{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:25:08Z","timestamp":1788175508568,"version":"build-2803163510"},"reference-count":132,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>Schwann cells (SCs), the predominant glial cell population in the peripheral nervous system (PNS), have undergone a paradigm shift from historically passive structural components of myelinated axons to active, multifunctional regulators of neural development, regeneration, and neuropathology. This review briefly outlines Schwann cell developmental origin as a biological backdrop, while centering on their inherent phenotypic plasticity and translational applications. Following peripheral nerve injury, SCs rapidly undergo context-dependent dedifferentiation and transcriptional reprogramming, acquiring a regenerative phenotype characterized by phagocytic activity, secretion of neurotrophic factors, and structural reorganization into B\u00fcngner bands. Notably, both endogenous and exogenously delivered SCs demonstrate capacity to migrate into lesioned central nervous system (CNS), including spinal cord injury sites, where they contribute to remyelination, modulation of glial scar formation, and partial restoration of electrophysiological connectivity and behavioral function. These attributes collectively establish SCs as phenotypically adaptable cellular mediators capable of facilitating neural repair across anatomically and functionally distinct compartments. To inform translational efforts, this review critically evaluates emerging strategies, including autologous cell transplantation and SC-derived exosomes, by appraising their mechanisms, limitations, and future perspectives. This review aims to deepen the mechanistic understanding of Schwann cell biology and provide a theoretical basis for the development of regenerative treatments for peripheral nerve injury and spinal cord injury.<\/jats:p>","DOI":"10.3389\/fncel.2026.1845736","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:33:00Z","timestamp":1780896780000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Plasticity, injury-induced reprogramming, and translational applications of Schwann cells in neural regeneration"],"prefix":"10.3389","volume":"20","author":[{"given":"Ye","family":"Zhu","sequence":"first","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Nantong University Xinglin College","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Gu","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University","place":["Nantong, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1523\/JNEUROSCI.3351-09.2010","article-title":"Astrocyte-produced ephrins inhibit Schwann cell migration via VAV2 signaling","volume":"30","author":"Afshari","year":"2010","journal-title":"J. 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J. Mol. Sci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"C-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nn.4541","article-title":"Cell transplantation therapy for spinal cord injury","volume":"20","author":"Assinck","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9919","DOI":"10.1038\/s41598-026-40236-9","article-title":"Altered NGF and GDNF levels reveal neuroimmune dysregulation in COVID-19 patients","volume":"16","author":"Baraz","year":"2026","journal-title":"Sci. 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Cell Biol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1093\/brain\/awr086","article-title":"Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy","volume":"134","author":"Ebenezer","year":"2011","journal-title":"Brain"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1083\/jcb.129.2.443","article-title":"Transforming growth factor-beta 1 regulates axon\/Schwann cell interactions","volume":"129","author":"Einheber","year":"1995","journal-title":"J. Cell Biol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"32482","DOI":"10.1021\/acsnano.5c08885","article-title":"Natural polyphenol-functionalized Schwann cell-derived exosomes as a temporal neuromodulation strategy for diabetic periodontitis therapy","volume":"19","author":"Fan","year":"2025","journal-title":"ACS Nano"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1083\/jcb.200912142","article-title":"Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage","volume":"189","author":"Finzsch","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e17907","DOI":"10.15252\/emmm.202317907","article-title":"Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury","volume":"15","author":"Fuentes-Flores","year":"2023","journal-title":"EMBO Mol. 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Neurotrauma"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s00401-019-02011-1","article-title":"Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph\/ephrin signaling","volume":"138","author":"Garcia-Diaz","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1002\/glia.24568","article-title":"Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters","volume":"72","author":"Gargareta","year":"2024","journal-title":"Glia"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.conb.2013.06.010","article-title":"Signals regulating myelination in peripheral nerves and the Schwann cell response to injury","volume":"23","author":"Glenn","year":"2013","journal-title":"Curr. Opin. 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Neurol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"dev205209","DOI":"10.1242\/dev.205209","article-title":"A dual role for GLI3 signaling in neural crest development","volume":"153","author":"Han","year":"2026","journal-title":"Development"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"28358","DOI":"10.1021\/acsnano.4c10653","article-title":"Chiral hydrogel nerve conduit boosts peripheral nerve regeneration via regulation of Schwann cell reprogramming","volume":"18","author":"Han","year":"2024","journal-title":"ACS Nano"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"7872","DOI":"10.1038\/s41467-025-62964-8","article-title":"Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies","volume":"16","author":"Heming","year":"2025","journal-title":"Nat. Commun."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1077071","DOI":"10.3389\/fncel.2022.1077071","article-title":"Schwann cells-derived exosomes promote functional recovery after spinal cord injury by promoting angiogenesis","volume":"16","author":"Huang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"101985","DOI":"10.1016\/j.tice.2022.101985","article-title":"Low-intensity pulsed ultrasound promotes proliferation and myelinating genes expression of Schwann cells through NRG1\/ErbB signaling pathway","volume":"80","author":"Huang","year":"2023","journal-title":"Tissue Cell"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1038\/s41593-024-01785-2","article-title":"DOR activation in mature oligodendrocytes regulates \u03b1-ketoglutarate metabolism leading to enhanced remyelination in aged mice","volume":"27","author":"Huang","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.actbio.2024.03.029","article-title":"Dual-layer conduit containing VEGF-A \u2013 Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis","volume":"180","author":"Huang","year":"2024","journal-title":"Acta Biomater."