bioluminescent imaging of Mapk function with intein-mediated reporter gene assay","volume":"574","author":"Kanno","year":"2009","journal-title":"Methods Mol. 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Res."},{"key":"ref100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2015.04.024","article-title":"Remote ischemic post-conditioning improves neurological function by Aqp4 down-regulation in astrocytes","volume":"289","author":"Li","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref101","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nm.4331","article-title":"Pericytes impair capillary blood flow and motor function after chronic spinal cord injury","volume":"23","author":"Li","year":"2017","journal-title":"Nat. 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Surg. Res."},{"key":"ref151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/792639","article-title":"Mitogen-activated protein kinases and reactive oxygen species: how can Ros activate Mapk pathways?","volume":"2011","author":"Son","year":"2011","journal-title":"J. Signal Transd."},{"key":"ref152","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.jtcvs.2009.07.014","article-title":"Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats","volume":"138","author":"Su","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref153","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. 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J."},{"key":"ref165","doi-asserted-by":"publisher","first-page":"102682","DOI":"10.1016\/j.redox.2023.102682","article-title":"Git1-Pgk1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1\/Nrf2 signaling","volume":"62","author":"Xu","year":"2023","journal-title":"Redox Biol."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.5114\/aoms.2015.54863","article-title":"Apelin-13 protects the heart against ischemia-reperfusion injury through the risk-Gsk-3\u03b2-mptp pathway","volume":"11","author":"Yang","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"ref167","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"Ros and diseases: role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"ref168","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.2174\/18715273113129990085","article-title":"Rosuvastatin may have neuroprotective effect on spinal cord ischemia reperfusion injury","volume":"12","author":"Yavuz","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref169","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/s13018-019-1299-2","article-title":"Effects of ginsenoside Rb1 on spinal cord ischemia-reperfusion injury in rats","volume":"14","author":"Ye","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"ref170","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.lfs.2016.03.046","article-title":"Advance in spinal cord ischemia reperfusion injury: blood-spinal cord barrier and remote ischemic preconditioning","volume":"154","author":"Yu","year":"2016","journal-title":"Life Sci."},{"key":"ref171","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12012-015-9342-y","article-title":"Triptolide attenuates myocardial ischemia\/reperfusion injuries in rats by inducing the activation of Nrf2\/ho-1 defense pathway","volume":"16","author":"Yu","year":"2016","journal-title":"Cardiovasc. Toxicol."},{"key":"ref172","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1002\/jnr.25221","article-title":"Oxidative stress following spinal cord injury: from molecular mechanisms to therapeutic targets","volume":"101","author":"Yu","year":"2023","journal-title":"J. Neurosci. Res."},{"key":"ref173","doi-asserted-by":"publisher","first-page":"7283639","DOI":"10.1155\/2019\/7283639","article-title":"Mln4924 exerts a neuroprotective effect against oxidative stress via Sirt1 in spinal cord ischemia-reperfusion injury","volume":"2019","author":"Yu","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref174","doi-asserted-by":"publisher","first-page":"137359","DOI":"10.1016\/j.neulet.2023.137359","article-title":"Usp18 overexpression protects against spinal cord ischemia\/reperfusion injury via regulating autophagy","volume":"810","author":"Yuan","year":"2023","journal-title":"Neurosci. Lett."},{"key":"ref175","doi-asserted-by":"publisher","first-page":"590","DOI":"10.2176\/nmc.ra.2017-0062","article-title":"Ischemic tolerance of the brain and spinal cord: a review","volume":"57","author":"Yunoki","year":"2017","journal-title":"Neurol. Med. Chir."},{"key":"ref176","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1186\/s12967-024-05089-8","article-title":"Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the Sirt1\/Pgc1\u03b1\/Drp1 signaling pathway","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref177","doi-asserted-by":"publisher","first-page":"e2905-e","DOI":"10.1038\/cddis.2017.286","article-title":"Necroptosis in neurodegenerative diseases: a potential therapeutic target","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref178","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/WNR.0000000000001757","article-title":"Ginsenoside Rg1 inhibits oxidative stress and inflammation in rats with spinal cord injury via Nrf2\/ho-1 signaling pathway","volume":"33","author":"Zhang","year":"2022","journal-title":"Neuroreport"},{"key":"ref179","doi-asserted-by":"publisher","first-page":"326","DOI":"10.22074\/cellj.2018.5412","article-title":"Chronic obstructive pulmonary disease molecular subtyping and pathway deviation-based candidate gene identification","volume":"20","author":"Zhao","year":"2018","journal-title":"Cell J."},{"key":"ref180","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.bbrc.2016.09.156","article-title":"5-Aminolevulinic acid with sodium ferrous citrate induces autophagy and protects cardiomyocytes from hypoxia-induced cellular injury through Mapk-Nrf-2-ho-1 signaling cascade","volume":"479","author":"Zhao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref181","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jss.2021.06.055","article-title":"Perillaldehyde alleviates spinal cord ischemia-reperfusion injury via activating the Nrf2 pathway","volume":"268","author":"Zheng","year":"2021","journal-title":"J. Surg. Res."},{"key":"ref182","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","article-title":"New mitochondrial DNA synthesis enables NLRP3 inflammasome activation","volume":"560","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"ref183","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.intimp.2018.05.022","article-title":"Protective role of \u03b2-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury","volume":"61","author":"Zhou","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref184","doi-asserted-by":"publisher","first-page":"e13193","DOI":"10.1111\/cpr.13193","article-title":"Roles of necroptosis in alcoholic liver disease and hepatic pathogenesis","volume":"55","author":"Zhou","year":"2022","journal-title":"Cell Prolif."},{"key":"ref185","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3390\/biom12030403","article-title":"Mitochondrial oxidative stress and cell death in Podocytopathies","volume":"12","author":"Zhu","year":"2022","journal-title":"Biomol. Ther."},{"key":"ref186","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.it.2024.02.002","article-title":"Unlocking potential: the role of the electron transport chain in immunometabolism","volume":"45","author":"Zotta","year":"2024","journal-title":"Trends Immunol."}],"updated-by":[{"DOI":"10.3389\/fncel.2025.1742278","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000}}],"container-title":["Frontiers in Cellular Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2025.1590493\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T16:08:15Z","timestamp":1763654895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fncel.2025.1590493\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":186,"alternative-id":["10.3389\/fncel.2025.1590493"],"URL":"https:\/\/doi.org\/10.3389\/fncel.2025.1590493","relation":{},"ISSN":["1662-5102"],"issn-type":[{"value":"1662-5102","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"article-number":"1590493"}}