{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:23:09Z","timestamp":1787743389657,"version":"build-2784847793"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic stroke is a leading cause of disability and mortality worldwide. Ferroptosis\u2014an iron-dependent, lipid peroxidation-driven programmed cell death\u2014has emerged as a key contributor to post-stroke neuronal injury, with research expanding rapidly since 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study employs bibliometric methods to systematically analyze literature on ferroptosis in ischemic stroke from 2017 to 2025, aiming to elucidate the field\u2019s development trajectory, research hotspots, emerging frontiers, and collaborative networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were retrieved from the Web of Science Core Collection and PubMed, limited to English articles and reviews published between 2017 and 2025. For PubMed, an additional search was conducted to capture empirical studies on ferroptosis inhibitors. Bibliometric analyses were performed using VOSviewer, CiteSpace, and Bibliometrix R package.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 646 WoS-indexed articles were analyzed. Annual publication output showed exponential growth. China, the United States, and India led in publication volume, with China accounting for over half of global output; international collaboration centered on China\u2013US partnerships. Research hotspots focused on molecular mechanisms (GPX4, System Xc\n                      <jats:sup>\u2212<\/jats:sup>\n                      , Nrf2\/HO-1), key regulators (ACSL4, FSP1), and therapeutic strategies (ferroptosis inhibitors, natural compounds). Analysis of 64 PubMed-indexed studies on ferroptosis inhibitors revealed that China also dominated this area, with the National Natural Science Foundation of China as the primary funding source. Emerging frontiers indicate a shift from mechanistic studies toward clinical translation, including biomarker development, nano-targeted delivery, and neurovascular unit protection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>From 2017 to 2025, research on ferroptosis in ischemic stroke has rapidly evolved from concept introduction and mechanistic exploration toward clinical translation. Bibliometric analysis delineates a clear trajectory and evolving knowledge framework. Future research will likely emphasize interdisciplinary integration, clinical translation, and personalized therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fncel.2026.1836830","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:59:45Z","timestamp":1787741985000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The research landscape of ferroptosis in ischemic stroke: a bibliometric analysis of the literature from 2017 to 2025 based on the WOS and PubMed databases"],"prefix":"10.3389","volume":"20","author":[{"given":"Hongmei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]},{"name":"School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]},{"name":"School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]},{"name":"School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e808","DOI":"10.1016\/s2214-109x(25)00013-0","article-title":"Co-occurrence patterns and related risk factors of ischaemic heart disease and ischaemic stroke across 203 countries and territories: a spatial correspondence and systematic analysis","volume":"13","author":"An","year":"2025","journal-title":"Lancet Glob. 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