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12951-023-02289-0","article-title":"Endothelial cell-derived exosomes boost and maintain repair-related phenotypes of Schwann cells via miR199-5p to promote nerve regeneration","volume":"22","author":"Huang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1002\/glia.24049","article-title":"Mek\/ERK1\/2-MAPK and PI3K\/Akt\/mTOR signaling plays both independent and cooperative roles in Schwann cell differentiation, myelination and dysmyelination","volume":"69","author":"Ishii","year":"2021","journal-title":"Glia"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"6112","DOI":"10.1523\/Jneurosci.5212-13.2014","article-title":"Hdac1 and Hdac2 control the specification of neural crest cells into peripheral glia","volume":"34","author":"Jacob","year":"2014","journal-title":"J. Neurosci."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/glia.23532","article-title":"Repair Schwann cell update: adaptive reprogramming, EMT, and stemness in regenerating nerves","volume":"67","author":"Jessen","year":"2019","journal-title":"Glia"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1002\/glia.20761","article-title":"Negative regulation of myelination: relevance for development, injury, and demyelinating disease","volume":"56","author":"Jessen","year":"2008","journal-title":"Glia"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/glia.23710","article-title":"Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging","volume":"68","author":"Jha","year":"2020","journal-title":"Glia"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"102670","DOI":"10.1016\/j.omtn.2025.102670","article-title":"Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer","volume":"36","author":"Kalpachidou","year":"2025","journal-title":"Molecular Therapy Nucleic Acids"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"4690","DOI":"10.1016\/j.cell.2024.07.033","article-title":"Schwann cell-secreted PGE(2) promotes sensory neuron excitability during development","volume":"187","author":"Kantarci","year":"2024","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2023.10.011","article-title":"The comparative effects of Schwann cells and Wharton's jelly mesenchymal stem cells on the AIM2 inflammasome activity in an experimental model of spinal cord injury","volume":"535","author":"Kharazinejad","year":"2023","journal-title":"Neuroscience"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"6330","DOI":"10.1073\/pnas.82.18.6330","article-title":"Transplants of Schwann cell cultures promote axonal regeneration in th e adult mammalian brain","volume":"82","author":"Kromer","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"110005","DOI":"10.1016\/j.envint.2025.110005","article-title":"Developmental neurotoxicity evaluation of di(2-ethylhexyl) phthalate (DEHP) and three alternative plasticizers in human neurospheres","volume":"207","author":"K\u00fchne","year":"2026","journal-title":"Environ. Int."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/s41419-021-04099-4","article-title":"SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells","volume":"12","author":"Lai","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"859349","DOI":"10.3389\/fnmol.2022.859349","article-title":"Activin a secreted from peripheral nerve fibroblasts promotes proliferation and migration of Schwann cells","volume":"15","author":"Li","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1023\/a:1007026001189","article-title":"Death of oligodendrocytes and microglial phagocytosis of myelin precede immigration of Schwann cells into the spinal cord","volume":"28","author":"Li","year":"1999","journal-title":"J. Neurocytol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.7150\/thno.40919","article-title":"Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1007\/s12264-025-01427-y","article-title":"The dance between Schwann cells and macrophages during the repair of peripheral nerve injury","volume":"41","author":"Li","year":"2025","journal-title":"Neurosci. Bull."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s13287-024-03952-5","article-title":"Exosomes as promising bioactive materials in the treatment of spinal cord injury","volume":"15","author":"Li","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1089\/wound.2021.0194","article-title":"Pulse capacitive coupling electric field regulates cell migration, proliferation, polarization, and vascularization to accelerate wound healing","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Wound Care"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1007\/s12035-022-03182-x","article-title":"The TGR5 agonist INT-777 promotes peripheral nerve regeneration by activating cAMP-dependent protein kinase a in Schwann cells","volume":"60","author":"Liu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"22347","DOI":"10.1073\/pnas.1910292116","article-title":"Myelin sheath structure and regeneration in peripheral nerve injury repair","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"8284","DOI":"10.1097\/JS9.0000000000002955","article-title":"Application and challenge of Schwann cell transplantation in spinal cord injury and clinical trial","volume":"111","author":"Lu","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1083\/jcb.201011077","article-title":"FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk","volume":"194","author":"Martinez-Morales","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"eadu2896","DOI":"10.1126\/science.adu2896","article-title":"Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors","volume":"391","author":"Mironova","year":"2026","journal-title":"Science"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"690894","DOI":"10.3389\/fncel.2021.690894","article-title":"Human Schwann cell transplantation for spinal cord injury: prospects and challenges in translational medicine","volume":"15","author":"Monje","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/jnc.14913","article-title":"TGF-beta1 activates RSC96 Schwann cells migration and invasion through MMP-2 and MMP-9 activities","volume":"153","author":"Muscella","year":"2020","journal-title":"J. Neurochem."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/nano12010003","article-title":"Cytochalasin B treatment and osmotic pressure enhance the production of extracellular vesicles (EVs) with improved drug loading capacity","volume":"12","author":"Nair","year":"2021","journal-title":"Nanomaterials (Basel)"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.15252\/emmm.201607257","article-title":"CXCL12alpha\/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axon terminals","volume":"9","author":"Negro","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1146\/annurev-biochem-100924-012717","article-title":"Extracellular vesicles and cellular homeostasis","volume":"94","author":"Ngo","year":"2025","journal-title":"Annu. Rev. 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