{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:00:30Z","timestamp":1793293230941,"version":"4.5.0"},"reference-count":204,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Neurodegenerative diseases are frequently accompanied by inflammatory responses and alterations in lipid metabolism, both of which are believed to negatively affect neural regeneration in mammals. In addition to immune cells, glial cells such as astrocytes and microglia contribute significantly to these inflammatory processes, and it is now recognized that lipid droplet accumulation and cholesterol metabolism are dysregulated in these glial cells. Consequently, recent studies have examined inflammation and lipid metabolism from the standpoint of glial cell function; however, effective therapeutic strategies remain unestablished. By contrast, in zebrafish, a teleost species, robust neural regeneration occurs within a short period after injury to the telencephalon or spinal cord. In this review, we aimed to identify candidate functional factors by comparing mouse and zebrafish disease models and to explore molecules with potential therapeutic relevance for mammalian neurological disorders.<\/jats:p>","DOI":"10.3389\/fncel.2025.1708775","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:29:37Z","timestamp":1765175377000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models"],"prefix":"10.3389","volume":"19","author":[{"given":"Kei","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Ikeshima-Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"5328","DOI":"10.1128\/JVI.00037-14","article-title":"Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-\u03baB activation through TBK1","volume":"88","author":"Abe","year":"2014","journal-title":"J. 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Rec."},{"key":"ref9006","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05023-z","article-title":"SG06, a Chalcone Derivative Targets PI3K\/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer\u2019s Disease-Like Zebrafish Model","author":"Dharshan","year":"2025","journal-title":"Mol Neurobiol."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"568930","DOI":"10.3389\/fnins.2020.568930","article-title":"Common and distinct features of adult neurogenesis and regeneration in the telencephalon of zebrafish and mammals","volume":"14","author":"Diotel","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/s0959-437x(00)00074-5","article-title":"Zebrafish: a model system for the study of human disease","volume":"10","author":"Dooley","year":"2000","journal-title":"Curr. Opin. Genet. 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Neuroinflammation"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s12035-013-8460-4","article-title":"Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury","volume":"48","author":"Gao","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"113395","DOI":"10.1016\/j.celrep.2023.113395","article-title":"Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia","volume":"42","author":"Garza","year":"2023","journal-title":"Cell Rep."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archpsyc.63.2.168","article-title":"Role of genes and environments for explaining Alzheimer disease","volume":"63","author":"Gatz","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"7477","DOI":"10.1523\/JNEUROSCI.0758-12.2012","article-title":"Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish","volume":"32","author":"Goldshmit","year":"2012","journal-title":"J. Neurosci."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4954","DOI":"10.1172\/JCI138179","article-title":"Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration","volume":"130","author":"Gratuze","year":"2020","journal-title":"J. Clin. Invest."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1002\/cne.22511","article-title":"Astroglial structures in the zebrafish brain","volume":"518","author":"Grupp","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer\u2019s disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"9715","DOI":"10.1038\/s41598-018-27990-1","article-title":"2-carba cyclic phosphatidic acid suppresses inflammation via regulation of microglial polarisation in the stab-wounded mouse cerebral cortex","volume":"8","author":"Hashimoto","year":"2018","journal-title":"Sci. Rep."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.ymthe.2023.01.031","article-title":"Astrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation","volume":"31","author":"He","year":"2023","journal-title":"Mol. 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Genet."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-024-03143-2","article-title":"CD36 deletion prevents white matter injury by modulating microglia polarization through the Traf5-MAPK signal pathway","volume":"21","author":"Hou","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.1038\/s12276-024-01355-3","article-title":"Astrocyte-neuron crosstalk through extracellular vesicle-shuttled miRNA-382-5p promotes traumatic brain injury","volume":"56","author":"Hu","year":"2024","journal-title":"Exp. Mol. 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Adv."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mcn.2013.02.002","article-title":"Immunological function of aquaporin-4 in stab-wounded mouse brain in concert with a pro-inflammatory cytokine inducer, osteopontin","volume":"56","author":"Ikeshima-Kataoka","year":"2013","journal-title":"Mol. Cell. Neurosci."},{"key":"ref68","first-page":"409","article-title":"Alteration of inflammatory cytokine production in the injured central nervous system of tenascin-deficient mice","volume":"22","author":"Ikeshima-Kataoka","year":"2008","journal-title":"In Vivo"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/WNR.0000000000000619","article-title":"Correlation between astrocyte activity and recovery from blood-brain barrier breakdown caused by brain injury","volume":"27","author":"Ikeshima-Kataoka","year":"2016","journal-title":"Neuroreport"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. 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Anat."},{"key":"ref156","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0304-4157(84)90005-4","article-title":"The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function","volume":"779","author":"Stubbs","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"ref157","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.freeradbiomed.2012.09.027","article-title":"Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain","volume":"62","author":"Sultana","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref158","doi-asserted-by":"publisher","first-page":"E476","DOI":"10.1073\/pnas.1618657114","article-title":"Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of A\u03b242 and A\u03b240 peptides by \u03b3-secretase","volume":"114","author":"Sun","year":"2017","journal-title":"Proc. Natl. Acad. Sci. 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A practical scale","volume":"304","author":"Teasdale","year":"1974","journal-title":"Lancet"},{"key":"ref162","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41531-024-00640-2","article-title":"Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson\u2019s disease mouse model","volume":"10","author":"Thi Lai","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"ref163","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12974-021-02197-w","article-title":"Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon response","volume":"18","author":"Todd","year":"2021","journal-title":"J. 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Med."},{"key":"ref9009","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-025-01392-x","article-title":"Neuroprotective Effects of Berberine Chloride Against the Aluminium Chloride-Induced Alzheimer\u2019s Disease in Zebra Fish Larvae","author":"Uvarajan","year":"2025","journal-title":"Mol Biotechnol."},{"key":"ref166","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1093\/brain\/awz319","article-title":"Decreased microglial Wnt\/\u03b2-catenin signalling drives microglial pro-inflammatory activation in the developing brain","volume":"142","author":"Van Steenwinckel","year":"2019","journal-title":"Brain"},{"key":"ref167","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12974-023-02934-3","article-title":"IL-1R1 signaling in TBI: assessing chronic impacts and neuroinflammatory dynamics in a mouse model of mild closed-head injury","volume":"20","author":"Vincent","year":"2023","journal-title":"J. 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Neuroinflammation"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/dev.096107","article-title":"Notch3 establishes brain vascular integrity by regulating pericyte number","volume":"141","author":"Wang","year":"2014","journal-title":"Development"},{"key":"ref172","doi-asserted-by":"publisher","first-page":"109151","DOI":"10.1016\/j.cbpc.2021.109151","article-title":"Treatment of Parkinson\u2019s disease in zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments","volume":"249","author":"Wang","year":"2021","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. 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Pathol."},{"key":"ref176","doi-asserted-by":"publisher","first-page":"e202305003","DOI":"10.1083\/jcb.202305003","article-title":"APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size","volume":"223","author":"Windham","year":"2024","journal-title":"J. Cell Biol."},{"key":"ref177","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s13577-024-01161-z","article-title":"\u03b2-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas\/FasL signaling axis","volume":"38","author":"Xia","year":"2024","journal-title":"Hum. 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