{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:24:45Z","timestamp":1789050285185,"version":"build-2803163510"},"reference-count":267,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell. Neurosci."],"abstract":"<jats:p>\n                    Glutamate receptors in the CNS sensitive to the analog AMPA regulate neuronal excitability and synaptic plasticity. AMPA receptors are usually hetero-tetramers and the human\n                    <jats:italic>GRIA3<\/jats:italic>\n                    gene and GluA3 protein product have been implicated in various CNS abnormalities including epilepsy, multiple sclerosis, schizophrenia, and cognitive disorders. Although not generally found in the immune system,\n                    <jats:italic>GRIA3<\/jats:italic>\n                    has recently been demonstrated in a highly specialized group of immune system cells\u2013plasmacytoid dendritic cells (pDCs). These are among the first cells to be activated by infecting viruses and they express\n                    <jats:italic>GRIA3<\/jats:italic>\n                    in the absence of other AMPA receptor subunits, suggesting a possible role for the subunit in those neuroimmune disorders. The potential for molecular interactions between pDCs and neurons or glia is discussed, with the implications for linking viral infections, pDC activation, and chronic diseases. With growing evidence that the tryptophan metabolite kynurenic acid\u2014an AMPA antagonist\u2014is involved with a similar range of disorders, its role in those links is also discussed.\n                  <\/jats:p>","DOI":"10.3389\/fncel.2026.1885761","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:22:51Z","timestamp":1786335771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["GRIA3: proposal for a neuroimmune role linking infection, stress, chronic disorders and the activity of kynurenic acid"],"prefix":"10.3389","volume":"20","author":[{"given":"Trevor W.","family":"Stone","sequence":"first","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Disorders, The Kennedy Institute of Rheumatology, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix I. 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