{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:42:20Z","timestamp":1776231740262,"version":"3.50.1"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>\n                    N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) is a dynamic RNA modification that regulates RNA stability, processing, and translation and is increasingly recognized as a key modulator of neuronal plasticity. However, how psychostimulant exposure reshapes m\n                    <jats:sup>6<\/jats:sup>\n                    A-dependent regulatory networks across coding and non-coding RNA species remains poorly understood. We investigated the impact of volatilized cocaine (vCOC) exposure on m\n                    <jats:sup>6<\/jats:sup>\n                    A RNA methylation, m\n                    <jats:sup>6<\/jats:sup>\n                    A pathway components, transcriptome, and cocaine-induced locomotor sensitization in\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . Acute vCOC administration significantly increased global m\n                    <jats:sup>6<\/jats:sup>\n                    A levels in total and poly(A)-enriched RNA, with a stronger effect in polyadenylated transcripts. This increase occurred without changes in the m\n                    <jats:sup>6<\/jats:sup>\n                    A methyltransferases Mettl3 and Mettl14 transcripts, but was accompanied by robust upregulation of the levels of m\n                    <jats:sup>6<\/jats:sup>\n                    A reader YTHDC and YTHDF transcripts. Genetic and cell-type-specific analyses revealed distinct and context-dependent roles for m\n                    <jats:sup>6<\/jats:sup>\n                    A writers and readers in neurons and glia, with m\n                    <jats:sup>6<\/jats:sup>\n                    A readers being essential for vCOC-induced locomotor sensitization. Integration of RNA-seq and MeRIP-seq demonstrated that vCOC selectively amplifies m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of regulatory and plasticity-associated RNA classes, including mRNAs involved in RNA processing, antisense RNAs, long non-coding RNAs, and transposable element-derived transcripts. In contrast, m\n                    <jats:sup>6<\/jats:sup>\n                    A-modified RNAs shared in CTRL and vCOC were enriched for core metabolic and mitochondrial pathways, such as oxidative phosphorylation. Notably, vCOC increased m\n                    <jats:sup>6<\/jats:sup>\n                    A modification of non-coding RNAs and transposable elements with minimal overlap with control conditions, indicating cocaine-induced engagement of epitranscriptomic regulation at multiple layers of the transcriptome. Together, these findings reveal that cocaine exposure reinforces an m\n                    <jats:sup>6<\/jats:sup>\n                    A-defined regulatory RNA network, spanning coding and non-coding transcripts that is mechanistically linked to m\n                    <jats:sup>6<\/jats:sup>\n                    A reader-dependent behavioral plasticity.\n                  <\/jats:p>","DOI":"10.3389\/fncel.2026.1810118","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:42:45Z","timestamp":1776228165000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cocaine remodels m6A RNA-dependent signaling to drive locomotor plasticity in Drosophila melanogaster"],"prefix":"10.3389","volume":"20","author":[{"given":"Ana","family":"Filo\u0161evi\u0107 Vujnovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka","place":["Rijeka, Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Miloti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka","place":["Rijeka, Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobana","family":"Samard\u017eija","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka","place":["Rijeka, Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Rubini\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka","place":["Rijeka, Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozi","family":"Andreti\u0107 Waldowski","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Drug Development, University of Rijeka","place":["Rijeka, Croatia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Soldano","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Scuola Internazionale Superiore di Studi Avanzati (SISSA)","place":["Trieste, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1126\/science.285.5430.1066","article-title":"Requirement of circadian genes for cocaine sensitization in Drosophila","volume":"285","author":"Andretic","year":"1999","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e2104131118","DOI":"10.1073\/pnas.2104131118","article-title":"Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster","volume":"118","author":"Baker","year":"","journal-title":"Proc. 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