{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:08:55Z","timestamp":1792282135535,"version":"4.4.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammation causes reduced markers of GABAergic interneurons and brain-derived neurotrophic factor (BDNF) in the hippocampus, features often associated with neuropsychiatric disease pathophysiology. However, the mechanism connecting inflammation to GABAergic markers remains unclear. We hypothesized that reduced BDNF mediates the effects of LPS on GABAergic markers and that hippocampal BDNF infusion would prevent LPS-induced reduction in somatostatin (SST), and coexpressed markers, including cortistatin (CORT), and neuropeptide Y (NPY).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>C57BL\/6 mice (<jats:italic>n<\/jats:italic>\u202f=\u202f14; 12\u201314\u202fweeks old; 50% female) received intracerebral administration of BDNF (250\u202fng) or vehicle control in the hippocampus via stereotaxic surgery (unilateral). Thirty minutes after BDNF administration, intraperitoneal injection of LPS (2\u202fmg\/kg) or phosphate buffered saline (PBS) was performed and mice were euthanized 18\u202fh post LPS-injection. The hippocampus was collected for investigation of cellular markers using quantitative PCR and enzyme-linked immunosorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LPS administration in mice that did not receive pre-treatment with BDNF led to a significant reduction in <jats:italic>mRNA<\/jats:italic> levels of <jats:italic>Bdnf<\/jats:italic> (<jats:italic>p<\/jats:italic>\u202f=\u202f0.0049), <jats:italic>Sst<\/jats:italic> (<jats:italic>p<\/jats:italic>\u202f=\u202f0.0416), <jats:italic>Npy<\/jats:italic> (<jats:italic>p<\/jats:italic>\u202f=\u202f0.0088), and <jats:italic>Cort<\/jats:italic> (<jats:italic>p<\/jats:italic>\u202f=\u202f0.0055). BDNF infusion into the hippocampus prior to LPS injection prevented the reduction in <jats:italic>Bdnf, Sst,<\/jats:italic> and <jats:italic>Cort m<\/jats:italic>RNA expression. BDNF also prevented the LPS-induced effect on protein levels of BDNF, SST and NPY. BDNF prevention of LPS effects occurred in the context of sustained elevation of inflammatory markers (interleukin 1-beta and glial fibrillary acidic protein).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BDNF may protect SST GABAergic interneurons from LPS-induced inflammation, providing novel insights into the molecular mechanisms linking inflammation and GABAergic dysfunction in neuropsychiatric diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fncel.2025.1675003","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T05:28:18Z","timestamp":1758778098000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain-derived neurotrophic factor prevents LPS-induced dysregulation of GABAergic interneuron markers in mouse hippocampus"],"prefix":"10.3389","volume":"19","author":[{"given":"Sara","family":"Rezaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Banasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Prevot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashika","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Sibille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neures.2023.02.001","article-title":"Astrocytes and brain-derived neurotrophic factor (BDNF)","volume":"197","author":"Albini","year":"2023","journal-title":"Neurosci. 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